RecQ protein-like 4 (RECQL4) - coding DNA reference sequence

(used for variant description)

(last modified October 25, 2017)


This file was created to facilitate the description of sequence variants on transcript NM_004260.3 in the RECQL4 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_016430.1, covering RECQL4 transcript NM_004260.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                     .         .         .         .                g.5042
                   ctggacgatcgcaagcgcggaggccgggcgggcgcgcgcgcc       c.-1

          .         .         .         .         .         .       g.5102
 ATGGAGCGGCTGCGGGACGTGCGGGAGCGGCTGCAGGCGTGGGAGCGCGCGTTCCGACGG       c.60
 M  E  R  L  R  D  V  R  E  R  L  Q  A  W  E  R  A  F  R  R         p.20

          .         .     | 02   .         .         .         | 03 g.5320
 CAGCGCGGGCGGCGACCGAGCCAG | GACGACGTGGAGGCGGCGCCGGAGGAGACCCGCG | CG c.120
 Q  R  G  R  R  P  S  Q   | D  D  V  E  A  A  P  E  E  T  R  A |    p.40

          .         .         .         .         .         .       g.5380
 CTCTACCGGGAATACCGCACTCTGAAGCGTACCACGGGCCAGGCCGGCGGCGGGCTCCGC       c.180
 L  Y  R  E  Y  R  T  L  K  R  T  T  G  Q  A  G  G  G  L  R         p.60

          .         .         .    | 04    .         .         .    g.5663
 AGCTCCGAGTCGCTCCCCGCGGCGGCCGAAGAG | GCGCCAGAGCCCCGCTGCTGGGGGCCC    c.240
 S  S  E  S  L  P  A  A  A  E  E   | A  P  E  P  R  C  W  G  P      p.80

          .         .         .         .         .         .       g.5723
 CATCTGAATCGGGCTGCGACCAAGAGTCCACAGCCTACGCCAGGGCGGAGCCGCCAGGGC       c.300
 H  L  N  R  A  A  T  K  S  P  Q  P  T  P  G  R  S  R  Q  G         p.100

          .         .         .         .         .     | 05   .    g.6068
 TCGGTGCCGGACTACGGGCAGCGGCTCAAGGCCAATCTGAAAGGCACCCTGCAG | GCCGGA    c.360
 S  V  P  D  Y  G  Q  R  L  K  A  N  L  K  G  T  L  Q   | A  G      p.120

          .         .         .         .         .         .       g.6128
 CCAGCCCTGGGCCGCAGACCGTGGCCTCTAGGAAGAGCCTCATCTAAGGCATCCACCCCA       c.420
 P  A  L  G  R  R  P  W  P  L  G  R  A  S  S  K  A  S  T  P         p.140

          .         .         .         .         .         .       g.6188
 AAGCCCCCAGGTACAGGGCCTGTCCCCTCCTTTGCAGAAAAAGTCAGTGATGAGCCTCCA       c.480
 K  P  P  G  T  G  P  V  P  S  F  A  E  K  V  S  D  E  P  P         p.160

          .         .         .         .         .         .       g.6248
 CAGCTCCCTGAGCCCCAGCCAAGGCCAGGCCGGCTCCAGCATCTGCAGGCATCCCTGAGC       c.540
 Q  L  P  E  P  Q  P  R  P  G  R  L  Q  H  L  Q  A  S  L  S         p.180

          .         .         .         .         .         .       g.6308
 CAGCGGCTGGGCTCCCTAGATCCTGGCTGGTTACAGCGATGTCACAGTGAGGTCCCAGAT       c.600
 Q  R  L  G  S  L  D  P  G  W  L  Q  R  C  H  S  E  V  P  D         p.200

          .         .         .         .         .         .       g.6368
 TTTCTGGGGGCCCCCAAAGCCTGCAGGCCTGATCTAGGCTCAGAGGAATCACAACTTCTG       c.660
 F  L  G  A  P  K  A  C  R  P  D  L  G  S  E  E  S  Q  L  L         p.220

