pseudouridylate synthase 7 homolog (S. cerevisiae) (PUS7) - coding DNA reference sequence

(used for variant description)

(last modified October 31, 2021)


This file was created to facilitate the description of sequence variants on transcript NM_019042.3 in the PUS7 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000007.13, covering PUS7 transcript NM_019042.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                               .         .         .                g.5039
                      gtgcgagcccggccgccggtgagtcggctggagcgcatc       c.-181

 .         .         .         .         .         .                g.5099
 tggtcctccgcgcggaaagcgctgcttttgcctggccgccctagccgctggctcatccaa       c.-121

 .         .         .         .         .         .                g.5159
 gtggccttcgccgctctcttgcgtcccaaccagagcgctggccacctcgccgcccagctc       c.-61

 .         .         .        | 02.         .         .             g.18726
 acgccgcgcccgcgctcccaggctccgg | gttttcttaaatgttttcttggagccttaaag    c.-1

          .         .         .         .         .         .       g.18786
 ATGGAGATGACAGAAATGACTGGTGTGTCGCTGAAACGTGGGGCACTGGTTGTCGAAGAT       c.60
 M  E  M  T  E  M  T  G  V  S  L  K  R  G  A  L  V  V  E  D         p.20

          .         .         .         .         .         .       g.18846
 AATGACAGTGGAGTCCCAGTTGAAGAGACAAAAAAACAGAAGCTGTCGGAATGCAGTCTA       c.120
 N  D  S  G  V  P  V  E  E  T  K  K  Q  K  L  S  E  C  S  L         p.40

          .         .         .         .         .         .       g.18906
 ACCAAAGGTCAAGATGGGCTACAGAATGACTTTCTGTCCATCAGTGAAGACGTGCCTCGG       c.180
 T  K  G  Q  D  G  L  Q  N  D  F  L  S  I  S  E  D  V  P  R         p.60

          .         .         .         .         .         .       g.18966
 CCTCCTGACACTGTCAGTACTGGGAAAGGTGGAAAGAATTCTGAGGCTCAGTTGGAAGAT       c.240
 P  P  D  T  V  S  T  G  K  G  G  K  N  S  E  A  Q  L  E  D         p.80

          .         .         .         .         .         .       g.19026
 GAGGAAGAAGAGGAGGAAGATGGACTTTCAGAGGAGTGCGAGGAGGAGGAATCAGAGAGT       c.300
 E  E  E  E  E  E  D  G  L  S  E  E  C  E  E  E  E  S  E  S         p.100

          .         .         .         .         .         .       g.19086
 TTTGCAGACATGATGAAGCATGGACTCACTGAGGCTGACGTAGGCATCACCAAGTTTGTG       c.360
 F  A  D  M  M  K  H  G  L  T  E  A  D  V  G  I  T  K  F  V         p.120

          .         .         .         | 03         .         .    g.20987
 AGTTCTCATCAAGGGTTCTCGGGAATCTTAAAAGAAAG | ATACTCCGACTTCGTTGTTCAT    c.420
 S  S  H  Q  G  F  S  G  I  L  K  E  R  |  Y  S  D  F  V  V  H      p.140

          .         .         .         .         .         .       g.21047
 GAAATAGGAAAAGATGGACGGATCAGCCATTTGAATGACTTGTCCATTCCAGTGGATGAG       c.480
 E  I  G  K  D  G  R  I  S  H  L  N  D  L  S  I  P  V  D  E         p.160

     | 04    .         .         .         .         .         .    g.21239
 GAG | GACCCTTCAGAAGACATATTTACAGTTTTGACAGCTGAAGAAAAGCAGCGATTGGAA    c.540
 E   | D  P  S  E  D  I  F  T  V  L  T  A  E  E  K  Q  R  L  E      p.180

          .         .         .         .      | 05  .         .    g.24689
 GAGCTCCAGCTGTTCAAAAATAAGGAAACCAGTGTTGCCATTGAG | GTTATCGAGGACACC    c.600
 E  L  Q  L  F  K  N  K  E  T  S  V  A  I  E   | V  I  E  D  T      p.200

          .         .         .         .         .         .       g.24749
 AAAGAGAAAAGAACCATCATCCATCAGGCTATCAAATCTCTGTTTCCAGGATTAGAGACA       c.660
 K  E  K  R  T  I  I  H  Q  A  I  K  S  L  F  P  G  L  E  T         p.220

          .         .         .         .         .         .       g.24809
 AAAACAGAGGATAGGGAGGGGAAGAAATACATTGTAGCCTACCACGCAGCTGGGAAAAAG       c.720
 K  T  E  D  R  E  G  K  K  Y  I  V  A  Y  H  A  A  G  K  K         p.240

          . | 06       .         .         .         .         .    g.32035
 GCTTTGGCAA | ATCCAAGAAAACATTCTTGGCCAAAATCTAGGGGAAGTTACTGCCACTTC    c.780
 A  L  A  N |   P  R  K  H  S  W  P  K  S  R  G  S  Y  C  H  F      p.260

