RAB3 GTPase activating protein subunit 1 (catalytic) (RAB3GAP1) - coding DNA reference sequence

(used for variant description)

(last modified December 10, 2012)


This file was created to facilitate the description of sequence variants on transcript NM_001172435.1 in the RAB3GAP1 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000002.11, covering RAB3GAP1 transcript NM_001172435.1.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                     .         .         .         .                g.5043
                  cttcttcccggcagccttagcgccaggcccggcgctcctcaag       c.-1

          .         | 02         .         .         .         .    g.5207
 ATGGCTGCCGACAGTGAG | CCCGAATCCGAGGTATTTGAGATCACGGACTTCACCACTGCC    c.60
 M  A  A  D  S  E   | P  E  S  E  V  F  E  I  T  D  F  T  T  A      p.20

          .     | 03   .         .         .         .         .    g.10792
 TCGGAATGGGAAAG | GTTTATTTCCAAAGTTGAAGAAGTCTTGAATGACTGGAAACTGATT    c.120
 S  E  W  E  R  |  F  I  S  K  V  E  E  V  L  N  D  W  K  L  I      p.40

          .         .         . | 04       .         .         .    g.43763
 GGAAACTCTTTGGGAAAGCCACTCGAAAAG | GGTATATTTACTTCTGGCACATGGGAAGAG    c.180
 G  N  S  L  G  K  P  L  E  K   | G  I  F  T  S  G  T  W  E  E      p.60

          .         .         .         .         .         .       g.43823
 AAATCAGATGAAATTTCCTTTGCTGACTTCAAGTTCTCAGTCACTCATCATTATCTTGTA       c.240
 K  S  D  E  I  S  F  A  D  F  K  F  S  V  T  H  H  Y  L  V         p.80

          .         .         .         .    | 05    .         .    g.46367
 CAAGAGTCCACTGATAAAGAAGGAAAGGATGAGTTATTAGAGG | ATGTTGTTCCACAATCT    c.300
 Q  E  S  T  D  K  E  G  K  D  E  L  L  E  D |   V  V  P  Q  S      p.100

          .         .         .         .         .         .       g.46427
 ATGCAAGATTTGCTGGGTATGAATAATGACTTTCCTCCAAGAGCACATTGCCTGGTAAGA       c.360
 M  Q  D  L  L  G  M  N  N  D  F  P  P  R  A  H  C  L  V  R         p.120

    | 06     .         .         .         .         .         .    g.65944
 TG | GTATGGGCTACGTGAGTTCGTGGTGATTGCCCCTGCTGCACACAGTGACGCTGTTCTC    c.420
 W  |  Y  G  L  R  E  F  V  V  I  A  P  A  A  H  S  D  A  V  L      p.140

          .         .         .         .         .         .       g.66004
 AGCGAATCTAAGTGCAACCTTCTTCTGAGTTCTGTTTCTATTGCCTTGGGAAACACTGGC       c.480
 S  E  S  K  C  N  L  L  L  S  S  V  S  I  A  L  G  N  T  G         p.160

    | 07     .         .         .         .         .         .    g.68009
 TG | TCAGGTGCCACTCTTTGTGCAAATTCACCACAAATGGCGAAGAATGTATGTAGGAGAA    c.540
 C  |  Q  V  P  L  F  V  Q  I  H  H  K  W  R  R  M  Y  V  G  E      p.180

          .         .         .         .         .         .       g.68069
 TGTCAAGGTCCTGGTGTACGAACTGATTTCGAAATGGTTCATCTTAGAAAAGTGCCAAAT       c.600
 C  Q  G  P  G  V  R  T  D  F  E  M  V  H  L  R  K  V  P  N         p.200

          .         .         .         .         | 08         .    g.73566
 CAGTACACTCACTTATCAGGTCTGCTGGATATCTTCAAATCAAAGATT | GGATGTCCTTTA    c.660
 Q  Y  T  H  L  S  G  L  L  D  I  F  K  S  K  I   | G  C  P  L      p.220

          .         .         .         .         .         .       g.73626
 ACTCCATTGCCTCCAGTTAGTATTGCTATTCGATTTACCTATGTACTTCAAGATTGGCAG       c.720
 T  P  L  P  P  V  S  I  A  I  R  F  T  Y  V  L  Q  D  W  Q         p.240

