Rap guanine nucleotide exchange factor (GEF) 2 (RAPGEF2) - coding DNA reference sequence

(used for variant description)

(last modified December 19, 2019)


This file was created to facilitate the description of sequence variants on transcript NM_014247.2 in the RAPGEF2 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_063926.1, covering RAPGEF2 transcript NM_014247.2.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                   .                g.5010
                                                   aaatgatctt       c.-301

 .         .         .         .         .         .                g.5070
 gttctcttggaagactgagagctgtgtgaggttttctcagtcttgtcatagcctaggatg       c.-241

 .         .         .         .         .         .                g.5130
 gttagagtttcaatgttataaaaatggagacgaacactgttgttcggattccttttctgg       c.-181

 .         .         .         .         .         .                g.5190
 tctacaagtgtgaagggtttttaagcttaccagtagtgacactttaagctgcagcttggt       c.-121

 .         .         .         .         .         .                g.5250
 tttccctcctccctttttttttttcctttttcttttaatttaatgctgtagagggtgact       c.-61

 .         .         .         .         .         .                g.5310
 tgccatcgtgagagattggtacatgatgtgtaaattcagttcagcatatgtttcttcatt       c.-1

          .         .         .         .         .         .       g.5370
 ATGAAACCACTAGCAATCCCAGCTAACCATGGAGTTATGGGCCAGCAGGAGAAACACTCA       c.60
 M  K  P  L  A  I  P  A  N  H  G  V  M  G  Q  Q  E  K  H  S         p.20

  | 02       .         .         .         .         .         .    g.41556
  | CTTCCTGCAGATTTCACAAAACTGCATCTTACTGACAGTCTCCACCCACAGGTGACCCAC    c.120
  | L  P  A  D  F  T  K  L  H  L  T  D  S  L  H  P  Q  V  T  H      p.40

          .         .         .         .         .         .       g.41616
 GTTTCTTCTAGCCATTCAGGATGTAGTATCACTAGTGATTCTGGGAGCAGCAGTCTTTCT       c.180
 V  S  S  S  H  S  G  C  S  I  T  S  D  S  G  S  S  S  L  S         p.60

          .   | 03     .         .         .         .         .    g.51793
 GATATCTACCAG | GCCACAGAAAGCGAGGCTGGTGATATGGACCTGAGTGGGTTGCCAGAA    c.240
 D  I  Y  Q   | A  T  E  S  E  A  G  D  M  D  L  S  G  L  P  E      p.80

          .         .         .         .         .         .       g.51853
 ACAGCAGTGGATTCCGAAGACGACGACGATGAAGAAGACATTGAGAGAGCATCAGATCCT       c.300
 T  A  V  D  S  E  D  D  D  D  E  E  D  I  E  R  A  S  D  P         p.100

          .         .         .         .         .         .       g.51913
 CTGATGAGCAGGGACATTGTGAGAGACTGCCTAGAGAAGGACCCAATTGACCGGACAGAT       c.360
 L  M  S  R  D  I  V  R  D  C  L  E  K  D  P  I  D  R  T  D         p.120

          . | 04       .         .         .         .         .    g.59551
 GATGACATTG | AACAACTCTTGGAATTTATGCACCAGTTGCCTGCTTTTGCCAATATGACA    c.420
 D  D  I  E |   Q  L  L  E  F  M  H  Q  L  P  A  F  A  N  M  T      p.140

          .         .         .         .         .         .       g.59611
 ATGTCAGTGAGGCGAGAACTCTGTGCTGTGATGGTGTTCGCAGTGGTGGAAAGAGCAGGG       c.480
 M  S  V  R  R  E  L  C  A  V  M  V  F  A  V  V  E  R  A  G         p.160

          .         .        | 05.         .         .         .    g.60646
 ACCATAGTGTTAAATGATGGTGAAGAG | CTGGACTCCTGGTCAGTGATTCTCAATGGATCT    c.540
 T  I  V  L  N  D  G  E  E   | L  D  S  W  S  V  I  L  N  G  S      p.180

          .         .         .         .         .         .       g.60706
 GTGGAAGTGACTTATCCAGATGGAAAAGCAGAAATACTGTGCATGGGAAATAGTTTTGGT       c.600
 V  E  V  T  Y  P  D  G  K  A  E  I  L  C  M  G  N  S  F  G         p.200

