glutaminyl-peptide cyclotransferase-like (QPCTL) - coding DNA reference sequence

(used for variant description)

(last modified May 27, 2025)


This file was created to facilitate the description of sequence variants on transcript NM_017659.3 in the QPCTL gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000019.9, covering QPCTL transcript NM_017659.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                     .         .         .         .                g.5041
                    catttgggtcgtgccattctcaggggaaccaaccccaatac       c.-181

 .         .         .         .         .         .                g.5101
 ctaagggaggctgggaggcgtgtcctcaggaccgtagttcttattggtttcgctgctcgc       c.-121

 .         .         .         .         .         .                g.5161
 tgtggggtgggctggtgcagccgcagctgttgcttattggcccaccgattccatggggag       c.-61

 .         .         .         .         .         .                g.5221
 gaacttggctgggcctaaactcaatccgtggtctggtacaggtttcagggcaaagcggcc       c.-1

          .         .         .         .         .         .       g.5281
 ATGCGTTCCGGGGGCCGCGGGCGACCCCGCCTGCGGCTGGGGGAACGTGGCCTCATGGAG       c.60
 M  R  S  G  G  R  G  R  P  R  L  R  L  G  E  R  G  L  M  E         p.20

          .         .         .         .         .         .       g.5341
 CCACTCTTGCCGCCGAAGCGCCGCCTGCTACCGCGGGTTCGGCTCTTGCCTCTGTTGCTG       c.120
 P  L  L  P  P  K  R  R  L  L  P  R  V  R  L  L  P  L  L  L         p.40

          .         .         .         .         .         .       g.5401
 GCGCTGGCCGTGGGCTCGGCGTTCTACACCATTTGGAGCGGCTGGCACCGCAGGACTGAG       c.180
 A  L  A  V  G  S  A  F  Y  T  I  W  S  G  W  H  R  R  T  E         p.60

          .         .        | 02.         .         .         .    g.5963
 GAGCTGCCGCTGGGCCGGGAGCTGCGG | GTCCCATTGATCGGAAGCCTCCCCGAAGCCCGG    c.240
 E  L  P  L  G  R  E  L  R   | V  P  L  I  G  S  L  P  E  A  R      p.80

          .         .         .         .         .         .       g.6023
 CTGCGGAGGGTGGTGGGACAACTGGATCCACAGCGTCTCTGGAGCACTTATCTGCGCCCC       c.300
 L  R  R  V  V  G  Q  L  D  P  Q  R  L  W  S  T  Y  L  R  P         p.100

          .         .         .         .         .  | 03      .    g.7963
 CTGCTGGTTGTGCGAACCCCGGGCAGCCCGGGAAATCTCCAAGTCAGAAAG | TTCCTGGAG    c.360
 L  L  V  V  R  T  P  G  S  P  G  N  L  Q  V  R  K   | F  L  E      p.120

          .         .         .         .         .         .       g.8023
 GCCACGCTGCGGTCCCTGACAGCAGGTTGGCACGTGGAGCTGGATCCCTTCACAGCCTCA       c.420
 A  T  L  R  S  L  T  A  G  W  H  V  E  L  D  P  F  T  A  S         p.140

          .         .         .         .         .         .       g.8083
 ACACCCCTGGGGCCAGTGGACTTTGGCAATGTGGTGGCCACACTGGACCCAAGGGCTGCC       c.480
 T  P  L  G  P  V  D  F  G  N  V  V  A  T  L  D  P  R  A  A         p.160

          .         .         .         .         .         .       g.8143
 CGTCACCTCACCCTTGCCTGCCATTATGACTCGAAGCTCTTCCCACCCGGATCGACCCCC       c.540
 R  H  L  T  L  A  C  H  Y  D  S  K  L  F  P  P  G  S  T  P         p.180

          .         .         .         .         .         .       g.8203
 TTTGTAGGGGCCACGGATTCGGCTGTGCCCTGTGCCCTGCTGCTGGAGCTGGCCCAAGCA       c.600
 F  V  G  A  T  D  S  A  V  P  C  A  L  L  L  E  L  A  Q  A         p.200

          .         .         .    | 04    .         .         .    g.11091
 CTTGACCTGGAGCTGAGCAGGGCCAAAAAACAG | GCAGCCCCGGTGACCCTGCAACTGCTC    c.660
 L  D  L  E  L  S  R  A  K  K  Q   | A  A  P  V  T  L  Q  L  L      p.220

          .         .         .         .         .         .       g.11151
 TTCTTGGATGGTGAAGAGGCGCTGAAGGAGTGGGGACCCAAGGACTCCCTTTACGGTTCC       c.720
 F  L  D  G  E  E  A  L  K  E  W  G  P  K  D  S  L  Y  G  S         p.240

