glutaminyl-tRNA synthase (glutamine-hydrolyzing)-like 1 (QRSL1) - coding DNA reference sequence

(used for variant description)

(last modified February 22, 2017)


This file was created to facilitate the description of sequence variants on transcript NM_018292.4 in the QRSL1 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000006.11, covering QRSL1 transcript NM_018292.4.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
           .         .         .         .         .                g.5056
     gttgaagggctcagtgacaattaaagatggctgcgcccatgtaacatcactagcga       c.-61

 .         .         .         .         .         .                g.5116
 ccggtgacctctttttcccccttgcctggctcctgtggtggcaggctgggcacgaggacc       c.-1

          .         .     | 02   .         .         .         .    g.15819
 ATGCTGGGCCGGAGCCTCCGAGAA | GTTTCTGCGGCACTGAAACAAGGCCAAATTACACCA    c.60
 M  L  G  R  S  L  R  E   | V  S  A  A  L  K  Q  G  Q  I  T  P      p.20

          .         .         .         .         .         .       g.15879
 ACAGAGCTCTGTCAAAAATGTCTCTCTCTTATCAAGAAGACCAAGTTTCTAAATGCCTAC       c.120
 T  E  L  C  Q  K  C  L  S  L  I  K  K  T  K  F  L  N  A  Y         p.40

          .         .         .         .         .         .       g.15939
 ATTACTGTGTCAGAAGAGGTGGCCTTAAAACAAGCTGAAGAATCAGAAAAGAGATATAAG       c.180
 I  T  V  S  E  E  V  A  L  K  Q  A  E  E  S  E  K  R  Y  K         p.60

      | 03   .         .         .         .         .         .    g.16313
 AATG | GACAGTCACTTGGGGATTTAGATGGAATTCCTATTGCAGTAAAAGACAATTTCAGC    c.240
 N  G |   Q  S  L  G  D  L  D  G  I  P  I  A  V  K  D  N  F  S      p.80

          .         .         .         .    | 04    .         .    g.18445
 ACTTCTGGCATTGAGACAACATGTGCATCAAATATGCTGAAAG | GTTATATACCACCTTAT    c.300
 T  S  G  I  E  T  T  C  A  S  N  M  L  K  G |   Y  I  P  P  Y      p.100

          .         .         .         .         .         .       g.18505
 AATGCTACAGTAGTTCAGAAGTTGTTGGATCAGGGAGCTCTACTAATGGGAAAAACAAAT       c.360
 N  A  T  V  V  Q  K  L  L  D  Q  G  A  L  L  M  G  K  T  N         p.120

          .         . | 05       .         .         .         .    g.24499
 TTAGATGAGTTTGCTATGGG | ATCTGGGAGCACAGATGGTGTATTTGGACCAGTTAAAAAC    c.420
 L  D  E  F  A  M  G  |  S  G  S  T  D  G  V  F  G  P  V  K  N      p.140

          .         .         .         .         .         .       g.24559
 CCCTGGAGTTATTCAAAACAATATAGAGAAAAGAGGAAGCAGAATCCCCACAGCGAGAAT       c.480
 P  W  S  Y  S  K  Q  Y  R  E  K  R  K  Q  N  P  H  S  E  N         p.160

          .         .         .         .         .         .       g.24619
 GAAGATTCAGACTGGCTGATAACTGGAGGAAGCTCAGGTGGGAGTGCAGCTGCTGTATCG       c.540
 E  D  S  D  W  L  I  T  G  G  S  S  G  G  S  A  A  A  V  S         p.180

          .        | 06.         .         .         .         .    g.27686
 GCGTTCACATGCTACGC | GGCTTTAGGATCAGATACAGGAGGATCGACCAGAAATCCTGCT    c.600
 A  F  T  C  Y  A  |  A  L  G  S  D  T  G  G  S  T  R  N  P  A      p.200

