RAB9B, member RAS oncogene family (RAB9B) - coding DNA reference sequence

(used for variant description)

(last modified April 21, 2017)

This file was created to facilitate the description of sequence variants on transcript NM_016370.2 in the RAB9B gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_016452.1, covering RAB9B transcript NM_016370.2.

Please note that introns are available by clicking on the exon numbers above the sequence.

 (upstream sequence)
                               .         .         .                g.5039
                      ccctggcgggcgcgggcgcgggctcgagacgctgcgcgg       c.-301

 .         .         .         .         .         .                g.5099
 cggcagcggcgggcgcgagcggcagctgtcaggccaccgaggtccaagccgcacttgctg       c.-241

 .         .         .         .         .         .                g.5159
 ccccattgaggacgaggaggcagcaggagcagtgacggtgactctaaggagccggattcc       c.-181

 .         .         .         .         .         .                g.5219
 cggcacgcagagctgacctgcctggcacccgcggccctctcctgtttccttcccattgtg       c.-121

 .    | 02    .         .         .         .         .             g.10260
 ttgg | caccctaaaaagaaagaataaaacaacaacaggaaaaaaaggaaaatatttaaatt    c.-61

 .         .        | 03.         .         .         .             g.11498
 gtgacaaaaacccactgg | gttctcttggttacaaactccttcccttctggtgctgcaaaa    c.-1

          .         .         .         .         .         .       g.11558
 ATGAGTGGGAAATCCCTGCTCTTAAAGGTCATTCTCTTGGGTGATGGTGGAGTTGGGAAA       c.60
 M  S  G  K  S  L  L  L  K  V  I  L  L  G  D  G  G  V  G  K         p.20

          .         .         .         .         .         .       g.11618
 AGTTCGCTTATGAACCGTTACGTAACCAACAAATTTGACTCCCAGGCTTTTCACACCATA       c.120
 S  S  L  M  N  R  Y  V  T  N  K  F  D  S  Q  A  F  H  T  I         p.40

          .         .         .         .         .         .       g.11678
 GGGGTAGAGTTCTTAAATCGAGATCTGGAGGTAGATGGACGCTTTGTAACCCTCCAGATC       c.180
 G  V  E  F  L  N  R  D  L  E  V  D  G  R  F  V  T  L  Q  I         p.60

          .         .         .         .         .         .       g.11738
 TGGGACACTGCAGGGCAGGAACGTTTCAAGAGCCTTAGGACACCCTTCTACAGGGGAGCA       c.240
 W  D  T  A  G  Q  E  R  F  K  S  L  R  T  P  F  Y  R  G  A         p.80

          .         .         .         .         .         .       g.11798
 GACTGCTGCCTCTTGACCTTCAGCGTGGATGATCGGCAGAGCTTCGAGAATCTTGGTAAC       c.300
 D  C  C  L  L  T  F  S  V  D  D  R  Q  S  F  E  N  L  G  N         p.100

          .         .         .         .         .         .       g.11858
 TGGCAGAAAGAATTTATTTACTATGCGGATGTGAAGGACCCTGAGCATTTCCCCTTTGTA       c.360
 W  Q  K  E  F  I  Y  Y  A  D  V  K  D  P  E  H  F  P  F  V         p.120

          .         .         .         .         .         .       g.11918
 GTTCTGGGTAACAAGGTAGACAAAGAGGATAGGCAAGTGACTACTGAGGAGGCACAAACC       c.420
 V  L  G  N  K  V  D  K  E  D  R  Q  V  T  T  E  E  A  Q  T         p.140

          .         .         .         .         .         .       g.11978
 TGGTGCATGGAGAATGGGGATTACCCTTATTTAGAAACTAGTGCCAAAGATGATACTAAT       c.480
 W  C  M  E  N  G  D  Y  P  Y  L  E  T  S  A  K  D  D  T  N         p.160

          .         .         .         .         .         .       g.12038
 GTGACAGTGGCCTTTGAAGAAGCTGTCAGGCAGGTGCTGGCTGTAGAGGAACAGCTGGAG       c.540
 V  T  V  A  F  E  E  A  V  R  Q  V  L  A  V  E  E  Q  L  E         p.180

