retinol dehydrogenase 5 (11-cis/9-cis) (RDH5) - coding DNA reference sequence

(used for variant description)

(last modified August 20, 2018)


This file was created to facilitate the description of sequence variants on transcript NM_002905.3 in the RDH5 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_008606.1, covering RDH5 transcript NM_002905.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                                    g.5003
                                                          aat       c.-181

 .         .         .         .         .         .                g.5063
 acgcctggcatccaagtccacccactccggactttggccttagcagtagttagtgtggga       c.-121

 .         .         .         .         .         .                g.5123
 ggctgggaagactgggagcagtctcttaaacaaaagcaaaagaataagcttcgggcgctg       c.-61

 .         .         .        | 02.         .         .             g.5818
 tagtacctgccagctttcgccacaggag | gctgccacctgtaggtcacttgggctccagct    c.-1

          .         .         .         .         .         .       g.5878
 ATGTGGCTGCCTCTTCTGCTGGGTGCCTTACTCTGGGCAGTGCTGTGGTTGCTCAGGGAC       c.60
 M  W  L  P  L  L  L  G  A  L  L  W  A  V  L  W  L  L  R  D         p.20

          .         .         .         .         .         .       g.5938
 CGGCAGAGCCTGCCCGCCAGCAATGCCTTTGTCTTCATCACCGGCTGTGACTCAGGCTTT       c.120
 R  Q  S  L  P  A  S  N  A  F  V  F  I  T  G  C  D  S  G  F         p.40

          .         .         .         .         .         .       g.5998
 GGGCGCCTTCTGGCACTGCAGCTGGACCAGAGAGGCTTCCGAGTCCTGGCCAGCTGCCTG       c.180
 G  R  L  L  A  L  Q  L  D  Q  R  G  F  R  V  L  A  S  C  L         p.60

          .         .         .         .         .         .       g.6058
 ACCCCCTCCGGGGCCGAGGACCTGCAGCGGGTGGCCTCCTCCCGCCTCCACACCACCCTG       c.240
 T  P  S  G  A  E  D  L  Q  R  V  A  S  S  R  L  H  T  T  L         p.80

          .         .         .         .         .         .       g.6118
 TTGGATATCACTGATCCCCAGAGCGTCCAGCAGGCAGCCAAGTGGGTGGAGATGCACGTT       c.300
 L  D  I  T  D  P  Q  S  V  Q  Q  A  A  K  W  V  E  M  H  V         p.100

          . | 03       .         .         .         .         .    g.6372
 AAGGAAGCAG | GGCTTTTTGGTCTGGTGAATAATGCTGGTGTGGCTGGTATCATCGGACCC    c.360
 K  E  A  G |   L  F  G  L  V  N  N  A  G  V  A  G  I  I  G  P      p.120

          .         .         .         .         .         .       g.6432
 ACACCATGGCTGACCCGGGACGATTTCCAGCGGGTGCTGAATGTGAACACAATGGGTCCC       c.420
 T  P  W  L  T  R  D  D  F  Q  R  V  L  N  V  N  T  M  G  P         p.140

          .         .         .         .         .         .       g.6492
 ATCGGGGTCACCCTTGCCCTGCTGCCTCTGCTGCAGCAAGCCCGGGGCCGGGTGATCAAC       c.480
 I  G  V  T  L  A  L  L  P  L  L  Q  Q  A  R  G  R  V  I  N         p.160

          .         .         .         .         .         .       g.6552
 ATCACCAGCGTCCTGGGTCGCCTGGCAGCCAATGGTGGGGGCTACTGTGTCTCCAAATTT       c.540
 I  T  S  V  L  G  R  L  A  A  N  G  G  G  Y  C  V  S  K  F         p.180

          .         .          | 04        .         .         .    g.8550
 GGCCTGGAGGCCTTCTCTGACAGCCTGAG | GCGGGATGTAGCTCATTTTGGGATACGAGTC    c.600
 G  L  E  A  F  S  D  S  L  R  |  R  D  V  A  H  F  G  I  R  V      p.200

          .         .         .         .         .         .       g.8610
 TCCATCGTGGAGCCTGGCTTCTTCCGAACCCCTGTGACCAACCTGGAGAGTCTGGAGAAA       c.660
 S  I  V  E  P  G  F  F  R  T  P  V  T  N  L  E  S  L  E  K         p.220

          .         .         .         .         .         .       g.8670
 ACCCTGCAGGCCTGCTGGGCACGGCTGCCTCCTGCCACACAGGCCCACTATGGGGGGGCC       c.720
 T  L  Q  A  C  W  A  R  L  P  P  A  T  Q  A  H  Y  G  G  A         p.240

          .    | 05    .         .         .         .         .    g.9002
 TTCCTCACCAAGT | ACCTGAAAATGCAACAGCGCATCATGAACCTGATCTGTGACCCGGAC    c.780
 F  L  T  K  Y |   L  K  M  Q  Q  R  I  M  N  L  I  C  D  P  D      p.260

          .         .         .         .         .         .       g.9062
 CTAACCAAGGTGAGCCGATGCCTGGAGCATGCCCTGACTGCTCGACACCCCCGAACCCGC       c.840
 L  T  K  V  S  R  C  L  E  H  A  L  T  A  R  H  P  R  T  R         p.280

          .         .         .         .         .         .       g.9122
 TACAGCCCAGGTTGGGATGCCAAGCTGCTCTGGCTGCCTGCCTCCTACCTGCCAGCCAGC       c.900
 Y  S  P  G  W  D  A  K  L  L  W  L  P  A  S  Y  L  P  A  S         p.300

          .         .         .         .         .                 g.9179
 CTGGTGGATGCTGTGCTCACCTGGGTCCTTCCCAAGCCTGCCCAAGCAGTCTACTGA          c.957
 L  V  D  A  V  L  T  W  V  L  P  K  P  A  Q  A  V  Y  X            p.318

          .         .         .         .         .         .       g.9239
 atccagccttccagcaagagattgtttttcaaggacaaggactttgatttatttctgccc       c.*60

          .         .         .         .         .         .       g.9299
 ccaccctggtactgcctggtgcctgccacaaaataagcactaacaaaagtgtattgttta       c.*120

          .         .         .         .         .         .       g.9359
 aaaaataaaaagaaggtgggcagaaatgtgcccagtggaaggctgaccccatttaagtgc       c.*180

          .                                                         g.9376
 caactactccaaaccga                                                  c.*197

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Retinol dehydrogenase 5 (11-cis/9-cis) protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

Powered by LOVD v.3.0 Build 21
©2004-2018 Leiden University Medical Center