pyridine nucleotide-disulphide oxidoreductase domain 1 (PYROXD1) - coding DNA reference sequence

(used for variant description)

(last modified October 19, 2018)


This file was created to facilitate the description of sequence variants on transcript NM_024854.3 in the PYROXD1 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_053196.1, covering PYROXD1 transcript NM_024854.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                                    g.5007
                                                      agcaccc       c.-121

 .         .         .         .         .         .                g.5067
 gtaggtcggattatctggtaaggcaccggaagtgaccgcctcgcggctgcttcctctcct       c.-61

 .         .         .         .         .         .                g.5127
 ggagtccagagtcccgttgctccgccgcgatattcagtaaaccactgggagtccggcagc       c.-1

          .         .         .         .         .         .       g.5187
 ATGGAGGCAGCGCGCCCTCCCCCGACGGCAGGGAAGTTCGTGGTGGTCGGCGGCGGCATC       c.60
 M  E  A  A  R  P  P  P  T  A  G  K  F  V  V  V  G  G  G  I         p.20

          .         .     | 02   .         .         .         .    g.7800
 GCGGGCGTCACTTGTGCGGAGCAG | TTGGCTACTCACTTTCCATCGGAAGATATTCTCTTG    c.120
 A  G  V  T  C  A  E  Q   | L  A  T  H  F  P  S  E  D  I  L  L      p.40

          .         .         .         .      | 03  .         .    g.12758
 GTAACAGCTTCTCCTGTTATTAAAGCAGTTACAAATTTCAAGCAG | ATTTCTAAAATATTG    c.180
 V  T  A  S  P  V  I  K  A  V  T  N  F  K  Q   | I  S  K  I  L      p.60

          .         .         .         .         .         .       g.12818
 GAAGAATTCGATGTTGAAGAACAATCAAGTACCATGTTAGGAAAACGCTTTCCCAACATT       c.240
 E  E  F  D  V  E  E  Q  S  S  T  M  L  G  K  R  F  P  N  I         p.80

          .         .         .         .      | 04  .         .    g.16974
 AAGGTTATAGAATCTGGCGTAAAGCAACTGAAGAGTGAAGAACAC | TGCATTGTAACAGAA    c.300
 K  V  I  E  S  G  V  K  Q  L  K  S  E  E  H   | C  I  V  T  E      p.100

          .         .         .         .         .         .       g.17034
 GATGGCAATCAGCACGTATATAAGAAACTCTGTCTGTGTGCTGGAGCTAAACCAAAGTTG       c.360
 D  G  N  Q  H  V  Y  K  K  L  C  L  C  A  G  A  K  P  K  L         p.120

          .         .         .         .         .     | 05   .    g.19483
 ATATGTGAAGGAAATCCTTATGTATTAGGAATCCGTGATACAGACAGTGCTCAG | GAATTT    c.420
 I  C  E  G  N  P  Y  V  L  G  I  R  D  T  D  S  A  Q   | E  F      p.140

          .         .         .         .         .         .       g.19543
 CAGAAACAGCTTACTAAAGCTAAAAGAATAATGATCATAGGGAACGGTGGTATTGCACTT       c.480
 Q  K  Q  L  T  K  A  K  R  I  M  I  I  G  N  G  G  I  A  L         p.160

          | 06         .         .         .         .         .    g.22580
 GAGTTAGT | GTATGAAATTGAAGGCTGTGAAGTGATTTGGGCCATTAAAGATAAAGCTATA    c.540
 E  L  V  |  Y  E  I  E  G  C  E  V  I  W  A  I  K  D  K  A  I      p.180

          .         .         .         .         .         .       g.22640
 GGGAATACTTTCTTCGATGCAGGAGCAGCTGAATTCTTGACTTCAAAGCTCATTGCTGAA       c.600
 G  N  T  F  F  D  A  G  A  A  E  F  L  T  S  K  L  I  A  E         p.200

          .         .         .         .          | 07        .    g.23402
 AAATCAGAGGCTAAAATTGCACATAAAAGAACCAGATATACAACTGAAG | GAAGGAAAAAG    c.660
 K  S  E  A  K  I  A  H  K  R  T  R  Y  T  T  E  G |   R  K  K      p.220

          .         .         .         .         .         .       g.23462
 GAAGCTAGAAGCAAATCTAAAGCAGATAATGTAGGAAGTGCATTGGGACCAGATTGGCAT       c.720
 E  A  R  S  K  S  K  A  D  N  V  G  S  A  L  G  P  D  W  H         p.240

          .         .         . | 08       .         .         .    g.28451
 GAAGGCTTGAATCTTAAAGGAACAAAAGAG | TTTTCTCATAAGATTCACCTTGAAACTATG    c.780
 E  G  L  N  L  K  G  T  K  E   | F  S  H  K  I  H  L  E  T  M      p.260

          .         .         .         .         .         .       g.28511
 TGTGAAGTAAAGAAAATCTACCTTCAGGATGAGTTTAGAATTTTGAAGAAAAAGTCCTTC       c.840
 C  E  V  K  K  I  Y  L  Q  D  E  F  R  I  L  K  K  K  S  F         p.280