          .         .         .         .         .         .       g.12098
 CATTGCATGTTGGGTCACACCATTGACTTGAACAGTGGCTCCAAAGCAGGGTCTTCGTGC       c.600
 H  C  M  L  G  H  T  I  D  L  N  S  G  S  K  A  G  S  S  C         p.200

                                                                    g.12104
 TGTTAA                                                             c.606
 C  X                                                               p.201

          .         .         .         .         .         .       g.12164
 agatagggagccttttaaaaatgtgccccaaattgatcagtcagtagtgtaagaataact       c.*60

          .         .         .         .         .         .       g.12224
 gtgcccctctaagagtgcacacacacgcacacaagagggtaagagacaaggttctgattg       c.*120

          .         .         .         .         .         .       g.12284
 tgaaacagagcctttcaaattgaagtgtagattgatttaaaaaaattaaaaattaaaaaa       c.*180

          .         .         .         .         .         .       g.12344
 aatgaagctctatcaagccaagtgtattttgcgtgatttctgctatttccccttcttgtg       c.*240

          .         .         .         .         .         .       g.12404
 tgtctcaggacatatcagaaaattttagtcctgagacagttaaatattttttaaatcaca       c.*300

          .         .         .         .         .         .       g.12464
 gtttaaacctagaacccagctgcatgaaggagttaaagagctacaactatttcttaaagt       c.*360

          .         .         .         .         .         .       g.12524
 gttccattaatcaactaacaaatgtcactatcagactcttgccaagcagtttctgacatt       c.*420

          .         .         .         .         .         .       g.12584
 tctgccaaaggggaaaaaaatcagactttgagctgtattacaataaaaataataatgcaa       c.*480

          .         .         .         .         .         .       g.12644
 ataaggattcctaggcttgaattaaagaagttgtaatgattaggagtgcaaaagtataat       c.*540

          .         .         .         .         .         .       g.12704
 gatatacactgacttgtttaaatccttatgtatggttcgctcccatctgagcttttcaaa       c.*600

          .         .         .         .         .         .       g.12764
 aaatcccatctcaataagagatactctaatgacactggcaattgattatacttcttgtgt       c.*660

          .         .         .         .         .         .       g.12824
 ttgaagtcataggatactagtgaatggattatgcttaaatatgccaaccacctttgcaaa       c.*720

          .         .         .         .         .         .       g.12884
 taaatggttggtctgcttttaattcctaagtctacttttgctgcatagagatgttgcttc       c.*780

          .         .         .         .         .         .       g.12944
 tctgacaacctcttaccaatttagcaatgctgcttagtatatgaatttggatgcagtgct       c.*840

          .         .         .         .         .         .       g.13004
 ctctgctcatcatttagatggtcctttgatccaacatgctgggctcatggagaaggcttc       c.*900

          .         .         .         .         .         .       g.13064
 ataaaagattgggggataatgaacttttctcacaaggctccttaactcaaatatttattg       c.*960

          .         .         .         .         .         .       g.13124
 cagaagaaggaactggtttcttatatgttgcactgtatgttcaactagcctaattaggac       c.*1020

          .         .         .         .         .         .       g.13184
 attgaaagtgacagaagagcagatcttaacccagtgttagaatgaatttcccataaacag       c.*1080

          .         .         .         .         .         .       g.13244
 agttgtccaacagtggaatggactgccttaatagtgagctccctgcctctgaaaatattc       c.*1140

          .         .         .         .         .         .       g.13304
 actggatgaccatctgttagaataccataaaaagattttctgtgctggctacatgttcaa       c.*1200

          .         .         .         .         .         .       g.13364
 tataaagtcctttctggctctaagttctatgaatatataaactacatcagtgccatgctg       c.*1260

          .         .         .         .         .         .       g.13424
 tggttagatttatctgatgataacagctaagactatggagagggactttaaaaattctca       c.*1320

          .         .         .         .         .         .       g.13484
 aaccattctgtgatcaatctttaacagcaactacatagctcttccttttgcttttgcact       c.*1380

