retinol binding protein 4, plasma (RBP4) - coding DNA reference sequence

(used for variant description)

(last modified November 26, 2020)

This file was created to facilitate the description of sequence variants on transcript NM_006744.3 in the RBP4 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_009104.1, covering RBP4 transcript NM_006744.3.

Please note that introns are available by clicking on the exon numbers above the sequence.

 (upstream sequence)
                                         .         .                g.5024
                                     cgcctccctcgctccacgcgcgcc       c.-61

 .         .         .         .         .  | 02      .             g.5208
 cggactcggcggccaggcttgcgcgcggttcccctcccggtg | ggcggattcctgggcaag    c.-1

          .         .         .         .         .         .       g.5268
 ATGAAGTGGGTGTGGGCGCTCTTGCTGTTGGCGGCGCTGGGCAGCGGCCGCGCGGAGCGC       c.60
 M  K  W  V  W  A  L  L  L  L  A  A  L  G  S  G  R  A  E  R         p.20

          .         .         .         .         .  | 03      .    g.5442
 GACTGCCGAGTGAGCAGCTTCCGAGTCAAGGAGAACTTCGACAAGGCTCGC | TTCTCTGGG    c.120
 D  C  R  V  S  S  F  R  V  K  E  N  F  D  K  A  R   | F  S  G      p.40

          .         .         .         .         .         .       g.5502
 ACCTGGTACGCCATGGCCAAGAAGGACCCCGAGGGCCTCTTTCTGCAGGACAACATCGTC       c.180
 T  W  Y  A  M  A  K  K  D  P  E  G  L  F  L  Q  D  N  I  V         p.60

          .         .         .         .         .         .       g.5562
 GCGGAGTTCTCCGTGGACGAGACCGGCCAGATGAGCGCCACAGCCAAGGGCCGAGTCCGT       c.240
 A  E  F  S  V  D  E  T  G  Q  M  S  A  T  A  K  G  R  V  R         p.80

          | 04         .         .         .         .         .    g.5789
 CTTTTGAA | TAACTGGGACGTGTGCGCAGACATGGTGGGCACCTTCACAGACACCGAGGAC    c.300
 L  L  N  |  N  W  D  V  C  A  D  M  V  G  T  F  T  D  T  E  D      p.100

          .         .         .         .         .      | 05  .    g.12206
 CCTGCCAAGTTCAAGATGAAGTACTGGGGCGTAGCCTCCTTTCTCCAGAAAGGAA | ATGAT    c.360
 P  A  K  F  K  M  K  Y  W  G  V  A  S  F  L  Q  K  G  N |   D      p.120

          .         .         .         .         .         .       g.12266
 GACCACTGGATCGTCGACACAGACTACGACACGTATGCCGTGCAGTACTCCTGCCGCCTC       c.420
 D  H  W  I  V  D  T  D  Y  D  T  Y  A  V  Q  Y  S  C  R  L         p.140

          .         .         .         .         .         .       g.12326
 CTGAACCTCGATGGCACCTGTGCTGACAGCTACTCCTTCGTGTTTTCCCGGGACCCCAAC       c.480
 L  N  L  D  G  T  C  A  D  S  Y  S  F  V  F  S  R  D  P  N         p.160

          .         .         .         .         .         .       g.12386
 GGCCTGCCCCCAGAAGCGCAGAAGATTGTAAGGCAGCGGCAGGAGGAGCTGTGCCTGGCC       c.540
 G  L  P  P  E  A  Q  K  I  V  R  Q  R  Q  E  E  L  C  L  A         p.180

          .         .         | 06         .         .         .    g.14156
 AGGCAGTACAGGCTGATCGTCCACAACG | GTTACTGCGATGGCAGATCAGAAAGAAACCTT    c.600
 R  Q  Y  R  L  I  V  H  N  G |   Y  C  D  G  R  S  E  R  N  L      p.200

                                                                    g.14162
 TTGTAG                                                             c.606
 L  X                                                               p.201

          .         .         .         .         .         .       g.14222
 caatatcaagaatctagtttcatctgagaacttctgattagctctcagtcttcagctcta       c.*60

          .         .         .         .         .         .       g.14282
 tttatcttaggagtttaatttgcccttctctccccatcttccctcagttcccataaaacc       c.*120

          .         .         .         .         .         .       g.14342
 ttcattacacataaagatacacgtgggggtcagtgaatctgcttgcctttcctgaaagtt       c.*180

          .         .         .         .         .                 g.14401
 tctggggcttaagattccagactctgattcattaaactatagtcacccgtgtcctgtga        c.*239

 (downstream sequence)

Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10^th nucleotide is indicated by a "." above the sequence. The Retinol binding protein 4, plasma protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10^th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.