RAB11B, member RAS oncogene family (RAB11B) - coding DNA reference sequence

(used for variant description)

(last modified December 29, 2017)

This file was created to facilitate the description of sequence variants on transcript NM_004218.3 in the RAB11B gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000019.9, covering RAB11B transcript NM_004218.3.

Please note that introns are available by clicking on the exon numbers above the sequence.

 (upstream sequence)
                               .         .         .                g.5036
                         cattcaaccgccgctctgcgcggcgccggctccgcc       c.-61

 .         .         .         .         .         .                g.5096
 cccgtcgggtgtttgtggtggggctgcggagtcgccgatcccgccggaagcgccaggaca       c.-1

          .         .         .         . | 02       .         .    g.14562
 ATGGGGACCCGGGACGACGAGTACGACTACCTATTCAAAG | TGGTGCTCATCGGGGACTCA    c.60
 M  G  T  R  D  D  E  Y  D  Y  L  F  K  V |   V  L  I  G  D  S      p.20

          .         .         .         .         .         .       g.14622
 GGCGTGGGCAAGAGCAACCTGCTGTCGCGCTTCACCCGCAACGAGTTCAACCTGGAGAGC       c.120
 G  V  G  K  S  N  L  L  S  R  F  T  R  N  E  F  N  L  E  S         p.40

          .         .         .         .         .         .       g.14682
 AAGAGCACCATCGGCGTGGAGTTCGCCACCCGCAGCATCCAGGTGGACGGCAAGACCATC       c.180
 K  S  T  I  G  V  E  F  A  T  R  S  I  Q  V  D  G  K  T  I         p.60

          .         .         .         .         .       | 03 .    g.16769
 AAGGCGCAGATCTGGGACACCGCTGGCCAGGAGCGCTACCGCGCCATCACCTCCGC | GTAC    c.240
 K  A  Q  I  W  D  T  A  G  Q  E  R  Y  R  A  I  T  S  A  |  Y      p.80

          .         .         .         .         .         .       g.16829
 TACCGTGGTGCAGTGGGCGCCCTGCTGGTGTACGACATCGCCAAGCACCTGACCTATGAG       c.300
 Y  R  G  A  V  G  A  L  L  V  Y  D  I  A  K  H  L  T  Y  E         p.100

          .         .         .         .         .         .       g.16889
 AACGTGGAGCGCTGGCTGAAGGAGCTGCGGGACCACGCAGACAGCAACATCGTCATCATG       c.360
 N  V  E  R  W  L  K  E  L  R  D  H  A  D  S  N  I  V  I  M         p.120

          .         .         .         .         .         .       g.16949
 CTGGTGGGCAACAAGAGTGACCTGCGCCACCTGCGGGCTGTGCCCACTGACGAGGCCCGC       c.420
 L  V  G  N  K  S  D  L  R  H  L  R  A  V  P  T  D  E  A  R         p.140

          . | 04       .         .         .         .         .    g.17214
 GCCTTCGCAG | AAAAGAACAACTTGTCCTTCATCGAGACCTCAGCCTTGGATTCCACTAAC    c.480
 A  F  A  E |   K  N  N  L  S  F  I  E  T  S  A  L  D  S  T  N      p.160

          .         .         .  | 05      .         .         .    g.18121
 GTAGAGGAAGCATTCAAGAACATCCTCACAG | AGATCTACCGCATCGTGTCACAGAAACAG    c.540
 V  E  E  A  F  K  N  I  L  T  E |   I  Y  R  I  V  S  Q  K  Q      p.180

          .         .         .         .         .         .       g.18181
 ATCGCAGACCGCGCTGCCCACGACGAGTCCCCGGGGAACAACGTGGTGGACATCAGCGTG       c.600
 I  A  D  R  A  A  H  D  E  S  P  G  N  N  V  V  D  I  S  V         p.200

          .         .         .         .         .                 g.18238
 CCGCCCACCACGGACGGACAGAAGCCCAACAAGCTGCAGTGCTGCCAGAACCTGTGA          c.657
 P  P  T  T  D  G  Q  K  P  N  K  L  Q  C  C  Q  N  L  X            p.218

          .         .         .         .         .         .       g.18298
 cccctgcgcctccacccagcgtgcgtgcacgtcctccgcccgcccccgccacggtatcct       c.*60

          .         .         .         .         .         .       g.18358
 ctggcccctccctgctgtccctctgtggccggctcgttccagccctcccagtgagctctg       c.*120

          .         .         .         .         .         .       g.18418
 cacggccgggccggggcccaggaaggacaggagccagtgctaccccgtcctgcccgggga       c.*180

          .         .         .         .         .         .       g.18478
 aaagctagaagccccggtttgctgcacccatgaaactcgggtccccacagcgtcttggcg       c.*240

          .         .         .         .         .         .       g.18538
 gggtggggagggcggcaggatggacggggctggccagaggcgaggaggacgggcggacgg       c.*300

          .         .         .         .         .         .       g.18598
 cgccgccttctccccttttccttggccgactctagggagcgattgcctccctccctccgt       c.*360

          .         .         .         .         .         .       g.18658
 gaccgggtggcccagccagcccgtcgtccccacccagaaccgtgctctgggccaaagccc       c.*420

          .         .         .         .         .         .       g.18718
 gaagaaccaggcagcgggggccggggcaggcggaccccccgggctctcagcgcccacccg       c.*480

          .         .         .         .         .         .       g.18778
 ctcctccgcacacagcagctcgcacaggcctcccacctctgcctgttgattgatgcaggg       c.*540

          .         .         .         .         .         .       g.18838
 agaagcccgtccccccctctcccctctcccctcccctctcctgcacgcaacgcgccctct       c.*600

          .         .         .         .         .         .       g.18898
 cggccctccctgtccccctcctctgtctcgtctccccatctggtctggaacctgtttgca       c.*660

          .         .         .         .         .         .       g.18958
 agtgaagcaatatctccgtgttttgtatatacaaccgctcttgtagcctttggtttttgt       c.*720

          .         .         .         .         .         .       g.19018
 taatgtagagaaacacagattctttatacactttgtaagatttacgccaaaccccagctc       c.*780

          .         .         .         .         .         .       g.19078
 tcgatctcttcttctccctgtggcccctgcgctgttgccccgtccccgtcaccccgcccg       c.*840

          .         .         .                                     g.19114
 ttactgaaatgtataatctgacttcctgtacagaaa                               c.*876

 (downstream sequence)

Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10^th nucleotide is indicated by a "." above the sequence. The RAB11B, member RAS oncogene family protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10^th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.