          .         .         .         .         .         .       g.13544
 gtggcaggaaaaattcttgagctctgagtaatctttatgtgactgataaaaaacatctta       c.*1440

          .         .         .         .         .         .       g.13604
 aagctcccatgttaaaatataaaaatggtttgacaatttttgattaccatgactgtcagt       c.*1500

          .         .         .         .         .         .       g.13664
 tatatactatattatgaatatgcagtgtggttcttgttggttgatctgtttaccctgcat       c.*1560

          .         .         .         .         .         .       g.13724
 agattttaatctgtactttaaaacatctatgataaaaatagtgacagacagaaattaccc       c.*1620

          .         .         .         .         .         .       g.13784
 caaaaagagacctaggccaggaagggggtgggagctttcataggaatacagcctagaact       c.*1680

          .         .         .         .         .         .       g.13844
 ctccattgtagccacgtatggaatcagccttacttacatgtaggacctttgtgctttaag       c.*1740

          .         .         .         .         .         .       g.13904
 agctctgggacatattggccaaatagaaaagaagaggacagtatttcaactcagtcatac       c.*1800

          .         .         .         .         .         .       g.13964
 tcaatatttccaattaagatataatcctgacaccattgttcaattaactttgacgccaga       c.*1860

          .         .         .         .         .         .       g.14024
 agtcaaagccagaactgggaccccacagctcttaagtactggtccctatcctgcctatgc       c.*1920

          .         .         .         .         .         .       g.14084
 ctatagccagccacactggtttccaagttctgtgatcattttgctacaatcatgttaggg       c.*1980

          .         .         .         .         .         .       g.14144
 tgaaaatctgtacgtcagaactgttaaatgctaattatttttaagtgcatgagacctggg       c.*2040

          .         .         .         .         .         .       g.14204
 gccttctctttctacttgcactctgcttatactagtttctatttgtagatctcaggcctt       c.*2100

          .         .         .         .         .         .       g.14264
 catcataaagacctctatcaactcacaaaagtatttgtctctattagagtggcatgtggt       c.*2160

          .         .         .         .         .         .       g.14324
 catttgagtaaaaaaaaaaaaattacatgggtatcggattcataggcatcctgtccatct       c.*2220

          .         .         .         .         .         .       g.14384
 aagacaagtgttaattttattggcccatcagctggagcccctttcctcttagccatacca       c.*2280

          .         .         .         .         .         .       g.14444
 ttgttttctaccaaattaccactcaatatcttaatgaaagcactcaacattaagtgacat       c.*2340

          .         .         .         .         .         .       g.14504
 aaacagtggcatttgggtaagcaacactcagtggggtgctgacatacagtttgggtaaga       c.*2400

          .         .         .         .         .         .       g.14564
 ttaaaaaacaccaaaggctgaaatctgtgagtaccaagaactgtgcatataggtttagaa       c.*2460

          .         .         .         .         .         .       g.14624
 attgactgtgtaccctagaatgtgcagtgtaatattttcaataggtgtttttttaaagaa       c.*2520

          .         .         .         .         .         .       g.14684
 cactagatttttggaataatatatttctaattaggactatactgtttttcaatggtctgt       c.*2580

          .         .         .         .         .         .       g.14744
 taaaacatcatacagaatatttatttagtttattgtcatgtattggctaactttcagggg       c.*2640

          .         .         .         .         .         .       g.14804
 cctcagattccatatgtcttcagtggattgatgaatatcaggttaatttgtgcctgcccc       c.*2700

          .         .         .         .         .         .       g.14864
 agccatctctactttattctgaggtattccacaatcctcttgttgcaggtgctgctaaaa       c.*2760

          .         .         .         .         .         .       g.14924
 aaaactcaaaattgtgtatcaaatattttctttcaactgtaaaaaatcatctgtgttaaa       c.*2820

          .         .         .                                     g.14958
 gtgaataaaaagtgcattttgaataaccagcaca                                 c.*2854

 (downstream sequence)

Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10^th nucleotide is indicated by a "." above the sequence. The RAB9B, member RAS oncogene family protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10^th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.