RAB11A, member RAS oncogene family (RAB11A) - coding DNA reference sequence

(used for variant description)

(last modified October 23, 2023)
This file was created to facilitate the description of sequence variants on transcript NM_004663.4 in the RAB11A gene based on a coding DNA reference sequence following the HGVS recommendations.
The sequence was taken from NC_000015.9, covering RAB11A transcript NM_004663.4.
Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                                    g.5007
                                                      gcggcag       c.-121

 .         .         .         .         .         .                g.5067
 ggaggggctcttcacccagtccggcagttgaagctcggcgctcgggttacccctgcagcg       c.-61

 .         .         .         .         .         .                g.5127
 acgccccctggtcccacagataccactgctgctcccgccctttcgctcctcggccgcgca       c.-1

          .         .         .         . | 02       .         .    g.12893
 ATGGGCACCCGCGACGACGAGTACGACTACCTCTTTAAAG | TTGTCCTTATTGGAGATTCT    c.60
 M  G  T  R  D  D  E  Y  D  Y  L  F  K  V |   V  L  I  G  D  S      p.20

          .         .         .         .         .         .       g.12953
 GGTGTTGGAAAGAGTAATCTCCTGTCTCGATTTACTCGAAATGAGTTTAATCTGGAAAGC       c.120
 G  V  G  K  S  N  L  L  S  R  F  T  R  N  E  F  N  L  E  S         p.40

          .         .         .         .         .         .       g.13013
 AAGAGCACCATTGGAGTAGAGTTTGCAACAAGAAGCATCCAGGTTGATGGAAAAACAATA       c.180
 K  S  T  I  G  V  E  F  A  T  R  S  I  Q  V  D  G  K  T  I         p.60

          .         .         .         .         .       | 03 .    g.13307
 AAGGCACAGATATGGGACACAGCAGGGCAAGAGCGATATCGAGCTATAACATCAGC | ATAT    c.240
 K  A  Q  I  W  D  T  A  G  Q  E  R  Y  R  A  I  T  S  A  |  Y      p.80

          .         .         .         .         .         .       g.13367
 TATCGTGGAGCTGTAGGTGCCTTATTGGTTTATGACATTGCTAAACATCTCACATATGAA       c.300
 Y  R  G  A  V  G  A  L  L  V  Y  D  I  A  K  H  L  T  Y  E         p.100

          .         .         .         .         .         .       g.13427
 AATGTAGAGCGATGGCTGAAAGAACTGAGAGATCATGCTGATAGTAACATTGTTATCATG       c.360
 N  V  E  R  W  L  K  E  L  R  D  H  A  D  S  N  I  V  I  M         p.120

          .         .         .         .         .         .       g.13487
 CTTGTGGGCAATAAGAGTGATCTACGTCATCTCAGGGCAGTTCCTACAGATGAAGCAAGA       c.420
 L  V  G  N  K  S  D  L  R  H  L  R  A  V  P  T  D  E  A  R         p.140

          . | 04       .         .         .         .         .    g.15262
 GCTTTTGCAG | AAAAGAATGGTTTGTCATTCATTGAAACTTCGGCCCTAGACTCTACAAAT    c.480
 A  F  A  E |   K  N  G  L  S  F  I  E  T  S  A  L  D  S  T  N      p.160

          .         .         .  | 05      .         .         .    g.23271
 GTAGAAGCTGCTTTTCAGACAATTTTAACAG | AGATTTACCGCATTGTTTCTCAGAAGCAA    c.540
 V  E  A  A  F  Q  T  I  L  T  E |   I  Y  R  I  V  S  Q  K  Q      p.180

          .         .         .         .         .         .       g.23331
 ATGTCAGACAGACGCGAAAATGACATGTCTCCAAGCAACAATGTGGTTCCTATTCATGTT       c.600
 M  S  D  R  R  E  N  D  M  S  P  S  N  N  V  V  P  I  H  V         p.200

          .         .         .         .         .                 g.23382
 CCACCAACCACTGAAAACAAGCCAAAGGTGCAGTGCTGTCAGAACATCTAA                c.651
 P  P  T  T  E  N  K  P  K  V  Q  C  C  Q  N  I  X                  p.216

          .         .         .         .         .         .       g.23442
 ggcatttctcttctcccctagaaggctgtgtatagtccatttcccaggtctgagatttaa       c.*60

          .         .         .         .         .         .       g.23502
 atatatttgtaattcttgtgtcacttttgtgttttattacttcatacttatgaatttttc       c.*120

          .         .         .         .         .         .       g.23562
 catgtcctaagtcttttgattttagctttataaaatcatccacttgtcccgaatgactgc       c.*180

          .         .         .         .         .         .       g.23622
 agctttttttcatgctatggcttcactagccttagtttaataaactgaatgtttggattc       c.*240

          .         .         .         .         .         .       g.23682
 ctcagttattgtttacttttcatcatggaagcctgtcactgtatgtaggacataatagaa       c.*300

          .         .         .         .         .         .       g.23742
 cttgatcacttgaagctcagacctattggtcttgatcaaatcaaactaagaagaccttag       c.*360

