RAS p21 protein activator (GTPase activating protein) 1 (RASA1) - coding DNA reference sequence

(used for variant description)

(last modified May 11, 2018)


This file was created to facilitate the description of sequence variants on transcript NM_002890.2 in the RASA1 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_011650.1, covering RASA1 transcript NM_002890.2.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                   .                g.4938
                                          cgtaacccaggcagctggg       c.-181

 .         .         .         .         .         .                g.4998
 gagcctgggctgtggccctaggagggggcgcggcggcgggctctctccttttgttgttgt       c.-121

 .         .         .         .         .         .                g.5058
 ttcctcagcctggggagctgaaggggagacgcgtctgggtggggctgctcggagcccggg       c.-61

 .         .         .         .         .         .                g.5118
 cctggtggcccctggggctcccgggcgggcagggtagggcagagtagagcgggcttcaac       c.-1

          .         .         .         .         .         .       g.5178
 ATGATGGCGGCCGAGGCCGGCAGTGAGGAGGGCGGCCCGGTAACAGCCGGAGCTGGAGGA       c.60
 M  M  A  A  E  A  G  S  E  E  G  G  P  V  T  A  G  A  G  G         p.20

          .         .         .         .         .         .       g.5238
 GGCGGCGCGGCAGCGGGCTCCAGTGCCTATCCCGCAGTGTGTCGGGTGAAGATACCCGCG       c.120
 G  G  A  A  A  G  S  S  A  Y  P  A  V  C  R  V  K  I  P  A         p.40

          .         .         .         .         .         .       g.5298
 GCCCTGCCTGTGGCAGCCGCCCCCTATCCTGGGCTGGTGGAGACCGGAGTGGCTGGAACT       c.180
 A  L  P  V  A  A  A  P  Y  P  G  L  V  E  T  G  V  A  G  T         p.60

          .         .         .         .         .         .       g.5358
 CTGGGTGGCGGAGCCGCTTTGGGGTCAGAGTTCCTAGGAGCCGGGTCTGTGGCAGGGGCA       c.240
 L  G  G  G  A  A  L  G  S  E  F  L  G  A  G  S  V  A  G  A         p.80

          .         .         .         .         .         .       g.5418
 CTGGGGGGAGCTGGACTGACAGGGGGAGGTACTGCTGCTGGCGTAGCTGGTGCTGCTGCT       c.300
 L  G  G  A  G  L  T  G  G  G  T  A  A  G  V  A  G  A  A  A         p.100

          .         .         .         .         .         .       g.5478
 GGCGTGGCCGGTGCTGCTGTTGCTGGACCTAGTGGAGACATGGCTCTCACCAAACTGCCC       c.360
 G  V  A  G  A  A  V  A  G  P  S  G  D  M  A  L  T  K  L  P         p.120

          .         .         .         .         .         .       g.5538
 ACTTCGTTGCTTGCTGAGACTCTCGGGCCAGGCGGCGGTTTTCCCCCTCTGCCCCCTCCC       c.420
 T  S  L  L  A  E  T  L  G  P  G  G  G  F  P  P  L  P  P  P         p.140

          .         .         .         .         .         .       g.5598
 CCTTACCTGCCCCCTTTGGGGGCGGGCCTCGGGACAGTGGACGAAGGTGACTCTCTGGAT       c.480
 P  Y  L  P  P  L  G  A  G  L  G  T  V  D  E  G  D  S  L  D         p.160

          .         .         .         .         .          | 02    g.68015
 GGACCAGAATACGAGGAGGAAGAGGTGGCCATACCGTTGACCGCTCCTCCAACTAACCA | G    c.540
 G  P  E  Y  E  E  E  E  V  A  I  P  L  T  A  P  P  T  N  Q  |      p.180

          .         .         .         .         .         .       g.68075
 TGGTATCACGGAAAACTTGACAGAACGATAGCAGAAGAACGCCTCAGGCAGGCAGGGAAG       c.600
 W  Y  H  G  K  L  D  R  T  I  A  E  E  R  L  R  Q  A  G  K         p.200

