recombination activating gene 2 (RAG2) - coding DNA reference sequence

(used for variant description)

(last modified January 13, 2018)


This file was created to facilitate the description of sequence variants on transcript NM_000536.2 in the RAG2 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_007573.1, covering RAG2 transcript NM_000536.2.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                                    g.4982
                                                     aagaacat       c.-181

 .         .         .         .         .         .                g.5042
 ctgtaggcacacatacacactctctttacagtcagccttctgcttgccacagtcatagtg       c.-121

 .         .         .         .         .         .                g.5102
 ggcagtcagtgaatcttccccaagtgctgacaattaatacctggtttagcggcaaagatt       c.-61

 .         .         .         .   | 02     .         .             g.9068
 cagagaggcgtgagcagcccctctggccttcag | acaaaaatctacgtaccatcagaaact    c.-1

          .         .         .         .         .         .       g.9128
 ATGTCTCTGCAGATGGTAACAGTCAGTAATAACATAGCCTTAATTCAGCCAGGCTTCTCA       c.60
 M  S  L  Q  M  V  T  V  S  N  N  I  A  L  I  Q  P  G  F  S         p.20

          .         .         .         .         .         .       g.9188
 CTGATGAATTTTGATGGACAAGTTTTCTTCTTTGGACAAAAAGGCTGGCCCAAAAGATCC       c.120
 L  M  N  F  D  G  Q  V  F  F  F  G  Q  K  G  W  P  K  R  S         p.40

          .         .         .         .         .         .       g.9248
 TGCCCCACTGGAGTTTTCCATCTGGATGTAAAGCATAACCATGTCAAACTGAAGCCTACA       c.180
 C  P  T  G  V  F  H  L  D  V  K  H  N  H  V  K  L  K  P  T         p.60

          .         .         .         .         .         .       g.9308
 ATTTTCTCTAAGGATTCCTGCTACCTCCCTCCTCTTCGCTACCCAGCCACTTGCACATTC       c.240
 I  F  S  K  D  S  C  Y  L  P  P  L  R  Y  P  A  T  C  T  F         p.80

          .         .         .         .         .         .       g.9368
 AAAGGCAGCTTGGAGTCTGAAAAGCATCAATACATCATCCATGGAGGGAAAACACCAAAC       c.300
 K  G  S  L  E  S  E  K  H  Q  Y  I  I  H  G  G  K  T  P  N         p.100

          .         .         .         .         .         .       g.9428
 AATGAGGTTTCAGATAAGATTTATGTCATGTCTATTGTTTGCAAGAACAACAAAAAGGTT       c.360
 N  E  V  S  D  K  I  Y  V  M  S  I  V  C  K  N  N  K  K  V         p.120

          .         .         .         .         .         .       g.9488
 ACTTTTCGCTGCACAGAGAAAGACTTGGTAGGAGATGTTCCTGAAGCCAGATATGGTCAT       c.420
 T  F  R  C  T  E  K  D  L  V  G  D  V  P  E  A  R  Y  G  H         p.140

          .         .         .         .         .         .       g.9548
 TCCATTAATGTGGTGTACAGCCGAGGGAAAAGTATGGGTGTTCTCTTTGGAGGACGCTCA       c.480
 S  I  N  V  V  Y  S  R  G  K  S  M  G  V  L  F  G  G  R  S         p.160

          .         .         .         .         .         .       g.9608
 TACATGCCTTCTACCCACAGAACCACAGAAAAATGGAATAGTGTAGCTGACTGCCTGCCC       c.540
 Y  M  P  S  T  H  R  T  T  E  K  W  N  S  V  A  D  C  L  P         p.180

          .         .         .         .         .         .       g.9668
 TGTGTTTTCCTGGTGGATTTTGAATTTGGGTGTGCTACATCATACATTCTTCCAGAACTT       c.600
 C  V  F  L  V  D  F  E  F  G  C  A  T  S  Y  I  L  P  E  L         p.200

          .         .         .         .         .         .       g.9728
 CAGGATGGGCTATCTTTTCATGTCTCTATTGCCAAAAATGACACCATCTATATTTTAGGA       c.660
 Q  D  G  L  S  F  H  V  S  I  A  K  N  D  T  I  Y  I  L  G         p.220

          .         .         .         .         .         .       g.9788
 GGACATTCACTTGCCAATAATATCCGGCCTGCCAACCTGTACAGAATAAGGGTTGATCTT       c.720
 G  H  S  L  A  N  N  I  R  P  A  N  L  Y  R  I  R  V  D  L         p.240

          .         .         .         .         .         .       g.9848
 CCCCTGGGTAGCCCAGCTGTGAATTGCACAGTCTTGCCAGGAGGAATCTCTGTCTCCAGT       c.780
 P  L  G  S  P  A  V  N  C  T  V  L  P  G  G  I  S  V  S  S         p.260

          .         .         .         .         .         .       g.9908
 GCAATCCTGACTCAAACTAACAATGATGAATTTGTTATTGTTGGTGGCTATCAGCTTGAA       c.840
 A  I  L  T  Q  T  N  N  D  E  F  V  I  V  G  G  Y  Q  L  E         p.280

          .         .         .         .         .         .       g.9968
 AATCAAAAAAGAATGATCTGCAACATCATCTCTTTAGAGGACAACAAGATAGAAATTCGT       c.900
 N  Q  K  R  M  I  C  N  I  I  S  L  E  D  N  K  I  E  I  R         p.300

