pyrroline-5-carboxylate reductase family, member 2 (PYCR2) - coding DNA reference sequence

(used for variant description)

(last modified July 18, 2017)


This file was created to facilitate the description of sequence variants on transcript NM_013328.3 in the PYCR2 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_044963.1, covering PYCR2 transcript NM_013328.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
           .         .         .         .         .                g.5050
           gattggtcgcccggacggggcggggccacgtggcctaaggcgccatcagc       c.-181

 .         .         .         .         .         .                g.5110
 cgcccgggagatatccgccgggggagaatagggttgcaccatcccagaagctgctgttag       c.-121

 .         .         .         .         .         .                g.5170
 ctcgccggtcctcggcacgccgcccgttcgcccctgcgctgtccgcccttcccctagcgt       c.-61

 .         .         .         .         .         .                g.5230
 tacttccggtccctcgctgagggggttcgtgcggctcccaggaggcgtgaaccgcggacc       c.-1

          .         .         .         .         .         .       g.5290
 ATGAGCGTGGGCTTCATCGGGGCCGGCCAGCTGGCCTATGCTCTGGCGCGGGGCTTCACG       c.60
 M  S  V  G  F  I  G  A  G  Q  L  A  Y  A  L  A  R  G  F  T         p.20

         | 02.         .         .         .         .         .    g.5622
 GCCGCAG | GCATCCTGTCGGCTCACAAGATAATAGCCAGCTCCCCAGAAATGAACCTGCCC    c.120
 A  A  G |   I  L  S  A  H  K  I  I  A  S  S  P  E  M  N  L  P      p.40

          .         | 03         .         .         .         .    g.6999
 ACGGTGTCCGCGCTCAGG | AAGATGGGTGTGAACCTGACACGCAGCAACAAGGAGACGGTG    c.180
 T  V  S  A  L  R   | K  M  G  V  N  L  T  R  S  N  K  E  T  V      p.60

          .         .         .         .         .         .       g.7059
 AAGCACAGCGACGTCCTGTTTCTGGCTGTGAAGCCACATATCATCCCCTTCATCCTGGAT       c.240
 K  H  S  D  V  L  F  L  A  V  K  P  H  I  I  P  F  I  L  D         p.80

          .         .         .         .         .         .       g.7119
 GAGATTGGGGCCGACGTGCAAGCCAGACACATCGTGGTCTCCTGTGCGGCTGGTGTCACC       c.300
 E  I  G  A  D  V  Q  A  R  H  I  V  V  S  C  A  A  G  V  T         p.100

          .         | 04         .         .         .         .    g.7303
 ATCAGCTCTGTGGAGAAG | AAGCTGATGGCATTCCAGCCAGCCCCCAAAGTGATTCGCTGC    c.360
 I  S  S  V  E  K   | K  L  M  A  F  Q  P  A  P  K  V  I  R  C      p.120

          .         .         .         .         .         .       g.7363
 ATGACCAACACACCTGTGGTAGTGCAGGAAGGCGCTACAGTGTACGCCACGGGCACCCAT       c.420
 M  T  N  T  P  V  V  V  Q  E  G  A  T  V  Y  A  T  G  T  H         p.140

          .         .         .         .         .         .       g.7423
 GCCCTGGTGGAGGATGGGCAGCTCCTGGAGCAGCTCATGAGCAGCGTGGGCTTCTGCACT       c.480
 A  L  V  E  D  G  Q  L  L  E  Q  L  M  S  S  V  G  F  C  T         p.160

          .         .         .         .         .         .       g.7483
 GAGGTGGAAGAGGACCTCATCGATGCCGTCACGGGGCTCAGTGGCAGCGGGCCTGCCTAT       c.540
 E  V  E  E  D  L  I  D  A  V  T  G  L  S  G  S  G  P  A  Y         p.180

  | 05       .         .         .         .         .         .    g.7756
  | GCATTCATGGCTCTGGACGCATTGGCTGATGGTGGGGTGAAGATGGGTTTGCCACGGCGC    c.600
  | A  F  M  A  L  D  A  L  A  D  G  G  V  K  M  G  L  P  R  R      p.200