          .         .         .         .         .         .       g.60766
 GTCTCTCCTACCATGGACAAAGAATACATGAAAGGAGTGATGAGAACAAAGGTGGATGAC       c.660
 V  S  P  T  M  D  K  E  Y  M  K  G  V  M  R  T  K  V  D  D         p.220

        | 06 .         .         .         .         .         .    g.67066
 TGCCAG | TTTGTCTGCATAGCCCAGCAAGATTACTGCCGTATTCTCAATCAAGTAGAAAAG    c.720
 C  Q   | F  V  C  I  A  Q  Q  D  Y  C  R  I  L  N  Q  V  E  K      p.240

          .         .         .         .         .         .       g.67126
 AACATGCAAAAAGTTGAAGAGGAAGGAGAGATTGTTATGGTGAAAGAACACCGAGAACTT       c.780
 N  M  Q  K  V  E  E  E  G  E  I  V  M  V  K  E  H  R  E  L         p.260

          .         .         .          | 07        .         .    g.67509
 GATCGAACTGGAACAAGAAAGGGACACATTGTCATCAAG | GGTACCTCAGAAAGGTTAACA    c.840
 D  R  T  G  T  R  K  G  H  I  V  I  K   | G  T  S  E  R  L  T      p.280

          .         .         .         .         .         .       g.67569
 ATGCATTTGGTGGAAGAGCATTCAGTAGTAGATCCAACATTCATAGAAGACTTTCTGTTG       c.900
 M  H  L  V  E  E  H  S  V  V  D  P  T  F  I  E  D  F  L  L         p.300

          .         .         .         .         .         .       g.67629
 ACCTATAGGACTTTTCTTTCTAGCCCAATGGAAGTGGGCAAAAAGTTATTGGAGTGGTTT       c.960
 T  Y  R  T  F  L  S  S  P  M  E  V  G  K  K  L  L  E  W  F         p.320

          .         .     | 08   .         .         .         .    g.68621
 AATGACCCGAGCCTCAGGGATAAG | GTTACACGGGTAGTATTATTGTGGGTAAATAATCAC    c.1020
 N  D  P  S  L  R  D  K   | V  T  R  V  V  L  L  W  V  N  N  H      p.340

          .         .         .         .         .         .       g.68681
 TTCAATGACTTTGAAGGAGATCCTGCAATGACTCGATTTTTAGAAGAATTTGAAAACAAT       c.1080
 F  N  D  F  E  G  D  P  A  M  T  R  F  L  E  E  F  E  N  N         p.360

          .   | 09     .         .         .         .         .    g.68832
 CTGGAAAGAGAG | AAAATGGGTGGACACCTAAGGCTGTTGAATATCGCGTGTGCTGCTAAA    c.1140
 L  E  R  E   | K  M  G  G  H  L  R  L  L  N  I  A  C  A  A  K      p.380

          .         .         .         .         .         .       g.68892
 GCAAAAAGAAGATTGATGACGTTAACAAAACCATCCCGAGAAGCTCCTTTGCCTTTTATC       c.1200
 A  K  R  R  L  M  T  L  T  K  P  S  R  E  A  P  L  P  F  I         p.400

          .         .         .         .         .         .       g.68952
 TTACTTGGAGGCTCTGAGAAGGGATTTGGAATCTTTGTTGACAGTGTAGATTCAGGTAGC       c.1260
 L  L  G  G  S  E  K  G  F  G  I  F  V  D  S  V  D  S  G  S         p.420

          .         .         .       | 10 .         .         .    g.69104
 AAAGCAACTGAAGCAGGCTTGAAACGGGGGGATCAG | ATATTAGAAGTAAATGGCCAAAAC    c.1320
 K  A  T  E  A  G  L  K  R  G  D  Q   | I  L  E  V  N  G  Q  N      p.440

          .         .         .         .         .         .       g.69164
 TTTGAAAACATTCAGCTGTCAAAAGCTATGGAAATTCTTAGAAATAACACACATTTATCT       c.1380
 F  E  N  I  Q  L  S  K  A  M  E  I  L  R  N  N  T  H  L  S         p.460

          .         .      | 11  .         .         .         .    g.69640
 ATCACTGTGAAAACCAATTTATTTG | TATTTAAAGAACTTCTAACAAGATTGTCAGAAGAG    c.1440
 I  T  V  K  T  N  L  F  V |   F  K  E  L  L  T  R  L  S  E  E      p.480

