pumilio homolog 1 (Drosophila) (PUM1) - coding DNA reference sequence

(used for variant description)

(last modified August 4, 2017)


This file was created to facilitate the description of sequence variants on transcript NM_001020658.1 in the PUM1 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000001.10, covering PUM1 transcript NM_001020658.1.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
           .         .         .         .         .                g.5053
        agtgggccgccatgttgtcggagtgaaaggtaagggggagcgagagcgccaga       c.-61

 .         .         .         .         .         | 02             g.11151
 gagagaagatcggggggctgaaatccatcttcatcctaccgctccgccc | gtgttggtgga    c.-1

          .         .         .         .         .         .       g.11211
 ATGAGCGTTGCATGTGTCTTGAAGAGAAAAGCAGTGCTTTGGCAGGACTCTTTCAGCCCC       c.60
 M  S  V  A  C  V  L  K  R  K  A  V  L  W  Q  D  S  F  S  P         p.20

          .         .         .         .         .         .       g.11271
 CACCTGAAACATCACCCTCAAGAACCAGCTAATCCCAACATGCCTGTTGTTTTGACATCT       c.120
 H  L  K  H  H  P  Q  E  P  A  N  P  N  M  P  V  V  L  T  S         p.40

          .         .         .         .         .         .       g.11331
 GGAACAGGGTCGCAAGCGCAGCCACAACCAGCTGCAAATCAGGCTCTTGCAGCTGGGACT       c.180
 G  T  G  S  Q  A  Q  P  Q  P  A  A  N  Q  A  L  A  A  G  T         p.60

          .         .         .         .         .         .       g.11391
 CACTCCAGCCCTGTCCCAGGATCTATAGGAGTTGCAGGCCGTTCCCAGGACGACGCTATG       c.240
 H  S  S  P  V  P  G  S  I  G  V  A  G  R  S  Q  D  D  A  M         p.80

          .         .         .         .         .         .       g.11451
 GTGGACTACTTCTTTCAGAGGCAGCATGGTGAGCAGCTTGGGGGAGGAGGAAGTGGAGGA       c.300
 V  D  Y  F  F  Q  R  Q  H  G  E  Q  L  G  G  G  G  S  G  G         p.100

          .         .         .         .         .         .       g.11511
 GGCGGCTATAATAATAGCAAACATCGATGGCCTACTGGGGATAACATTCATGCAGAACAT       c.360
 G  G  Y  N  N  S  K  H  R  W  P  T  G  D  N  I  H  A  E  H         p.120

     | 03    .         .         .         .         .         .    g.41910
 CAG | GTGCGTTCCATGGATGAACTGAATCATGATTTTCAAGCACTTGCTCTGGAGGGAAGA    c.420
 Q   | V  R  S  M  D  E  L  N  H  D  F  Q  A  L  A  L  E  G  R      p.140

          .   | 04     .         .         .         .         .    g.63663
 GCGATGGGAGAG | CAGCTCTTGCCAGGTAAAAAGTTTTGGGAAACAGATGAATCCAGCAAA    c.480
 A  M  G  E   | Q  L  L  P  G  K  K  F  W  E  T  D  E  S  S  K      p.160

          .         .         .         .         .         .       g.63723
 GATGGACCAAAAGGAATATTCCTGGGTGATCAATGGCGAGACAGTGCCTGGGGAACATCA       c.540
 D  G  P  K  G  I  F  L  G  D  Q  W  R  D  S  A  W  G  T  S         p.180

   | 05      .         .         .         .         .         .    g.64745
 G | ATCATTCAGTTTCCCAGCCAATCATGGTGCAGAGAAGACCTGGTCAGAGTTTCCATGTG    c.600
 D |   H  S  V  S  Q  P  I  M  V  Q  R  R  P  G  Q  S  F  H  V      p.200

          .         .         .         .         .         .       g.64805
 AACAGTGAGGTCAATTCTGTACTGTCCCCACGATCGGAGAGTGGGGGACTAGGCGTTAGC       c.660
 N  S  E  V  N  S  V  L  S  P  R  S  E  S  G  G  L  G  V  S         p.220