          .         .         | 09         .         .         .    g.76932
 CAGTATTTTTGGCCTCAGCAACCTCCAG | ACATAGATGCCCTTGTAGGAGGAGAAGTTGGA    c.780
 Q  Y  F  W  P  Q  Q  P  P  D |   I  D  A  L  V  G  G  E  V  G      p.260

          .         .         .         .         . | 10       .    g.78926
 GGCTTGGAGTTTGGCAAGTTACCATTTGGTGCCTGCGAAGATCCTATTAG | TGAACTCCAT    c.840
 G  L  E  F  G  K  L  P  F  G  A  C  E  D  P  I  S  |  E  L  H      p.280

          .         .         .         .         .          | 11    g.79319
 TTAGCTACTACATGGCCTCATCTGACCGAAGGGATCATTGTGGATAATGATGTTTATTC | T    c.900
 L  A  T  T  W  P  H  L  T  E  G  I  I  V  D  N  D  V  Y  S  |      p.300

          .         .         .         .         .         .       g.79379
 GATTTGGATCCTATTCAAGCTCCACATTGGTCTGTTAGAGTTCGAAAAGCTGAGAATCCT       c.960
 D  L  D  P  I  Q  A  P  H  W  S  V  R  V  R  K  A  E  N  P         p.320

          .    | 12    .         .         .         .         .    g.82777
 CAGTGTTTGCTAG | GTGATTTTGTCACTGAATTTTTTAAAATTTGCCGTCGAAAGGAGTCA    c.1020
 Q  C  L  L  G |   D  F  V  T  E  F  F  K  I  C  R  R  K  E  S      p.340

          .         .         .         .       | 13 .         .    g.83301
 ACTGATGAGATTCTTGGACGATCTGCATTTGAGGAAGAAGGCAAAG | AAACTGCTGATATA    c.1080
 T  D  E  I  L  G  R  S  A  F  E  E  E  G  K  E |   T  A  D  I      p.360

          .         .         .         .         .         .       g.83361
 ACTCATGCTTTGTCAAAATTGACAGAGCCGGCATCAGTTCCAATTCATAAATTATCAGTT       c.1140
 T  H  A  L  S  K  L  T  E  P  A  S  V  P  I  H  K  L  S  V         p.380

          .         .         .         .         .         .       g.83421
 TCAAATATGGTACACACTGCAAAGAAGAAAATCCGAAAACACAGAGGTGTAGAGGAGTCA       c.1200
 S  N  M  V  H  T  A  K  K  K  I  R  K  H  R  G  V  E  E  S         p.400

          .         .         .       | 14 .         .         .    g.85654
 CCGCTAAATAATGATGTTCTTAATACTATTCTCCTG | TTCTTATTCCCTGATGCTGTTTCT    c.1260
 P  L  N  N  D  V  L  N  T  I  L  L   | F  L  F  P  D  A  V  S      p.420

          .         .         .         .         .         .       g.85714
 GAGAAACCATTAGATGGAACTACTTCAACAGATAATAATAATCCTCCATCAGAGAGTGAA       c.1320
 E  K  P  L  D  G  T  T  S  T  D  N  N  N  P  P  S  E  S  E         p.440

        | 15 .         .         .         .         .         .    g.86650
 GACTAT | AATCTCTACAATCAGTTCAAGTCTGCACCATCTGACAGTTTAACATACAAACTG    c.1380
 D  Y   | N  L  Y  N  Q  F  K  S  A  P  S  D  S  L  T  Y  K  L      p.460

          .         .         .         .         .         .       g.86710
 GCTTTGTGTCTCTGTATGATCAATTTTTACCATGGAGGGTTGAAAGGAGTGGCACACCTC       c.1440
 A  L  C  L  C  M  I  N  F  Y  H  G  G  L  K  G  V  A  H  L         p.480

          .         .         .         .         .          | 16    g.88001
 TGGCAGGAATTTGTTCTTGAAATGCGTTTCCGATGGGAAAACAACTTTCTGATTCCAGG | A    c.1500
 W  Q  E  F  V  L  E  M  R  F  R  W  E  N  N  F  L  I  P  G  |      p.500

          .         .         .         .         .     | 17   .    g.88305
 TTAGCAAGTGGACCCCCAGATCTGAGGTGTTGTTTACTGCATCAGAAACTACAG | ATGTTA    c.1560
 L  A  S  G  P  P  D  L  R  C  C  L  L  H  Q  K  L  Q   | M  L      p.520