          .         .         .         .         .         .       g.69700
 AAAAGAAATGGTGCCCCCCACCTTCCTAAAATTGGTGACATTAAAAAGGCCAGTCGCTAC       c.1500
 K  R  N  G  A  P  H  L  P  K  I  G  D  I  K  K  A  S  R  Y         p.500

          .         .         .         .         .         .       g.69760
 TCCATTCCAGATCTTGCTGTAGATGTAGAACAGGTGATAGGACTTGAAAAAGTGAACAAA       c.1560
 S  I  P  D  L  A  V  D  V  E  Q  V  I  G  L  E  K  V  N  K         p.520

          .         .         .         .         .         .       g.69820
 AAAAGTAAAGCCAACACTGTGGGAGGAAGGAACAAGCTGAAAAAGATACTCGACAAGACT       c.1620
 K  S  K  A  N  T  V  G  G  R  N  K  L  K  K  I  L  D  K  T         p.540

          .         .         .   | 12     .         .         .    g.75493
 CGGATCAGTATCTTGCCACAGAAACCATACAA | TGATATTGGGATTGGTCAGTCTCAAGAT    c.1680
 R  I  S  I  L  P  Q  K  P  Y  N  |  D  I  G  I  G  Q  S  Q  D      p.560

          .         .         .         .         .         .       g.75553
 GACAGCATAGTAGGATTAAGGCAGACAAAGCACATCCCAACTGCATTGCCTGTCAGTGGA       c.1740
 D  S  I  V  G  L  R  Q  T  K  H  I  P  T  A  L  P  V  S  G         p.580

          .         .         .         .         .         .       g.75613
 ACCTTATCATCCAGTAATCCTGATTTATTGCAGTCACATCATCGCATTTTAGACTTCAGT       c.1800
 T  L  S  S  S  N  P  D  L  L  Q  S  H  H  R  I  L  D  F  S         p.600

          . | 13       .         .         .         .         .    g.76318
 GCTACTCCTG | ACTTGCCAGATCAAGTGCTAAGGGTTTTTAAGGCTGATCAGCAAAGCCGC    c.1860
 A  T  P  D |   L  P  D  Q  V  L  R  V  F  K  A  D  Q  Q  S  R      p.620

          .         .         .         .         .         .       g.76378
 TACATCATGATCAGTAAGGACACTACAGCAAAGGAAGTGGTCATTCAGGCTATCAGGGAG       c.1920
 Y  I  M  I  S  K  D  T  T  A  K  E  V  V  I  Q  A  I  R  E         p.640

          .         .         .         .         .         .       g.76438
 TTTGCTGTTACTGCCACCCCGGATCAATATTCACTATGTGAGGTCTCTGTCACACCTGAG       c.1980
 F  A  V  T  A  T  P  D  Q  Y  S  L  C  E  V  S  V  T  P  E         p.660

          .         .         .         .         .         .       g.76498
 GGAGTAATCAAACAAAGAAGACTTCCAGATCAGCTTTCCAAACTTGCAGACAGAATACAA       c.2040
 G  V  I  K  Q  R  R  L  P  D  Q  L  S  K  L  A  D  R  I  Q         p.680

          .  | 14      .         .         .         .         .    g.78767
 CTGAGTGGAAG | GTATTATCTGAAAAACAACATGGAAACAGAAACTCTTTGTTCAGATGAA    c.2100
 L  S  G  R  |  Y  Y  L  K  N  N  M  E  T  E  T  L  C  S  D  E      p.700

          .         .         .         .         .         .       g.78827
 GATGCTCAGGAGTTGTTGAGAGAGAGTCAAATTTCCCTCCTTCAGCTCAGCACTGTGGAA       c.2160
 D  A  Q  E  L  L  R  E  S  Q  I  S  L  L  Q  L  S  T  V  E         p.720

          .         .         .         .         .         .       g.78887
 GTTGCAACACAGCTCTCTATGCGAAATTTTGAACTCTTTCGCAACATTGAACCTACTGAA       c.2220
 V  A  T  Q  L  S  M  R  N  F  E  L  F  R  N  I  E  P  T  E         p.740

          .         .         .         .         .         .       g.78947
 TATATAGATGATTTATTTAAACTCAGATCAAAAACCAGCTGTGCCAACCTGAAGAGATTT       c.2280
 Y  I  D  D  L  F  K  L  R  S  K  T  S  C  A  N  L  K  R  F         p.760