          .         .         .         .         .         .       g.27746
 GCCCACTGTGGGCTTGTTGGTTTCAAACCAAGCTATGGCTTAGTTTCCCGTCATGGTCTC       c.660
 A  H  C  G  L  V  G  F  K  P  S  Y  G  L  V  S  R  H  G  L         p.220

          .         .         .         .         .         .       g.27806
 ATTCCCCTGGTGAATTCGATGGATGTGCCAGGAATCTTAACCAGATGTGTGGATGATGCA       c.720
 I  P  L  V  N  S  M  D  V  P  G  I  L  T  R  C  V  D  D  A         p.240

          .    | 07    .         .         .         .         .    g.27948
 GCAATTGTGTTGG | GTGCACTGGCCGGACCTGACCCCAGGGACTCTACCACAGTACATGAA    c.780
 A  I  V  L  G |   A  L  A  G  P  D  P  R  D  S  T  T  V  H  E      p.260

          .         .         .         .         .         .       g.28008
 CCTATTAATAAACCATTCATGCTTCCCAGTTTGGCAGATGTGAGCAAACTATGTATAGGA       c.840
 P  I  N  K  P  F  M  L  P  S  L  A  D  V  S  K  L  C  I  G         p.280

           | 08        .         .         .         .         .    g.30215
 ATTCCAAAG | GAATATCTTGTACCGGAATTATCAAGTGAAGTACAGTCTCTTTGGTCCAAA    c.900
 I  P  K   | E  Y  L  V  P  E  L  S  S  E  V  Q  S  L  W  S  K      p.300

          .         .         .         .         .         .       g.30275
 GCTGCTGACCTCTTTGAGTCTGAGGGGGCCAAAGTAATTGAAGTATCCCTTCCTCACACC       c.960
 A  A  D  L  F  E  S  E  G  A  K  V  I  E  V  S  L  P  H  T         p.320

          .         .         .         .         .         .       g.30335
 AGTTATTCAATTGTCTGCTACCATGTATTGTGCACATCAGAAGTGGCATCGAATATGGCA       c.1020
 S  Y  S  I  V  C  Y  H  V  L  C  T  S  E  V  A  S  N  M  A         p.340

          .         .   | 09     .         .         .         .    g.31087
 AGATTTGATGGGCTACAATATG | GTCACAGATGTGACATTGATGTGTCCACTGAAGCCATG    c.1080
 R  F  D  G  L  Q  Y  G |   H  R  C  D  I  D  V  S  T  E  A  M      p.360

          .         .         .         .         .         .       g.31147
 TATGCTGCAACCAGACGAGAAGGGTTTAATGATGTGGTGAGAGGAAGAATTCTCTCAGGA       c.1140
 Y  A  A  T  R  R  E  G  F  N  D  V  V  R  G  R  I  L  S  G         p.380

          .         . | 10       .         .         .         .    g.38454
 AACTTTTTCTTATTAAAAGA | AAACTATGAAAATTATTTTGTCAAAGCACAGAAAGTGAGA    c.1200
 N  F  F  L  L  K  E  |  N  Y  E  N  Y  F  V  K  A  Q  K  V  R      p.400

          .         .         .         .         .         .       g.38514
 CGCCTCATTGCTAATGACTTTGTAAATGCTTTTAACTCTGGAGTAGATGTCTTGCTAACT       c.1260
 R  L  I  A  N  D  F  V  N  A  F  N  S  G  V  D  V  L  L  T         p.420

          .         .         .         .         .         .       g.38574
 CCCACCACCTTGAGTGAGGCAGTACCATACTTGGAGTTCATCAAAGAGGACAACAGAACC       c.1320
 P  T  T  L  S  E  A  V  P  Y  L  E  F  I  K  E  D  N  R  T         p.440

          .         .         .         .       | 11 .         .    g.41230
 CGAAGTGCCCAGGATGATATTTTTACACAAGCTGTAAATATGGCAG | GATTGCCAGCAGTG    c.1380
 R  S  A  Q  D  D  I  F  T  Q  A  V  N  M  A  G |   L  P  A  V      p.460