          .         .         .         .         .         .       g.88365
 AATTGTTGTATTGAAAGAAAGAAGGCACGTGATGAGGGGAAAAAGACAAGTGCTTCAGAT       c.1620
 N  C  C  I  E  R  K  K  A  R  D  E  G  K  K  T  S  A  S  D         p.540

          .         .         .         .         .         .       g.88425
 GTCACTAATATATATCCAGGGGATGCTGGAAAAGCAGGAGACCAGTTGGTGCCAGATAAT       c.1680
 V  T  N  I  Y  P  G  D  A  G  K  A  G  D  Q  L  V  P  D  N         p.560

          .         .         .         .         .         .       g.88485
 CTAAAAGAAACAGATAAGGAAAAGGGAGAGGTAGGAAAATCTTGGGATTCCTGGAGTGAC       c.1740
 L  K  E  T  D  K  E  K  G  E  V  G  K  S  W  D  S  W  S  D         p.580

          .         .         .         .         .         .       g.88545
 AGCGAAGAAGAATTTTTTGAATGCCTAAGTGATACTGAAGAACTTAAAGGAAATGGACAA       c.1800
 S  E  E  E  F  F  E  C  L  S  D  T  E  E  L  K  G  N  G  Q         p.600

          .         .         .         .         .         .       g.88605
 GAGAGTGGCAAGAAAGGAGGACCTAAGGAGATGGCAAATTTAAGGCCGGAAGGACGGCTC       c.1860
 E  S  G  K  K  G  G  P  K  E  M  A  N  L  R  P  E  G  R  L         p.620

          .         .         .         .         .         .       g.88665
 TATCAGCATGGGAAACTTACACTGCTGCATAATGGAGAACCTCTCTACATTCCAGTAACC       c.1920
 Y  Q  H  G  K  L  T  L  L  H  N  G  E  P  L  Y  I  P  V  T         p.640

     | 18    .         .         .         .         .         .    g.103161
 CAG | GAACCAGCACCTATGACAGAAGATCTGCTAGAAGAGCAGTCTGAAGTTTTAGCTAAA    c.1980
 Q   | E  P  A  P  M  T  E  D  L  L  E  E  Q  S  E  V  L  A  K      p.660

          .         .         .         .         .         .       g.103221
 TTAGGTACATCGGCAGAGGGGGCTCACCTTCGAGCACGCATGCAGAGTGCCTGTCTGCTC       c.2040
 L  G  T  S  A  E  G  A  H  L  R  A  R  M  Q  S  A  C  L  L         p.680

          .         .  | 19      .         .         .         .    g.106423
 TCAGATATGGAGTCTTTTAAG | GCAGCTAATCCAGGTTGCTCCCTGGAAGATTTTGTGAGG    c.2100
 S  D  M  E  S  F  K   | A  A  N  P  G  C  S  L  E  D  F  V  R      p.700

          .         .         .         .         .         .       g.106483
 TGGTATTCACCCCGGGATTATATTGAAGAGGAGGTGATTGATGAAAAGGGCAATGTGGTG       c.2160
 W  Y  S  P  R  D  Y  I  E  E  E  V  I  D  E  K  G  N  V  V         p.720

          .         .         .         .         .         .       g.106543
 CTGAAAGGAGAACTGAGTGCCCGGATGAAGATTCCAAGCAATATGTGGGTAGAAGCCTGG       c.2220
 L  K  G  E  L  S  A  R  M  K  I  P  S  N  M  W  V  E  A  W         p.740

          .         .         .         .         .         .       g.106603
 GAAACAGCTAAGCCAATTCCTGCTAGAAGGCAAAGGAGACTCTTTGATGATACACGGGAA       c.2280
 E  T  A  K  P  I  P  A  R  R  Q  R  R  L  F  D  D  T  R  E         p.760

           | 20        .         .         .         .         .    g.115341
 GCAGAAAAG | GTGCTGCACTATCTGGCAATCCAGAAACCTGCAGACCTTGCTCGGCACCTG    c.2340
 A  E  K   | V  L  H  Y  L  A  I  Q  K  P  A  D  L  A  R  H  L      p.780