          .         .         .         .         .         .       g.23802
 aaataagctaccattttgccacagagcagcttataggtaatacactcttctctcagtgca       c.*420

          .         .         .         .         .         .       g.23862
 gtgtacatttccacaaatctaagaattgccctataaacatagcaggattttgagagcttg       c.*480

          .         .         .         .         .         .       g.23922
 aaaattttccattattctggacatgaatttctaaaatgccttaataggtttatgtagttg       c.*540

          .         .         .         .         .         .       g.23982
 agtaaattttgttttttaatttttgtaagcatcaaagttgattagagaggggggcacttt       c.*600

          .         .         .         .         .         .       g.24042
 ttctggagaattctcttagtaaacacaaaagattgttacggtttcattagtagtatggtt       c.*660

          .         .         .         .         .         .       g.24102
 gtggggccataagttaaacagtgctgcctggtaggctgggaactgaagagacttgtggta       c.*720

          .         .         .         .         .         .       g.24162
 ttccatctcgggtgcctctgttggcaatgatcaggcagcccaaaagatttaaatgatcta       c.*780

          .         .         .         .         .         .       g.24222
 taataatttccaagcggtagattatgtggcattttattgctcaggcaataattggtttaa       c.*840

          .         .         .         .         .         .       g.24282
 tgctggtagtgtcaaattttgaagtgttaattttgtcttagaaccttccagtaagtgaaa       c.*900

          .         .         .         .         .         .       g.24342
 tacaacctagttttatcaccatatccaccagcaggcatggataattattttaacaatgct       c.*960

          .         .         .         .         .         .       g.24402
 aatatttgagttttgcagtatattatagaatatagtccagttaaatctttggtttcagta       c.*1020

          .         .         .         .         .         .       g.24462
 tgtctgaagagtacagtgagaggttaatttctgctcaagtggtaccacttaaaggcatgt       c.*1080

          .         .         .         .         .         .       g.24522
 attcttttagtatgtaaaatgaaatagtaccttgagtttaaatagaatgcatttaggcat       c.*1140

          .         .         .         .         .         .       g.24582
 tgtagagatctgaaatagttttcttccactacattgttgaaatcaatgaagcaattagtt       c.*1200

          .         .         .         .         .         .       g.24642
 tctcattcagaaatgtgcacactaatatttagttttgctttctcgtggataatattaagc       c.*1260

          .         .         .         .         .         .       g.24702
 acttactctgcagtttcctggaagttgtgtcaactgcagtgatactattcaggatggtgg       c.*1320

          .         .         .         .         .         .       g.24762
 gaaatccccaaaaatatgtatgtgtgggcttgcttagattactatatttcatagttaatc       c.*1380

          .         .         .         .         .         .       g.24822
 ttttgtctcttgcggtgctcatgatgtgtggggcacacggaaggcattgctgtagtcagt       c.*1440

          .         .         .         .         .         .       g.24882
 cattttggttttcttctatagccattttattattttagtgtattagttatgaagataata       c.*1500

          .         .         .         .         .         .       g.24942
 ttatctatttgtaaattgctactttgtattttatgcatgctctgtaatttgatttttttt       c.*1560

          .         .         .         .         .         .       g.25002
 tagttattgatttggattatattcacattctaataaacagttatagggggattatttctt       c.*1620

          .         .         .         .         .         .       g.25062
 atgctgtcagattacatttttcctttgagtgctttgggtgcagccgtggaatcctgatgt       c.*1680

          .         .         .         .         .         .       g.25122
 aaaagcataggttcttgcattactgagtaaacattgaattgggagcatcagtgtgtgaat       c.*1740

          .         .         .         .         .         .       g.25182
 tcagctttgattttagaactgcagttcaattatgctttccttggaaaaagtatgtccaaa       c.*1800

          .         .         .         .         .         .       g.25242
 aacattaggaaagtagtgtgtattttcatatataacagtgtcaccagacccaggaaaaga       c.*1860

          .         .         .         .         .         .       g.25302
 aaccatctctattttattgaaagttggtggtagattttttacaaagtaaggagaaaagag       c.*1920

          .         .         .         .         .         .       g.25362
 aaaaactaaatagtgaattgaaaatgaataaagtaaacttagaatttttacccaagtgta       c.*1980

          .         .         .         .         .         .       g.25422
 gacttaaatgttgctttgagtatggctggatcttgggagaattccaggaaatattaggta       c.*2040

          .         .         .         .         .         .       g.25482
 ttagaaaatgactttgattgcatttcagcaggtgtctttattctgagtagtatcttagga       c.*2100

          .         .         .         .         .         .       g.25542
 gacaaactgtctcaagcaagaaacaataaatttttaaatattatgacagttcagggctta       c.*2160

          .         .         .         .         .         .       g.25602
 aggcagtttagaagtattttgctacttgaccttgattttcagttattttaactttgaatt       c.*2220

          .         .         .         .         .         .       g.25662
 tttttttttttttttgagacggagtcttgctctgttgcccaggctggagtacaatggcac       c.*2280

