RecQ protein-like 5 (RECQL5) - coding DNA reference sequence

(used for variant description)

(last modified December 10, 2016)


This file was created to facilitate the description of sequence variants on transcript NM_004259.6 in the RECQL5 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_029617.1, covering RECQL5 transcript NM_004259.6.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                     .         .         .         .                g.5040
                     acggatataagattgcgtgggttctgcctaaagctgaatt       c.-121

 .         .         .         .         .         .                g.5100
 cccagcgctttggcttctctgagttggggttgtgtataggggtcttcgaacagttccgga       c.-61

 .         .         .         .         .      | 02  .             g.5632
 accagccagcagcctttaattcttgggcggaccacggccggttctg | tgttcttggctaag    c.-1

          .         .         .         .         .         .       g.5692
 ATGAGCAGCCACCATACCACCTTTCCTTTTGACCCTGAGCGGCGAGTCCGGAGTACGCTG       c.60
 M  S  S  H  H  T  T  F  P  F  D  P  E  R  R  V  R  S  T  L         p.20

          .         .         .         .         .         .       g.5752
 AAGAAGGTCTTTGGGTTTGACTCTTTTAAGACGCCTTTACAGGAGAGTGCGACCATGGCT       c.120
 K  K  V  F  G  F  D  S  F  K  T  P  L  Q  E  S  A  T  M  A         p.40

          . | 03       .         .         .         .         .    g.7067
 GTAGTAAAAG | GTAACAAGGACGTCTTTGTGTGCATGCCCACAGGGGCAGGAAAATCCCTA    c.180
 V  V  K  G |   N  K  D  V  F  V  C  M  P  T  G  A  G  K  S  L      p.60

          .         .         .         .         .         .       g.7127
 TGCTATCAGCTCCCTGCTCTGTTGGCCAAAGGCATCACCATTGTAGTCTCTCCTCTCATT       c.240
 C  Y  Q  L  P  A  L  L  A  K  G  I  T  I  V  V  S  P  L  I         p.80

          .   | 04     .         .         .         .         .    g.9240
 GCTTTGATTCAG | GACCAAGTGGACCACTTGCTAACCCTAAAGGTACGAGTAAGTTCCCTG    c.300
 A  L  I  Q   | D  Q  V  D  H  L  L  T  L  K  V  R  V  S  S  L      p.100

          .         .         .         .         .         .       g.9300
 AACTCGAAGCTCTCTGCACAGGAAAGGAAGGAGCTGCTTGCTGACCTGGAGCGAGAAAAG       c.360
 N  S  K  L  S  A  Q  E  R  K  E  L  L  A  D  L  E  R  E  K         p.120

          .         .         .         .         .         .       g.9360
 CCCCAGACCAAGATTCTGTACATCACCCCAGAGATGGCAGCTTCATCCTCCTTCCAGCCC       c.420
 P  Q  T  K  I  L  Y  I  T  P  E  M  A  A  S  S  S  F  Q  P         p.140

          .         .         .         .         .         .       g.9420
 ACCCTGAACTCCCTGGTGTCCCGCCACCTGCTGTCTTACTTGGTGGTGGATGAAGCTCAT       c.480
 T  L  N  S  L  V  S  R  H  L  L  S  Y  L  V  V  D  E  A  H         p.160

          .         .         .         .         .         .       g.9480
 TGTGTTTCCCAATGGGGGCATGACTTTCGTCCTGACTACTTGCGTCTGGGTGCCCTGCGC       c.540
 C  V  S  Q  W  G  H  D  F  R  P  D  Y  L  R  L  G  A  L  R         p.180

          .         .         .         .         .         .       g.9540
 TCCCGCCTGGGACATGCCCCTTGTGTGGCTCTGACCGCCACAGCCACCCCACAGGTCCAA       c.600
 S  R  L  G  H  A  P  C  V  A  L  T  A  T  A  T  P  Q  V  Q         p.200

          .         .         .         .         .         .       g.9600
 GAGGACGTGTTTGCTGCCCTGCACCTGAAGAAACCAGTTGCCATCTTCAAGACTCCCTGC       c.660
 E  D  V  F  A  A  L  H  L  K  K  P  V  A  I  F  K  T  P  C         p.220

          .         .         .         .         .         .       g.9660
 TTCCGGGCCAACCTCTTCTATGATGTGCAATTCAAGGAACTGATTTCTGATCCCTATGGG       c.720
 F  R  A  N  L  F  Y  D  V  Q  F  K  E  L  I  S  D  P  Y  G         p.240