          .         .         .         .         .         .       g.64865
 ATGGTGGAGTATGTGTTGAGCTCATCCCCGGGCGATTCCTGTCTAAGAAAAGGAGGATTT       c.720
 M  V  E  Y  V  L  S  S  S  P  G  D  S  C  L  R  K  G  G  F         p.240

  | 06       .         .         .         .         .         .    g.75557
  | GGCCCAAGGGATGCAGACAGTGATGAAAACGACAAAGGTGAAAAGAAGAACAAGGGTACG    c.780
  | G  P  R  D  A  D  S  D  E  N  D  K  G  E  K  K  N  K  G  T      p.260

          .         .         .         .         .         .       g.75617
 TTTGATGGAGATAAGCTAGGAGATTTGAAGGAGGAGGGTGATGTGATGGACAAGACCAAT       c.840
 F  D  G  D  K  L  G  D  L  K  E  E  G  D  V  M  D  K  T  N         p.280

          .         .         .         .        | 07.         .    g.78070
 GGTTTACCAGTGCAGAATGGGATTGATGCAGACGTCAAAGATTTTAG | CCGTACCCCTGGT    c.900
 G  L  P  V  Q  N  G  I  D  A  D  V  K  D  F  S  |  R  T  P  G      p.300

          .         .         .         .         .         .       g.78130
 AATTGCCAGAACTCTGCTAATGAAGTGGATCTTCTGGGTCCAAACCAGAATGGTTCTGAG       c.960
 N  C  Q  N  S  A  N  E  V  D  L  L  G  P  N  Q  N  G  S  E         p.320

          .         .         .         .         .         .       g.78190
 GGCTTAGCCCAGCTGACCAGCACCAATGGTGCCAAGCCTGTGGAGGATTTCTCCAACATG       c.1020
 G  L  A  Q  L  T  S  T  N  G  A  K  P  V  E  D  F  S  N  M         p.340

          .         .         .         .         .         .       g.78250
 GAGTCCCAGAGTGTCCCCTTGGACCCCATGGAACATGTGGGCATGGAGCCTCTTCAGTTT       c.1080
 E  S  Q  S  V  P  L  D  P  M  E  H  V  G  M  E  P  L  Q  F         p.360

          .         .         .         .         .         .       g.78310
 GATTATTCAGGCACGCAGGTACCTGTGGACTCAGCAGCAGCAACTGTGGGACTTTTTGAC       c.1140
 D  Y  S  G  T  Q  V  P  V  D  S  A  A  A  T  V  G  L  F  D         p.380

          .         | 08         .         .         .         .    g.89354
 TACAATTCTCAACAACAG | CTGTTCCAAAGACCTAATGCGCTTGCTGTCCAGCAGTTGACA    c.1200
 Y  N  S  Q  Q  Q   | L  F  Q  R  P  N  A  L  A  V  Q  Q  L  T      p.400

          .         .         .         .         .   | 09     .    g.90562
 GCTGCTCAGCAGCAGCAGTATGCACTGGCAGCTGCTCATCAGCCGCACATCG | GTTTAGCT    c.1260
 A  A  Q  Q  Q  Q  Y  A  L  A  A  A  H  Q  P  H  I  G |   L  A      p.420

          .         .         .         .         .         .       g.90622
 CCCGCTGCGTTTGTCCCCAATCCATACATCATCAGCGCTGCTCCCCCAGGGACGGACCCC       c.1320
 P  A  A  F  V  P  N  P  Y  I  I  S  A  A  P  P  G  T  D  P         p.440

          .         .         .     | 10   .         .         .    g.95941
 TACACAGCTGGATTGGCTGCAGCAGCGACACTAG | GCCCAGCTGTGGTCCCTCACCAGTAT    c.1380
 Y  T  A  G  L  A  A  A  A  T  L  G |   P  A  V  V  P  H  Q  Y      p.460

          .         .         .         .         .         .       g.96001
 TATGGAGTTACTCCCTGGGGAGTCTACCCTGCCAGTCTTTTCCAGCAGCAAGCTGCCGCT       c.1440
 Y  G  V  T  P  W  G  V  Y  P  A  S  L  F  Q  Q  Q  A  A  A         p.480

