RAD51 homolog B (S. cerevisiae) (RAD51B) - coding DNA reference sequence

(used for variant description)

(last modified November 7, 2014)


This file was created to facilitate the description of sequence variants on transcript NM_133509.3 in the RAD51B gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_023267.1, covering RAD51B transcript NM_133509.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                   .                g.5004
                                            gttgctttgcggcgttt       c.-61

 .         .         .         .         .         .        | 02    g.8752
 tccgcggggaaactgtgtaaagggtggggaaacttgaaagttggatgctgcagacccg | gc    c.-1

          .         .         .         .         .         .       g.8812
 ATGGGTAGCAAGAAACTAAAACGAGTGGGTTTATCACAAGAGCTGTGTGACCGTCTGAGT       c.60
 M  G  S  K  K  L  K  R  V  G  L  S  Q  E  L  C  D  R  L  S         p.20

          .         .     | 03   .         .         .         .    g.10708
 AGACATCAGATCCTTACCTGTCAG | GACTTTTTATGTCTTTCCCCACTGGAGCTTATGAAG    c.120
 R  H  Q  I  L  T  C  Q   | D  F  L  C  L  S  P  L  E  L  M  K      p.40

          .         .         .         .         .         .       g.10768
 GTGACTGGTCTGAGTTATCGAGGTGTCCATGAACTTCTATGTATGGTCAGCAGGGCCTGT       c.180
 V  T  G  L  S  Y  R  G  V  H  E  L  L  C  M  V  S  R  A  C         p.60

          .         | 04         .         .         .         .    g.20330
 GCCCCAAAGATGCAAACG | GCTTATGGGATAAAAGCACAAAGGTCTGCTGATTTCTCACCA    c.240
 A  P  K  M  Q  T   | A  Y  G  I  K  A  Q  R  S  A  D  F  S  P      p.80

          .         .         .         .         .         .       g.20390
 GCATTCTTATCTACTACCCTTTCTGCTTTGGACGAAGCCCTGCATGGTGGTGTGGCTTGT       c.300
 A  F  L  S  T  T  L  S  A  L  D  E  A  L  H  G  G  V  A  C         p.100

          .      | 05  .         .         .         .         .    g.50256
 GGATCCCTCACAGAG | ATTACAGGTCCACCAGGTTGTGGAAAAACTCAGTTTTGTATAATG    c.360
 G  S  L  T  E   | I  T  G  P  P  G  C  G  K  T  Q  F  C  I  M      p.120

          .         .         .         .         .         .       g.50316
 ATGAGCATTTTGGCTACATTACCCACCAACATGGGAGGATTAGAAGGAGCTGTGGTGTAC       c.420
 M  S  I  L  A  T  L  P  T  N  M  G  G  L  E  G  A  V  V  Y         p.140

          .         .         .   | 06     .         .         .    g.71105
 ATTGACACAGAGTCTGCATTTAGTGCTGAAAG | ACTGGTTGAAATAGCAGAATCCCGTTTT    c.480
 I  D  T  E  S  A  F  S  A  E  R  |  L  V  E  I  A  E  S  R  F      p.160

          .         .         .         .         .         .       g.71165
 CCCAGATATTTTAACACTGAAGAAAAGTTACTTTTGACAAGTAGTAAAGTTCATCTTTAT       c.540
 P  R  Y  F  N  T  E  E  K  L  L  L  T  S  S  K  V  H  L  Y         p.180

          .         .         .   | 07     .         .         .    g.72257
 CGGGAACTCACCTGTGATGAAGTTCTACAAAG | GATTGAATCTTTGGAAGAAGAAATTATC    c.600
 R  E  L  T  C  D  E  V  L  Q  R  |  I  E  S  L  E  E  E  I  I      p.200

          .         .         .         .         .         .       g.72317
 TCAAAAGGAATTAAACTTGTGATTCTTGACTCTGTTGCTTCTGTGGTCAGAAAGGAGTTT       c.660
 S  K  G  I  K  L  V  I  L  D  S  V  A  S  V  V  R  K  E  F         p.220

          .         .         .         .         .         .       g.72377
 GATGCACAACTTCAAGGCAATCTCAAAGAAAGAAACAAGTTCTTGGCAAGAGAGGCATCC       c.720
 D  A  Q  L  Q  G  N  L  K  E  R  N  K  F  L  A  R  E  A  S         p.240

          .         .         .       | 08 .         .         .    g.477116
 TCCTTGAAGTATTTGGCTGAGGAGTTTTCAATCCCA | GTTATCTTGACGAATCAGATTACA    c.780
 S  L  K  Y  L  A  E  E  F  S  I  P   | V  I  L  T  N  Q  I  T      p.260

          .         .         .         .         .         .       g.477176
 ACCCATCTGAGTGGAGCCCTGGCTTCTCAGGCAGACCTGGTGTCTCCAGCTGATGATTTG       c.840
 T  H  L  S  G  A  L  A  S  Q  A  D  L  V  S  P  A  D  D  L         p.280

          .    | 09    .         .         .         .         .    g.596679
 TCCCTGTCTGAAG | GCACTTCTGGATCCAGCTGTGTGATAGCCGCACTAGGAAATACCTGG    c.900
 S  L  S  E  G |   T  S  G  S  S  C  V  I  A  A  L  G  N  T  W      p.300