          .         .         .         .         .  | 05      .    g.10490
 AACCTGAAGGACTTCTGCCTTAAGGCTCTTGGACAGGAGGCTGATAAAGGG | TTATCTGGC    c.780
 N  L  K  D  F  C  L  K  A  L  G  Q  E  A  D  K  G   | L  S  G      p.260

          .         .         .         .         .         .       g.10550
 TGCGGCATTGTGTACTGCAGGACTAGAGAGGCTTGTGAACAGCTGGCCATAGAGCTCAGC       c.840
 C  G  I  V  Y  C  R  T  R  E  A  C  E  Q  L  A  I  E  L  S         p.280

          .         .         .     | 06   .         .         .    g.11149
 TGCAGGGGTGTGAACGCCAAGGCTTACCATGCAG | GGCTGAAGGCCTCTGAAAGAACGCTG    c.900
 C  R  G  V  N  A  K  A  Y  H  A  G |   L  K  A  S  E  R  T  L      p.300

          .         .         .         .         .         .       g.11209
 GTGCAGAACGACTGGATGGAGGAGAAGGTCCCTGTAATTGTTGCAACCATTAGTTTTGGG       c.960
 V  Q  N  D  W  M  E  E  K  V  P  V  I  V  A  T  I  S  F  G         p.320

          .         .       | 07 .         .         .         .    g.13763
 ATGGGAGTGGATAAAGCCAATGTCAG | GTTTGTCGCCCATTGGAATATTGCCAAGTCTATG    c.1020
 M  G  V  D  K  A  N  V  R  |  F  V  A  H  W  N  I  A  K  S  M      p.340

          .         .         .         .         .         .       g.13823
 GCTGGGTACTACCAGGAGTCTGGCCGGGCTGGCAGGGATGGGAAGCCTTCCTGGTGCCGT       c.1080
 A  G  Y  Y  Q  E  S  G  R  A  G  R  D  G  K  P  S  W  C  R         p.360

          .         .         .         .         .         .       g.13883
 CTCTATTACTCCAGGAATGACCGGGACCAAGTCAGCTTCCTGATCAGGAAGGAAGTAGCA       c.1140
 L  Y  Y  S  R  N  D  R  D  Q  V  S  F  L  I  R  K  E  V  A         p.380

           | 08        .         .         .         .         .    g.20975
 AAACTCCAG | GAAAAGAGAGGAAACAAAGCATCTGATAAAGCCACTATCATGGCCTTTGAT    c.1200
 K  L  Q   | E  K  R  G  N  K  A  S  D  K  A  T  I  M  A  F  D      p.400

          .         .          | 09        .         .         .    g.40552
 GCCCTGGTGACCTTCTGTGAAGAACTGGG | GTGCCGCCATGCCGCCATTGCCAAGTACTTC    c.1260
 A  L  V  T  F  C  E  E  L  G  |  C  R  H  A  A  I  A  K  Y  F      p.420

          .         .         .         .         .         .       g.40612
 GGGGATGCGCTGCCTGCCTGCGCCAAAGGCTGCGACCACTGCCAGAACCCCACGGCCGTG       c.1320
 G  D  A  L  P  A  C  A  K  G  C  D  H  C  Q  N  P  T  A  V         p.440

          .         .         .         .         .         .       g.40672
 CGGAGGCGGCTGGAGGCCTTGGAGCGCAGCAGCAGCTGGAGCAAGACCTGCATCGGGCCC       c.1380
 R  R  R  L  E  A  L  E  R  S  S  S  W  S  K  T  C  I  G  P         p.460

          .         .         .         .         .         .       g.40732
 TCCCAGGGGAACGGCTTTGACCCCGAGCTGTACGAGGGAGGCCGCAAGGGCTACGGGGAC       c.1440
 S  Q  G  N  G  F  D  P  E  L  Y  E  G  G  R  K  G  Y  G  D         p.480

          | 10         .         .         .         .         .    g.40992
 TTCAGCAG | GTATGACGAAGGTTCTGGAGGCAGCGGGGATGAAGGCAGAGATGAGGCCCAC    c.1500
 F  S  R  |  Y  D  E  G  S  G  G  S  G  D  E  G  R  D  E  A  H      p.500

          .         .         .         .         | 11         .    g.41191
 AAGCGGGAGTGGAACCTCTTCTATCAGAAGCAGATGCAGCTGCGCAAG | GGCAAAGACCCC    c.1560
 K  R  E  W  N  L  F  Y  Q  K  Q  M  Q  L  R  K   | G  K  D  P      p.520