          .         .         .         .         .         .       g.32095
 GTACTATATAAGGAAAACAAAGACACCATGGATGCTATTAATGTACTCTCCAAATACTTA       c.840
 V  L  Y  K  E  N  K  D  T  M  D  A  I  N  V  L  S  K  Y  L         p.280

    | 07     .         .         .         .         .         .    g.35679
 AG | AGTCAAGCCAAATATATTCTCCTACATGGGAACCAAAGATAAAAGGGCTATAACAGTT    c.900
 R  |  V  K  P  N  I  F  S  Y  M  G  T  K  D  K  R  A  I  T  V      p.300

          .         . | 08       .         .         .         .    g.44838
 CAAGAAATTGCTGTTCTCAA | AATAACTGCACAAAGACTTGCCCACCTGAATAAGTGCTTG    c.960
 Q  E  I  A  V  L  K  |  I  T  A  Q  R  L  A  H  L  N  K  C  L      p.320

          .         .         .         .         .         .       g.44898
 ATGAACTTTAAGCTAGGGAATTTCAGCTATCAAAAAAACCCACTGAAATTGGGAGAGCTT       c.1020
 M  N  F  K  L  G  N  F  S  Y  Q  K  N  P  L  K  L  G  E  L         p.340

          .         .          | 09        .         .         .    g.46092
 CAAGGAAACCACTTCACTGTTGTTCTCAG | AAATATAACAGGAACTGATGACCAAGTACAG    c.1080
 Q  G  N  H  F  T  V  V  L  R  |  N  I  T  G  T  D  D  Q  V  Q      p.360

          .         .         .         .         .         .       g.46152
 CAAGCTATGAACTCTCTCAAGGAGATTGGATTTATTAACTACTATGGAATGCAAAGATTT       c.1140
 Q  A  M  N  S  L  K  E  I  G  F  I  N  Y  Y  G  M  Q  R  F         p.380

          .         .         .      | 10  .         .         .    g.55070
 GGAACCACAGCTGTCCCTACGTATCAGGTTGGAAG | AGCTATACTACAAAATTCCTGGACA    c.1200
 G  T  T  A  V  P  T  Y  Q  V  G  R  |  A  I  L  Q  N  S  W  T      p.400

          .         .         .        | 11.         .         .    g.56413
 GAAGTCATGGATTTAATATTGAAACCCCGCTCTGGAG | CTGAAAAGGGCTACTTGGTTAAA    c.1260
 E  V  M  D  L  I  L  K  P  R  S  G  A |   E  K  G  Y  L  V  K      p.420

          .         .         .         .         .         .       g.56473
 TGCAGAGAAGAATGGGCAAAGACCAAAGACCCAACTGCTGCCCTCAGAAAACTACCTGTC       c.1320
 C  R  E  E  W  A  K  T  K  D  P  T  A  A  L  R  K  L  P  V         p.440

          .         .         .         .         .         .       g.56533
 AAAAGGTGTGTGGAAGGGCAGCTGCTTCGAGGACTTTCAAAATATGGAATGAAGAATATA       c.1380
 K  R  C  V  E  G  Q  L  L  R  G  L  S  K  Y  G  M  K  N  I         p.460

          .         | 12         .         .         .         .    g.58817
 GTCTCTGCATTTGGCATA | ATACCCAGAAATAATCGCTTAATGTATATTCATAGCTACCAA    c.1440
 V  S  A  F  G  I   | I  P  R  N  N  R  L  M  Y  I  H  S  Y  Q      p.480

          .         .         .         .         .         .       g.58877
 AGCTATGTGTGGAATAACATGGTAAGCAAGAGGATAGAAGACTATGGACTAAAACCTGTT       c.1500
 S  Y  V  W  N  N  M  V  S  K  R  I  E  D  Y  G  L  K  P  V         p.500

          .         .      | 13  .         .         .         .    g.61859
 CCAGGGGACCTCGTTCTCAAAGGAG | CCACAGCCACCTATATTGAGGAAGATGATGTTAAT    c.1560
 P  G  D  L  V  L  K  G  A |   T  A  T  Y  I  E  E  D  D  V  N      p.520

          .         .         .         .         .         .       g.61919
 AATTACTCTATCCATGATGTGGTAATGCCCTTGCCTGGTTTCGATGTTATCTACCCAAAG       c.1620
 N  Y  S  I  H  D  V  V  M  P  L  P  G  F  D  V  I  Y  P  K         p.540

         | 14.         .         .         .         .         .    g.64541
 CATAAAA | TTCAAGAAGCCTACAGGGAAATGCTCACAGCTGACAATCTTGATATTGACAAC    c.1680
 H  K  I |   Q  E  A  Y  R  E  M  L  T  A  D  N  L  D  I  D  N      p.560

          .         .         .         .         .         .       g.64601
 ATGAGACACAAAATTCGAGATTATTCCTTGTCAGGGGCCTACCGAAAGATCATTATTCGT       c.1740
 M  R  H  K  I  R  D  Y  S  L  S  G  A  Y  R  K  I  I  I  R         p.580