          .         .         .         .         .         .       g.41290
 AGTATCCCTGTTGCACTCTCAAACCAAGGGTTGCCAATAGGACTGCAGTTTATTGGACGT       c.1440
 S  I  P  V  A  L  S  N  Q  G  L  P  I  G  L  Q  F  I  G  R         p.480

          .         .         .         .         .         .       g.41350
 GCGTTTTGTGACCAGCAGCTTCTTACAGTAGCCAAATGGTTTGAAAAACAAGTACAGTTT       c.1500
 A  F  C  D  Q  Q  L  L  T  V  A  K  W  F  E  K  Q  V  Q  F         p.500

          .         .         .         .         .         .       g.41410
 CCTGTTATTCAACTTCAAGAACTCATGGATGATTGTTCAGCAGTCCTTGAAAATGAAAAG       c.1560
 P  V  I  Q  L  Q  E  L  M  D  D  C  S  A  V  L  E  N  E  K         p.520

          .         .                                               g.41437
 TTAGCCTCTGTCTCTCTAAAACAGTAA                                        c.1587
 L  A  S  V  S  L  K  Q  X                                          p.528

          .         .         .         .         .         .       g.41497
 acatatcttacaaattaaaatgacttttaggctgggtgcagtggctcacacctgtaatcc       c.*60

          .         .         .         .         .         .       g.41557
 cagcactttgggaggccaaggcgagcggatcatgaggtcagaagatctagaacagcctgg       c.*120

          .         .         .         .         .         .       g.41617
 tcaacatggtgaaaccccgtctctactaaaaatacaaaaattagccaggcttagtggcgg       c.*180

          .         .         .         .         .         .       g.41677
 gcatctgtagtcccagctactcaggaggctgaggcaggagaatcacttgaaccctggagg       c.*240

          .         .         .         .         .         .       g.41737
 tggaggttgcagtgagccgagatcatgccactgcactgcactccagcctgggtgacaaag       c.*300

          .         .         .         .         .         .       g.41797
 caagactgtgtctcaaaataaataaataaaataaaataaaatgacgtacagagattctat       c.*360

          .         .         .         .         .         .       g.41857
 attctagagagtcaaatggtcttgctcaattcttgtaattaggttcttgttaatacagtc       c.*420

          .         .         .         .         .         .       g.41917
 attccatggaattactttttaaaattcctgtgacaattaataataaataacgtgtcagca       c.*480

          .         .         .         .         .         .       g.41977
 tttagtaagcatccactaagtgtacaatacttctacaataacacaagatacctgttcctc       c.*540

          .         .         .         .         .         .       g.42037
 aaagacaatgcattctgccataatgttcattaaagagtttacagtaaaaataagattagg       c.*600

          .         .         .         .         .         .       g.42097
 gataaacttctcaaaaattgtacatctgtgtaactaaagcactaacaaaaacatgaatag       c.*660

          .         .         .         .         .         .       g.42157
 tccttctagaggtaacttggatagcctaggcaggcaacttatcatgtggtgaaggccgcc       c.*720

          .         .         .         .         .         .       g.42217
 tcaggggttgttaaaaatgcacagaaacaattgagtgcgattattggcttctgagcgctg       c.*780

          .         .         .         .         .         .       g.42277
 agcagagcaggtggaagaggaactttgagcacaggaggaaatgcaaccagtcagggccca       c.*840

          .         .         .         .         .         .       g.42337
 gaatcatgcaaatctcaggggtatgcctctctggggaggagctccacttgcagggactcc       c.*900

          .         .         .         .         .         .       g.42397
 ttttatttccctaagaaagagctgaaatgactgagaactttcctttcctccttagagtta       c.*960

          .         .         .         .         .         .       g.42457
 caattttacttctgctattccggagcccatgcctagaagccagaacaactccatgttaca       c.*1020