          .         .         .         .         .         .       g.79007
 GAAGAAGTCATTAACCAGGAAACATTTTGGGTAGCATCTGAAATTCTCAGAGAAACAAAC       c.2340
 E  E  V  I  N  Q  E  T  F  W  V  A  S  E  I  L  R  E  T  N         p.780

          .         .         .         .         .         .       g.79067
 CAGCTGAAGAGGATGAAGATCATTAAGCATTTCATCAAGATAGCACTGCACTGTAGGGAA       c.2400
 Q  L  K  R  M  K  I  I  K  H  F  I  K  I  A  L  H  C  R  E         p.800

          .         .         .      | 15  .         .         .    g.80158
 TGCAAGAATTTTAACTCAATGTTTGCAATCATCAG | TGGCCTAAACCTGGCACCAGTGGCA    c.2460
 C  K  N  F  N  S  M  F  A  I  I  S  |  G  L  N  L  A  P  V  A      p.820

          .         .         .         .         .         .       g.80218
 AGACTGCGAACGACCTGGGAGAAACTTCCCAATAAATACGAAAAACTATTTCAAGATCTC       c.2520
 R  L  R  T  T  W  E  K  L  P  N  K  Y  E  K  L  F  Q  D  L         p.840

          .         .         .         .         .         .       g.80278
 CAAGACCTGTTTGATCCTTCCAGAAACATGGCAAAATATCGTAATGTTCTCAATAGTCAA       c.2580
 Q  D  L  F  D  P  S  R  N  M  A  K  Y  R  N  V  L  N  S  Q         p.860

          .         .         .         .         .         .       g.80338
 AATCTACAACCTCCCATAATCCCTCTATTCCCAGTTATCAAAAAGGATCTCACCTTCCTT       c.2640
 N  L  Q  P  P  I  I  P  L  F  P  V  I  K  K  D  L  T  F  L         p.880

         | 16.         .         .         .         .         .    g.80488
 CACGAAG | GAAATGACTCAAAAGTAGACGGGCTGGTCAATTTTGAGAAGCTAAGGATGATT    c.2700
 H  E  G |   N  D  S  K  V  D  G  L  V  N  F  E  K  L  R  M  I      p.900

          .         .         .         .         .         .       g.80548
 GCAAAAGAAATTCGTCACGTTGGCCGAATGGCTTCAGTGAACATGGACCCTGCCCTCATG       c.2760
 A  K  E  I  R  H  V  G  R  M  A  S  V  N  M  D  P  A  L  M         p.920

          .  | 17      .         .      | 18  .         .         . g.82285
 TTCAGGACTCG | GAAGAAGAAATGGCGGAGTTTGGG | GTCTCTCAGCCAGGGTAGTACAAAT c.2820
 F  R  T  R  |  K  K  K  W  R  S  L  G  |  S  L  S  Q  G  S  T  N   p.940

          .         .         .         .         .         .       g.82345
 GCAACAGTGCTAGATGTTGCTCAGACAGGTGGTCATAAAAAGCGGGTACGTCGTAGTTCC       c.2880
 A  T  V  L  D  V  A  Q  T  G  G  H  K  K  R  V  R  R  S  S         p.960

          .         .         .         .         .         .       g.82405
 TTTCTCAATGCCAAAAAGCTTTATGAAGATGCCCAAATGGCTCGAAAAGTGAAGCAGTAC       c.2940
 F  L  N  A  K  K  L  Y  E  D  A  Q  M  A  R  K  V  K  Q  Y         p.980

          .         .         .         .         .         .       g.82465
 CTTTCCAATTTGGAGCTAGAAATGGACGAGGAGAGTCTTCAGACATTATCTCTGCAGTGT       c.3000
 L  S  N  L  E  L  E  M  D  E  E  S  L  Q  T  L  S  L  Q  C         p.1000

          .          | 19        .         .         .         .    g.83984
 GAGCCAGCAACCAACACAT | TGCCTAAGAATCCTGGTGACAAAAAGCCTGTCAAATCCGAG    c.3060
 E  P  A  T  N  T  L |   P  K  N  P  G  D  K  K  P  V  K  S  E      p.1020