          .         .         .         .       | 21 .         .    g.115497
 TTACCTTGTGTGATTCATGCAGCTGTACTCAAGGTAAAGGAAGAAG | AAAGTCTCGAAAAC    c.2400
 L  P  C  V  I  H  A  A  V  L  K  V  K  E  E  E |   S  L  E  N      p.800

          .         .         .         .         .         .       g.115557
 ATTTCTTCAGTTAAGAAGATCATAAAGCAGATAATATCCCATTCCAGTAAAGTTTTGCAC       c.2460
 I  S  S  V  K  K  I  I  K  Q  I  I  S  H  S  S  K  V  L  H         p.820

          .         .         . | 22       .         .         .    g.115751
 TTCCCCAATCCAGAAGACAAGAAATTGGAA | GAAATCATTCACCAGATTACTAATGTGGAA    c.2520
 F  P  N  P  E  D  K  K  L  E   | E  I  I  H  Q  I  T  N  V  E      p.840

          .         .         .         .         .         .       g.115811
 GCTCTCATTGCCAGAGCTCGGTCACTAAAAGCCAAGTTTGGAACTGAGAAATGTGAACAG       c.2580
 A  L  I  A  R  A  R  S  L  K  A  K  F  G  T  E  K  C  E  Q         p.860

          .         .       | 23 .         .         .         .    g.117363
 GAGGAGGAAAAGGAAGATCTTGAAAG | GTTTGTGAGTTGCCTGCTGGAGCAGCCTGAAGTG    c.2640
 E  E  E  K  E  D  L  E  R  |  F  V  S  C  L  L  E  Q  P  E  V      p.880

          .         .         .         .         .         .       g.117423
 TTAGTCACCGGTGCAGGAAGAGGACATGCTGGCAGGATCATTCACAAGCTGTTTGTGAAT       c.2700
 L  V  T  G  A  G  R  G  H  A  G  R  I  I  H  K  L  F  V  N         p.900

           | 24        .         . | 25       .         .         . g.121310
 GCCCAGAGG | CTGACTGAATCTTCTGATGAG | GCTGCAGCTATGACTCCACCAGAGGAGGAA c.2760
 A  Q  R   | L  T  E  S  S  D  E   | A  A  A  M  T  P  P  E  E  E   p.920

          .         .         .         .         .         .       g.121370
 TTGAAGAGAATGGGCTCCCCAGAGGAAAGAAGGCAGAACTCCGTGTCAGACTTCCCACCC       c.2820
 L  K  R  M  G  S  P  E  E  R  R  Q  N  S  V  S  D  F  P  P         p.940

          .         .         .         .         .         .       g.121430
 CCTGCTGGCCGGGAATTCATTTTGCGCACCACTGTGCCGCGCCCTGCTCCCTACTCCAAA       c.2880
 P  A  G  R  E  F  I  L  R  T  T  V  P  R  P  A  P  Y  S  K         p.960

          .         .         .         .         .         .       g.121490
 GCTCTGCCTCAGCGGATGTACAGTGTTCTCACCAAAGAGGACTTTAGACTTGCAGGTGCC       c.2940
 A  L  P  Q  R  M  Y  S  V  L  T  K  E  D  F  R  L  A  G  A         p.980

          .         .                                               g.121517
 TTTTCATCAGATACTTCCTTCTTCTGA                                        c.2967
 F  S  S  D  T  S  F  F  X                                          p.988

          .         .         .         .         .         .       g.121577
 ttcttctagcattactcgttggtggcttcagagacagtgctgcctcctcctgagggaggg       c.*60

          .         .         .         .         .         .       g.121637
 aaggtaccagggagaacctgggaggtcctggagagggccctgtccagttgggtgatcagg       c.*120

          .         .         .         .         .         .       g.121697
 aatcaaaccagcatcggaaagacttcccagcaccaagcttgagctgtgtcgtttcgtgga       c.*180

          .         .         .         .         .         .       g.121757
 gggggcagcgaggatgggcttgagctgttgagagatttctgccctagagatggcctttgt       c.*240

          .         .         .         .         .         .       g.121817
 atatgggggggtggtggggggacacaaacacatcagacactccgtcctcacactggcagg       c.*300

          .         .         .         .         .         .       g.121877
 acggtgttcatcgcattctcttctgtgaccagcctctaggctagcggctgcattcgtggt       c.*360

