replication factor C (activator 1) 1, 145kDa (RFC1) - coding DNA reference sequence

(used for variant description)

(last modified July 31, 2019)


This file was created to facilitate the description of sequence variants on transcript NM_002913.4 in the RFC1 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000004.11, covering RFC1 transcript NM_002913.4.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                         .         .                g.5020
                                         gtcatcaccgcgcgccactg       c.-121

 .         .         .         .         .         .                g.5080
 tcttcgccttcttgcacttcgcgggagaagttgttggcgcgaatggatcctgagcctcga       c.-61

 .         .         .         .         .         .                g.5140
 taacagattcctcaaccggcccacccgccagccagccagcgccttcatcctggggctgcg       c.-1

     | 02    .         .         .         .         .         .    g.19962
 ATG | GACATTCGGAAATTCTTTGGAGTAATACCAAGTGGAAAGAAACTTGTAAGTGAAACA    c.60
 M   | D  I  R  K  F  F  G  V  I  P  S  G  K  K  L  V  S  E  T      p.20

          .         .         .         .         .         .       g.20022
 GTAAAGAAGAATGAGAAAACAAAGTCTGATGAAGAAACTTTAAAAGCAAAGAAAGGAATA       c.120
 V  K  K  N  E  K  T  K  S  D  E  E  T  L  K  A  K  K  G  I         p.40

          .   | 03     .         .         .         .         .    g.25953
 AAGGAAATCAAG | GTAAATAGCTCCCGTAAAGAGGATGACTTCAAACAAAAGCAACCAAGC    c.180
 K  E  I  K   | V  N  S  S  R  K  E  D  D  F  K  Q  K  Q  P  S      p.60

          .         .         | 04         .         .         .    g.28946
 AAGAAAAAGAGGATCATCTATGATTCAG | ATTCAGAGTCAGAGGAGACGTTGCAGGTAAAA    c.240
 K  K  K  R  I  I  Y  D  S  D |   S  E  S  E  E  T  L  Q  V  K      p.80

          .         .         .         .         .         .       g.29006
 AATGCCAAAAAGCCACCAGAAAAACTGCCAGTATCTTCTAAACCTGGTAAAATTTCACGG       c.300
 N  A  K  K  P  P  E  K  L  P  V  S  S  K  P  G  K  I  S  R         p.100

          .         .         .  | 05      .         .         .    g.43654
 CAGGATCCTGTTACATACATTTCAGAAACAG | ATGAAGAAGATGACTTTATGTGTAAGAAG    c.360
 Q  D  P  V  T  Y  I  S  E  T  D |   E  E  D  D  F  M  C  K  K      p.120

          .         .         .         .         .         .       g.43714
 GCGGCCTCTAAATCAAAAGAGAATGGAAGATCTACAAATAGTCATCTTGGAACATCAAAC       c.420
 A  A  S  K  S  K  E  N  G  R  S  T  N  S  H  L  G  T  S  N         p.140

          .         .         .         .         .         .       g.43774
 ATGAAAAAGAATGAAGAAAACACTAAGACCAAGAATAAGCCTTTATCACCAATAAAACTT       c.480
 M  K  K  N  E  E  N  T  K  T  K  N  K  P  L  S  P  I  K  L         p.160

          .         .         .         .         .         .       g.43834
 ACACCCACATCAGTACTTGATTATTTTGGAACTGGAAGTGTCCAAAGATCTAATAAGAAG       c.540
 T  P  T  S  V  L  D  Y  F  G  T  G  S  V  Q  R  S  N  K  K         p.180

          .         .     | 06   .         .         .         .    g.44777
 ATGGTGGCAAGCAAAAGAAAAGAG | CTTTCACAAAATACAGATGAGTCTGGATTAAATGAT    c.600
 M  V  A  S  K  R  K  E   | L  S  Q  N  T  D  E  S  G  L  N  D      p.200

          .         .         .         .   | 07     .         .    g.47982
 GAAGCCATCGCCAAGCAATTACAGCTTGATGAAGATGCGGAG | CTGGAGAGGCAGTTGCAT    c.660
 E  A  I  A  K  Q  L  Q  L  D  E  D  A  E   | L  E  R  Q  L  H      p.220

          .         .         .         .         .         .       g.48042
 GAAGATGAAGAGTTTGCCAGAACATTAGCCATGTTGGATGAAGAACCCAAGACCAAAAAG       c.720
 E  D  E  E  F  A  R  T  L  A  M  L  D  E  E  P  K  T  K  K         p.240

  | 08       .         .         .         .         .         .    g.50067
  | GCTCGAAAGGACACAGAAGCGGGAGAAACGTTTTCATCTGTCCAAGCCAATTTAAGTAAA    c.780
  | A  R  K  D  T  E  A  G  E  T  F  S  S  V  Q  A  N  L  S  K      p.260