          .         .         .         .         .         .       g.6428
 ATCCCTGGTGAGTCGGCTGTCCTTGGTCCTGGTGCTGGCTCCCAGGGCCCAGAGGCTTCA       c.720
 I  P  G  E  S  A  V  L  G  P  G  A  G  S  Q  G  P  E  A  S         p.240

          .         .         .         .         .         .       g.6488
 GCCTTCCAAGAAGTCAGCATCCGTGTGGGGAGCCCCCAGCCCAGCAGCAGTGGAGGCGAG       c.780
 A  F  Q  E  V  S  I  R  V  G  S  P  Q  P  S  S  S  G  G  E         p.260

          .         .         .         .         .         .       g.6548
 AAGCGGAGATGGAACGAGGAGCCCTGGGAGAGCCCCGCACAGGTCCAGCAGGAGAGCAGC       c.840
 K  R  R  W  N  E  E  P  W  E  S  P  A  Q  V  Q  Q  E  S  S         p.280

          .         .         .         .         .         .       g.6608
 CAAGCTGGACCCCCATCGGAGGGGGCTGGGGCTGTAGCAGTTGAGGAAGACCCTCCAGGG       c.900
 Q  A  G  P  P  S  E  G  A  G  A  V  A  V  E  E  D  P  P  G         p.300

          .         .         .         .         .         .       g.6668
 GAACCTGTACAGGCACAGCCACCTCAGCCCTGCAGCAGCCCATCGAACCCCAGGTACCAC       c.960
 E  P  V  Q  A  Q  P  P  Q  P  C  S  S  P  S  N  P  R  Y  H         p.320

          .         .         .         .         .         .       g.6728
 GGACTCAGCCCCTCCAGTCAAGCTAGGGCTGGGAAGGCTGAGGGCACAGCCCCCCTGCAC       c.1020
 G  L  S  P  S  S  Q  A  R  A  G  K  A  E  G  T  A  P  L  H         p.340

          .         .         .         .         .         .       g.6788
 ATCTTCCCTCGGCTGGCCCGCCATGACAGGGGCAATTACGTACGGCTCAACATGAAGCAG       c.1080
 I  F  P  R  L  A  R  H  D  R  G  N  Y  V  R  L  N  M  K  Q         p.360

          .         .         .         .         .  | 06      .    g.6945
 AAACACTACGTGCGGGGCCGGGCACTCCGTAGCAGGCTCCTCCGCAAGCAG | GCATGGAAG    c.1140
 K  H  Y  V  R  G  R  A  L  R  S  R  L  L  R  K  Q   | A  W  K      p.380

          .         .         .         .         .         .       g.7005
 CAGAAGTGGCGGAAGAAAGGGGAGTGTTTTGGGGGTGGTGGTGCCACAGTCACAACCAAG       c.1200
 Q  K  W  R  K  K  G  E  C  F  G  G  G  G  A  T  V  T  T  K         p.400

          .         .         .         .         .         | 07    g.7371
 GAGTCTTGTTTCCTGAACGAGCAGTTCGATCACTGGGCAGCCCAGTGTCCCCGGCCAG | CA    c.1260
 E  S  C  F  L  N  E  Q  F  D  H  W  A  A  Q  C  P  R  P  A |       p.420

          .         .         .         .         .         .       g.7431
 AGTGAGGAAGACACAGATGCTGTTGGGCCTGAGCCACTGGTTCCTTCACCACAACCTGTA       c.1320
 S  E  E  D  T  D  A  V  G  P  E  P  L  V  P  S  P  Q  P  V         p.440

          .         .         .         .         .         .       g.7491
 CCTGAGGTGCCCAGCCTGGACCCCACCGTGCTGCCACTCTACTCCCTGGGGCCCTCAGGG       c.1380
 P  E  V  P  S  L  D  P  T  V  L  P  L  Y  S  L  G  P  S  G         p.460

          . | 08       .         .         .         .         .    g.7634
 CAGTTGGCAG | AGACGCCGGCTGAGGTGTTCCAGGCCCTGGAGCAGCTGGGGCACCAAGCC    c.1440
 Q  L  A  E |   T  P  A  E  V  F  Q  A  L  E  Q  L  G  H  Q  A      p.480

