regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1 (RCBTB1) - coding DNA reference sequence

(used for variant description)

(last modified July 14, 2017)


This file was created to facilitate the description of sequence variants on transcript NM_018191.3 in the RCBTB1 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_046892.1, covering RCBTB1 transcript NM_018191.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                         .         .                g.5044
                                        gacccggcgggcccggcgccc       c.-241

 .         .         .         .         .         .                g.5104
 tggcgctcctcctcttcgctgccggtgggcaccgccgctcgctcgcacttctgcgcccat       c.-181

 .         .         .         .         .         .         | 02    g.10023
 tggagcttcggagatccctgcggtcccgcgggacggcgcggcagcagctgacctcgcag | a    c.-121

 .         .         .         .         .         .                g.10083
 caggatcttgctctcttgcccagactggaatacagtggtgtgaacacggctcactgcagc       c.-61

 .         .         | 03         .         .         .             g.23327
 ctcaacctcctggactcag | agatgtcggcttatttataggaattgcttgaagccagagtc    c.-1

          .         .         .         .         .         .       g.23387
 ATGGTGGATGTCGGAAAGTGGCCCATCTTCACTCTACTCTCCCCTCAAGAGATCGCGTCT       c.60
 M  V  D  V  G  K  W  P  I  F  T  L  L  S  P  Q  E  I  A  S         p.20

          .         .         .         .         .         .       g.23447
 ATTCGGAAGGCGTGTGTCTTCGGCACCTCAGCCAGTGAAGCACTGTACGTTACTGACAAT       c.120
 I  R  K  A  C  V  F  G  T  S  A  S  E  A  L  Y  V  T  D  N         p.40

        | 04 .         .         .         .         .         .    g.23892
 GATGAG | GTCTTTGTATTTGGACTGAACTATAGTAACTGTCTAGGAACTGGAGATAACCAG    c.180
 D  E   | V  F  V  F  G  L  N  Y  S  N  C  L  G  T  G  D  N  Q      p.60

          .         .         .         .         .         .       g.23952
 AGTACACTTGTACCCAAAAAGCTAGAAGGCTTATGTGGAAAGAAGATTAAAAGCCTCAGT       c.240
 S  T  L  V  P  K  K  L  E  G  L  C  G  K  K  I  K  S  L  S         p.80

          .         .         .        | 05.         .         .    g.30545
 TACGGGAGTGGACCACATGTTCTTCTCAGCACCGAAG | ATGGAGTGGTTTATGCCTGGGGC    c.300
 Y  G  S  G  P  H  V  L  L  S  T  E  D |   G  V  V  Y  A  W  G      p.100

          .         .         .         .         .         .       g.30605
 CACAATGGATATAGCCAGCTTGGGAATGGGACGACCAACCAAGGCATTGCTCCCGTCCAG       c.360
 H  N  G  Y  S  Q  L  G  N  G  T  T  N  Q  G  I  A  P  V  Q         p.120

          .         .         .         .         .         .       g.30665
 GTCTGTACCAATCTCTTGATCAAGCAAGTGGTGGAAGTAGCTTGTGGCTCACATCATTCA       c.420
 V  C  T  N  L  L  I  K  Q  V  V  E  V  A  C  G  S  H  H  S         p.140

          .         .     | 06   .         .         .         .    g.34969
 ATGGCTCTGGCAGCTGATGGAGAG | GTGTTTGCTTGGGGTTATAACAACTGTGGCCAAGTG    c.480
 M  A  L  A  A  D  G  E   | V  F  A  W  G  Y  N  N  C  G  Q  V      p.160

          .         .         .         .         .         .       g.35029
 GGATCAGGTTCTACAGCAAATCAACCAACTCCTCGAAAAGTTACAAACTGTTTACATATT       c.540
 G  S  G  S  T  A  N  Q  P  T  P  R  K  V  T  N  C  L  H  I         p.180

          .         .         .         .         .         .       g.35089
 AAGAGGGTAGTTGGCATTGCCTGTGGTCAGACTTCATCCATGGCTGTTCTGGACAATGGC       c.600
 K  R  V  V  G  I  A  C  G  Q  T  S  S  M  A  V  L  D  N  G         p.200

     | 07    .         .         .         .         .         .    g.38378
 GAG | GTATATGGCTGGGGTTACAATGGCAACGGTCAGCTGGGCCTGGGAAACAATGGCAAC    c.660
 E   | V  Y  G  W  G  Y  N  G  N  G  Q  L  G  L  G  N  N  G  N      p.220

          .         .         .         .         .  | 08      .    g.39147
 CAGCTGACCCCTGTGAGAGTGGCAGCTTTGCACAGCGTGTGTGTGAACCAG | ATTGTCTGC    c.720
 Q  L  T  P  V  R  V  A  A  L  H  S  V  C  V  N  Q   | I  V  C      p.240

          .         .         .         .         .         .       g.39207
 GGTTACGCACATACTCTAGCACTAACAGATGAGGGCTTGCTGTATGCCTGGGGAGCTAAC       c.780
 G  Y  A  H  T  L  A  L  T  D  E  G  L  L  Y  A  W  G  A  N         p.260