          .         .         .         .         .         .       g.96061
 GCCGCTGCAGCAACTAATTCAGCTAATCAACAGACCACCCCACAGGCTCAGCAAGGACAG       c.1500
 A  A  A  A  T  N  S  A  N  Q  Q  T  T  P  Q  A  Q  Q  G  Q         p.500

        | 11 .         .         .         .         .         .    g.102279
 CAGCAG | GTTCTCCGTGGAGGAGCCAGCCAACGTCCTTTGACCCCAAACCAGAACCAGCAG    c.1560
 Q  Q   | V  L  R  G  G  A  S  Q  R  P  L  T  P  N  Q  N  Q  Q      p.520

          .         .         .         .         .         .       g.102339
 GGACAGCAAACGGATCCCCTTGTGGCAGCTGCAGCAGTGAATTCTGCCCTTGCATTTGGA       c.1620
 G  Q  Q  T  D  P  L  V  A  A  A  A  V  N  S  A  L  A  F  G         p.540

          .         .      | 12  .         .         .         .    g.103442
 CAAGGTCTGGCAGCAGGCATGCCAG | GTTATCCGGTGTTGGCTCCTGCTGCTTACTATGAC    c.1680
 Q  G  L  A  A  G  M  P  G |   Y  P  V  L  A  P  A  A  Y  Y  D      p.560

          .         .         .         .         .         .       g.103502
 CAAACTGGTGCCCTTGTAGTGAATGCAGGCGCGAGAAATGGTCTTGGAGCTCCTGTTCGA       c.1740
 Q  T  G  A  L  V  V  N  A  G  A  R  N  G  L  G  A  P  V  R         p.580

          .         .         .         .          | 13        .    g.104450
 CTTGTAGCTCCTGCCCCAGTCATCATTAGTTCCTCAGCTGCACAAGCAG | CTGTTGCAGCA    c.1800
 L  V  A  P  A  P  V  I  I  S  S  S  A  A  Q  A  A |   V  A  A      p.600

          .         .         .         .         .         .       g.104510
 GCCGCAGCTTCAGCAAATGGAGCAGCTGGTGGTCTTGCTGGAACAACAAATGGACCATTT       c.1860
 A  A  A  S  A  N  G  A  A  G  G  L  A  G  T  T  N  G  P  F         p.620

          .         .         .         .         .         .       g.104570
 CGCCCTTTAGGAACACAGCAGCCTCAGCCCCAGCCCCAGCAGCAGCCCAATAACAACCTG       c.1920
 R  P  L  G  T  Q  Q  P  Q  P  Q  P  Q  Q  Q  P  N  N  N  L         p.640

          .         .         .         .         .         .       g.104630
 GCATCCAGTTCTTTCTACGGCAACAACTCTCTGAACAGCAATTCACAGAGCAGCTCCCTC       c.1980
 A  S  S  S  F  Y  G  N  N  S  L  N  S  N  S  Q  S  S  S  L         p.660

          .         .         .         .         .         .       g.104690
 TTCTCCCAGGGCTCTGCCCAGCCTGCCAACACATCCTTGGGATTCGGAAGTAGCAGTTCT       c.2040
 F  S  Q  G  S  A  Q  P  A  N  T  S  L  G  F  G  S  S  S  S         p.680

          .         .         .         .       | 14 .         .    g.105821
 CTCGGCGCCACCCTGGGATCCGCCCTTGGAGGGTTTGGAACAGCAG | TTGCAAACTCCAAC    c.2100
 L  G  A  T  L  G  S  A  L  G  G  F  G  T  A  V |   A  N  S  N      p.700

          .         .         .         .         .         .       g.105881
 ACTGGCAGTGGCTCCCGCCGTGACTCCCTGACTGGCAGCAGTGACCTTTATAAGAGGACA       c.2160
 T  G  S  G  S  R  R  D  S  L  T  G  S  S  D  L  Y  K  R  T         p.720