          .         .         .         .         .         .       g.42517
 ctgagttcatgctcctatttactgatcacaaatgagctcattaatgtcatcgaaacattt       c.*1080

          .         .         .         .         .         .       g.42577
 attgtaacctaacagaccatcacagattggaaacttggtagatagcagagcatggtatta       c.*1140

          .         .         .         .         .         .       g.42637
 gtgaaaaaggttcaaaatacacaagtaacatacactctgaaaaacatgcagataatttgc       c.*1200

          .         .         .         .         .         .       g.42697
 tgatgaagcagaagaggggatgcgcatggcaagaacttgccttaccccagattctctata       c.*1260

          .         .         .         .         .         .       g.42757
 tctcatggtttccttttcctcttgactgtctttacgagtgttttttatttgggaccctcg       c.*1320

          .         .         .         .         .         .       g.42817
 agcccagagatattaatggatatctgtattcaatatttgacaaaatctaatggaaaccat       c.*1380

          .         .         .         .         .         .       g.42877
 ccatttactcatgataaggcttcatcactggatttctgtgtcttcactagaacaccattg       c.*1440

          .         .         .         .         .         .       g.42937
 tcatctcatattgatcaggtattttaatctagcacttacatattgttgataaatgaaagc       c.*1500

          .         .         .         .         .         .       g.42997
 tgaattgttacttaataaattcactttgtttagtaaaaaaaaattgttttctaaatatga       c.*1560

          .         .         .         .         .         .       g.43057
 cgttcatgaagagaaaataatgagtcagaatcatctgcagaaccactggaatgtttcatc       c.*1620

          .         .         .         .         .         .       g.43117
 gtcacctgttagttttcataaacagttttctgtcctctctgagatcctcccgctcccaaa       c.*1680

          .         .         .         .         .         .       g.43177
 tactcaacctgattaacttcacataaaagtcttatgtgccaggcttagtaatattcctat       c.*1740

          .         .         .         .         .         .       g.43237
 agattttgactctgaatccctgaaagaggaagaaatccatgagagaaaattgcattactt       c.*1800

          .         .         .         .         .         .       g.43297
 tatagcaagaggaaaccgttttaagttttttaattgctcagacaccacaacatcctagat       c.*1860

          .         .         .         .         .         .       g.43357
 ggaggaaaccattttagttgaaggagcaaatatgatgtcaaaagcaagtaaataaacaaa       c.*1920

          .         .         .         .         .         .       g.43417
 ccgttgccccaatctgtttttatgtaatgaatttaaaaaaaaagagagagagagagagat       c.*1980

          .         .         .         .         .         .       g.43477
 gggctctccctgtgttgcccaggctagtctcaaactcctgggctcaagtgatctgcctcc       c.*2040

          .         .         .         .         .         .       g.43537
 ctcagcctcccaaagtgctgagattaaagacgtgagccaccacacctggccgaaataata       c.*2100

          .         .         .         .         .         .       g.43597
 atattcaatattatatattcaatgatattattcagtattcaatattatttcaaataatat       c.*2160

          .         .         .         .         .         .       g.43657
 taaatctcttgttcctgtatctctacatgagctgcactaataatttgaatctggaaatta       c.*2220

          .         .         .         .         .         .       g.43717
 aaaagtgaaacatttaccgttctcatatactgatacccaactaccatgaaatgataccta       c.*2280

          .         .         .         .         .         .       g.43777
 atttgtttttcttttctcttcatttttactcttaatctagtaggtctcattttgccaagt       c.*2340

          .         .         .         .         .         .       g.43837
 cactgtctgggaatttaagtggcaaatactttctttgtctcagctaattaaactctaaaa       c.*2400

          .                                                         g.43852
 ttattagcaacagaa                                                    c.*2415

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Glutaminyl-tRNA synthase (glutamine-hydrolyzing)-like 1 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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