phosphorylase, glycogen, liver (PYGL) - coding DNA reference sequence

(used for variant description)

(last modified January 13, 2017)


This file was created to facilitate the description of sequence variants on transcript NM_002863.4 in the PYGL gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_012796.1, covering PYGL transcript NM_002863.4.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                                    g.5007
                                                      aaacttt       c.-121

 .         .         .         .         .         .                g.5067
 cgtgcgcgttgaaagctgctggcgcggcggggcggactccacccctgcccggcagcccag       c.-61

 .         .         .         .         .         .                g.5127
 cgcctccggccgcacttccagctctctgcgcagcccgccgcgcagcccgccgccccagcc       c.-1

          .         .         .         .         .         .       g.5187
 ATGGCGAAGCCCCTGACGGACCAGGAGAAGCGGCGGCAGATCAGCATCCGCGGCATCGTG       c.60
 M  A  K  P  L  T  D  Q  E  K  R  R  Q  I  S  I  R  G  I  V         p.20

          .         .         .         .         .         .       g.5247
 GGCGTGGAGAACGTGGCAGAGCTGAAGAAGAGTTTCAACCGGCACCTGCACTTCACGCTG       c.120
 G  V  E  N  V  A  E  L  K  K  S  F  N  R  H  L  H  F  T  L         p.40

          .         .         .         .         .         .       g.5307
 GTCAAGGACCGCAACGTGGCCACCACCCGCGACTACTACTTCGCGCTGGCGCACACGGTG       c.180
 V  K  D  R  N  V  A  T  T  R  D  Y  Y  F  A  L  A  H  T  V         p.60

          .         .         .         .         .         .       g.5367
 CGCGACCACCTGGTGGGGCGCTGGATCCGCACGCAGCAGCACTACTACGACAAGTGCCCC       c.240
 R  D  H  L  V  G  R  W  I  R  T  Q  Q  H  Y  Y  D  K  C  P         p.80

     | 02    .         .         .         .         .         .    g.11750
 AAG | AGGGTATATTACCTCTCTCTGGAATTTTACATGGGCCGAACATTACAGAACACCATG    c.300
 K   | R  V  Y  Y  L  S  L  E  F  Y  M  G  R  T  L  Q  N  T  M      p.100

          .         .         .         .      | 03  .         .    g.14360
 ATCAACCTCGGTCTGCAAAATGCCTGTGATGAGGCCATTTACCAG | CTTGGATTGGATATA    c.360
 I  N  L  G  L  Q  N  A  C  D  E  A  I  Y  Q   | L  G  L  D  I      p.120

          .         .         .         .         .         .       g.14420
 GAAGAGTTAGAAGAAATTGAAGAAGATGCTGGACTTGGCAATGGTGGTCTTGGGAGACTT       c.420
 E  E  L  E  E  I  E  E  D  A  G  L  G  N  G  G  L  G  R  L         p.140

      | 04   .         .         .         .         .         .    g.17810
 GCTG | CCTGCTTCTTGGATTCCATGGCAACCCTGGGACTTGCAGCCTATGGATACGGCATT    c.480
 A  A |   C  F  L  D  S  M  A  T  L  G  L  A  A  Y  G  Y  G  I      p.160

          .         .         .         .         | 05         .    g.25442
 CGGTATGAATATGGGATTTTCAATCAGAAGATCCGAGATGGATGGCAG | GTAGAAGAAGCA    c.540
 R  Y  E  Y  G  I  F  N  Q  K  I  R  D  G  W  Q   | V  E  E  A      p.180

          .         .         .         .         .         .       g.25502
 GATGATTGGCTCAGATATGGAAACCCTTGGGAGAAGTCCCGCCCAGAATTCATGCTGCCT       c.600
 D  D  W  L  R  Y  G  N  P  W  E  K  S  R  P  E  F  M  L  P         p.200

          .         .         .         .         .         .       g.25562
 GTGCACTTCTATGGAAAAGTAGAACACACCAACACCGGGACCAAGTGGATTGACACTCAA       c.660
 V  H  F  Y  G  K  V  E  H  T  N  T  G  T  K  W  I  D  T  Q         p.220

  | 06       .         .         .         .         .         .    g.28523
  | GTGGTCCTGGCTCTGCCATATGACACCCCCGTGCCCGGCTACATGAATAACACTGTCAAC    c.720
  | V  V  L  A  L  P  Y  D  T  P  V  P  G  Y  M  N  N  T  V  N      p.240

          .         .         .         .         .   | 07     .    g.28915
 ACCATGCGCCTCTGGTCTGCTCGGGCACCAAATGACTTTAACCTCAGAGACT | TTAATGTT    c.780
 T  M  R  L  W  S  A  R  A  P  N  D  F  N  L  R  D  F |   N  V      p.260