          .         .         .         .         .         .       g.105941
 TCGAGCAGCTTGACCCCCATTGGACACAGTTTTTATAACGGCCTTAGCTTTTCCTCCTCT       c.2220
 S  S  S  L  T  P  I  G  H  S  F  Y  N  G  L  S  F  S  S  S         p.740

          .         .         .         .         .         .       g.106001
 CCTGGACCCGTGGGCATGCCTCTCCCTAGTCAGGGACCAGGACATTCACAGACACCACCT       c.2280
 P  G  P  V  G  M  P  L  P  S  Q  G  P  G  H  S  Q  T  P  P         p.760

          .         .         .         .    | 15    .         .    g.116753
 CCTTCCCTCTCTTCACATGGATCCTCTTCAAGCTTAAACCTGG | GAGGACTCACGAATGGC    c.2340
 P  S  L  S  S  H  G  S  S  S  S  L  N  L  G |   G  L  T  N  G      p.780

          .         .         .         .         .         .       g.116813
 AGTGGAAGATACATCTCTGCTGCTCCAGGCGCTGAAGCCAAGTACCGCAGTGCAAGCAGC       c.2400
 S  G  R  Y  I  S  A  A  P  G  A  E  A  K  Y  R  S  A  S  S         p.800

          .         .         .         .         .         .       g.116873
 GCCTCCAGCCTCTTCAGCCCGAGCAGCACTCTTTTCTCTTCCTCTCGTTTGCGATATGGA       c.2460
 A  S  S  L  F  S  P  S  S  T  L  F  S  S  S  R  L  R  Y  G         p.820

          .         .         .         .         .         .       g.116933
 ATGTCTGATGTCATGCCTTCTGGCAGGAGCAGGCTTTTGGAAGATTTTCGAAACAACCGG       c.2520
 M  S  D  V  M  P  S  G  R  S  R  L  L  E  D  F  R  N  N  R         p.840

          .         .         .         .         .         .       g.116993
 TACCCCAATTTACAACTGCGGGAGATTGCTGGACATATAATGGAATTTTCCCAAGACCAG       c.2580
 Y  P  N  L  Q  L  R  E  I  A  G  H  I  M  E  F  S  Q  D  Q         p.860

          .  | 16      .         .         .         .         .    g.118403
 CATGGGTCCAG | ATTCATTCAGCTGAAACTGGAGCGTGCCACACCAGCTGAGCGCCAGCTT    c.2640
 H  G  S  R  |  F  I  Q  L  K  L  E  R  A  T  P  A  E  R  Q  L      p.880

          .         .         .         .         .         .       g.118463
 GTCTTCAATGAAATCCTCCAGGCTGCCTACCAACTCATGGTGGATGTGTTTGGTAATTAC       c.2700
 V  F  N  E  I  L  Q  A  A  Y  Q  L  M  V  D  V  F  G  N  Y         p.900

          .         .  | 17      .         .         .         .    g.120495
 GTCATTCAGAAGTTCTTTGAA | TTTGGCAGTCTTGAACAGAAGCTGGCTTTGGCAGAACGG    c.2760
 V  I  Q  K  F  F  E   | F  G  S  L  E  Q  K  L  A  L  A  E  R      p.920

          .         .         .         .         .         .       g.120555
 ATTCGAGGCCACGTCCTGTCATTGGCACTACAGATGTATGGCTGCCGTGTTATCCAGAAA       c.2820
 I  R  G  H  V  L  S  L  A  L  Q  M  Y  G  C  R  V  I  Q  K         p.940

          .         .         .       | 18 .         .         .    g.125258
 GCTCTTGAGTTTATTCCTTCAGACCAGCAGGTAATT | AATGAGATGGTTCGGGAACTAGAT    c.2880
 A  L  E  F  I  P  S  D  Q  Q  V  I   | N  E  M  V  R  E  L  D      p.960

          .         .         .         .         .         .       g.125318
 GGCCATGTCTTGAAGTGTGTGAAAGATCAGAATGGCAATCACGTGGTTCAGAAATGCATT       c.2940
 G  H  V  L  K  C  V  K  D  Q  N  G  N  H  V  V  Q  K  C  I         p.980