          .         .         .         .         .         .       g.39267
 ACATATGGGCAGCTGGGAACTGGCAATAAAAATAACCTGCTAAGCCCAGCACACATCATG       c.840
 T  Y  G  Q  L  G  T  G  N  K  N  N  L  L  S  P  A  H  I  M         p.280

          .     | 09   .         .         .         .         .    g.41004
 GTGGAGAAAGAAAG | GGTGGTAGAGATTGCAGCCTGTCACTCTGCCCACACGTCTGCAGCC    c.900
 V  E  K  E  R  |  V  V  E  I  A  A  C  H  S  A  H  T  S  A  A      p.300

          .         .         .         .         .         .       g.41064
 AAGACGCAGGGTGGGCACGTGTACATGTGGGGCCAGTGCCGGGGTCAGTCCGTGATCCTC       c.960
 K  T  Q  G  G  H  V  Y  M  W  G  Q  C  R  G  Q  S  V  I  L         p.320

          .         .         .         .         .         .       g.41124
 CCGCACCTCACCCACTTCTCCTGCACCGACGACGTGTTTGCCTGCTTTGCCACTCCCGCC       c.1020
 P  H  L  T  H  F  S  C  T  D  D  V  F  A  C  F  A  T  P  A         p.340

          .         .      | 10  .         .         .         .    g.45778
 GTCTCGTGGCGCCTCCTGTCTGTGG | AGCATGAAGACTTTTTAACAGTTGCAGAGTCACTG    c.1080
 V  S  W  R  L  L  S  V  E |   H  E  D  F  L  T  V  A  E  S  L      p.360

          .         .         .         .         .         .       g.45838
 AAGAAAGAATTTGATAGTCCAGAAACTGCTGATCTGAAGTTTCGAATTGATGGAAAATAT       c.1140
 K  K  E  F  D  S  P  E  T  A  D  L  K  F  R  I  D  G  K  Y         p.380

          .         .         .   | 11     .         .         .    g.48807
 ATTCATGTCCATAAAGCTGTTTTGAAAATCAG | GTGTGAGCATTTTCGATCCATGTTCCAG    c.1200
 I  H  V  H  K  A  V  L  K  I  R  |  C  E  H  F  R  S  M  F  Q      p.400

          .         .         .         .         .         .       g.48867
 TCGTATTGGAATGAAGACATGAAGGAAGTGATAGAAATCGATCAGTTTTCTTACCCAGTG       c.1260
 S  Y  W  N  E  D  M  K  E  V  I  E  I  D  Q  F  S  Y  P  V         p.420

          .         .         .         .         .         .       g.48927
 TATCGTGCCTTTCTCCAGTACCTCTACACAGACACAGTCGACCTGCCGCCAGAAGATGCT       c.1320
 Y  R  A  F  L  Q  Y  L  Y  T  D  T  V  D  L  P  P  E  D  A         p.440

      | 12   .         .         .         .         .         .    g.49656
 ATAG | GTCTTCTGGATTTGGCGACATCTTACTGTGAAAACAGACTGAAAAAACTTTGTCAG    c.1380
 I  G |   L  L  D  L  A  T  S  Y  C  E  N  R  L  K  K  L  C  Q      p.460

          .         .         .         .         .         .       g.49716
 CACATTATCAAGAGAGGAATTACTGTGGAGAATGCCTTTTCGCTATTCTCTGCTGCAGTC       c.1440
 H  I  I  K  R  G  I  T  V  E  N  A  F  S  L  F  S  A  A  V         p.480

          .      | 13  .         .         .         .         .    g.56389
 AGATATGATGCAGAG | GATTTAGAAGAATTCTGCTTTAAGTTTTGCATCAATCATTTGACA    c.1500
 R  Y  D  A  E   | D  L  E  E  F  C  F  K  F  C  I  N  H  L  T      p.500

          .         .         .         .         .         .       g.56449
 GAAGTTACACAGACTGCAGCATTTTGGCAAATGGATGGCCCTCTGCTAAAGGAATTCATT       c.1560
 E  V  T  Q  T  A  A  F  W  Q  M  D  G  P  L  L  K  E  F  I         p.520

          .         .         .                                     g.56485
 GCTAAAGCCAGTAAATGTGGAGCCTTTAAGAACTGA                               c.1596
 A  K  A  S  K  C  G  A  F  K  N  X                                 p.531

          .         .         .         .         .         .       g.56545
 agcgcaaggctgctgggttctgtgtgagtgctctggggcactgttgaggatgtgtccagt       c.*60

          .         .         .         .         .         .       g.56605
 ttgtgctctacgggtgatgtgattctgcaggtaaaagaccatcaggttgtttttttccac       c.*120

          .         .         .         .         .         .       g.56665
 atctgggacacagttgtttgtgtaggaacataacaagggtgtacggcttttcttgagccc       c.*180

          .         .         .         .         .         .       g.56725
 attttaaacaacccttgtttccagataagtgtattttaaatgtgacctttcgtaaatttg       c.*240