          .         .         .         .         .         .       g.10028
 GAGATGGAGACCCCAGATTGGACCCCAGACATTAAGCACAGCAAGATATGGTTTGGAAGC       c.960
 E  M  E  T  P  D  W  T  P  D  I  K  H  S  K  I  W  F  G  S         p.320

          .         .         .         .         .         .       g.10088
 AACATGGGAAATGGAACTGTTTTTCTTGGCATACCAGGAGACAATAAACAAGTTGTTTCA       c.1020
 N  M  G  N  G  T  V  F  L  G  I  P  G  D  N  K  Q  V  V  S         p.340

          .         .         .         .         .         .       g.10148
 GAAGGATTCTATTTCTATATGTTGAAATGTGCTGAAGATGATACTAATGAAGAGCAGACA       c.1080
 E  G  F  Y  F  Y  M  L  K  C  A  E  D  D  T  N  E  E  Q  T         p.360

          .         .         .         .         .         .       g.10208
 ACATTCACAAACAGTCAAACATCAACAGAAGATCCAGGGGATTCCACTCCCTTTGAAGAC       c.1140
 T  F  T  N  S  Q  T  S  T  E  D  P  G  D  S  T  P  F  E  D         p.380

          .         .         .         .         .         .       g.10268
 TCTGAAGAATTTTGTTTCAGTGCAGAAGCAAATAGTTTTGATGGTGATGATGAATTTGAC       c.1200
 S  E  E  F  C  F  S  A  E  A  N  S  F  D  G  D  D  E  F  D         p.400

          .         .         .         .         .         .       g.10328
 ACCTATAATGAAGATGATGAAGAAGATGAGTCTGAGACAGGCTACTGGATTACATGCTGC       c.1260
 T  Y  N  E  D  D  E  E  D  E  S  E  T  G  Y  W  I  T  C  C         p.420

          .         .         .         .         .         .       g.10388
 CCTACTTGTGATGTGGATATCAACACTTGGGTACCATTCTATTCAACTGAGCTCAACAAA       c.1320
 P  T  C  D  V  D  I  N  T  W  V  P  F  Y  S  T  E  L  N  K         p.440

          .         .         .         .         .         .       g.10448
 CCCGCCATGATCTACTGCTCTCATGGGGATGGGCACTGGGTCCATGCTCAGTGCATGGAT       c.1380
 P  A  M  I  Y  C  S  H  G  D  G  H  W  V  H  A  Q  C  M  D         p.460

          .         .         .         .         .         .       g.10508
 CTGGCAGAACGCACACTCATCCATCTGTCAGCAGGAAGCAACAAGTATTACTGCAATGAG       c.1440
 L  A  E  R  T  L  I  H  L  S  A  G  S  N  K  Y  Y  C  N  E         p.480

          .         .         .         .         .         .       g.10568
 CATGTGGAGATAGCAAGAGCTCTACACACTCCCCAAAGAGTCCTACCCTTAAAAAAGCCT       c.1500
 H  V  E  I  A  R  A  L  H  T  P  Q  R  V  L  P  L  K  K  P         p.500

          .         .         .         .         .         .       g.10628
 CCAATGAAATCCCTCCGTAAAAAAGGTTCTGGAAAAATCTTGACTCCTGCCAAGAAATCC       c.1560
 P  M  K  S  L  R  K  K  G  S  G  K  I  L  T  P  A  K  K  S         p.520

          .         .                                               g.10652
 TTTCTTAGAAGGTTGTTTGATTAG                                           c.1584
 F  L  R  R  L  F  D  X                                             p.527

          .         .         .         .         .         .       g.10712
 ttttgcaaaagcctttcagattcaggtgtatggaatttttgaatctatttttaaaatcat       c.*60

          .         .         .         .         .         .       g.10772
 aacattgattttaaaaatacatttttgtttatttaaaatgcctatgttttcttttagtta       c.*120

          .         .         .         .         .         .       g.10832
 catgaattaagggccagaaaaaagtgtttataatgcaatgataaataaagtcattctaga       c.*180

          .         .         .         .         .         .       g.10892
 ccctatacattttgaaaatattttacccaaatactcaatttactaatttattcttcactg       c.*240

          .         .         .         .         .         .       g.10952
 aggatttctgatctgattttttattcaacaaaccttaaacacccagaagcagtaataatc       c.*300

          .         .         .         .         .         .       g.11012
 atcgaggtatgtttatatttattatataagtcttggtaacaaataacctataaagtgttt       c.*360

          .         .         .         .         .         .       g.11072
 atgacaaatttagccaataaagaaattaacacccaaaagaattaaattgattattttgtg       c.*420

          .         .         .         .         .         .       g.11132
 caacataacaattcggcagttggccaaaacttaaaagcaagatctactacatcccacatt       c.*480

          .         .         .         .         .         .       g.11192
 agtgttctttatataccttcaagcaaccctttggattatgcccatgaacaagttagtttc       c.*540

          .         .         .         .         .         .       g.11252
 tcatagctttacagatgtagatataaatataaatatatgtatacatatagatagataatg       c.*600

          .         .         .         .                           g.11294
 ttctccactgacacaaaagaagaaataaataatctacatcaa                         c.*642

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Recombination activating gene 2 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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