          .         .         | 09         .         .         .    g.50744
 GCAGAAAAACATAAATATCCTCATAAAG | TAAAAACAGCACAAGTTTCAGATGAAAGAAAG    c.840
 A  E  K  H  K  Y  P  H  K  V |   K  T  A  Q  V  S  D  E  R  K      p.280

          .         .         .         .         .         .       g.50804
 AGCTACAGTCCTAGGAAGCAAAGTAAATATGAAAGTTCAAAAGAATCTCAGCAACATTCC       c.900
 S  Y  S  P  R  K  Q  S  K  Y  E  S  S  K  E  S  Q  Q  H  S         p.300

          .         .         .         .         .         .       g.50864
 AAGTCATCAGCTGACAAAATAGGAGAAGTCTCTTCTCCCAAGGCCAGTTCTAAGCTGGCA       c.960
 K  S  S  A  D  K  I  G  E  V  S  S  P  K  A  S  S  K  L  A         p.320

          .         .         .         .         .         .       g.50924
 ATTATGAAAAGAAAAGAAGAGAGCTCTTATAAAGAAATAGAGCCTGTGGCCTCAAAAAGA       c.1020
 I  M  K  R  K  E  E  S  S  Y  K  E  I  E  P  V  A  S  K  R         p.340

          .         .         .         .         .         .       g.50984
 AAAGAAAATGCCATTAAATTGAAAGGAGAGACAAAAACTCCTAAGAAAACCAAAAGTTCT       c.1080
 K  E  N  A  I  K  L  K  G  E  T  K  T  P  K  K  T  K  S  S         p.360

          .      | 10  .         .         .         .         .    g.54404
 CCAGCTAAAAAAGAG | TCTGTAAGTCCTGAAGATTCTGAAAAGAAACGCACTAATTATCAA    c.1140
 P  A  K  K  E   | S  V  S  P  E  D  S  E  K  K  R  T  N  Y  Q      p.380

          .         .         .         .         .         .       g.54464
 GCTTATCGAAGCTACTTAAATCGAGAAGGTCCCAAGGCTCTGGGCTCCAAAGAAATACCA       c.1200
 A  Y  R  S  Y  L  N  R  E  G  P  K  A  L  G  S  K  E  I  P         p.400

     | 11    .         .         .         .         .         .    g.58507
 AAG | GGAGCTGAAAATTGCTTGGAAGGCCTTATATTTGTAATCACAGGCGTGCTGGAGTCT    c.1260
 K   | G  A  E  N  C  L  E  G  L  I  F  V  I  T  G  V  L  E  S      p.420

          .         .         .         .         .         .       g.58567
 ATTGAACGAGATGAGGCCAAGTCTCTAATTGAACGTTATGGGGGAAAAGTAACAGGAAAT       c.1320
 I  E  R  D  E  A  K  S  L  I  E  R  Y  G  G  K  V  T  G  N         p.440

          .         .         .         .         .         .       g.58627
 GTCAGCAAGAAAACAAATTATCTTGTCATGGGTCGTGATAGTGGACAGTCCAAGAGTGAT       c.1380
 V  S  K  K  T  N  Y  L  V  M  G  R  D  S  G  Q  S  K  S  D         p.460

     | 12    .         .         .         .         .         .    g.59889
 AAG | GCCGCAGCCTTGGGGACAAAAATTATTGATGAAGATGGCCTGTTGAATCTGATTCGG    c.1440
 K   | A  A  A  L  G  T  K  I  I  D  E  D  G  L  L  N  L  I  R      p.480

          .         .         .         .         | 13         .    g.62361
 ACTATGCCAGGCAAGAAATCCAAGTATGAAATAGCAGTTGAAACTGAG | ATGAAGAAAGAG    c.1500
 T  M  P  G  K  K  S  K  Y  E  I  A  V  E  T  E   | M  K  K  E      p.500

          .         .         .         .         .         .       g.62421
 TCCAAACTGGAGAGAACACCCCAAAAAAATGTCCAAGGAAAAAGAAAAATTAGTCCATCT       c.1560
 S  K  L  E  R  T  P  Q  K  N  V  Q  G  K  R  K  I  S  P  S         p.520

          .         .         .         .         .         .       g.62481
 AAAAAGGAATCAGAATCTAAAAAGAGCAGGCCGACTTCCAAAAGGGACAGTTTGGCAAAG       c.1620
 K  K  E  S  E  S  K  K  S  R  P  T  S  K  R  D  S  L  A  K         p.540

