v-raf-1 murine leukemia viral oncogene homolog 1 (RAF1) - coding DNA reference sequence

(used for variant description)

(last modified June 20, 2018)


This file was created to facilitate the description of sequence variants on transcript NM_002880.3 in the RAF1 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_007467.1, covering RAF1 transcript NM_002880.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
           .         .         .         .         .                g.5033
      agaatcggagagccggtggcgtcgcaggtcgggaggacgagcaccgagtcgaggg       c.-361

 .         .         .         .         .         .                g.5093
 ctcgctcgtctgggccgcccgagagtcttaatcgcgggcgcttgggccgccatcttagat       c.-301

 .         .         .         .         .         .                g.5153
 ggcgggagtaagaggaaaacgattgtgaggcgggaacggctttctgctgccttttttggg       c.-241

 .         .         .         .         .         .                g.5213
 ccccgaaaagggtcagctggccgggctttggggcgcgtgccctgaggcgcggagcgcgtt       c.-181

 .         .         .         .         .         .                g.5273
 tgctacgatgcgggggctgctcggggctccgtcccctgggctggggacgcgccgaatgtg       c.-121

 .         .         .         .         .         .                g.5333
 accgcctcccgctccctcacccgccgcggggaggaggagcgggcgagaagctgccgccga       c.-61

 .         .         .         .    | 02    .         .             g.50458
 acgacaggacgttggggcggcctggctccctcag | gtttaagaattgtttaagctgcatca    c.-1

          .         .         .         .         .         .       g.50518
 ATGGAGCACATACAGGGAGCTTGGAAGACGATCAGCAATGGTTTTGGATTCAAAGATGCC       c.60
 M  E  H  I  Q  G  A  W  K  T  I  S  N  G  F  G  F  K  D  A         p.20

          .         .         .         .         .         .       g.50578
 GTGTTTGATGGCTCCAGCTGCATCTCTCCTACAATAGTTCAGCAGTTTGGCTATCAGCGC       c.120
 V  F  D  G  S  S  C  I  S  P  T  I  V  Q  Q  F  G  Y  Q  R         p.40

          .         .         .         .         .         .       g.50638
 CGGGCATCAGATGATGGCAAACTCACAGATCCTTCTAAGACAAGCAACACTATCCGTGTT       c.180
 R  A  S  D  D  G  K  L  T  D  P  S  K  T  S  N  T  I  R  V         p.60

          .         .        | 03.         .         .         .    g.57150
 TTCTTGCCGAACAAGCAAAGAACAGTG | GTCAATGTGCGAAATGGAATGAGCTTGCATGAC    c.240
 F  L  P  N  K  Q  R  T  V   | V  N  V  R  N  G  M  S  L  H  D      p.80

          .         .         .         .         .         .       g.57210
 TGCCTTATGAAAGCACTCAAGGTGAGGGGCCTGCAACCAGAGTGCTGTGCAGTGTTCAGA       c.300
 C  L  M  K  A  L  K  V  R  G  L  Q  P  E  C  C  A  V  F  R         p.100

          .         . | 04       .         .         .         .    g.59884
 CTTCTCCACGAACACAAAGG | TAAAAAAGCACGCTTAGATTGGAATACTGATGCTGCGTCT    c.360
 L  L  H  E  H  K  G  |  K  K  A  R  L  D  W  N  T  D  A  A  S      p.120

          .         .         .         .         .         .       g.59944
 TTGATTGGAGAAGAACTTCAAGTAGATTTCCTGGATCATGTTCCCCTCACAACACACAAC       c.420
 L  I  G  E  E  L  Q  V  D  F  L  D  H  V  P  L  T  T  H  N         p.140

     | 05    .         .         .         .         .         .    g.60313
 TTT | GCTCGGAAGACGTTCCTGAAGCTTGCCTTCTGTGACATCTGTCAGAAATTCCTGCTC    c.480
 F   | A  R  K  T  F  L  K  L  A  F  C  D  I  C  Q  K  F  L  L      p.160

          .         .         .         .         .         .       g.60373
 AATGGATTTCGATGTCAGACTTGTGGCTACAAATTTCATGAGCACTGTAGCACCAAAGTA       c.540
 N  G  F  R  C  Q  T  C  G  Y  K  F  H  E  H  C  S  T  K  V         p.180

          .         .         .         .  | 06      .         .    g.62899
 CCTACTATGTGTGTGGACTGGAGTAACATCAGACAACTCTT | ATTGTTTCCAAATTCCACT    c.600
 P  T  M  C  V  D  W  S  N  I  R  Q  L  L  |  L  F  P  N  S  T      p.200

          .         .         .         .         .         .       g.62959
 ATTGGTGATAGTGGAGTCCCAGCACTACCTTCTTTGACTATGCGTCGTATGCGAGAGTCT       c.660
 I  G  D  S  G  V  P  A  L  P  S  L  T  M  R  R  M  R  E  S         p.220