          .         .         .         .         .         .       g.56785
 ggctggaacatgtaaaagggtgaaagttagtcgtttttggtcttcttttcatttttgatt       c.*300

          .         .         .         .         .         .       g.56845
 agaggaacttctgaacttggaaaggggaagttggcagcaactctcctgggccacgtatca       c.*360

          .         .         .         .         .         .       g.56905
 acaatcttctgacagcaggagcagtgatagttggggaattgtgagatgaatggagaggcc       c.*420

          .         .         .         .         .         .       g.56965
 ccatcgtgaattaaagatgctgacctggggattgttaagtgctgccttagttgctagttt       c.*480

          .         .         .         .         .         .       g.57025
 agtagccttactgtgaaggaataattaagattgtttcagacttttgtttgtgtgcttgcg       c.*540

          .         .         .         .         .         .       g.57085
 ttgatgacttttttaacttcaagataaatcaaagtaataagtttaacgtatattaaacct       c.*600

          .         .         .         .         .         .       g.57145
 gttgaaatgataattatgtaaagataaatattctaggttagtcaagatttctcttaagat       c.*660

          .         .         .         .         .         .       g.57205
 ttaagtgcataaagaatagtaatttagaagtatccgtgaaaagttgataatgaaagaaat       c.*720

          .         .         .         .         .         .       g.57265
 ttgatgaaggtgaatattttataaattagaatctccactacttatccaatggtgttttat       c.*780

          .         .         .         .         .         .       g.57325
 ttcattaaggtagaacttgagaactcaagtttaaattgtcccccaccaccttcttctata       c.*840

          .         .         .         .         .         .       g.57385
 aatgcaaacttaagaggaaaataatgacatgtatagtatactcttgccttcctaaattat       c.*900

          .         .         .         .         .         .       g.57445
 gactgctgaatcatcatatctactatatatgactggaagaagtggttcttcaagtcaacc       c.*960

          .         .         .         .         .         .       g.57505
 ctcttacaagacttagtggaatttgctttatctactttaggccaaatccatcacacattg       c.*1020

          .         .         .         .         .         .       g.57565
 gcttatgtgaaactttatcatctttcacttttggttttcctctgtttttaaacatcttag       c.*1080

          .         .         .         .         .         .       g.57625
 gtataacagcacaatttcaccttgaaaaagcaccaaaattatggtgttcctgaaaagatc       c.*1140

          .         .         .         .         .         .       g.57685
 ctattaaaagacagtagtttatttgaactggttatggaaggtgactttgggatgtaagag       c.*1200

          .         .         .         .         .         .       g.57745
 tgttcaactgtgagtttcatcatgtgtgtccgttgagcttgcttttaagagcaatgtttt       c.*1260

          .         .         .         .         .         .       g.57805
 gctttgctctctggtccatgaactcatttccatttgagtgagttcccttagtgaattttg       c.*1320

          .         .         .         .         .         .       g.57865
 tctcctgcttggaaagtctctcttctgaacctggagcctgaatacattttcagagccaaa       c.*1380

          .         .         .         .         .         .       g.57925
 ttacaagtgggtgaagacatgctacaactactatttttagcaatgtttttaaatttgtgt       c.*1440

          .         .         .         .         .         .       g.57985
 ctattggggtgggaaggggagtgaggccctaaagataggaattcactgatagctgaaata       c.*1500

          .         .         .         .         .         .       g.58045
 gatacaagcctaggagccccagcccccttttcttgaccatatcacaagtgattgaagccc       c.*1560

          .         .         .         .         .         .       g.58105
 agtgaattagtcggttagaattcgttctacaacatgatagaacttttcttactagcttca       c.*1620

          .         .         .         .         .         .       g.58165
 gaaatgcacattgatttgtgctatgatgggtggtgtttgtaacaatcactgttctatagg       c.*1680

          .         .         .         .         .         .       g.58225
 cttatgatctgagcaaaatgtgaacttcagtatgtttactattgctcttacttgaaaact       c.*1740

          .         .         .         .         .         .       g.58285
 ttttttcaaaaaaagcacaaattaaagtagtaaattcatatccatagatagttcattcat       c.*1800

          .         .         .         .         .         .       g.58345
 tcaacaaatatttaccaagttcctaatataagtgaaggaccacttctcatattagattac       c.*1860

          .         .         .         .         .         .       g.58405
 taagtcatttgtatgaatatgtgtggcagtgaagagaacaggtctttcaaaaagcatttg       c.*1920

          .         .         .         .         .         .       g.58465
 attattttttttaaatacactctcttatttttctacttgtttttttgttaatcatagcag       c.*1980

          .         .         .         .         .         .       g.58525
 gatatgacaactcttatttgaattgattttttcatctaatgtaataatggaagccaaagt       c.*2040

          .         .         .         .         .         .       g.58585
 attcatatttcttaagatagccctaaatgtactcttgaacttcttactggaacaatgttt       c.*2100

          .         .         .         .         .         .       g.58645
 gatactctagtatgtaagctgtatttatgtaatatttagaacgacatgttaataaacaaa       c.*2160

          .                                                         g.58661
 gtaacattaaaacagg                                                   c.*2176

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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