          .         .      | 12  .         .         .         .    g.41387
 AAGATAGAAGAATTTGTACCCCCAG | ATGAGAACTGTCCCCTGAAAGAGGCTTCTAGCAGG    c.1620
 K  I  E  E  F  V  P  P  D |   E  N  C  P  L  K  E  A  S  S  R      p.540

          .         .     | 13   .         .         .         .    g.41533
 AGGATCCCCAGGCTGACTGTGAAG | GCACGGGAGCACTGCCTGCGGCTTCTGGAGGAGGCG    c.1680
 R  I  P  R  L  T  V  K   | A  R  E  H  C  L  R  L  L  E  E  A      p.560

          .         .         .         | 14         .         .    g.41934
 CTGAGCAGCAACCGCCAGTCAACACGTACCGCTGATGA | AGCTGACCTCCGGGCCAAGGCC    c.1740
 L  S  S  N  R  Q  S  T  R  T  A  D  E  |  A  D  L  R  A  K  A      p.580

          .         .         .         .         .         .       g.41994
 GTGGAGCTGGAACATGAGACATTCCGGAACGCCAAGGTGGCCAACCTCTACAAGGCCAGC       c.1800
 V  E  L  E  H  E  T  F  R  N  A  K  V  A  N  L  Y  K  A  S         p.600

          .   | 15     .         .         .         .         .    g.42395
 GTGCTGAAGAAG | GTGGCCGATATCCACAGAGCCTCCAAGGATGGGCAGCCCTATGACATG    c.1860
 V  L  K  K   | V  A  D  I  H  R  A  S  K  D  G  Q  P  Y  D  M      p.620

          .         .         .         .         .         .       g.42455
 GGAGGCAGTGCCAAGAGCTGCAGTGCCCAAGCTGAGCCCCCGGAGCCCAATGAGTATGAC       c.1920
 G  G  S  A  K  S  C  S  A  Q  A  E  P  P  E  P  N  E  Y  D         p.640

          .         .        | 16.         .         .         .    g.42747
 ATTCCACCAGCCTCCCATGTGTACTCG | CTCAAACCCAAGCGGGTGGGAGCTGGTTTCCCC    c.1980
 I  P  P  A  S  H  V  Y  S   | L  K  P  K  R  V  G  A  G  F  P      p.660

          .         .         .         .         .         .       g.42807
 AAAGGCTCCTGCCCGTTCCAGACGGCCACGGAACTGATGGAGACGACTCGGATCAGGGAG       c.2040
 K  G  S  C  P  F  Q  T  A  T  E  L  M  E  T  T  R  I  R  E         p.680

          .         .         .         .         .         .       g.42867
 CAAGCCCCCCAGCCCGAGCGGGGAGGCGAGCACGAGCCCCCGAGCCGGCCCTGTGGCCTC       c.2100
 Q  A  P  Q  P  E  R  G  G  E  H  E  P  P  S  R  P  C  G  L         p.700

          .         .         .         .         .         .       g.42927
 CTGGATGAGGATGGGAGTGAGCCCCTCCCTGGGCCCAGAGGGGAGGTCCCTGGAGGCAGC       c.2160
 L  D  E  D  G  S  E  P  L  P  G  P  R  G  E  V  P  G  G  S         p.720

          .         .         .         .         .         .       g.42987
 GCTCACTATGGGGGGCCCTCCCCTGAGAAGAAGGCAAAAAGTTCCTCTGGGGGCAGCTCC       c.2220
 A  H  Y  G  G  P  S  P  E  K  K  A  K  S  S  S  G  G  S  S         p.740

          .         .         .         .         .         .       g.43047
 CTTGCCAAGGGCCGGGCTAGCAAGAAACAGCAGCTCCTAGCCACAGCGGCCCACAAGGAT       c.2280
 L  A  K  G  R  A  S  K  K  Q  Q  L  L  A  T  A  A  H  K  D         p.760

          .         .         .         .         .         .       g.43107
 TCTCAGAGCATCGCCCGCTTCTTCTGCCGAAGGGTGGAAAGCCCAGCTCTGCTGGCATCA       c.2340
 S  Q  S  I  A  R  F  F  C  R  R  V  E  S  P  A  L  L  A  S         p.780

          .         .         .         .         .         .       g.43167
 GCCCCAGAGGCAGAAGGTGCCTGCCCCTCCTGTGAGGGGGTTCAGGGACCCCCGATGGCC       c.2400
 A  P  E  A  E  G  A  C  P  S  C  E  G  V  Q  G  P  P  M  A         p.800

          .         .         .         .         .         .       g.43227
 CCAGAGAAGTACACAGGGGAGGAAGATGGAGCCGGGGGACATTCGCCTGCCCCTCCCCAG       c.2460
 P  E  K  Y  T  G  E  E  D  G  A  G  G  H  S  P  A  P  P  Q         p.820