          .         .         .         .         .         .       g.84044
 ACCTCTCCAGTAGCTCCAAGGGCAGGGTCACAACAGAAAGCTCAGTCCCTGCCACAGCCC       c.3120
 T  S  P  V  A  P  R  A  G  S  Q  Q  K  A  Q  S  L  P  Q  P         p.1040

          .         .         .         .         .         .       g.84104
 CAGCAGCAGCCACCACCAGCACATAAAATCAACCAGGGACTACAGGTTCCCGCCGTGTCC       c.3180
 Q  Q  Q  P  P  P  A  H  K  I  N  Q  G  L  Q  V  P  A  V  S         p.1060

          .         .         .         .          | 20        .    g.87302
 CTTTATCCTTCACGGAAGAAAGTGCCCGTAAAGGATCTCCCACCTTTTG | GCATAAACTCT    c.3240
 L  Y  P  S  R  K  K  V  P  V  K  D  L  P  P  F  G |   I  N  S      p.1080

          .         .         .         .         .         .       g.87362
 CCACAAGCTTTAAAAAAAATTCTTTCTTTGTCTGAAGAAGGAAGTTTGGAACGTCACAAG       c.3300
 P  Q  A  L  K  K  I  L  S  L  S  E  E  G  S  L  E  R  H  K         p.1100

          .         .         .         .         .         .       g.87422
 AAACAGGCTGAAGATACAATATCAAATGCATCTTCGCAGCTTTCTTCTCCTCCTACTTCT       c.3360
 K  Q  A  E  D  T  I  S  N  A  S  S  Q  L  S  S  P  P  T  S         p.1120

          .         .   | 21     .         .         .         .    g.89877
 CCACAGAGTTCTCCAAGGAAAG | GCTATACTTTGGCTCCCAGTGGTACTGTGGATAATTTT    c.3420
 P  Q  S  S  P  R  K  G |   Y  T  L  A  P  S  G  T  V  D  N  F      p.1140

          .         .         .         .         .         .       g.89937
 TCAGATTCTGGTCACAGTGAAATTTCTTCACGATCCAGTATTGTTAGCAATTCGTCTTTT       c.3480
 S  D  S  G  H  S  E  I  S  S  R  S  S  I  V  S  N  S  S  F         p.1160

          .         .         .         .         .         .       g.89997
 GACTCAGTGCCAGTCTCACTGCACGATGAGAGGCGCCAGAGGCATTCTGTCAGCATCGTG       c.3540
 D  S  V  P  V  S  L  H  D  E  R  R  Q  R  H  S  V  S  I  V         p.1180

          .         .         .         .         .         .       g.90057
 GAAACAAACCTAGGGATGGGCAGGATGGAGAGGCGGACCATGATTGAACCTGATCAGTAT       c.3600
 E  T  N  L  G  M  G  R  M  E  R  R  T  M  I  E  P  D  Q  Y         p.1200

          | 22         .         .         .         .         .    g.90693
 AGCTTGGG | GTCCTATGCACCAATGTCCGAGGGCCGAGGCTTATATGCTACAGCTACAGTA    c.3660
 S  L  G  |  S  Y  A  P  M  S  E  G  R  G  L  Y  A  T  A  T  V      p.1220

          .         .         .         .         .         .       g.90753
 ATTTCTTCTCCAAGCACAGAGGAACTTTCCCAGGATCAGGGGGATCGCGCGTCACTTGAT       c.3720
 I  S  S  P  S  T  E  E  L  S  Q  D  Q  G  D  R  A  S  L  D         p.1240

          .         .         .         .         .         .       g.90813
 GCTGCTGACAGTGGCCGTGGGAGCTGGACGTCATGCTCAAGTGGCTCCCATGATAATATA       c.3780
 A  A  D  S  G  R  G  S  W  T  S  C  S  S  G  S  H  D  N  I         p.1260

          .         .         .         .         .         .       g.90873
 CAGACGATCCAGCACCAGAGAAGCTGGGAGACTCTTCCATTCGGGCATACTCACTTTGAT       c.3840
 Q  T  I  Q  H  Q  R  S  W  E  T  L  P  F  G  H  T  H  F  D         p.1280

          .         .         .         .         .         .       g.90933
 TATTCAGGGGATCCTGCAGGTTTATGGGCATCAAGCAGCCATATGGACCAAATTATGTTT       c.3900
 Y  S  G  D  P  A  G  L  W  A  S  S  S  H  M  D  Q  I  M  F         p.1300