          .         . | 07       .         .         .         .    g.64930
 GTTTCCAGGATGCCTGTTAG | TTCTCAGCACAGATATTCTACACCTCACGCCTTCACCTTT    c.720
 V  S  R  M  P  V  S  |  S  Q  H  R  Y  S  T  P  H  A  F  T  F      p.240

          .         .         .         .         .         .       g.64990
 AACACCTCCAGTCCCTCATCTGAAGGTTCCCTCTCCCAGAGGCAGAGGTCGACATCCACA       c.780
 N  T  S  S  P  S  S  E  G  S  L  S  Q  R  Q  R  S  T  S  T         p.260

          .         .         .         .         .     | 08   .    g.68770
 CCTAATGTCCACATGGTCAGCACCACCCTGCCTGTGGACAGCAGGATGATTGAG | GATGCA    c.840
 P  N  V  H  M  V  S  T  T  L  P  V  D  S  R  M  I  E   | D  A      p.280

          .         .   | 09     .         .         .         .    g.68938
 ATTCGAAGTCACAGCGAATCAG | CCTCACCTTCAGCCCTGTCCAGTAGCCCCAACAATCTG    c.900
 I  R  S  H  S  E  S  A |   S  P  S  A  L  S  S  S  P  N  N  L      p.300

          .         .         .         .         .         .       g.68998
 AGCCCAACAGGCTGGTCACAGCCGAAAACCCCCGTGCCAGCACAAAGAGAGCGGGCACCA       c.960
 S  P  T  G  W  S  Q  P  K  T  P  V  P  A  Q  R  E  R  A  P         p.320

          .         .         . | 10       .         .         .    g.69401
 GTATCTGGGACCCAGGAGAAAAACAAAATT | AGGCCTCGTGGACAGAGAGATTCAAGCTAT    c.1020
 V  S  G  T  Q  E  K  N  K  I   | R  P  R  G  Q  R  D  S  S  Y      p.340

          .         .         .         .         .         .       g.69461
 TATTGGGAAATAGAAGCCAGTGAAGTGATGCTGTCCACTCGGATTGGGTCAGGCTCTTTT       c.1080
 Y  W  E  I  E  A  S  E  V  M  L  S  T  R  I  G  S  G  S  F         p.360

          .         .         | 11         .         .         .    g.77419
 GGAACTGTTTATAAGGGTAAATGGCACG | GAGATGTTGCAGTAAAGATCCTAAAGGTTGTC    c.1140
 G  T  V  Y  K  G  K  W  H  G |   D  V  A  V  K  I  L  K  V  V      p.380

          .         .         .         .         .    | 12    .    g.78212
 GACCCAACCCCAGAGCAATTCCAGGCCTTCAGGAATGAGGTGGCTGTTCTGCG | CAAAACA    c.1200
 D  P  T  P  E  Q  F  Q  A  F  R  N  E  V  A  V  L  R  |  K  T      p.400

          .         .         .         .         .         .       g.78272
 CGGCATGTGAACATTCTGCTTTTCATGGGGTACATGACAAAGGACAACCTGGCAATTGTG       c.1260
 R  H  V  N  I  L  L  F  M  G  Y  M  T  K  D  N  L  A  I  V         p.420

          .         .         .         .         .         .       g.78332
 ACCCAGTGGTGCGAGGGCAGCAGCCTCTACAAACACCTGCATGTCCAGGAGACCAAGTTT       c.1320
 T  Q  W  C  E  G  S  S  L  Y  K  H  L  H  V  Q  E  T  K  F         p.440

          .         .         .         .         . | 13       .    g.81552
 CAGATGTTCCAGCTAATTGACATTGCCCGGCAGACGGCTCAGGGAATGGA | CTATTTGCAT    c.1380
 Q  M  F  Q  L  I  D  I  A  R  Q  T  A  Q  G  M  D  |  Y  L  H      p.460

          .         .         .        | 14.         .         .    g.83403
 GCAAAGAACATCATCCATAGAGACATGAAATCCAACA | ATATATTTCTCCATGAAGGCTTA    c.1440
 A  K  N  I  I  H  R  D  M  K  S  N  N |   I  F  L  H  E  G  L      p.480

          .         .         .         .         .         .       g.83463
 ACAGTGAAAATTGGAGATTTTGGTTTGGCAACAGTAAAGTCACGCTGGAGTGGTTCTCAG       c.1500
 T  V  K  I  G  D  F  G  L  A  T  V  K  S  R  W  S  G  S  Q         p.500