          .         .          | 17        .         .         .    g.43458
 ACTGAGGAGTGCCTCAGGGAGAGGCCAAG | CACCTGCCCGCCCAGAGACCAGGGCACCCCT    c.2520
 T  E  E  C  L  R  E  R  P  S  |  T  C  P  P  R  D  Q  G  T  P      p.840

          .         .         .         .         .         .       g.43518
 GAAGTCCAGCCCACCCCTGCAAAGGACACATGGAAGGGCAAGCGGCCTCGATCCCAGCAG       c.2580
 E  V  Q  P  T  P  A  K  D  T  W  K  G  K  R  P  R  S  Q  Q         p.860

  | 18       .         .         .         .         .         .    g.43807
  | GAGAACCCAGAGAGCCAGCCTCAGAAGAGGCCACGCCCCTCAGCCAAGCCCTCCGTCGTA    c.2640
  | E  N  P  E  S  Q  P  Q  K  R  P  R  P  S  A  K  P  S  V  V      p.880

          .         .         .         .         .         .       g.43867
 GCTGAGGTCAAGGGCAGCGTCTCGGCCAGCGAACAGGGCACCTTGAATCCCACGGCTCAA       c.2700
 A  E  V  K  G  S  V  S  A  S  E  Q  G  T  L  N  P  T  A  Q         p.900

          .         .         .         .         .         .       g.43927
 GACCCCTTCCAGCTCTCCGCTCCTGGCGTCTCCTTGAAGGAGGCTGCAAATGTTGTGGTC       c.2760
 D  P  F  Q  L  S  A  P  G  V  S  L  K  E  A  A  N  V  V  V         p.920

          .         .         .         .      | 19  .         .    g.44512
 AAGTGCCTCACCCCTTTCTACAAGGAGGGCAAGTTTGCTTCCAAG | GAGTTGTTTAAAGGC    c.2820
 K  C  L  T  P  F  Y  K  E  G  K  F  A  S  K   | E  L  F  K  G      p.940

          .         .         .         .         .      | 20  .    g.44672
 TTTGCCCGCCACCTCTCACACTTGCTGACTCAGAAGACCTCTCCTGGAAGGAGCG | TGAAA    c.2880
 F  A  R  H  L  S  H  L  L  T  Q  K  T  S  P  G  R  S  V |   K      p.960

          .         .         .         .         .         .       g.44732
 GAAGAGGCCCAGAACCTCATCAGGCACTTCTTCCATGGCCGGGCCCGGTGCGAGAGCGAA       c.2940
 E  E  A  Q  N  L  I  R  H  F  F  H  G  R  A  R  C  E  S  E         p.980

          .         .         .                                     g.44768
 GCTGACTGGCATGGCCTGTGTGGCCCCCAGAGATGA                               c.2976
 A  D  W  H  G  L  C  G  P  Q  R  X                                 p.991

          .         .         .         .         .         .       g.44828
 ccaactgctggctgggcagggcccgcgtcctcccccagattctagcatgggtcatcctgg       c.*60

          .         .         .         .         .         .       g.44888
 gcctcacctgctgatgccagggccatcgtcttttctcagtccttctcctttccaaccata       c.*120

          .         .         .         .         .         .       g.44948
 cttggctttggggatgaccccagacaccccctgaatccaggtcagaggtcagcccacctt       c.*180

          .         .         .         .         .         .       g.45008
 tctttctgcttgcaaagcctatagacccttctcagagcggtcctcatggctgggttttct       c.*240

          .         .         .         .         .         .       g.45068
 gggacacatgtcgaggacagaaggtggagggtggtggagctgctgctggaagaaggggaa       c.*300

          .         .         .         .         .         .       g.45128
 ggaagagtggcccctccccgagttctaagtcaggatgaggcccacctgtccaaggtatcg       c.*360

          .         .         .         .         .         .       g.45188
 gaacctacccaggggaccctcagatcctccacccactcccccatccattacgatgccagc       c.*420

          .         .         .         .         .         .       g.45248
 ttccagccttgcccaggtcagagctgtggcagaggagaggcagccaggccctgttcctgc       c.*480

          .         .         .         .         .         .       g.45308
 tcagctcctgctcaggaaggccaggcctgacagatgtttgggagaggaataaagttgtgt       c.*540

          .         .         .                                     g.45345
 tgttgtggggcatgcaggcgtgcacacagcccttttc                              c.*577

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The RecQ protein-like 5 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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