          .         .         .         . | 09       .         .    g.29424
 ACTTTTCCAAGAGACCATAAGTCAGTTACAGCTGATACAG | AGATGTGGCCTGTCTATGTG    c.900
 T  F  P  R  D  H  K  S  V  T  A  D  T  E |   M  W  P  V  Y  V      p.300

          .         .         .         .         .         .       g.29484
 GAATTGACCAATGAAAAGATATATGGCTGCGATTTCATTGTCAGTGCTACAGGAGTTACA       c.960
 E  L  T  N  E  K  I  Y  G  C  D  F  I  V  S  A  T  G  V  T         p.320

          .         .         .    | 10    .         .         .    g.30163
 CCAAATGTAGAACCTTTTCTCCATGGTAACAGT | TTTGATCTAGGAGAAGATGGTGGCCTG    c.1020
 P  N  V  E  P  F  L  H  G  N  S   | F  D  L  G  E  D  G  G  L      p.340

          .         .         .         .         .         .       g.30223
 AAAGTGGATGATCATATGCACACATCCCTTCCTGATATCTATGCTGCCGGTGACATCTGT       c.1080
 K  V  D  D  H  M  H  T  S  L  P  D  I  Y  A  A  G  D  I  C         p.360

          .         .         .       | 11 .         .         .    g.34901
 ACTACATCCTGGCAGCTGAGCCCAGTCTGGCAGCAG | ATGAGGCTGTGGACCCAGGCTAGA    c.1140
 T  T  S  W  Q  L  S  P  V  W  Q  Q   | M  R  L  W  T  Q  A  R      p.380

          .         .         .         .         .         .       g.34961
 CAGATGGGATGGTATGCAGCAAAGTGCATGGCTGCAGCGAGTTCAGGAGACTCTATTGAC       c.1200
 Q  M  G  W  Y  A  A  K  C  M  A  A  A  S  S  G  D  S  I  D         p.400

          .         .         .         .         .     | 12   .    g.35908
 ATGGATTTCAGCTTTGAACTGTTTGCTCATGTGACAAAATTTTTTAACTATAAG | GTTGTA    c.1260
 M  D  F  S  F  E  L  F  A  H  V  T  K  F  F  N  Y  K   | V  V      p.420

          .         .         .         .         .         .       g.35968
 CTGCTGGGAAAATACAATGCACAGGGCTTAGGTTCAGATCATGAATTAATGCTGAGATGT       c.1320
 L  L  G  K  Y  N  A  Q  G  L  G  S  D  H  E  L  M  L  R  C         p.440

          .         .         .         .         .         .       g.36028
 ACCAAAGGACGAGAATACATCAAAGTCGTCATGCAAAATGGACGAATGATGGGAGCTGTC       c.1380
 T  K  G  R  E  Y  I  K  V  V  M  Q  N  G  R  M  M  G  A  V         p.460

          .         .         .         .         .         .       g.36088
 TTAATTGGTGAAACCGATTTAGAAGAAACATTTGAAAACCTAATCTTAAACCAAATGAAT       c.1440
 L  I  G  E  T  D  L  E  E  T  F  E  N  L  I  L  N  Q  M  N         p.480

          .         .         .         .         .         .       g.36148
 CTTTCATCATATGGAGAAGATCTGCTAGATCCAAATATTGATATAGAAGATTATTTTGAC       c.1500
 L  S  S  Y  G  E  D  L  L  D  P  N  I  D  I  E  D  Y  F  D         p.500

                                                                    g.36151
 TAA                                                                c.1503
 X                                                                  p.500

          .         .         .         .         .         .       g.36211
 aaatggaatttcttcaggaatcatataaagttccaaatgacaccagaaaaatcacaagtc       c.*60

          .         .         .         .         .         .       g.36271
 aataaaatgaatgactgtattgagttaatgatgaccacactgaaaattacagaagtgata       c.*120

          .         .         .         .         .         .       g.36331
 atgatattagtggaaaaatataaaaacataaattctaagtttgaaatcagttcaaagttt       c.*180

          .         .         .         .         .         .       g.36391
 atttatagatatatctttccaatacaacactgaccgcttagataaaaatcttaagttatt       c.*240

          .         .         .         .         .         .       g.36451
 tatttctgtgttttaaacataaatatgtttacttgtgatttagctttggagcaaatttag       c.*300

          .         .         .         .         .         .       g.36511
 gtaagttatctacttagccaaatgtactctagtagactagaaccattctttgtgaaatgt       c.*360

          .         .         .         .         .         .       g.36571
 caaaatatggctatggtttcaggaactttaaaatcggttgtattttactttaaatagaga       c.*420

          .         .         .         .         .         .       g.36631
 tgtagcaatatctcgtttgctaatatttatattgatgacttactccttttttgttgaatt       c.*480

          .         .         .         .         .         .       g.36691
 gtacttctggttttataacctgaaatcatctacaagcttgtccaactctagcccacgggt       c.*540

          .         .         .         .         .         .       g.36751
 ctaatgcagcccagaacagctttgaatgcagcccaacacaaatctgtaaactttcttaaa       c.*600