          .         .         .         .         .     | 19   .    g.128600
 GAATGTGTACAGCCCCAGTCTTTGCAATTTATCATCGATGCGTTTAAGGGACAG | GTATTT    c.3000
 E  C  V  Q  P  Q  S  L  Q  F  I  I  D  A  F  K  G  Q   | V  F      p.1000

          .         .         .         .         .         .       g.128660
 GCCTTATCCACACATCCTTATGGCTGCCGAGTGATTCAGAGAATCCTGGAGCACTGTCTC       c.3060
 A  L  S  T  H  P  Y  G  C  R  V  I  Q  R  I  L  E  H  C  L         p.1020

          .         .         .         .         .         .       g.128720
 CCTGACCAGACACTCCCTATTTTAGAGGAGCTTCACCAGCACACAGAGCAGCTTGTACAG       c.3120
 P  D  Q  T  L  P  I  L  E  E  L  H  Q  H  T  E  Q  L  V  Q         p.1040

  | 20       .         .         .         .         .         .    g.129505
  | GATCAATATGGAAATTATGTAATCCAACATGTACTGGAGCACGGTCGTCCTGAGGATAAA    c.3180
  | D  Q  Y  G  N  Y  V  I  Q  H  V  L  E  H  G  R  P  E  D  K      p.1060

          .         .         .         .         .         .       g.129565
 AGCAAAATTGTAGCAGAAATCCGAGGCAATGTACTTGTATTGAGTCAGCACAAATTTGCA       c.3240
 S  K  I  V  A  E  I  R  G  N  V  L  V  L  S  Q  H  K  F  A         p.1080

    | 21     .         .         .         .         .         .    g.133940
 AG | CAATGTTGTGGAGAAGTGTGTTACTCACGCCTCACGTACGGAGCGCGCTGTGCTCATC    c.3300
 S  |  N  V  V  E  K  C  V  T  H  A  S  R  T  E  R  A  V  L  I      p.1100

          .         .         .         .         .         .       g.134000
 GATGAGGTGTGCACCATGAACGACGGTCCCCACAGTGCCTTATACACCATGATGAAGGAC       c.3360
 D  E  V  C  T  M  N  D  G  P  H  S  A  L  Y  T  M  M  K  D         p.1120

          .         .         .         .         .         .       g.134060
 CAGTATGCCAACTACGTGGTCCAGAAGATGATTGACGTGGCGGAGCCAGGCCAGCGGAAG       c.3420
 Q  Y  A  N  Y  V  V  Q  K  M  I  D  V  A  E  P  G  Q  R  K         p.1140

          .      | 22  .         .         .         .         .    g.137420
 ATCGTCATGCATAAG | ATCCGGCCCCACATCGCAACTCTTCGTAAGTACACCTATGGCAAG    c.3480
 I  V  M  H  K   | I  R  P  H  I  A  T  L  R  K  Y  T  Y  G  K      p.1160

          .         .         .         .         .         .       g.137480
 CACATTCTGGCCAAGCTGGAGAAGTACTACATGAAGAACGGTGTTGACTTAGGGCCCATC       c.3540
 H  I  L  A  K  L  E  K  Y  Y  M  K  N  G  V  D  L  G  P  I         p.1180

          .         .                                               g.137507
 TGTGGCCCCCCTAATGGTATCATCTGA                                        c.3567
 C  G  P  P  N  G  I  I  X                                          p.1188

          .         .         .         .         .         .       g.137567
 ggcagtgtcacccgctgttccctcattcccgctgacctcactggcccactggcaaatcca       c.*60

          .         .         .         .         .         .       g.137627
 accagcaaccagaaatgttctagtgtagagtctgagacgggcaagtggttgctccaggat       c.*120

          .         .         .         .         .         .       g.137687
 tactccctcctccaaaaaaggaatcaaatccacgagtggaaaagcctttgtaaatttaat       c.*180

          .         .         .         .         .         .       g.137747
 tttattacacataacatgtactattttttttaattgactaattgccctgctgttttactg       c.*240