          .         .         .         .         .         .       g.11211
 CGGCACCTGGCCCAGCTCATGGAGTCTATACCTCACAGCCCCGGCCCCACCAGGATCCAG       c.780
 R  H  L  A  Q  L  M  E  S  I  P  H  S  P  G  P  T  R  I  Q         p.260

        | 05 .         .         .         .         .         .    g.11372
 GCTATT | GAGCTCTTTATGCTTCTTGATCTCCTGGGAGCCCCCAATCCCACCTTCTACAGC    c.840
 A  I   | E  L  F  M  L  L  D  L  L  G  A  P  N  P  T  F  Y  S      p.280

          .         .         .         .       | 06 .         .    g.14329
 CACTTCCCTCGCACGGTCCGCTGGTTCCATCGGCTGAGGAGCATTG | AGAAGCGTCTGCAC    c.900
 H  F  P  R  T  V  R  W  F  H  R  L  R  S  I  E |   K  R  L  H      p.300

          .         .         .         .         .         .       g.14389
 CGTTTGAACCTGCTGCAGTCTCATCCCCAGGAAGTGATGTACTTCCAACCCGGGGAGCCC       c.960
 R  L  N  L  L  Q  S  H  P  Q  E  V  M  Y  F  Q  P  G  E  P         p.320

          .         .         .         .    | 07    .         .    g.15438
 TTTGGCTCTGTGGAAGACGACCACATCCCCTTCCTCCGCAGAG | GGGTACCCGTGCTCCAT    c.1020
 F  G  S  V  E  D  D  H  I  P  F  L  R  R  G |   V  P  V  L  H      p.340

          .         .         .         .         .         .       g.15498
 CTCATCTCCACGCCCTTCCCTGCTGTCTGGCACACCCCTGCGGACACCGAGGTCAATCTC       c.1080
 L  I  S  T  P  F  P  A  V  W  H  T  P  A  D  T  E  V  N  L         p.360

          .         .         .         .         .         .       g.15558
 CACCCACCCACGGTACACAACTTGTGCCGCATTCTCGCTGTGTTCCTGGCTGAATACCTG       c.1140
 H  P  P  T  V  H  N  L  C  R  I  L  A  V  F  L  A  E  Y  L         p.380

                                                                    g.15567
 GGGCTCTAG                                                          c.1149
 G  L  X                                                            p.382

          .         .         .         .         .         .       g.15627
 cgtgcttggccaatgactgtggagaggactgtgagagagaaggtcccagcgggggccagt       c.*60

          .         .         .         .         .         .       g.15687
 gaagctcaggcaggatctgcctagggtgtgctggtttgtccttttcatacctttgtctcc       c.*120

          .         .         .         .         .         .       g.15747
 taattgtgctacaattggaagaccttctttcttttgattgtctcaagctgccacccttca       c.*180

          .         .         .         .         .         .       g.15807
 aggacagggaagagaccactgtgggatgacagccagaggaataagaacttgctccctccc       c.*240

          .         .         .         .         .         .       g.15867
 cagaggtaaacacttggtccaaaggtttgcagggaccaaatactgttctttttttttttg       c.*300

          .         .         .         .         .         .       g.15927
 agacggagtctcactgtgttgcccaggctggagtgcagtggtgcgatctcggctcactgc       c.*360

          .         .         .         .         .         .       g.15987
 aaactccgcctcctgggttcacgccattctcctgcctcagcctcccaagtagctgggact       c.*420

          .         .         .         .         .         .       g.16047
 acaggtgcccgccaccacgctggctaattttttgtatttttagtagagacggggtttcac       c.*480

          .         .         .         .         .         .       g.16107
 cgtgttagccaggatggtctcgatctcctgaccttgtaatccgccagcctcggcctccca       c.*540

          .         .         .         .         .         .       g.16167
 aagtgctgggattacaggtgtgagccaccgcacctggcaaaatgctgttctttaagtcag       c.*600

          .         .         .         .         .         .       g.16227
 cgaactgaaaaagtaaaagactgctgggtgtggtggctcacacctgtaatcccaacactt       c.*660

          .         .         .         .         .         .       g.16287
 tgagaggctgagggggaaggatcacccgaggtcaggagtttgagaccagcctggtcaaca       c.*720

          .         .         .         .         .         .       g.16347
 tggcgaaaccctgtctctactaaaaatacaataattagctgggcatggtggtgggcgcct       c.*780

          .         .         .         .         .         .       g.16407
 gtaatctcagctgcttgggaggctgaggcaggagaatcacttgtacgcaggaggcggagg       c.*840

          .         .         .         .         .         .       g.16467
 ttgcagtgagccaagatcacaccactgcactccagcctgggcaacagagcgagactccat       c.*900

          .         .         .         .                           g.16508
 ctcaataaataaataaataaataaatattttttaaaaagag                          c.*941

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Glutaminyl-peptide cyclotransferase-like protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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