          .         .         .         .         .         .       g.68135
 TCTGGCAGTTATCTTATAAGAGAGAGTGATCGGAGGCCAGGGTCCTTTGTACTTTCATTT       c.660
 S  G  S  Y  L  I  R  E  S  D  R  R  P  G  S  F  V  L  S  F         p.220

          .         .         .   | 03     .         .         .    g.69201
 CTTAGCCAGATGAATGTTGTCAACCATTTTAG | GATTATTGCTATGTGTGGAGATTACTAC    c.720
 L  S  Q  M  N  V  V  N  H  F  R  |  I  I  A  M  C  G  D  Y  Y      p.240

          .         .         .         .         .         .       g.69261
 ATTGGTGGAAGACGTTTTTCTTCACTGTCAGACCTAATAGGTTATTACAGTCATGTTTCT       c.780
 I  G  G  R  R  F  S  S  L  S  D  L  I  G  Y  Y  S  H  V  S         p.260

          .         .         .         .         | 04         .    g.69945
 TGTTTGCTTAAAGGAGAAAAATTACTTTACCCAGTTGCACCACCAGAG | CCAGTAGAAGAT    c.840
 C  L  L  K  G  E  K  L  L  Y  P  V  A  P  P  E   | P  V  E  D      p.280

          .         .         .         .         .          | 05    g.74641
 AGAAGGCGTGTACGAGCTATTCTACCTTACACAAAAGTACCAGACACTGATGAAATAAG | T    c.900
 R  R  R  V  R  A  I  L  P  Y  T  K  V  P  D  T  D  E  I  S  |      p.300

          .         .         .         .         .         .       g.74701
 TTCTTAAAAGGAGATATGTTCATTGTTCATAATGAATTAGAAGATGGATGGATGTGGGTT       c.960
 F  L  K  G  D  M  F  I  V  H  N  E  L  E  D  G  W  M  W  V         p.320

          .         .         .         .         .        | 06.    g.77959
 ACAAATTTAAGAACAGATGAACAAGGCCTTATTGTTGAAGACCTAGTAGAAGAGGTG | GGC    c.1020
 T  N  L  R  T  D  E  Q  G  L  I  V  E  D  L  V  E  E  V   | G      p.340

          .         .          | 07        .         .         .    g.83369
 CGGGAAGAAGATCCACATGAAGGAAAAAT | ATGGTTCCATGGGAAGATTTCCAAACAGGAA    c.1080
 R  E  E  D  P  H  E  G  K  I  |  W  F  H  G  K  I  S  K  Q  E      p.360

          .         .   | 08     .         .         .         .    g.85918
 GCTTATAATTTACTAATGACAG | TTGGTCAAGTCTGCAGTTTTCTTGTGAGGCCCTCAGAT    c.1140
 A  Y  N  L  L  M  T  V |   G  Q  V  C  S  F  L  V  R  P  S  D      p.380

          .         .         .         .         .         .       g.85978
 AATACTCCTGGCGATTATTCACTTTATTTCCGGACCAATGAAAATATTCAGCGATTTAAA       c.1200
 N  T  P  G  D  Y  S  L  Y  F  R  T  N  E  N  I  Q  R  F  K         p.400

          .         .         .         .         .    | 09    .    g.89830
 ATATGTCCAACGCCAAACAATCAGTTTATGATGGGAGGCCGGTATTATAACAG | CATTGGG    c.1260
 I  C  P  T  P  N  N  Q  F  M  M  G  G  R  Y  Y  N  S  |  I  G      p.420

          .         .         .         .         .         .       g.89890
 GACATCATAGATCACTATCGAAAAGAACAGATTGTTGAAGGATATTATCTTAAGGAACCT       c.1320
 D  I  I  D  H  Y  R  K  E  Q  I  V  E  G  Y  Y  L  K  E  P         p.440

          .   | 10     .         .         .         .         .    g.99265
 GTACCAATGCAG | GATCAAGAACAAGTACTCAATGACACAGTGGATGGCAAGGAAATCTAT    c.1380
 V  P  M  Q   | D  Q  E  Q  V  L  N  D  T  V  D  G  K  E  I  Y      p.460