          .         .         .         .    | 09    .         .    g.7771
 TTTCGCCCTGGGCAGGAGCGTGCAGTCATGCGGATCCTGTCTG | GCATCTCCACGCTGCTG    c.1500
 F  R  P  G  Q  E  R  A  V  M  R  I  L  S  G |   I  S  T  L  L      p.500

          .         .         .         .         .         .       g.7831
 GTGCTGCCTACAGGTGCCGGCAAGTCCCTGTGCTACCAGCTCCCAGCGCTGCTCTACAGC       c.1560
 V  L  P  T  G  A  G  K  S  L  C  Y  Q  L  P  A  L  L  Y  S         p.520

          .         .         .         .         .         .       g.7891
 CGGCGCAGCCCCTGCCTCACGTTGGTCGTCTCTCCCCTGCTGTCACTCATGGATGACCAG       c.1620
 R  R  S  P  C  L  T  L  V  V  S  P  L  L  S  L  M  D  D  Q         p.540

  | 10       .         .         .         .         .         .    g.8361
  | GTGTCTGGCCTGCCACCGTGTCTCAAGGCGGCCTGCATACACTCGGGCATGACCAGGAAG    c.1680
  | V  S  G  L  P  P  C  L  K  A  A  C  I  H  S  G  M  T  R  K      p.560

          .         .     | 11   .         .         .         .    g.8500
 CAACGGGAATCTGTCCTGCAGAAG | ATTCGGGCAGCCCAGGTACACGTGCTGATGCTGACA    c.1740
 Q  R  E  S  V  L  Q  K   | I  R  A  A  Q  V  H  V  L  M  L  T      p.580

          .         .         .         .         .         .       g.8560
 CCTGAGGCACTGGTGGGGGCGGGAGGCCTCCCTCCAGCCGCACAGCTGCCTCCAGTTGCT       c.1800
 P  E  A  L  V  G  A  G  G  L  P  P  A  A  Q  L  P  P  V  A         p.600

          .         .         .         .         .         .       g.8620
 TTTGCCTGCATTGATGAGGCCCACTGCCTCTCCCAGTGGTCCCACAACTTCCGGCCCTGC       c.1860
 F  A  C  I  D  E  A  H  C  L  S  Q  W  S  H  N  F  R  P  C         p.620

          .         | 12         .         .         .         .    g.8761
 TACCTGCGCGTCTGCAAG | GTGCTTCGGGAGCGCATGGGCGTGCACTGCTTCCTGGGCCTC    c.1920
 Y  L  R  V  C  K   | V  L  R  E  R  M  G  V  H  C  F  L  G  L      p.640

          .         .         .         .         .         .       g.8821
 ACAGCCACAGCCACACGCCGCACTGCCAGTGACGTGGCACAGCACCTGGCTGTGGCTGAA       c.1980
 T  A  T  A  T  R  R  T  A  S  D  V  A  Q  H  L  A  V  A  E         p.660

          .         .         .         .         .         .       g.8881
 GAGCCTGACCTCCACGGGCCAGCCCCAGTTCCCACCAACCTGCACCTTTCCGTGTCCATG       c.2040
 E  P  D  L  H  G  P  A  P  V  P  T  N  L  H  L  S  V  S  M         p.680

          .         | 13         .         .         .         .    g.9156
 GACAGGGACACAGACCAG | GCACTGTTGACGCTGCTGCAAGGCAAACGTTTTCAAAACCTC    c.2100
 D  R  D  T  D  Q   | A  L  L  T  L  L  Q  G  K  R  F  Q  N  L      p.700

          .         .         .         .         .         .       g.9216
 GATTCCATTATCATTTACTGCAACCGGCGCGAGGACACAGAGCGGATCGCTGCGCTCCTC       c.2160
 D  S  I  I  I  Y  C  N  R  R  E  D  T  E  R  I  A  A  L  L         p.720

          .         .         .         . | 14       .         .    g.9366
 CGAACCTGCCTGCACGCAGCCTGGGTCCCAGGGTCTGGAG | GTCGTGCCCCCAAAACCACA    c.2220
 R  T  C  L  H  A  A  W  V  P  G  S  G  G |   R  A  P  K  T  T      p.740