          .         .         .         .         .         .       g.25722
 catctcagctcactgcaagctccacctccagggttcatgccattctcctgcctcagcctc       c.*2340

          .         .         .         .         .         .       g.25782
 ccgagtagctgggattataggcgccagccaccacgactggctaattttttgtatttttag       c.*2400

          .         .         .         .         .         .       g.25842
 tagagacggggtttcaccatgttagccagggtggtctcgatctcctgacctggtgataca       c.*2460

          .         .         .         .         .         .       g.25902
 cccacctcggcctcccaaagtgctgggattaaaggcgtgagccaccgtgcctggccttga       c.*2520

          .         .         .         .         .         .       g.25962
 atttttttttaacctgttatatagtctcctgaatagttagccatggtgccttgatttaat       c.*2580

          .         .         .         .         .         .       g.26022
 cttatgtcattgttctcaaatgccatgatttctctttaatagtagttgtcattatgtaag       c.*2640

          .         .         .         .         .         .       g.26082
 ggtaagttattgcccatttaattgtaattataagaagaggtgccagctagtgaccttaca       c.*2700

          .         .         .         .         .         .       g.26142
 tcagtgatcttttaagttctgaagggttctgcagaaaagttacacttcttgagtttgggt       c.*2760

          .         .         .         .         .         .       g.26202
 tgcccatcagagctggtcacatttctttgatcattgaaaaaatgaatatcttaatttttg       c.*2820

          .         .         .         .         .         .       g.26262
 tctttgctgactggtatttataaaatacaaatgcttttagtgggttgagctgttgtgata       c.*2880

          .         .         .         .         .         .       g.26322
 atctcttccatctaccttagagaagaagctgtactatttagacagttttggccaacacta       c.*2940

          .         .         .         .         .         .       g.26382
 gaagcaaaagaattcaaaggctgggtggatatttaagaacttattctaacctgtcaggtt       c.*3000

          .         .         .         .         .         .       g.26442
 tcaatttgtggggcttggtttaacagaggaaaaaaatataaattgattttctgatgtctc       c.*3060

          .         .         .         .         .         .       g.26502
 acaaatatcacatacctggaaaaaaattaaaacaaaaaatgaattttgtaaaaggttatg       c.*3120

          .         .         .         .         .         .       g.26562
 tatgacttccatttgctctgtaaaaaaatgaacaaagattgtgaaaggatcctcttccac       c.*3180

          .         .         .         .         .         .       g.26622
 cacatcatttaatgggttagcggaacagatagggagctatgacactagcaccaaagagag       c.*3240

          .         .         .         .         .         .       g.26682
 atttttcttctggttgggtggtgctggtgccacgcccctttctgggatttgacaagtctt       c.*3300

          .         .         .         .         .         .       g.26742
 tcccactcacctatacaatatgccaaatcaactggagttgtcattctaatgttttaaaga       c.*3360

          .         .         .         .         .         .       g.26802
 atgattgggttcccccaaactgtaggaggtcgatggtaacaataaagtgatacaaaatgc       c.*3420

          .         .         .         .         .         .       g.26862
 ttatgtcattataatttatgtaagggagaccattaggctgagaatcaatatgattgaggt       c.*3480

          .         .         .         .         .         .       g.26922
 tatctattctcctgaaaagtgaattggagaataaagaaagaatatttgaaaggatgttgt       c.*3540

          .         .         .         .         .         .       g.26982
 gtactaggcaatatactagcatgtattagaaaatacggtaaactgtgggttagaagagtg       c.*3600

          .         .         .         .         .         .       g.27042
 aaagtagctggtatgatagagcactggactgagtaacgaagagattctagtcatggctct       c.*3660

          .         .         .         .         .         .       g.27102
 tgtggtcatttcatttttgagcctcacattcttccaattaatgagggtaccagattaaat       c.*3720

          .         .         .         .         .         .       g.27162
 aaactctggggattcatcccaattcgaactctgtaattctctgaatgaactctctcttca       c.*3780

          .         .         .         .         .         .       g.27222
 attaaagccaaattattaacattttaactcaagtttaaatttaatagagaagtcaaaatg       c.*3840

          .         .         .         .         .         .       g.27282
 aggtatgcactttgtggaatgtttttggtcttatcacaataacctgattaaaatggtgcc       c.*3900

          .         .         .         .         .         .       g.27342
 tttatttccatgtttactcctttaaataagatgaaagctttcagaacatttatttgcaaa       c.*3960

          .         .         .         .         .         .       g.27402
 atgactgtcaatatcaacaatatgcatcaaagtaccatatatgctaagggagaggagcac       c.*4020

          .         .         .         .         .         .       g.27462
 ttgatgggctgctatgttaactgtaaattgagaactgcttgttttatggcttttgctgtt       c.*4080

          .         .         .         .         .         .       g.27522
 aaaaaaaaactgctggcttttaatatgtactttaaaatatactcatgtctgggagagaac       c.*4140

          .                                                         g.27533
 ttttaaaaaca                                                        c.*4151

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10^th nucleotide is indicated by a "." above the sequence. The RAB11A, member RAS oncogene family protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10^th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.