          .         .         .         .         .         .       g.99325
 AATACCATCCGTCGTAAAACAAAGGATGCCTTTTATAAAAACATTGTTAAGAAAGGTTAT       c.1440
 N  T  I  R  R  K  T  K  D  A  F  Y  K  N  I  V  K  K  G  Y         p.480

          .    | 11    .         .         .         .         .    g.100061
 CTTCTGAAAAAGG | GCAAAGGAAAACGTTGGAAAAATTTATATTTTATCTTAGAGGGTAGT    c.1500
 L  L  K  K  G |   K  G  K  R  W  K  N  L  Y  F  I  L  E  G  S      p.500

          .         .         .         .         .         .       g.100121
 GATGCCCAACTTATTTATTTTGAAAGCGAAAAACGAGCTACCAAACCAAAAGGATTAATA       c.1560
 D  A  Q  L  I  Y  F  E  S  E  K  R  A  T  K  P  K  G  L  I         p.520

          .         .         .         .         . | 12       .    g.106489
 GATCTCAGTGTATGTTCTGTCTATGTCGTTCATGATAGTCTCTTTGGCAG | GCCAAACTGT    c.1620
 D  L  S  V  C  S  V  Y  V  V  H  D  S  L  F  G  R  |  P  N  C      p.540

          .         .         .         .         .         .       g.106549
 TTTCAGATAGTAGTTCAGCACTTTAGTGAAGAACATTACATCTTTTACTTTGCAGGAGAA       c.1680
 F  Q  I  V  V  Q  H  F  S  E  E  H  Y  I  F  Y  F  A  G  E         p.560

          .         | 13         .         .         .         .    g.108826
 ACTCCAGAACAAGCAGAG | GATTGGATGAAAGGTCTGCAGGCATTTTGCAATTTACGGAAA    c.1740
 T  P  E  Q  A  E   | D  W  M  K  G  L  Q  A  F  C  N  L  R  K      p.580

          .         .         .       | 14 .         .         .    g.110853
 AGTAGTCCAGGGACATCCAATAAACGCCTTCGTCAG | GTCAGCAGCCTTGTTTTACATATT    c.1800
 S  S  P  G  T  S  N  K  R  L  R  Q   | V  S  S  L  V  L  H  I      p.600

          .         .         .         .         .         .       g.110913
 GAAGAAGCCCATAAACTCCCAGTAAAACATTTTACTAATCCATATTGTAACATCTACCTG       c.1860
 E  E  A  H  K  L  P  V  K  H  F  T  N  P  Y  C  N  I  Y  L         p.620

          .         .         .         .         .         .       g.110973
 AATAGTGTCCAAGTAGCAAAAACTCATGCAAGGGAAGGGCAAAACCCAGTATGGTCAGAA       c.1920
 N  S  V  Q  V  A  K  T  H  A  R  E  G  Q  N  P  V  W  S  E         p.640

          .     | 15   .         .         .         .         .    g.111552
 GAGTTTGTCTTTGA | TGATCTTCCTCCTGACATCAATAGATTTGAAATAACTCTTAGTAAT    c.1980
 E  F  V  F  D  |  D  L  P  P  D  I  N  R  F  E  I  T  L  S  N      p.660

          .         .         .  | 16      .         .         .    g.113088
 AAAACAAAGAAAAGCAAAGATCCTGATATCT | TATTTATGCGCTGCCAGTTGAGCCGATTA    c.2040
 K  T  K  K  S  K  D  P  D  I  L |   F  M  R  C  Q  L  S  R  L      p.680

          .         .         .         .         .         .       g.113148
 CAGAAAGGGCATGCCACAGATGAATGGTTTCTGCTCAGCTCCCATATACCATTAAAAGGT       c.2100
 Q  K  G  H  A  T  D  E  W  F  L  L  S  S  H  I  P  L  K  G         p.700

          .         .         .         .         .         .       g.113208
 ATTGAACCAGGGTCCCTGCGTGTTCGAGCACGATACTCTATGGAAAAAATCATGCCAGAA       c.2160
 I  E  P  G  S  L  R  V  R  A  R  Y  S  M  E  K  I  M  P  E         p.720