          .         .         .         .         .         .       g.62541
 ACAATAAAAAAGGAAACAGATGTGTTTTGGAAAAGCCTGGATTTCAAGGAGCAGGTGGCT       c.1680
 T  I  K  K  E  T  D  V  F  W  K  S  L  D  F  K  E  Q  V  A         p.560

          .         .         .         .         .         .       g.62601
 GAGGAGACAAGTGGTGACAGCAAGGCTAGGAATTTGGCTGATGACAGCAGTGAAAACAAA       c.1740
 E  E  T  S  G  D  S  K  A  R  N  L  A  D  D  S  S  E  N  K         p.580

          .         .         .         .         .         .       g.62661
 GTGGAAAATTTGCTCTGGGTGGATAAATATAAGCCAACCTCGCTCAAGACCATAATTGGA       c.1800
 V  E  N  L  L  W  V  D  K  Y  K  P  T  S  L  K  T  I  I  G         p.600

          .         .         .         .         .         .       g.62721
 CAGCAAGGTGACCAGAGCTGTGCCAACAAACTCCTACGCTGGCTCCGAAACTGGCAAAAG       c.1860
 Q  Q  G  D  Q  S  C  A  N  K  L  L  R  W  L  R  N  W  Q  K         p.620

          .         .      | 14  .         .         .         .    g.64715
 AGTTCTTCCGAAGATAAAAAACACG | CAAAGTTTGGTAAATTTTCCGGCAAAGATGATGGC    c.1920
 S  S  S  E  D  K  K  H  A |   K  F  G  K  F  S  G  K  D  D  G      p.640

          .         .         .         .         .         .       g.64775
 TCTAGTTTTAAAGCAGCGTTGCTGTCAGGCCCTCCTGGTGTTGGCAAAACCACCACAGCT       c.1980
 S  S  F  K  A  A  L  L  S  G  P  P  G  V  G  K  T  T  T  A         p.660

          .      | 15  .         .         .         .         .    g.66498
 TCCCTGGTGTGTCAG | GAGTTGGGATACAGCTACGTGGAACTGAATGCAAGTGACACCCGG    c.2040
 S  L  V  C  Q   | E  L  G  Y  S  Y  V  E  L  N  A  S  D  T  R      p.680

          .         .         .         .         .         .       g.66558
 AGTAAGAGCAGTTTGAAGGCGATTGTTGCTGAGTCACTGAACAATACCAGCATCAAAGGC       c.2100
 S  K  S  S  L  K  A  I  V  A  E  S  L  N  N  T  S  I  K  G         p.700

          . | 16       .         .         .         .         .    g.68280
 TTTTATTCAA | ATGGAGCAGCCTCTTCAGTAAGCACGAAACATGCTCTCATCATGGATGAA    c.2160
 F  Y  S  N |   G  A  A  S  S  V  S  T  K  H  A  L  I  M  D  E      p.720

          .         .         .         .   | 17     .         .    g.68525
 GTAGATGGCATGGCAGGCAATGAGGATAGGGGAGGAATTCAG | GAATTAATTGGCCTGATA    c.2220
 V  D  G  M  A  G  N  E  D  R  G  G  I  Q   | E  L  I  G  L  I      p.740

          .         .         .         .         .         .       g.68585
 AAACATACTAAAATTCCCATTATTTGTATGTGCAATGATAGAAATCATCCCAAGATTCGC       c.2280
 K  H  T  K  I  P  I  I  C  M  C  N  D  R  N  H  P  K  I  R         p.760

          .         .         .         .         .         .       g.68645
 TCTCTGGTTCATTATTGTTTTGATCTTCGTTTTCAAAGACCTCGGGTTGAACAGATTAAG       c.2340
 S  L  V  H  Y  C  F  D  L  R  F  Q  R  P  R  V  E  Q  I  K         p.780

  | 18       .         .         .         .         .         .    g.68846
  | GGTGCTATGATGTCTATTGCATTTAAAGAAGGTTTAAAGATTCCCCCTCCAGCTATGAAT    c.2400
  | G  A  M  M  S  I  A  F  K  E  G  L  K  I  P  P  P  A  M  N      p.800

          .         .         .       | 19 .         .         .    g.69029
 GAAATAATTTTGGGAGCCAATCAAGATATCAGACAG | GTTTTACATAATCTGAGTATGTGG    c.2460
 E  I  I  L  G  A  N  Q  D  I  R  Q   | V  L  H  N  L  S  M  W      p.820

          .         .         .         .         .         .       g.69089
 TGTGCACGAAGTAAAGCATTAACCTATGACCAGGCCAAAGCTGATTCTCACAGAGCCAAA       c.2520
 C  A  R  S  K  A  L  T  Y  D  Q  A  K  A  D  S  H  R  A  K         p.840