          .         .         .    | 06    .         .         .    g.7996
 CTGGCAATCCAACTCGGGGCCCAGGCTTTGCTG | GGAGCTGCCAAGATGCTGCTGGACTCG    c.660
 L  A  I  Q  L  G  A  Q  A  L  L   | G  A  A  K  M  L  L  D  S      p.220

          .         .         .         .         .         .       g.8056
 GAGCAGCATCCATGCCAGCTTAAGGACAATGTCTGCTCCCCTGGGGGAGCCACCATCCAC       c.720
 E  Q  H  P  C  Q  L  K  D  N  V  C  S  P  G  G  A  T  I  H         p.240

          .         .         .         .         .         .       g.8116
 GCCCTGCACTTTCTAGAGAGTGGGGGCTTCCGCTCTCTGCTCATCAATGCAGTTGAGGCC       c.780
 A  L  H  F  L  E  S  G  G  F  R  S  L  L  I  N  A  V  E  A         p.260

          .        | 07.         .         .         .         .    g.8763
 TCCTGTATCCGAACACG | AGAGCTACAGTCCATGGCCGACCAAGAAAAGATCTCCCCAGCT    c.840
 S  C  I  R  T  R  |  E  L  Q  S  M  A  D  Q  E  K  I  S  P  A      p.280

          .         .         .         .         .         .       g.8823
 GCCCTTAAGAAGACCCTCTTAGACAGAGTGAAGCTGGAATCCCCCACAGTCTCCACACTG       c.900
 A  L  K  K  T  L  L  D  R  V  K  L  E  S  P  T  V  S  T  L         p.300

          .         .         .         .         .         .       g.8883
 ACCCCCTCCAGCCCAGGGAAGCTCCTCACAAGAAGCCTGGCCCTGGGAGGCAAGAAGGAC       c.960
 T  P  S  S  P  G  K  L  L  T  R  S  L  A  L  G  G  K  K  D         p.320

                                                                    g.8886
 TAA                                                                c.963
 X                                                                  p.320

          .         .         .         .         .         .       g.8946
 ggcagcatctgtcccctctgtgattcagagcccttagttgagagcccctgccgcccctgc       c.*60

          .         .         .         .         .         .       g.9006
 cacccccctgccccgctcccaccattgcccctcctcagctgtgcaaggagaaagcatgct       c.*120

          .         .         .         .         .         .       g.9066
 taggaagttttcaggtccttgtgataaaacctccttaaatctgttcagaccaagcaatgc       c.*180

          .         .         .         .         .         .       g.9126
 gagcttcctctcctgtcccatgttggaagttgctctgaaggggtggtagatgctggaagc       c.*240

          .         .         .         .         .         .       g.9186
 cagacacaaccctgcgtacgctgctcagttggtggagactggggctgggactggagtcag       c.*300

          .         .         .         .         .         .       g.9246
 cccagctgggaggaggggctggggaggatctgcagctgaagcccgaggcagggttggtgt       c.*360

          .         .         .         .         .         .       g.9306
 gatgccaaggcaaagtggtgaggagaaaacaggaaacgggctttctctgaattggtaaat       c.*420

          .         .         .         .         .         .       g.9366
 gggaaagaagtgagcaacttaagattgtcacaattaatcacaagtgtacaggattagact       c.*480

          .         .         .         .         .         .       g.9426
 gggtttatatttaactcttgcttcataggtgtaccatttaaagagtgttatttaatgcta       c.*540

          .         .         .                                     g.9464
 agtttaactgctttaataaagtttatttttaaatatct                             c.*578

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Pyrroline-5-carboxylate reductase family, member 2 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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