RAD21 homolog (S. pombe) (RAD21) - coding DNA reference sequence

(used for variant description)

(last modified June 2, 2025)


This file was created to facilitate the description of sequence variants on transcript NM_006265.2 in the RAD21 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000008.10, covering RAD21 transcript NM_006265.2.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                     .         .         .         .                g.5048
             aggcgcacaggtaccattttgaccgtaaacatcctgccgatttgaacc       c.-241

 .         .         .         .         .         .                g.5108
 gaggatttgggcggcaggaagagccgcggcgtaacggcagccatcttgtttgtttgagtg       c.-181

 .         .         .         .         .         .                g.5168
 aatcggaaaggaggcgccggctgtggcggcggcgggagctgctcggaagctacacctcgc       c.-121

 .         .         .         .         .         .                g.5228
 aagggctcccccctttccccaccccctcccccgacccttttcccctccccgggccaccca       c.-61

 .         .         .        | 02.         .         .             g.13137
 gcccgcccaactcccagcggagagcaag | gttttcttctgttttcatagccagccagaaca    c.-1

          .         .         .         .         .         .       g.13197
 ATGTTCTACGCACATTTTGTTCTCAGTAAAAGAGGGCCTCTGGCCAAAATTTGGCTAGCG       c.60
 M  F  Y  A  H  F  V  L  S  K  R  G  P  L  A  K  I  W  L  A         p.20

          .         .         .         .         .         .       g.13257
 GCCCATTGGGATAAGAAGCTAACCAAAGCCCATGTGTTCGAGTGTAATTTAGAGAGCAGC       c.120
 A  H  W  D  K  K  L  T  K  A  H  V  F  E  C  N  L  E  S  S         p.40

          .         .     | 03   .         .         .         .    g.16643
 GTGGAGAGTATCATCTCACCAAAG | GTGAAAATGGCATTACGGACATCAGGACATCTCTTA    c.180
 V  E  S  I  I  S  P  K   | V  K  M  A  L  R  T  S  G  H  L  L      p.60

          .         .         .         .         .         .       g.16703
 CTGGGAGTAGTTCGAATCTATCACAGGAAAGCCAAATACCTTCTTGCAGACTGTAATGAA       c.240
 L  G  V  V  R  I  Y  H  R  K  A  K  Y  L  L  A  D  C  N  E         p.80

          .         .         .     | 04   .         .         .    g.17952
 GCATTCATTAAGATAAAGATGGCTTTTCGGCCAG | GTGTGGTTGACCTGCCTGAGGAAAAT    c.300
 A  F  I  K  I  K  M  A  F  R  P  G |   V  V  D  L  P  E  E  N      p.100

          .         .         .         .         .         .       g.18012
 CGGGAAGCAGCTTATAATGCCATTACTTTACCTGAAGAATTTCATGACTTTGATCAGCCA       c.360
 R  E  A  A  Y  N  A  I  T  L  P  E  E  F  H  D  F  D  Q  P         p.120

          .     | 05   .         .         .         .         .    g.21454
 CTGCCTGACTTAGA | TGACATCGATGTGGCCCAGCAGTTCAGCTTGAATCAGAGTAGAGTG    c.420
 L  P  D  L  D  |  D  I  D  V  A  Q  Q  F  S  L  N  Q  S  R  V      p.140

          .         .         .         .         .         .       g.21514
 GAAGAGATAACCATGAGAGAAGAAGTTGGGAACATCAGTATTTTACAAGAAAATGATTTT       c.480
 E  E  I  T  M  R  E  E  V  G  N  I  S  I  L  Q  E  N  D  F         p.160

   | 06      .         .         .         .         .         .    g.22452
 G | GTGATTTTGGAATGGATGATCGTGAGATAATGAGAGAAGGCAGTGCTTTTGAGGATGAC    c.540
 G |   D  F  G  M  D  D  R  E  I  M  R  E  G  S  A  F  E  D  D      p.180

          .         .         .         .         .         .       g.22512
 GACATGTTAGTAAGCACTACTACTTCTAACCTCCTATTAGAGTCTGAACAGAGCACCAGC       c.600
 D  M  L  V  S  T  T  T  S  N  L  L  L  E  S  E  Q  S  T  S         p.200

          .         .         .         .         .         .       g.22572
 AATCTGAATGAGAAAATTAACCATTTAGAATATGAAGATCAATATAAGGATGATAATTTT       c.660
 N  L  N  E  K  I  N  H  L  E  Y  E  D  Q  Y  K  D  D  N  F         p.220

          .         .         | 07         .         .         .    g.23127
 GGAGAAGGAAATGATGGTGGAATATTAG | ATGACAAACTTATTAGTAATAATGATGGCGGT    c.720
 G  E  G  N  D  G  G  I  L  D |   D  K  L  I  S  N  N  D  G  G      p.240

          .         .         .         .         .         .       g.23187
 ATCTTTGATGATCCCCCTGCCCTCTCTGAGGCAGGGGTGATGTTGCCAGAGCAGCCTGCA       c.780
 I  F  D  D  P  P  A  L  S  E  A  G  V  M  L  P  E  Q  P  A         p.260