          .         .         .       | 15 .         .         .    g.83950
 CAGGTTGAACAACCTACTGGCTCTGTCCTCTGGATG | GCCCCAGAGGTGATCCGAATGCAG    c.1560
 Q  V  E  Q  P  T  G  S  V  L  W  M   | A  P  E  V  I  R  M  Q      p.520

          .         .         .         .         .         .       g.84010
 GATAACAACCCATTCAGTTTCCAGTCGGATGTCTACTCCTATGGCATCGTATTGTATGAA       c.1620
 D  N  N  P  F  S  F  Q  S  D  V  Y  S  Y  G  I  V  L  Y  E         p.540

          .         .         .         .         | 16         .    g.84210
 CTGATGACGGGGGAGCTTCCTTATTCTCACATCAACAACCGAGATCAG | ATCATCTTCATG    c.1680
 L  M  T  G  E  L  P  Y  S  H  I  N  N  R  D  Q   | I  I  F  M      p.560

          .         .         .         .         .         .       g.84270
 GTGGGCCGAGGATATGCCTCCCCAGATCTTAGTAAGCTATATAAGAACTGCCCCAAAGCA       c.1740
 V  G  R  G  Y  A  S  P  D  L  S  K  L  Y  K  N  C  P  K  A         p.580

          .         .         .         .         .         .       g.84330
 ATGAAGAGGCTGGTAGCTGACTGTGTGAAGAAAGTAAAGGAAGAGAGGCCTCTTTTTCCC       c.1800
 M  K  R  L  V  A  D  C  V  K  K  V  K  E  E  R  P  L  F  P         p.600

     | 17    .         .         .         .         .         .    g.84579
 CAG | ATCCTGTCTTCCATTGAGCTGCTCCAACACTCTCTACCGAAGATCAACCGGAGCGCT    c.1860
 Q   | I  L  S  S  I  E  L  L  Q  H  S  L  P  K  I  N  R  S  A      p.620

          .         .         .         .         .         .       g.84639
 TCCGAGCCATCCTTGCATCGGGCAGCCCACACTGAGGATATCAATGCTTGCACGCTGACC       c.1920
 S  E  P  S  L  H  R  A  A  H  T  E  D  I  N  A  C  T  L  T         p.640

          .         .                                               g.84666
 ACGTCCCCGAGGCTGCCTGTCTTCTAG                                        c.1947
 T  S  P  R  L  P  V  F  X                                          p.648

          .         .         .         .         .         .       g.84726
 ttgactttgcacctgtcttcaggctgccaggggaggaggagaagccagcaggcaccactt       c.*60

          .         .         .         .         .         .       g.84786
 ttctgctccctttctccagaggcagaacacatgttttcagagaagctgctgctaaggacc       c.*120

          .         .         .         .         .         .       g.84846
 ttctagactgctcacagggccttaacttcatgttgccttcttttctatccctttgggccc       c.*180

          .         .         .         .         .         .       g.84906
 tgggagaaggaagccatttgcagtgctggtgtgtcctgctccctccccacattccccatg       c.*240

          .         .         .         .         .         .       g.84966
 ctcaaggcccagccttctgtagatgcgcaagtggatgttgatggtagtacaaaaagcagg       c.*300

          .         .         .         .         .         .       g.85026
 ggcccagccccagctgttggctacatgagtatttagaggaagtaaggtagcaggcagtcc       c.*360

          .         .         .         .         .         .       g.85086
 agccctgatgtggagacacatgggattttggaaatcagcttctggaggaatgcatgtcac       c.*420

          .         .         .         .         .         .       g.85146
 aggcgggactttcttcagagagtggtgcagcgccagacattttgcacataaggcaccaaa       c.*480

          .         .         .         .         .         .       g.85206
 cagcccaggactgccgagactctggccgcccgaaggagcctgctttggtactatggaact       c.*540

          .         .         .         .         .         .       g.85266
 tttcttaggggacacgtcctcctttcacagcttctaaggtgtccagtgcattgggatggt       c.*600

          .         .         .         .         .         .       g.85326
 tttccaggcaaggcactcggccaatccgcatctcagccctctcagggagcagtcttccat       c.*660

          .         .         .         .         .         .       g.85386
 catgctgaattttgtcttccaggagctgcccctatggggcggggccgcagggccagcctt       c.*720

          .         .         .         .         .         .       g.85446
 gtttctctaacaaacaaacaaacaaacagccttgtttctctagtcacatcatgtgtatac       c.*780

          .         .         .         .         .         .       g.85506
 aaggaagccaggaatacaggttttcttgatgatttgggttttaattttgtttttattgca       c.*840

          .         .         .         .         .         .       g.85566
 cctgacaaaatacagttatctgatggtccctcaattatgttattttaataaaataaatta       c.*900

          .                                                         g.85579
 aatttaggtgtaa                                                      c.*913

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The V-raf-1 murine leukemia viral oncogene homolog 1 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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