arginyl-tRNA synthetase 2, mitochondrial (RARS2) - coding DNA reference sequence

(used for variant description)

(last modified February 2, 2014)


This file was created to facilitate the description of sequence variants on transcript NM_020320.3 in the RARS2 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000006.11, covering RARS2 transcript NM_020320.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
 .         .         .         .         .         .                g.5060
 ataaggaggtggggcgaggccggaactggcggactgcggcgcacttccgtagaggtggac       c.-1

          .         .         .       | 02 .         .         .    g.25451
 ATGGCGTGCGGCTTTCGCCGCGCTATTGCTTGCCAG | CTTTCCAGAGTGTTGAATCTTCCA    c.60
 M  A  C  G  F  R  R  A  I  A  C  Q   | L  S  R  V  L  N  L  P      p.20

          .         .         .         .         . | 03       .    g.30795
 CCAGAAAACTTGATCACATCAATATCTGCAGTTCCAATTTCCCAAAAAGA | AGAAGTAGCT    c.120
 P  E  N  L  I  T  S  I  S  A  V  P  I  S  Q  K  E  |  E  V  A      p.40

          .         .         .         .         .         .       g.30855
 GATTTTCAGCTTTCTGTGGATTCTTTATTGGAAAAAGACAATGACCATTCAAGACCAGAT       c.180
 D  F  Q  L  S  V  D  S  L  L  E  K  D  N  D  H  S  R  P  D         p.60

          .         .         .    | 04    .         .         .    g.32259
 ATTCAAGTTCAAGCCAAGAGACTAGCAGAGAAG | CTAAGATGTGATACAGTGGTGAGTGAA    c.240
 I  Q  V  Q  A  K  R  L  A  E  K   | L  R  C  D  T  V  V  S  E      p.80

          .         .         .         .         .        | 05.    g.39515
 ATCAGTACTGGTCAAAGGACTGTAAATTTCAAAATAAACAGAGAGCTCTTAACAAAG | ACA    c.300
 I  S  T  G  Q  R  T  V  N  F  K  I  N  R  E  L  L  T  K   | T      p.100

          .         .         .         .         .         .       g.39575
 GTGCTACAACAAGTAATTGAAGATGGCTCAAAATATGGATTAAAAAGTGAACTTTTCTCT       c.360
 V  L  Q  Q  V  I  E  D  G  S  K  Y  G  L  K  S  E  L  F  S         p.120

          .         .         .      | 06  .         .         .    g.46396
 GGACTTCCCCAGAAGAAGATTGTGGTTGAATTCAG | TTCACCTAATGTTGCCAAAAAATTT    c.420
 G  L  P  Q  K  K  I  V  V  E  F  S  |  S  P  N  V  A  K  K  F      p.140

          .         .         .  | 07      .         .         .    g.49347
 CATGTTGGACATTTGCGTTCTACCATCATAG | GAAATTTTATAGCAAATCTCAAAGAAGCT    c.480
 H  V  G  H  L  R  S  T  I  I  G |   N  F  I  A  N  L  K  E  A      p.160

          .         .         .         .         .      | 08  .    g.53028
 TTAGGACATCAAGTAATAAGAATAAATTACCTTGGCGATTGGGGCATGCAGTTTG | GTCTT    c.540
 L  G  H  Q  V  I  R  I  N  Y  L  G  D  W  G  M  Q  F  G |   L      p.180

          .         .         .         .         .         .       g.53088
 CTGGGAACTGGCTTCCAGCTGTTTGGCTATGAGGAAAAACTGCAGTCCAATCCTCTACAG       c.600
 L  G  T  G  F  Q  L  F  G  Y  E  E  K  L  Q  S  N  P  L  Q         p.200

          .   | 09     .         .         .         .         .    g.64123
 CATCTCTTTGAA | GTTTATGTACAAGTTAATAAAGAAGCAGCAGATGATAAAAGTGTAGCA    c.660
 H  L  F  E   | V  Y  V  Q  V  N  K  E  A  A  D  D  K  S  V  A      p.220

          .         .         .         .         .         .       g.64183
 AAAGCAGCACAGGAGTTCTTCCAACGATTGGAACTGGGCGATGTGCAAGCACTTTCACTG       c.720
 K  A  A  Q  E  F  F  Q  R  L  E  L  G  D  V  Q  A  L  S  L         p.240

          .         .         .         .         .  | 10      .    g.65378
 TGGCAAAAATTTCGGGACTTGAGCATTGAAGAGTACATTCGGGTTTACAAG | CGTCTGGGA    c.780
 W  Q  K  F  R  D  L  S  I  E  E  Y  I  R  V  Y  K   | R  L  G      p.260

          .         .         .         .         .         .       g.65438
 GTATATTTTGATGAATATTCAGGAGAATCATTTTATCGTGAAAAATCTCAAGAGGTCTTA       c.840
 V  Y  F  D  E  Y  S  G  E  S  F  Y  R  E  K  S  Q  E  V  L         p.280