          .         .         .     | 08   .         .         .    g.23604
 CATGACGATATGGATGAGGATGATAATGTATCAA | TGGGTGGGCCTGATAGTCCTGATTCA    c.840
 H  D  D  M  D  E  D  D  N  V  S  M |   G  G  P  D  S  P  D  S      p.280

          .         .         .         .         .         .       g.23664
 GTGGATCCCGTTGAACCAATGCCAACCATGACTGATCAAACAACACTTGTTCCAAATGAG       c.900
 V  D  P  V  E  P  M  P  T  M  T  D  Q  T  T  L  V  P  N  E         p.300

          .         .         .        | 09.         .         .    g.25421
 GAAGAAGCATTTGCATTGGAGCCTATTGATATAACTG | TTAAAGAAACAAAAGCCAAGAGG    c.960
 E  E  A  F  A  L  E  P  I  D  I  T  V |   K  E  T  K  A  K  R      p.320

          .         .         .         .         .         .       g.25481
 AAGAGGAAGCTAATTGTTGACAGTGTCAAAGAGTTGGATAGCAAGACAATTAGAGCCCAA       c.1020
 K  R  K  L  I  V  D  S  V  K  E  L  D  S  K  T  I  R  A  Q         p.340

          .         .         .         .         .         .       g.25541
 CTTAGTGATTATTCAGATATTGTTACTACTTTGGATCTGGCACCGCCCACCAAGAAATTG       c.1080
 L  S  D  Y  S  D  I  V  T  T  L  D  L  A  P  P  T  K  K  L         p.360

          .         .         .         .         .         .       g.25601
 ATGATGTGGAAAGAGACAGGAGGAGTAGAAAAACTGTTTTCTTTACCTGCTCAGCCTTTG       c.1140
 M  M  W  K  E  T  G  G  V  E  K  L  F  S  L  P  A  Q  P  L         p.380

          .         .  | 10      .         .         .         .    g.27197
 TGGAATAACAGACTACTGAAG | CTCTTTACACGCTGTCTTACACCGCTTGTACCAGAAGAC    c.1200
 W  N  N  R  L  L  K   | L  F  T  R  C  L  T  P  L  V  P  E  D      p.400

          .         .         .         .         .         .       g.27257
 CTTAGAAAAAGGAGGAAAGGAGGAGAGGCAGATAATTTGGATGAATTCCTCAAAGAATTT       c.1260
 L  R  K  R  R  K  G  G  E  A  D  N  L  D  E  F  L  K  E  F         p.420

          .         .         .         .         .         .       g.27317
 GAAAATCCAGAGGTTCCTAGAGAGGACCAGCAACAGCAGCATCAGCAGCGTGATGTTATC       c.1320
 E  N  P  E  V  P  R  E  D  Q  Q  Q  Q  H  Q  Q  R  D  V  I         p.440

   | 11      .         .         .         .         .         .    g.27829
 G | ATGAGCCCATTATTGAAGAGCCAAGCCGCCTCCAGGAGTCAGTGATGGAGGCCAGCAGA    c.1380
 D |   E  P  I  I  E  E  P  S  R  L  Q  E  S  V  M  E  A  S  R      p.460

          .         .         .         .         .         .       g.27889
 ACAAACATAGATGAGTCAGCTATGCCTCCACCACCACCTCAGGGAGTTAAGCGAAAAGCT       c.1440
 T  N  I  D  E  S  A  M  P  P  P  P  P  Q  G  V  K  R  K  A         p.480

          .         .         . | 12       .         .         .    g.29129
 GGACAAATTGACCCAGAGCCTGTGATGCCT | CCTCAGCAGGTAGAGCAGATGGAAATACCA    c.1500
 G  Q  I  D  P  E  P  V  M  P   | P  Q  Q  V  E  Q  M  E  I  P      p.500

          .         .         .         .         .         .       g.29189
 CCTGTAGAGCTTCCCCCAGAAGAACCTCCAAATATCTGTCAGCTAATACCAGAGTTAGAA       c.1560
 P  V  E  L  P  P  E  E  P  P  N  I  C  Q  L  I  P  E  L  E         p.520

          .         .         .         .         .         .       g.29249
 CTTCTGCCAGAAAAAGAGAAGGAGAAAGAGAAGGAAAAAGAAGATGATGAAGAGGAAGAG       c.1620
 L  L  P  E  K  E  K  E  K  E  K  E  K  E  D  D  E  E  E  E         p.540

  | 13       .         .         .         .         .         .    g.30897
  | GATGAAGATGCATCAGGGGGCGATCAAGATCAGGAAGAAAGAAGATGGAACAAAAGGACT    c.1680
  | D  E  D  A  S  G  G  D  Q  D  Q  E  E  R  R  W  N  K  R  T      p.560

          .         .     | 14   .         .         .         .    g.32211
 CAGCAGATGCTTCATGGTCTTCAG | CGTGCTCTTGCTAAAACTGGAGCTGAATCTATCAGT    c.1740
 Q  Q  M  L  H  G  L  Q   | R  A  L  A  K  T  G  A  E  S  I  S      p.580