          .         .     | 17   .         .         .         .    g.113583
 GAAGAGTACAGTGAATTTAAAGAG | CTTATACTGCAAAAGGAACTTCATGTAGTCTATGCT    c.2220
 E  E  Y  S  E  F  K  E   | L  I  L  Q  K  E  L  H  V  V  Y  A      p.740

          .         .         .         .         .         .       g.113643
 TTATCACATGTATGTGGACAAGACCGAACACTACTGGCCAGCATCCTACTGAGGATTTTT       c.2280
 L  S  H  V  C  G  Q  D  R  T  L  L  A  S  I  L  L  R  I  F         p.760

          .         .         .         .         .         .       g.113703
 CTTCACGAAAAGCTTGAATCGTTGTTGTTATGCACACTAAATGACAGAGAAATAAGCATG       c.2340
 L  H  E  K  L  E  S  L  L  L  C  T  L  N  D  R  E  I  S  M         p.780

      | 18   .         .         .         .         .         .    g.115118
 GAAG | ATGAAGCCACTACCCTATTTCGAGCCACAACACTTGCAAGCACCTTGATGGAGCAG    c.2400
 E  D |   E  A  T  T  L  F  R  A  T  T  L  A  S  T  L  M  E  Q      p.800

          .         .         .         .         .         .       g.115178
 TATATGAAAGCCACTGCTACACAGTTTGTTCATCATGCTTTGAAAGACTCTATTTTAAAG       c.2460
 Y  M  K  A  T  A  T  Q  F  V  H  H  A  L  K  D  S  I  L  K         p.820

          .         .        | 19.         .         .         .    g.116434
 ATAATGGAAAGCAAGCAGTCTTGTGAG | TTAAGTCCATCAAAGTTAGAAAAAAATGAAGAT    c.2520
 I  M  E  S  K  Q  S  C  E   | L  S  P  S  K  L  E  K  N  E  D      p.840

          .         .         .         .         .         .       g.116494
 GTGAACACTAATTTAACACACCTATTGAACATACTTTCAGAGCTTGTGGAGAAAATATTC       c.2580
 V  N  T  N  L  T  H  L  L  N  I  L  S  E  L  V  E  K  I  F         p.860

          .         .    | 20    .         .         .         .    g.117212
 ATGGCTTCAGAAATACTTCCACC | GACATTGAGATATATTTATGGGTGTTTACAGAAATCT    c.2640
 M  A  S  E  I  L  P  P  |  T  L  R  Y  I  Y  G  C  L  Q  K  S      p.880

          .         .         .         .         . | 21       .    g.120389
 GTTCAGCATAAGTGGCCTACAAATACCACCATGAGAACAAGAGTTGTTAG | TGGTTTTGTT    c.2700
 V  Q  H  K  W  P  T  N  T  T  M  R  T  R  V  V  S  |  G  F  V      p.900

          .         .         .         .         .         | 22    g.121969
 TTTCTTCGACTCATCTGTCCTGCCATCCTGAATCCACGGATGTTCAATATCATCTCAG | AT    c.2760
 F  L  R  L  I  C  P  A  I  L  N  P  R  M  F  N  I  I  S  D |       p.920

          .         .         .         .         .         .       g.122029
 TCTCCATCTCCTATTGCTGCAAGAACACTGATATTAGTGGCTAAATCTGTGCAGAACTTA       c.2820
 S  P  S  P  I  A  A  R  T  L  I  L  V  A  K  S  V  Q  N  L         p.940

          .         .        | 23.         .         .         .    g.123525
 GCAAATCTTGTGGAATTTGGAGCTAAG | GAGCCCTACATGGAAGGTGTCAATCCATTCATC    c.2880
 A  N  L  V  E  F  G  A  K   | E  P  Y  M  E  G  V  N  P  F  I      p.960

          .         .         .         .      | 24  .         .    g.126074
 AAAAGCAACAAACATCGTATGATCATGTTTTTAGATGAACTTGGG | AATGTACCTGAACTT    c.2940
 K  S  N  K  H  R  M  I  M  F  L  D  E  L  G   | N  V  P  E  L      p.980