          .         .         .         .         .         .       g.9426
 GCCGAGGCCTACCACGCGGGCATGTGCAGCCGGGAACGGCGGCGGGTACAGCGAGCCTTC       c.2280
 A  E  A  Y  H  A  G  M  C  S  R  E  R  R  R  V  Q  R  A  F         p.760

          .         .         .         .         .         .       g.9486
 ATGCAGGGCCAGTTGCGGGTGGTGGTGGCCACGGTGGCCTTTGGGATGGGGCTGGACCGG       c.2340
 M  Q  G  Q  L  R  V  V  V  A  T  V  A  F  G  M  G  L  D  R         p.780

          .         .         .         .         .         .       g.9546
 CCAGATGTGCGGGCTGTGCTGCATCTGGGGCTGCCCCCAAGCTTCGAGAGCTACGTGCAG       c.2400
 P  D  V  R  A  V  L  H  L  G  L  P  P  S  F  E  S  Y  V  Q         p.800

          .         .         .         .         .         .       g.9606
 GCCGTGGGCCGGGCCGGGCGTGACGGGCAGCCTGCCCACTGCCACCTCTTCCTGCAGCCC       c.2460
 A  V  G  R  A  G  R  D  G  Q  P  A  H  C  H  L  F  L  Q  P         p.820

     | 15    .         .         .         .         .         .    g.9745
 CAG | GGCGAAGACCTGCGAGAGCTGCGCAGACATGTGCACGCCGACAGCACGGACTTCCTG    c.2520
 Q   | G  E  D  L  R  E  L  R  R  H  V  H  A  D  S  T  D  F  L      p.840

          .         .         .         .         .         .       g.9805
 GCTGTGAAGAGGCTGGTACAGCGCGTGTTCCCAGCCTGCACCTGCACCTGCACCAGGCCG       c.2580
 A  V  K  R  L  V  Q  R  V  F  P  A  C  T  C  T  C  T  R  P         p.860

          .         .         .         .         .         .       g.9865
 CCCTCGGAGCAGGAAGGGGCCGTGGGTGGGGAGAGGCCTGTGCCCAAGTACCCCCCTCAA       c.2640
 P  S  E  Q  E  G  A  V  G  G  E  R  P  V  P  K  Y  P  P  Q         p.880

          .         .         .         .         .         .       g.9925
 GAGGCTGAGCAGCTTAGCCACCAAGCAGCCCCAGGACCCAGAAGGGTCTGCATGGGCCAT       c.2700
 E  A  E  Q  L  S  H  Q  A  A  P  G  P  R  R  V  C  M  G  H         p.900

          .         .         .         .         .      | 16  .    g.10060
 GAGCGGGCACTCCCAATACAGCTTACCGTACAGGCTTTGGACATGCCGGAGGAGG | CCATC    c.2760
 E  R  A  L  P  I  Q  L  T  V  Q  A  L  D  M  P  E  E  A |   I      p.920

          .         .         .         .         .         .       g.10120
 GAGACTTTGCTGTGCTACCTGGAGCTGCACCCACACCACTGGCTGGAGCTGCTGGCGACC       c.2820
 E  T  L  L  C  Y  L  E  L  H  P  H  H  W  L  E  L  L  A  T         p.940

          .         .         .         .         .         .       g.10180
 ACCTATACCCATTGCCGTCTGAACTGCCCTGGGGGCCCTGCCCAGCTCCAGGCCCTGGCC       c.2880
 T  Y  T  H  C  R  L  N  C  P  G  G  P  A  Q  L  Q  A  L  A         p.960

       | 17  .         .         .         .         .         .    g.10320
 CACAG | GTGTCCCCCTTTGGCTGTGTGCTTGGCCCAGCAGCTGCCTGAGGACCCAGGGCAA    c.2940
 H  R  |  C  P  P  L  A  V  C  L  A  Q  Q  L  P  E  D  P  G  Q      p.980

          .         .         .         .         .         .       g.10380
 GGCAGCAGCTCCGTGGAGTTTGACATGGTCAAGCTGGTGGACTCCATGGGCTGGGAGCTG       c.3000
 G  S  S  S  V  E  F  D  M  V  K  L  V  D  S  M  G  W  E  L         p.1000