          .         .         .         | 11         .         .    g.70387
 AAGTTGCTGGAGAGTAAAGGACTCCTACTGAAAACAAT | AAAAGGAACGGCTGTAGTAGAT    c.900
 K  L  L  E  S  K  G  L  L  L  K  T  I  |  K  G  T  A  V  V  D      p.300

          .         .         .         .         .         .       g.70447
 CTCTCTGGGAATGGCGACCCCTCCTCAATTTGTACTGTAATGCGAAGTGATGGGACTTCT       c.960
 L  S  G  N  G  D  P  S  S  I  C  T  V  M  R  S  D  G  T  S         p.320

          .     | 12   .         .         .         .         .    g.73539
 CTCTATGCAACCAG | AGATCTTGCAGCTGCTATAGATCGAATGGACAAGTATAATTTTGAT    c.1020
 L  Y  A  T  R  |  D  L  A  A  A  I  D  R  M  D  K  Y  N  F  D      p.340

          .      | 13  .         .         .         .         .    g.74806
 ACAATGATATATGTG | ACAGATAAAGGACAAAAAAAGCATTTTCAGCAAGTATTCCAAATG    c.1080
 T  M  I  Y  V   | T  D  K  G  Q  K  K  H  F  Q  Q  V  F  Q  M      p.360

          .         .         .   | 14     .         .         .    g.75338
 CTGAAGATCATGGGATATGACTGGGCAGAAAG | GTGCCAGCACGTGCCCTTTGGAGTAGTA    c.1140
 L  K  I  M  G  Y  D  W  A  E  R  |  C  Q  H  V  P  F  G  V  V      p.380

          .         .         .         .         .         .       g.75398
 CAGGGAATGAAGACTCGAAGAGGAGATGTCACTTTCCTGGAAGATGTTTTAAATGAGATT       c.1200
 Q  G  M  K  T  R  R  G  D  V  T  F  L  E  D  V  L  N  E  I         p.400

          .         .         .        | 15.         .         .    g.76149
 CAATTAAGGATGCTACAGAACATGGCTTCAATTAAGA | CAACTAAAGAACTCAAGAACCCA    c.1260
 Q  L  R  M  L  Q  N  M  A  S  I  K  T |   T  K  E  L  K  N  P      p.420

          .         .         .         .      | 16  .         .    g.76293
 CAAGAGACTGCAGAGAGGGTCGGGCTCGCAGCACTCATTATTCAG | GACTTCAAAGGTTTA    c.1320
 Q  E  T  A  E  R  V  G  L  A  A  L  I  I  Q   | D  F  K  G  L      p.440

          .         .         .         .         .         .       g.76353
 CTCTTATCTGACTACAAGTTCAGCTGGGATCGTGTTTTCCAGAGTCGCGGGGACACAGGA       c.1380
 L  L  S  D  Y  K  F  S  W  D  R  V  F  Q  S  R  G  D  T  G         p.460

          .         .         .      | 17  .         .         .    g.76778
 GTCTTCCTACAGTACACACACGCCCGCCTCCACAG | TTTGGAAGAGACTTTTGGATGTGGG    c.1440
 V  F  L  Q  Y  T  H  A  R  L  H  S  |  L  E  E  T  F  G  C  G      p.480

          .         .         .         .         .         .       g.76838
 TACCTGAATGACTTCAACACTGCTTGTTTACAAGAGCCACAGTCTGTTTCAATTCTTCAG       c.1500
 Y  L  N  D  F  N  T  A  C  L  Q  E  P  Q  S  V  S  I  L  Q         p.500

          .  | 18      .         .         .         .         .    g.78186
 CATCTTCTCAG | GTTCGACGAGGTGCTTTATAAATCATCTCAGGACTTTCAACCCAGGCAT    c.1560
 H  L  L  R  |  F  D  E  V  L  Y  K  S  S  Q  D  F  Q  P  R  H      p.520

          .         .       | 19 .         .         .         .    g.80031
 ATCGTCAGTTACCTTCTAACTTTAAG | TCATCTTGCAGCTGTGGCACACAAAACACTACAA    c.1620
 I  V  S  Y  L  L  T  L  S  |  H  L  A  A  V  A  H  K  T  L  Q      p.540

          .         .         . | 20       .         .         .    g.80548
 ATAAAAGATAGTCCTCCTGAAGTGGCTGGG | GCCAGACTTCATCTTTTCAAAGCTGTCCGT    c.1680
 I  K  D  S  P  P  E  V  A  G   | A  R  L  H  L  F  K  A  V  R      p.560

          .         .         .         .         .                 g.80605
 TCTGTCCTAGCCAATGGAATGAAACTTCTTGGAATAACACCTGTATGTAGGATGTAA          c.1737
 S  V  L  A  N  G  M  K  L  L  G  I  T  P  V  C  R  M  X            p.578

          .         .         .                                     g.80640
 tttccattaaaatggcttttaaaatgtcaagtgaa                                c.*35

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Arginyl-tRNA synthetase 2, mitochondrial protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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