          .         .         .         .         .         .       g.28975
 GGAGACTACATTCAGGCTGTGCTGGACCGAAACCTGGCCGAGAACATCTCCCGGGTCCTC       c.840
 G  D  Y  I  Q  A  V  L  D  R  N  L  A  E  N  I  S  R  V  L         p.280

          .      | 08  .         .         .         .         .    g.32470
 TATCCCAATGACAAT | TTTTTTGAAGGGAAGGAGCTAAGATTGAAGCAGGAATACTTTGTG    c.900
 Y  P  N  D  N   | F  F  E  G  K  E  L  R  L  K  Q  E  Y  F  V      p.300

          .         .         .         .         .         .       g.32530
 GTGGCTGCAACCTTGCAAGATATCATCCGCCGTTTCAAAGCCTCCAAGTTTGGCTCCACC       c.960
 V  A  A  T  L  Q  D  I  I  R  R  F  K  A  S  K  F  G  S  T         p.320

          .         .         .          | 09        .         .    g.32817
 CGTGGTGCAGGAACTGTGTTTGATGCCTTCCCGGATCAG | GTGGCCATCCAGCTGAATGAC    c.1020
 R  G  A  G  T  V  F  D  A  F  P  D  Q   | V  A  I  Q  L  N  D      p.340

          .         .         .         .         .         .       g.32877
 ACTCACCCTGCACTCGCGATCCCTGAGCTGATGAGGATTTTTGTGGATATTGAAAAACTG       c.1080
 T  H  P  A  L  A  I  P  E  L  M  R  I  F  V  D  I  E  K  L         p.360

          .   | 10     .         .         .         .         .    g.33607
 CCCTGGTCCAAG | GCATGGGAGCTCACCCAGAAGACCTTCGCCTACACCAACCACACAGTG    c.1140
 P  W  S  K   | A  W  E  L  T  Q  K  T  F  A  Y  T  N  H  T  V      p.380

          .         .         .         .         .         .       g.33667
 CTCCCGGAAGCCCTGGAGCGCTGGCCCGTGGACCTGGTGGAGAAGCTGCTCCCTCGACAT       c.1200
 L  P  E  A  L  E  R  W  P  V  D  L  V  E  K  L  L  P  R  H         p.400

          .         .         .          | 11        .         .    g.34052
 TTGGAAATCATTTATGAGATAAATCAGAAGCATTTAGAT | AGAATTGTGGCCTTGTTTCCT    c.1260
 L  E  I  I  Y  E  I  N  Q  K  H  L  D   | R  I  V  A  L  F  P      p.420

          .         .         .         .         .         .       g.34112
 AAAGATGTGGACCGTCTGAGAAGGATGTCTCTGATAGAAGAGGAAGGAAGCAAAAGGATC       c.1320
 K  D  V  D  R  L  R  R  M  S  L  I  E  E  E  G  S  K  R  I         p.440

          .         .         .         .         .         .       g.34172
 AACATGGCCCATCTCTGCATTGTCGGTTCCCATGCTGTGAATGGCGTGGCTAAAATCCAC       c.1380
 N  M  A  H  L  C  I  V  G  S  H  A  V  N  G  V  A  K  I  H         p.460

          .         .    | 12    .         .         .         .    g.34752
 TCAGACATCGTGAAGACTAAAGT | ATTCAAGGACTTCAGTGAGCTAGAACCTGACAAGTTT    c.1440
 S  D  I  V  K  T  K  V  |  F  K  D  F  S  E  L  E  P  D  K  F      p.480

          .         .         .         .         .         .       g.34812
 CAGAATAAAACCAATGGGATCACTCCAAGGCGCTGGCTCCTACTCTGCAACCCAGGACTT       c.1500
 Q  N  K  T  N  G  I  T  P  R  R  W  L  L  L  C  N  P  G  L         p.500

          .         | 13         .         .         .         .    g.36442
 GCAGAGCTCATAGCAGAG | AAAATTGGAGAAGACTATGTGAAAGACCTGAGCCAGCTGACG    c.1560
 A  E  L  I  A  E   | K  I  G  E  D  Y  V  K  D  L  S  Q  L  T      p.520

          .         .         .         .         .         .       g.36502
 AAGCTCCACAGCTTCCTGGGTGATGATGTCTTCCTCCGGGAACTCGCCAAGGTGAAGCAG       c.1620
 K  L  H  S  F  L  G  D  D  V  F  L  R  E  L  A  K  V  K  Q         p.540

  | 14       .         .         .         .         .         .    g.37287
  | GAGAATAAGCTGAAGTTTTCTCAGTTCCTGGAGACGGAGTACAAAGTGAAGATCAACCCA    c.1680
  | E  N  K  L  K  F  S  Q  F  L  E  T  E  Y  K  V  K  I  N  P      p.560

          .         .         .         .         .         .       g.37347
 TCCTCCATGTTTGATGTCCAGGTGAAGAGGATACATGAGTACAAGCGACAGCTCTTGAAC       c.1740
 S  S  M  F  D  V  Q  V  K  R  I  H  E  Y  K  R  Q  L  L  N         p.580