          .         .         .         .         .         .       g.137807
 gtgtataggatacttgtacataggtaaccaatgtacatgggaggccacatattttgttca       c.*300

          .         .         .         .         .         .       g.137867
 ctgttgtatctatatttcacatgtggaaactttcagggtggttggtttaacaaaaaaaaa       c.*360

          .         .         .         .         .         .       g.137927
 aagctttaaaaaaaaaagaaaaaaaggaaaaggtttttagctcatttgcctggccggcaa       c.*420

          .         .         .         .         .         .       g.137987
 gttttgcaaatagctcttccccacctcctcattttagtaaaaaacaaacaaaaacaaaaa       c.*480

          .         .         .         .         .         .       g.138047
 aacctgagaagtttgaattgtagttaaatgaccccaaactggcatttaacactgtttata       c.*540

          .         .         .         .         .         .       g.138107
 aaaaatatatatatatatatatatatatataatgaaaaaggtttcagagttgctaaagct       c.*600

          .         .         .         .         .         .       g.138167
 tcagtttgtgacattaagtttatgaaattctaaaaaatgccttttttggagactatatta       c.*660

          .         .         .         .         .         .       g.138227
 tgctgaagaaggctgttcgtgaggaggagatgcgagcacccagaacgtcttttgaggctg       c.*720

          .         .         .         .         .         .       g.138287
 ggcgggtgtgattgtttactgcctactggatttttttctattaacattgaaaggtaaaat       c.*780

          .         .         .         .         .         .       g.138347
 ctgattatttagcatgagaaaaaaaaatccaactctgcttttggtcttgcttctataaat       c.*840

          .         .         .         .         .         .       g.138407
 atatagtgtatacttggtgtagactttgcatatatacaaatttgtagtattttcttgttt       c.*900

          .         .         .         .         .         .       g.138467
 tgatgtctaatctgtatctataatgtaccctagtagtcgaacatacttttgattgtacaa       c.*960

          .         .         .         .         .         .       g.138527
 ttgtacatttgtatacctgtaatgtaaatgtggagaagtttgaatcaacataaacacgtt       c.*1020

          .         .         .         .         .         .       g.138587
 ttttggtaagaaaagagaattagccagccctgtgcattcagtgtatattctcacctttta       c.*1080

          .         .         .         .         .         .       g.138647
 tggtcgtagcatatagtgttgtatattgtaaattgtaatttcaaccagaagtaaattttt       c.*1140

          .         .         .         .         .         .       g.138707
 ttcttttgaaggaataaatgttctttatacagcctagttaatgtttaaaaagaaaaaaat       c.*1200

          .         .         .         .         .         .       g.138767
 agcttggttttatttgtcatctagtctcaagtatagcgagattctttctaaatgttattc       c.*1260

          .         .         .         .         .         .       g.138827
 aagattgagttctcactagtgtttttttaatcctaaaaaagtaatgttttgattttgtga       c.*1320

          .         .         .         .         .         .       g.138887
 cagtcaaaaggacgtgcaaaagtctagccttgcccgagctttccttacaatcagagcccc       c.*1380

          .         .         .         .         .         .       g.138947
 tctcaccttgtaaagtgtgaatcgcccttcccttttgtacagaagatgaactgtattttg       c.*1440

          .         .         .         .         .         .       g.139007
 cattttgtctacttgtaagtgaatgtaacatactgtcaattttccttgtttgaatataga       c.*1500

          .         .         .         .         .         .       g.139067
 attgtaacactacacggtgtacatttccagagccttgtgtatatttccaatgaacttttt       c.*1560

          .         .         .         .         .         .       g.139127
 tgcaagcacacttgtaaccatatgtgtataattaacaaacctgtgtatgcttatgcctgg       c.*1620

          .         .         .         .         .         .       g.139187
 gcaactattttttgtaactcttgtgtagattgtctctaaacaatgtgtgatctttatttt       c.*1680

          .         .                                               g.139212
 gaaaaatacagaactttggaatctg                                          c.*1705

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Pumilio homolog 1 (Drosophila) protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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