          .         .         .         .         .        | 10.    g.653383
 AGTCACAGTGTGAATACCCGGCTGATCCTCCAGTACCTTGATTCAGAGAGAAGACAG | ATT    c.960
 S  H  S  V  N  T  R  L  I  L  Q  Y  L  D  S  E  R  R  Q   | I      p.320

          .         .         .         .         .         .       g.653443
 CTTATTGCCAAGTCCCCTCTGGCTCCCTTCACCTCATTTGTCTACACCATCAAGGAGGAA       c.1020
 L  I  A  K  S  P  L  A  P  F  T  S  F  V  Y  T  I  K  E  E         p.340

          .       | 11 .         .         .         .         .    g.779737
 GGCCTGGTTCTTCAAG | AGACAACATTTTGCTCTGTCACCCAAGCTGAACTGAACTGGGCT    c.1080
 G  L  V  L  Q  E |   T  T  F  C  S  V  T  Q  A  E  L  N  W  A      p.360

          .         .         .         .         .         .       g.779797
 CCAGAAATCCTCCCACCTCAGCCTCCTGAGCAGCTAGGACTACAGATGTGCCACCATACC       c.1140
 P  E  I  L  P  P  Q  P  P  E  Q  L  G  L  Q  M  C  H  H  T         p.380

          .                                                         g.779812
 CAGCTAATTTTTTAA                                                    c.1155
 Q  L  I  F  X                                                      p.384

          .         .         .         .         .         .       g.779872
 ttttttgtagaggtggggtctcattatgttgcccaagctgatctcaaactcctggcttca       c.*60

          .         .         .         .         .         .       g.779932
 agagatccacccacctcagcctcccaaagcgctaggattacaagtatgagactttgccat       c.*120

          .         .         .         .         .         .       g.779992
 tccaatgagaattttgtccttagcaatctcatccaatggccactggagatgtgtgtaggg       c.*180

          .         .         .         .         .         .       g.780052
 ccacaagaatgagaaagggggcaatggagtgacaggtgacctgctcaggtgcccctcccc       c.*240

          .         .         .         .         .         .       g.780112
 agaccaaatgtcccaggcacacagcccatgccctccaccatggagtacattttctccctg       c.*300

          .         .         .         .         .         .       g.780172
 gcttgctgctgagctaaaggaccagggacgtggaaacaggaggtgaactaaggcaccccg       c.*360

          .         .         .         .         .         .       g.780232
 ccacccactgtggcagcttgaatttcttgaggctgagacaaactaggatccagtagccta       c.*420

          .         .         .         .         .         .       g.780292
 gattttgccccagtttctccactgagtatttactcagtgctcctgagccgatgccttccc       c.*480

          .         .         .         .         .         .       g.780352
 ctctgcctagatgaaccacagcattttggtaaatgcctcagcatgttaggagcgctggaa       c.*540

          .         .         .         .         .         .       g.780412
 cgtttattctcttccctcccaattatccactctaatggagcagaacacttacatggaaaa       c.*600

          .         .         .         .         .         .       g.780472
 tcctaaacatggaagatgatttaaaaatgattcaccctggaatacatgcttccagttgct       c.*660

          .         .         .         .         .         .       g.780532
 tctacaggtttaccttgctaaaggcatttcgcttcctttgctgttacaataagcttgcct       c.*720

          .         .         .         .         .         .       g.780592
 gccttgaagaaaagaagaccagggccaaagggaaatcagtcaagggagcctgttttgtct       c.*780

          .         .         .         .         .         .       g.780652
 gaaataatgcatccatgaacaaatgaattgagtataactgtctttttacatcagtgtttc       c.*840

          .         .         .         .         .         .       g.780712
 tgtggaattaagagaacatccaaggccactcctagcttgagtagattaaatttgtccttg       c.*900

          .         .         .         .         .         .       g.780772
 tgtttggagcaagggttgtgaagtctgtctggcccatcaaatgaccaatggcttttaagg       c.*960

          .         .         .         .         .         .       g.780832
 aaggactaagtgacttatgaccagaacaagggagcagcctgagtcagtctccccaatgtc       c.*1020

          .         .         .         .         .         .       g.780892
 tacattgtgttatttatactagcaaaaaaatagacacaactaaatgttcgaccatatggt       c.*1080

          .         .         .         .         .         .       g.780952
 attggttaaattaacatctatacgatggaatactagatggtcattaaaattatgtgtcag       c.*1140

          .         .         .         .         .         .       g.781012
 aagaaggcttaatctcatgggaaagtgttcacaccatattattaaagagaaaaaacagat       c.*1200

          .         .         .         .         .         .       g.781072
 tataaagcaatatgcatacaatgtagtagttctgtaagaaaaaagtattatgtgcatttt       c.*1260

          .         .         .         .         .         .       g.781132
 aactggaaaaatatgtataaaaatgttaacagtgcaatctctgggcaataagattatact       c.*1320

          .         .         .         .         .         .       g.781192
 tgacttttatttcttttttggaattgtcttttttttttttttttcaagtttcctcccatt       c.*1380

          .         .         .                                     g.781230
 aacatgcatgttcccaaaatcaggggaaaaatacatta                             c.*1418

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The RAD51 homolog B (S. cerevisiae) protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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