          .         .         .         .         .         .       g.121937
 ctgtgcaaacacttcgtggttctatatatcagcagcaagtgtgcaaaataaaggacctgt       c.*420

          .         .         .         .         .         .       g.121997
 taactcagatttctggatattttggtggtagcttctagtcccagaatctgtgtttttaaa       c.*480

          .         .         .         .         .         .       g.122057
 atactacatgacattctgtctattcaatcacctggtggtcatctttcttgtactaattaa       c.*540

          .         .         .         .         .         .       g.122117
 ctgttgatgagcattttggatattctaggagaaagcctataatttcacatagtttctctt       c.*600

          .         .         .         .         .         .       g.122177
 tttcatgtaactgtaacctaaatgtattacttctgataaaactatatatcaaatgtcact       c.*660

          .         .         .         .         .         .       g.122237
 gcaaattagttttatatctgtcatgtgagatttgtcttacttatttttcttttggttgcc       c.*720

          .         .         .         .         .         .       g.122297
 atggaagttatggccctgaaaatcgtctccctccccttctcttgctgtacagcatgcgtt       c.*780

          .         .         .         .         .         .       g.122357
 ctctttttgtggttgctggctgggtactgtatttaatgaagtagagaatagcacttgcaa       c.*840

          .         .         .         .         .         .       g.122417
 aaatacagtcttggtacctagagactgtcatgcagatagtataatttggtatatgtgcta       c.*900

          .         .         .         .         .         .       g.122477
 atgcattgagtagaggattattttaacacactattttgcttttgtattttagttaaaata       c.*960

          .         .         .         .         .         .       g.122537
 atcgatggggatgtgtagcccccccgtgtgaggatgacatcaccacatttctagtttcat       c.*1020

          .         .         .         .         .         .       g.122597
 ggagctcaagatgtcttgtgtctgtgtggctagatggcctctgcttggtaatcttatttt       c.*1080

          .         .         .         .         .         .       g.122657
 taggcctaaaattcccacttaaatccaaagtaaaaatggttatactgaagcataaacctt       c.*1140

          .         .         .         .         .         .       g.122717
 gcctgtgtaattttaaaaaattaatagagctgtgcaaaccctgttatttttgtaaaaaaa       c.*1200

          .         .         .         .         .         .       g.122777
 aaaaaaaatacatatctatatataatatgtgtgtgtgtgtgacatatgcacacgtctctg       c.*1260

          .         .         .         .         .         .       g.122837
 tgtatgtgaagtaggggaggccctgggggatgacctcccagcctttatgatgcttttctc       c.*1320

          .         .         .         .         .         .       g.122897
 tatgctgctggacttcattcttactggtccacgcagatgcaggcggcctgaggccagtgc       c.*1380

          .         .         .         .         .         .       g.122957
 tgtaccaagtagaagacggttcctaaggacagagtttgtctgttttctaacaaagaaaaa       c.*1440

          .         .         .         .         .         .       g.123017
 ttctacaaaggagaggttgggcgttacaaaggcattgtgaatctaataaaaggaaagtgt       c.*1500

          .         .         .         .         .         .       g.123077
 cgctttctgtggcgttttctttcattttctcccgctgaggcatttcagtctaatttcatg       c.*1560

          .         .         .         .         .         .       g.123137
 tggttttgtgctgtctcagctctaatgtttgcagcctgctgagcctaacaaggcagtggt       c.*1620

          .         .         .         .         .         .       g.123197
 ctcaagaacattctttgtgcctttttaaagtactccattttatttttatgatagttatgt       c.*1680

          .         .         .         .         .         .       g.123257
 atttatttcacagatatatttaagtacccactttgtgtcaggtacagtacaagcaatgaa       c.*1740

          .         .         .         .         .         .       g.123317
 gataaaacagaaaccaaaacacactcccttacagggaaaactgacaccacgttgccacaa       c.*1800

          .         .         .         .         .         .       g.123377
 aatgttgagtatagtcaactctgctgtgtggatcggagggcctgcatttatcctacaaat       c.*1860

          .         .         .         .         .         .       g.123437
 aattgaatgtaatcctacattcatgtattcattggcagtacggagtaataaatgcagcaa       c.*1920

                                                                    g.123446
 tgtcataaa                                                          c.*1929

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The RAB3 GTPase activating protein subunit 1 (catalytic) protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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