          .         .         .         .         .         .       g.90993
 TCTGATCATAGCACAAAGTATAACAGGCAAAATCAAAGTAGAGAGAGCCTTGAACAAGCC       c.3960
 S  D  H  S  T  K  Y  N  R  Q  N  Q  S  R  E  S  L  E  Q  A         p.1320

          .         .         .         .         .         .       g.91053
 CAGTCCCGAGCAAGCTGGGCGTCTTCCACAGGTTACTGGGGAGAAGACTCAGAAGGTGAC       c.4020
 Q  S  R  A  S  W  A  S  S  T  G  Y  W  G  E  D  S  E  G  D         p.1340

          .         .         .         .         .         .       g.91113
 ACAGGCACAATAAAGCGGAGGGGTGGAAAGGATGTTTCCATTGAAGCCGAAAGCAGTAGC       c.4080
 T  G  T  I  K  R  R  G  G  K  D  V  S  I  E  A  E  S  S  S         p.1360

          .         .         .         .         .         .       g.91173
 CTAACGTCTGTGACTACGGAAGAAACCAAGCCTGTCCCCATGCCTGCCCACATAGCTGTG       c.4140
 L  T  S  V  T  T  E  E  T  K  P  V  P  M  P  A  H  I  A  V         p.1380

          .         .         | 23         .         .         .    g.93039
 GCATCAAGTACTACAAAGGGGCTCATTG | CACGAAAGGAGGGCAGGTATCGAGAGCCCCCG    c.4200
 A  S  S  T  T  K  G  L  I  A |   R  K  E  G  R  Y  R  E  P  P      p.1400

          .         .         .         .         .         .       g.93099
 CCCACCCCTCCCGGCTACATTGGAATTCCCATTACTGACTTTCCAGAAGGGCACTCCCAT       c.4260
 P  T  P  P  G  Y  I  G  I  P  I  T  D  F  P  E  G  H  S  H         p.1420

          .         .         .         .         .         .       g.93159
 CCAGCCAGGAAACCGCCGGACTACAACGTGGCCCTTCAGAGATCGCGGATGGTCGCACGA       c.4320
 P  A  R  K  P  P  D  Y  N  V  A  L  Q  R  S  R  M  V  A  R         p.1440

          .         .         .         .         .         .       g.93219
 TCCTCCGACACAGCTGGGCCTTCATCCGTACAGCAGCCACATGGGCATCCCACCAGCAGC       c.4380
 S  S  D  T  A  G  P  S  S  V  Q  Q  P  H  G  H  P  T  S  S         p.1460

          .         .         .         .         .         .       g.93279
 AGGCCTGTGAACAAACCTCAGTGGCATAAACCGAACGAGTCTGACCCGCGCCTCGCCCCC       c.4440
 R  P  V  N  K  P  Q  W  H  K  P  N  E  S  D  P  R  L  A  P         p.1480

          .         .         .     | 24   .         .         .    g.95294
 TATCAGTCCCAAGGGTTTTCCACCGAGGAGGATG | AAGATGAACAAGTTTCTGCTGTTTGA    c.4500
 Y  Q  S  Q  G  F  S  T  E  E  D  E |   D  E  Q  V  S  A  V  X      p.1499

          .         .         .         .         .         .       g.95354
 ggcacagacttttctggaagcagagcgagccacctgaaaggagagcacaagaagacgtcc       c.*60

          .         .         .         .         .         .       g.95414
 tgagcattggagccttggaactcacattctgaggacggtggaccagtttgcctccttccc       c.*120

          .         .         .         .         .         .       g.95474
 tgccttaaaagcagcatggggcttcttctccccttcttcctttcccctttgcatgtgaaa       c.*180

          .         .         .         .         .         .       g.95534
 tactgtgaagaaattgccctggcacttttcagactttgttgcttgaaatgcacagtgcag       c.*240

          .         .         .         .         .         .       g.95594
 caatcttcgagctcccactgttgctgcctgccacatcacacagtatcattccaaattcca       c.*300

          .         .         .         .         .         .       g.95654
 agatcatcacaacaagatgattcactctggctgcacttctcaatgcctggaaggattttt       c.*360

          .         .         .         .         .         .       g.95714
 tttaatcttccttttagatttcaatccagtcctagcacttgatctcattgggataatgag       c.*420