          .         .         | 15         .         .         .    g.37526
 TGTCTGCATGTGATCACGATGTACAACC | GCATTAAGAAAGACCCTAAGAAGTTATTCGTG    c.1800
 C  L  H  V  I  T  M  Y  N  R |   I  K  K  D  P  K  K  L  F  V      p.600

          .         .        | 16.         .         .         .    g.37692
 CCAAGGACAGTTATCATTGGTGGTAAA | GCTGCCCCAGGATATCACATGGCCAAAATGATC    c.1860
 P  R  T  V  I  I  G  G  K   | A  A  P  G  Y  H  M  A  K  M  I      p.620

          .         .         .         .         .         .       g.37752
 ATAAAGCTGATCACTTCAGTGGCAGATGTGGTGAACAATGACCCTATGGTTGGAAGCAAG       c.1920
 I  K  L  I  T  S  V  A  D  V  V  N  N  D  P  M  V  G  S  K         p.640

          .         .         .         .          | 17        .    g.39439
 TTGAAAGTCATCTTCTTGGAGAACTACAGAGTATCTCTTGCTGAAAAAG | TCATTCCAGCC    c.1980
 L  K  V  I  F  L  E  N  Y  R  V  S  L  A  E  K  V |   I  P  A      p.660

          .         .         .         .         .         .       g.39499
 ACAGATCTGTCAGAGCAGATTTCCACTGCAGGCACCGAAGCCTCGGGGACAGGCAATATG       c.2040
 T  D  L  S  E  Q  I  S  T  A  G  T  E  A  S  G  T  G  N  M         p.680

          .         .         .         .         .         .       g.39559
 AAGTTCATGCTAAATGGGGCCCTAACTATCGGGACCATGGATGGGGCCAATGTGGAAATG       c.2100
 K  F  M  L  N  G  A  L  T  I  G  T  M  D  G  A  N  V  E  M         p.700

          .         .         .         .         .         .       g.39619
 GCAGAAGAAGCTGGGGAAGAGAACCTGTTCATCTTTGGCATGAGGATAGATGATGTGGCT       c.2160
 A  E  E  A  G  E  E  N  L  F  I  F  G  M  R  I  D  D  V  A         p.720

          .        | 18.         .         .         .         .    g.40618
 GCTTTGGACAAGAAAGG | GTACGAGGCAAAAGAATACTATGAGGCACTTCCAGAGCTGAAG    c.2220
 A  L  D  K  K  G  |  Y  E  A  K  E  Y  Y  E  A  L  P  E  L  K      p.740

          .         .         .         .         .         .       g.40678
 CTGGTCATTGATCAAATTGACAATGGCTTTTTTTCTCCCAAGCAGCCTGACCTCTTCAAA       c.2280
 L  V  I  D  Q  I  D  N  G  F  F  S  P  K  Q  P  D  L  F  K         p.760

          .         .         .   | 19     .         .         .    g.41221
 GATATCATCAACATGCTATTTTATCATGACAG | GTTTAAAGTCTTTGCAGACTACGAAGCC    c.2340
 D  I  I  N  M  L  F  Y  H  D  R  |  F  K  V  F  A  D  Y  E  A      p.780

          .         .         .          | 20        .         .    g.43995
 TATGTCAAGTGTCAAGATAAAGTGAGTCAGCTGTACATG | AATCCAAAGGCCTGGAACACA    c.2400
 Y  V  K  C  Q  D  K  V  S  Q  L  Y  M   | N  P  K  A  W  N  T      p.800

          .         .         .         .         .         .       g.44055
 ATGGTACTCAAAAACATAGCTGCCTCGGGGAAATTCTCCAGTGACCGAACAATTAAAGAA       c.2460
 M  V  L  K  N  I  A  A  S  G  K  F  S  S  D  R  T  I  K  E         p.820

          .         .         .         .         .         .       g.44115
 TATGCCCAAAACATCTGGAACGTGGAACCTTCAGATCTAAAGATTTCTCTATCCAATGAA       c.2520
 Y  A  Q  N  I  W  N  V  E  P  S  D  L  K  I  S  L  S  N  E         p.840

          .         .                                               g.44139
 TCTAACAAAGTCAATGGAAATTGA                                           c.2544
 S  N  K  V  N  G  N  X                                             p.847

          .         .         .         .         .         .       g.44199
 actctagaattgtctctagaaaacatagcttcttactgaacttgaacatttttacaacat       c.*60

          .         .         .         .         .         .       g.44259
 tcactggtttttgttttgttagctaataatctataatagttgagtatctctgggaatggg       c.*120

          .         .         .         .         .                 g.44314
 gagggaaattatatgtaatagagcttaaaaataaagtgtcaatttccaagggcta            c.*175

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Phosphorylase, glycogen, liver protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

Powered by LOVD v.3.0 Build 18
©2004-2017 Leiden University Medical Center