          .        | 15.         .         .         .         .    g.68022
 CCTCAGAATGTTAGCTG | GGAAGTCGTTGCATATGATGATCCCAAAATTCCACTTTTCAAC    c.1800
 P  Q  N  V  S  W  |  E  V  V  A  Y  D  D  P  K  I  P  L  F  N      p.600

          .         .         .         .          | 16        .    g.69323
 ACAGATGTGGACAACCTAGAAGGGAAGACACCACCAGTTTTTGCTTCTG | AAGGCAAATAC    c.1860
 T  D  V  D  N  L  E  G  K  T  P  P  V  F  A  S  E |   G  K  Y      p.620

          .         .         .         .         .         .       g.69383
 AGGGCTCTGAAAATGGATTTTTCTCTACCCCCTTCTACTTACGCCACCATGGCCATTCGA       c.1920
 R  A  L  K  M  D  F  S  L  P  P  S  T  Y  A  T  M  A  I  R         p.640

          .         .         .         .         .         .       g.69443
 GAAGTGCTAAAAATGGATACCAGTATCAAGAACCAGACGCAGCTGAATACAACCTGGCTT       c.1980
 E  V  L  K  M  D  T  S  I  K  N  Q  T  Q  L  N  T  T  W  L         p.660

                                                                    g.69449
 CGCTGA                                                             c.1986
 R  X                                                               p.661

          .         .         .         .         .         .       g.69509
 gcagtaccttgtccacagattagaaaacgtacacaagtgtttgcttcctggctccctgtg       c.*60

          .         .         .         .         .         .       g.69569
 catttttgtcttagttcagactcatatatggatttcaaatctttgtaataaaaattattt       c.*120

          .         .         .         .         .         .       g.69629
 gtatttttaagtttttattagcttaaagaaataatttgcaatatttgtacatgtacacaa       c.*180

          .         .         .         .         .         .       g.69689
 atcctgaggttcttaattttagctcagaatataaattagtcaaaatacacttcaggtgct       c.*240

          .         .         .         .         .         .       g.69749
 taaatcagagtaaaatgtcagctttacaataataaaaaaaggactttggtttaaagtagc       c.*300

          .         .         .         .         .         .       g.69809
 aggtttaggttttgctacattctcaaaagacagcaggagtatttgacacatctgtgatgg       c.*360

          .         .         .         .         .         .       g.69869
 agtatacaacaatgcattttaagagcaaatgcaacaaaacaaatctggactatggataaa       c.*420

          .         .         .         .         .         .       g.69929
 taatttgagagctgccacccacaaatataaatacagtactcatgctgactgaaataataa       c.*480

          .         .         .         .         .         .       g.69989
 gacatctacaaatttataaacaaaaagtgattgtcattatcctgcttatgtactagattc       c.*540

          .         .         .         .         .         .       g.70049
 aggcaagcattatagactttttggttgcggtggcttttgcatttatattatcaatgcctt       c.*600

          .         .         .         .         .         .       g.70109
 gcaggaacgttgcattgataggcccattttatttttttattttttttttcgagacaggat       c.*660

          .         .         .         .         .         .       g.70169
 ctcactctgtagcacaggctggattgcagtgcaatcctgcaattctcaatcttgcactgc       c.*720

          .         .         .         .         .         .       g.70229
 agcctcgacctcccaggctccagtgactctcccacctcagcctcctaagtagctgggagt       c.*780

          .         .         .         .         .         .       g.70289
 acaggcgcgcaccaccacgcctagctgatttttgtatttttttgtagagacgggggtttg       c.*840

          .         .         .         .         .         .       g.70349
 gccatgttgccgaggctaactcctgggattacaggcatgagctgtgctggccgggttttt       c.*900

          .         .         .         .         .         .       g.70409
 ttttcttgatgtaaacgtgtacagctgttttattagttaaggtctaatttttactctagg       c.*960

          .         .         .         .         .         .       g.70469
 tgccttttatgttcagaactctttccactggactggtatttgctcaaaaataaataatgg       c.*1020

          .         .         .         .         .         .       g.70529
 tagagaagaaaactataaaaatggacaaggctttcttctatcagtagcgtttaccctttg       c.*1080

          .         .         .         .         .         .       g.70589
 tcaccagtggctttggtatttccatgtctggcattgcataaacttctctggtgtgaaagg       c.*1140

          .         .         .         .         .         .       g.70649
 ataaatatgcctttctaaagttgtatatcaaaattgtatcaatttttattttctatgatt       c.*1200

          .         .         .         .         .         .       g.70709
 tctagaaacaaatgtaataaatatttttaaaatctcctttctactggttatgtaaataaa       c.*1260

          .                                                         g.70728
 tcaaataaatatatcaaaa                                                c.*1279

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Pseudouridylate synthase 7 homolog (S. cerevisiae) protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

Powered by LOVD v.3.0 Build 27
©2004-2021 Leiden University Medical Center