          .         .         .         .         .         .       g.126134
 CCGGACACTACAGAGCATTCTAGAACGGACCTGTCCCGTGATTTAGCAGCATTGCATGAG       c.3000
 P  D  T  T  E  H  S  R  T  D  L  S  R  D  L  A  A  L  H  E         p.1000

          .         .         .         .         .         .       g.126194
 ATTTGCGTGGCTCATTCAGATGAACTTCGAACGCTCAGTAATGAGCGTGGTGCACAGCAG       c.3060
 I  C  V  A  H  S  D  E  L  R  T  L  S  N  E  R  G  A  Q  Q         p.1020

  | 25       .         .         .         .         .         .    g.127526
  | CACGTATTGAAAAAGCTTCTGGCTATAACAGAACTGCTTCAACAAAAACAAAACCAGTAT    c.3120
  | H  V  L  K  K  L  L  A  I  T  E  L  L  Q  Q  K  Q  N  Q  Y      p.1040

          .         .                                               g.127550
 ACAAAAACCAATGATGTCAGGTAG                                           c.3144
 T  K  T  N  D  V  R  X                                             p.1047

          .         .         .         .         .         .       g.127610
 cagccttcgccccagtgttctgcatggattcagcatgtccaacatggtaattcacttcag       c.*60

          .         .         .         .         .         .       g.127670
 tttaatgtctcctttgctcttgccaaaaaatagcacacttttccacattccagtgatgtg       c.*120

          .         .         .         .         .         .       g.127730
 tgagctatgcaaacaaaatccaagattctgctggtgaataactatgccagcaaccttgta       c.*180

          .         .         .         .         .         .       g.127790
 agctatctgtgcaggatatttgcactatttccacatggaatcaatctttaacaacctctg       c.*240

          .         .         .         .         .         .       g.127850
 agccttggtgtacagaccacctttcacaaaacgaaatgctatgactgtatcttgatatct       c.*300

          .         .         .         .         .         .       g.127910
 cgaactttcaaaatatattttcagtacacccagttgccaaagttttgctgtctcttagag       c.*360

          .         .         .         .         .         .       g.127970
 aaagaactatgaaatcaactgacaagaaacacattcttattgacaattgtgtataactgg       c.*420

          .         .         .         .         .         .       g.128030
 attgcagactgttcttactgtaactacttcctgattaggaatatgaccatttgactgttc       c.*480

          .         .         .         .         .         .       g.128090
 aatgattatttgtatttacagtttccagagtttgtcattataataggaacaatctttgct       c.*540

          .         .         .         .         .         .       g.128150
 gtatacttttaaaaaatactctgctatttctcttgctggaactgttgaaagaaaatatat       c.*600

          .         .         .         .         .         .       g.128210
 agaatgatctattgctcatcagctttattttttaaacatacgacttattttgttgaaatt       c.*660

          .         .         .         .         .         .       g.128270
 gtcaaagactgtatttagatctcataatgctttgttaaatgtttacaagtaaatagtttg       c.*720

          .         .         .         .         .         .       g.128330
 aattcagtaaatattattggttgttgtattgatcaatgcatgttacccattcaaccattt       c.*780

          .         .         .         .         .         .       g.128390
 tatagactaccaatttcttttatgttaactagaatgcttttgttaaaagttatttgttca       c.*840

          .         .         .         .         .         .       g.128450
 ttatttgtgctacccctttgattatgcagacaacctcatcagctgcctaacttatccatc       c.*900

          .         .         .         .         .         .       g.128510
 tttgaacttctgactacttgttgtatctgctggatatttagttcaactgtatagttttat       c.*960

          .         .         .         .         .         .       g.128570
 ttacttctgtatgtgtatttttgtgaagtattcacaaaggttaagttaaaataaaaccaa       c.*1020

          .         .                                               g.128593
 gggatatcttgcataattgatta                                            c.*1043

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The RAS p21 protein activator (GTPase activating protein) 1 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

Powered by LOVD v.3.0 Build 21
©2004-2018 Leiden University Medical Center