          .         .         .         .         .         .       g.32271
 TTGCTTGAGTTATGTCGAAATACGAACAGAAAACAAGCTGCCGCAAAGTTCTACAGCTTC       c.1800
 L  L  E  L  C  R  N  T  N  R  K  Q  A  A  A  K  F  Y  S  F         p.600

          .         .         .         .         .         .       g.32331
 TTGGTTCTTAAAAAGCAGCAAGCTATTGAGCTGACACAGGAAGAACCGTACAGTGACATC       c.1860
 L  V  L  K  K  Q  Q  A  I  E  L  T  Q  E  E  P  Y  S  D  I         p.620

          .         .         .                                     g.32367
 ATCGCAACACCTGGACCAAGGTTCCATATTATATAA                               c.1896
 I  A  T  P  G  P  R  F  H  I  I  X                                 p.631

          .         .         .         .         .         .       g.32427
 ggagctagaagcattatagctagtgtttgattcactagtgcttacaaattgcccccatgt       c.*60

          .         .         .         .         .         .       g.32487
 gtaggggacacagaaccctttgagaaaacttagatttttgtctgtacaaagtctttgcct       c.*120

          .         .         .         .         .         .       g.32547
 ttttccttcttcatttttttccagtacattaaatttgtcaatttcatctttgagggaaac       c.*180

          .         .         .         .         .         .       g.32607
 tgattagatgggttgtgtttgtgttctgatggagaaaacagcaccccaaggactcagaag       c.*240

          .         .         .         .         .         .       g.32667
 atgattttaacagttcagaacagatgtgtgcaatattggtgcatgtaataatgttgagtg       c.*300

          .         .         .         .         .         .       g.32727
 gcagtcaaaagtcatgatttttatcttagttcttcattactgcattgaaaaggaaaacct       c.*360

          .         .         .         .         .         .       g.32787
 gtctgagaaaatgcctgacagtttaatttaaaactatggtgtaagtctttgacaagaaaa       c.*420

          .         .         .         .         .         .       g.32847
 aaaaacaaacaaacacttctttccatcagtaacactggcaatcttcctgttaaccactct       c.*480

          .         .         .         .         .         .       g.32907
 ccttagggatggtatctgaaacaacaatggtcaccctcttgagattcgttttaagtgtaa       c.*540

          .         .         .         .         .         .       g.32967
 ttccataatgagcagaggtgtacgcgaaattgtgttatgactgatagccttcagctacaa       c.*600

          .         .         .         .         .         .       g.33027
 aaagataggactgacctggtttaaagtgttctattttgtaaatcattccatttgagtctt       c.*660

          .         .         .         .         .         .       g.33087
 tctgatgaacttggctatactgaaatctgttattttagtgaggctccaaaatgagcaaag       c.*720

          .         .         .         .         .         .       g.33147
 ctaggcctgattagagtagagtgactattaaaaaacataactttctaggagctataaatc       c.*780

          .         .         .         .         .         .       g.33207
 aaagttttaaaaagatgtttggatatatttgagtattccgatcatgaaaacagaaattgc       c.*840

          .         .         .         .         .         .       g.33267
 cctgcctactacaaggacagactgatgggaaattatgcacctggtcaacttagcttttaa       c.*900

          .         .         .         .         .         .       g.33327
 gcagacgatgctgtaaaaactaacggcttctctgatatttattgtaagttttagtactga       c.*960

          .         .         .         .         .         .       g.33387
 tctccttttccagtgctgcacactcctggtttggaactttaatagcgttgcaacgaaatc       c.*1020

          .         .         .         .         .         .       g.33447
 ctatatccagtttcctgtaatttaattgaagaaaaatacatccaaataaagactttatta       c.*1080

          .         .         .         .         .         .       g.33507
 ttaacagaccagatagcatcagaaatcatgtgactgttatgattatcagaatgtcttaac       c.*1140

          .         .         .         .         .         .       g.33567
 tttttagggcaaagttaacactgaaagttctagcttaagtgttgaaacttttgtgggaaa       c.*1200

          .         .         .         .         .         .       g.33627
 aaaaaatcacttttgaaactcagacttcagtgtatacccaataatttaaaattatgtgaa       c.*1260

          .         .         .         .         .         .       g.33687
 atgttttaaatttgtgaactcgtaattactgttttaatgattcagtttcttcagagtggt       c.*1320

          .         .         .         .         .         .       g.33747
 aattgtataaaattgctattgcagctttacattcaatatgatgtgcctgtaaaccaagga       c.*1380

          .         .         .         .         .         .       g.33807
 gttttccccgtttgtaaaaagacattgtagataattgaatgtttgattttagaaaggtca       c.*1440

          .         .         .         .         .         .       g.33867
 ttagtttcttgttacacattttgttagtctggtttttgttgcttatcgggtttaatattg       c.*1500

          .         .         .         .         .         .       g.33927
 ttcttgaaaatagttgatgctatgttatgtataacttttctaataaaagttgtgttataa       c.*1560

                                                                    g.33933
 gctgta                                                             c.*1566

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The RAD21 homolog (S. pombe) protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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