          .         .         .         .         .         .       g.36811
 acatgagatttttcttgcaatttttttttttttaagctcatcagctatcgtcagtgttag       c.*660

          .         .         .         .         .         .       g.36871
 catattttatgtgcggcccaagacaattcttcttccaatgtggctcagggaagccaaaag       c.*720

          .         .         .         .         .         .       g.36931
 attggacatccctgatctacatatttaacttaaagtatcactcagtgaacctctgtcagt       c.*780

          .         .         .         .         .         .       g.36991
 ataatattgctttcaaaaagatggttatgtcaaaagaaaaaatatagctaagtatataaa       c.*840

          .         .         .         .         .         .       g.37051
 ggcataaaaaacttaagacaattacatgaacttattctcaaatattttacattttttgta       c.*900

          .         .         .         .         .         .       g.37111
 aactttcttaaaacatgagatttttcttgcaattttttttttaagctcatcagctatcat       c.*960

          .         .         .         .         .         .       g.37171
 cagtgttagcatattttatgtgcggcccaagacaattcttcttccaatgtggctcaggga       c.*1020

          .         .         .         .         .         .       g.37231
 agccaaaagattggacatccttgatctacatatttaacttaaagtatcactcagtgagcc       c.*1080

          .         .         .         .         .         .       g.37291
 tctgtcagtataatattgctttcaaaaagatagttatgtcaaaagaaaaaatatagctaa       c.*1140

          .         .         .         .         .         .       g.37351
 gtatataaaggcataaaaaacttaagacgattgtatgaacttattctcaaatattttaca       c.*1200

          .         .         .         .         .         .       g.37411
 tttaaagggttttacataaaaatttttcccttgttttatactggaaaattatataattca       c.*1260

          .         .         .         .         .         .       g.37471
 tgatctctaattttcaaacattctcaaaagtttagatcttcagagataagctctgaaaat       c.*1320

          .         .         .         .         .         .       g.37531
 atagatccatacatataaaatatctatgaaattcttttaaaaactattgtctaactacaa       c.*1380

          .         .         .         .         .         .       g.37591
 aaataatggcatatacatgcataaaccatctttaattagaaaatttagtaacattcatat       c.*1440

          .         .         .         .         .         .       g.37651
 caggcatcatcgatttttcttttcttagctcctgtattcttagaaccagattgctgaagc       c.*1500

          .         .         .         .         .         .       g.37711
 atgtttgcagccttcttctggaagttgcctgaatttttttcctccatctttttatcacct       c.*1560

          .         .         .         .         .         .       g.37771
 tgttcagaatgacaagtttgagacgattcagcctacaaaaaaaaaaaaaaaacaaagcaa       c.*1620

          .         .         .         .         .         .       g.37831
 gcaccttggtaaaaatccagctattcagttttctcatgagattaaatatttcaaaatatt       c.*1680

          .         .         .         .         .         .       g.37891
 ctttctgtatcagttggctttttaagtatacaggggtctagttttttatctacaaatttc       c.*1740

          .         .         .         .         .         .       g.37951
 tattcaaatatgagctctattttgaataaaaggggctacgttgtgagagaagttctaaag       c.*1800

          .         .         .         .         .         .       g.38011
 acctcaaatgtccttagacacaatggcacttgacttgacatgcttttgcagacttgatag       c.*1860

          .         .         .         .         .         .       g.38071
 tatttggtttaaaacagtggtttctaaccactggaacagcagaaacagacttctcaacta       c.*1920

          .         .         .         .         .         .       g.38131
 ttagtaatcacaaccaaataagagcagagtgcataacaaaattagatattcaaacggagt       c.*1980

          .         .         .         .         .         .       g.38191
 cctcccattccaagaaactggaaacccctagtttatgttaaaaggccagtctaaattctt       c.*2040

          .         .         .         .         .         .       g.38251
 tcacttacatctttacagaaaactatattttctctcttccatacccagaaatctaatcag       c.*2100

          .         .         .         .         .         .       g.38311
 aaaactgacttttctcatgttcaactggacctaggggaatatgacagaaaagcatcccat       c.*2160

          .         .         .         .         .         .       g.38371
 aggctttaatatactttttaaaatatataaaactgaaaattaatagccatttaccctgaa       c.*2220

          .         .         .         .         .         .       g.38431
 agagttctgcgtggactttgtcacttgcatagtaatagcatgtgcctcattgttcagaag       c.*2280

          .         .         .         .         .         .       g.38491
 attagctttaggtcctattttcaaatacgaaatggtagcataagctgtaaaactgtagtc       c.*2340

          .         .         .         .         .         .       g.38551
 ttctctgcagaaaataaaggccaacaataagaaagcttttgaaggaatcacggaaaacaa       c.*2400

          .         .         .         .         .         .       g.38611
 atttataaaagaaataactatatgcgcagtaattcttaacacattgacttgaaataataa       c.*2460

          .         .         .                                     g.38647
 aatttacaagaatgcaaataaagcctttaaagaaaa                               c.*2496

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Pyridine nucleotide-disulphide oxidoreductase domain 1 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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