          .         .         .         .         .         .       g.95774
 aaaagctagccattgaactacttggggcctttaacccaccaaggaagacaaagaaaaaca       c.*480

          .         .         .         .         .         .       g.95834
 atgaaatcctttgagtacagtgcttgtccacttgtttacaatgtcctccttttaaaaaaa       c.*540

          .         .         .         .         .         .       g.95894
 aaaaatgagtttaaagattttgttcagagagtaaatatatatccatttaatgattacagt       c.*600

          .         .         .         .         .         .       g.95954
 attattttaaaccttaagtagggttgccagcctggtttctgaaaaaccaaatatgccgga       c.*660

          .         .         .         .         .         .       g.96014
 cagggtgtggccacaccaagaagacgggaagacctggcttgtgaccctggcttcccatgt       c.*720

          .         .         .         .         .         .       g.96074
 ccttctggtctcacccgcgaagtgccctatcctggaagtatgaaatgttagccaattaat       c.*780

          .         .         .         .         .         .       g.96134
 accaagacacctcatctgctccttccccagtggatggggttcttctgtaaaactgtttgc       c.*840

          .         .         .         .         .         .       g.96194
 acatggccaggggagggaactaggacccttgtgtcctgtctgagccttatggaggcagga       c.*900

          .         .         .         .         .         .       g.96254
 cggtgtcattggcggatgtgtcctgctccattgagatggatggcaaaccccatttttaag       c.*960

          .         .         .         .         .         .       g.96314
 ttatatttctttgatttttgttaatttagaggtgtaggttttgttttttgtttttttgtt       c.*1020

          .         .         .         .         .         .       g.96374
 tttttttaagagaaacatttataactggatagcattgcagtgaaagcagcttgggatgtt       c.*1080

          .         .         .         .         .         .       g.96434
 ggagctaatgccagctgtttatactgctctttcaagacagcctccctttattgaattggc       c.*1140

          .         .         .         .         .         .       g.96494
 attagggaataaacaagcctttaaacgtgataaaagatcaaaaacctggttagacatgcc       c.*1200

          .         .         .         .         .         .       g.96554
 agcctttgcaaggcaggttagtcaccaaagactaacctccaagtggctttatggacgctg       c.*1260

          .         .         .         .         .         .       g.96614
 catatagagaaggcctaagtgtagcaaccatctgctcacagctgctattaaccctataat       c.*1320

          .         .         .         .         .         .       g.96674
 gactgaaatgacccctccactctatttttgtgttgttttgcacagactccggaaaagtga       c.*1380

          .         .         .         .         .         .       g.96734
 aggctgccaatctgagtagtactcaaatgtgaggaactgctggtcttggattttttttcc       c.*1440

          .         .         .         .         .         .       g.96794
 attaaattcagctgatcatattgatcagtagataaacgtaaatagcttcaaattttaaaa       c.*1500

          .         .         .         .         .         .       g.96854
 gtggaattgcagtgttttttcactgtatcaaacaatgtcagtgctttatttaataattct       c.*1560

          .         .         .         .         .         .       g.96914
 cttctgtatcatggcatttgtctacttgcttattacattgtcaattatgcatttgtaatt       c.*1620

          .         .         .         .         .         .       g.96974
 ttacatgtaatatgcattatttgccagttttattatataggctatggacctcatgtgcat       c.*1680

          .         .         .         .         .         .       g.97034
 atagaaagacagaaatctagctctaccacaagttgcacaaatgttatctaagcattaagt       c.*1740

          .         .         .         .         .         .       g.97094
 aattgtagaacataggactgctaatctcagttcgctctgtgatgtcaagtgcagaatgta       c.*1800

          .         .         .         .         .         .       g.97154
 caattaactggtgatttcctcatacttttgatactacttgtacctgtatgtcttttagaa       c.*1860

          .         .         .         .         .         .       g.97214
 agacattggtggagtctgtatcccttttgtatttttaatacaataattgtacatattggt       c.*1920

          .         .         .         .         .         .       g.97274
 tatatttttgttgaagatggtagaaatgtactatgtttatgcttctacatccagtttgta       c.*1980

          .         .         .                                     g.97305
 caagctggaaaataaataaatataacataaa                                    c.*2011

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Rap guanine nucleotide exchange factor (GEF) 2 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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