          .         .         .         .         .      | 18  .    g.10507
 GCCTCTGTGCGGCGGGCTCTCTGCCAGCTGCAGTGGGACCACGAGCCCAGGACAG | GTGTG    c.3060
 A  S  V  R  R  A  L  C  Q  L  Q  W  D  H  E  P  R  T  G |   V      p.1020

          .         .         .         .         .         .       g.10567
 CGGCGTGGGACAGGGGTGCTTGTGGAGTTCAGTGAGCTGGCCTTCCACCTTCGCAGCCCG       c.3120
 R  R  G  T  G  V  L  V  E  F  S  E  L  A  F  H  L  R  S  P         p.1040

          .         .         .         .         .         .       g.10627
 GGGGACCTGACCGCTGAGGAGAAGGACCAGATATGTGACTTCCTCTATGGCCGTGTGCAG       c.3180
 G  D  L  T  A  E  E  K  D  Q  I  C  D  F  L  Y  G  R  V  Q         p.1060

          .         .         .         .         .       | 19 .    g.10763
 GCCCGGGAGCGCCAGGCCCTGGCCCGTCTGCGCAGAACCTTCCAGGCCTTTCACAG | CGTA    c.3240
 A  R  E  R  Q  A  L  A  R  L  R  R  T  F  Q  A  F  H  S  |  V      p.1080

          .         .         .         .         .         .       g.10823
 GCCTTCCCCAGCTGCGGGCCCTGCCTGGAGCAGCAGGATGAGGAGCGCAGCACCAGGCTC       c.3300
 A  F  P  S  C  G  P  C  L  E  Q  Q  D  E  E  R  S  T  R  L         p.1100

          .         .         .         .         .         .       g.10883
 AAGGACCTGCTCGGCCGCTACTTTGAGGAAGAGGAAGGGCAGGAGCCGGGAGGCATGGAG       c.3360
 K  D  L  L  G  R  Y  F  E  E  E  E  G  Q  E  P  G  G  M  E         p.1120

          .         .         .    | 20    .         .         .    g.11064
 GACGCACAGGGCCCCGAGCCAGGGCAGGCCAGA | CTCCAGGATTGGGAGGACCAGGTCCGC    c.3420
 D  A  Q  G  P  E  P  G  Q  A  R   | L  Q  D  W  E  D  Q  V  R      p.1140

          .         .         .         .         .         .       g.11124
 TGCGACATCCGCCAGTTCCTGTCCCTGAGGCCAGAGGAGAAGTTCTCCAGCAGGGCTGTG       c.3480
 C  D  I  R  Q  F  L  S  L  R  P  E  E  K  F  S  S  R  A  V         p.1160

          .         .   | 21     .         .         .         .    g.11309
 GCCCGCATCTTCCACGGCATCG | GAAGCCCCTGCTACCCGGCCCAGGTGTACGGGCAGGAC    c.3540
 A  R  I  F  H  G  I  G |   S  P  C  Y  P  A  Q  V  Y  G  Q  D      p.1180

          .         .         .         .         .         .       g.11369
 CGACGCTTCTGGAGAAAATACCTGCACCTGAGCTTCCATGCCCTGGTGGGCCTGGCCACG       c.3600
 R  R  F  W  R  K  Y  L  H  L  S  F  H  A  L  V  G  L  A  T         p.1200

          .         .                                               g.11396
 GAAGAGCTCCTGCAGGTGGCCCGCTGA                                        c.3627
 E  E  L  L  Q  V  A  R  X                                          p.1208

          .         .         .         .         .         .       g.11456
 ctgcactgcattgggggatgtcgggtagagctggggttgtcagaggctagggcagtgact       c.*60

          .         .         .         .         .         .       g.11516
 gaggacctgggcaaaacctgccacagggtgtgggaacgaggaggctccaaaatgcagaat       c.*120

          .         .                                               g.11543
 aaaaaatgctcactttgtttttatggg                                        c.*147

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The RecQ protein-like 4 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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