          .      | 20  .         .         .         .         .    g.71012
 AAGGATATCAAAATG | GGCCCATTTGATGTTGCCCGGAAAGTGTTTGCAGCTGGAGAGGAG    c.2580
 K  D  I  K  M   | G  P  F  D  V  A  R  K  V  F  A  A  G  E  E      p.860

          .         .         .         .         .         .       g.71072
 ACTGCTCACATGTCACTTGTGGACAAGTCAGATCTCTTTTTTCATGATTATTCAATAGCA       c.2640
 T  A  H  M  S  L  V  D  K  S  D  L  F  F  H  D  Y  S  I  A         p.880

          .         .         .         .         . | 21       .    g.71253
 CCCCTCTTCGTCCAGGAAAATTACATACACGTGAAGCCTGTAGCAGCAGG | GGGTGACATG    c.2700
 P  L  F  V  Q  E  N  Y  I  H  V  K  P  V  A  A  G  |  G  D  M      p.900

          .         .         .         .         .         .       g.71313
 AAAAAGCACCTGATGCTTTTAAGCAGAGCAGCAGACAGCATATGCGATGGTGACCTAGTG       c.2760
 K  K  H  L  M  L  L  S  R  A  A  D  S  I  C  D  G  D  L  V         p.920

          .         .         .         .         | 22         .    g.75634
 GACAGCCAGATCCGGAGTAAGCAAAACTGGAGTCTTCTGCCTGCGCAG | GCCATTTATGCC    c.2820
 D  S  Q  I  R  S  K  Q  N  W  S  L  L  P  A  Q   | A  I  Y  A      p.940

          .         .         .         .         .         .       g.75694
 AGTGTTCTTCCTGGAGAGTTGATGAGGGGGTACATGACCCAGTTTCCCACCTTCCCAAGC       c.2880
 S  V  L  P  G  E  L  M  R  G  Y  M  T  Q  F  P  T  F  P  S         p.960

          .         .         .         .         .         .       g.75754
 TGGCTGGGGAAGCACTCGTCTACAGGCAAACATGATCGTATTGTTCAGGACCTGGCCTTG       c.2940
 W  L  G  K  H  S  S  T  G  K  H  D  R  I  V  Q  D  L  A  L         p.980

          .     | 23   .         .         .         .         .    g.79575
 CATATGAGTCTCAG | AACTTACTCCAGCAAAAGGACTGTAAACATGGATTATCTGTCGCTT    c.3000
 H  M  S  L  R  |  T  Y  S  S  K  R  T  V  N  M  D  Y  L  S  L      p.1000

          .         .         .         .         .         .       g.79635
 CTAAGGGATGCACTTGTACAGCCCTTGACCTCACAAGGAGTAGACGGAGTACAGGATGTT       c.3060
 L  R  D  A  L  V  Q  P  L  T  S  Q  G  V  D  G  V  Q  D  V         p.1020

          .         .         .         .         .         .       g.79695
 GTTGCACTTATGGACACATATTATTTGATGAAAGAAGACTTTGAGAATATCATGGAAATC       c.3120
 V  A  L  M  D  T  Y  Y  L  M  K  E  D  F  E  N  I  M  E  I         p.1040

          .         .         .         .         | 24         .    g.81354
 AGCAGCTGGGGTGGCAAACCTAGTCCCTTTTCAAAGCTGGATCCCAAG | GTGAAAGCAGCC    c.3180
 S  S  W  G  G  K  P  S  P  F  S  K  L  D  P  K   | V  K  A  A      p.1060

          .         .         .         .         .         .       g.81414
 TTCACAAGAGCTTACAATAAGGAAGCCCACCTTACTCCATACTCACTTCAAGCTATAAAG       c.3240
 F  T  R  A  Y  N  K  E  A  H  L  T  P  Y  S  L  Q  A  I  K         p.1080

          .         .         .         .         .         .       g.81474
 GCATCTAGACACAGCACAAGCCCATCCCTGGATTCGGAATACAATGAAGAATTAAATGAA       c.3300
 A  S  R  H  S  T  S  P  S  L  D  S  E  Y  N  E  E  L  N  E         p.1100

          .         .         .         .         .         .       g.81534
 GATGACTCTCAATCTGATGAGAAAGACCAAGATGCTATAGAAACTGATGCCATGATCAAG       c.3360
 D  D  S  Q  S  D  E  K  D  Q  D  A  I  E  T  D  A  M  I  K         p.1120

  | 25       .         .         .         .         .         .    g.82597
  | AAAAAGACAAAATCTTCAAAGCCTTCAAAACCAGAAAAAGATAAGGAGCCCAGAAAAGGA    c.3420
  | K  K  T  K  S  S  K  P  S  K  P  E  K  D  K  E  P  R  K  G      p.1140

          .         .                                               g.82621
 AAAGGAAAAAGTTCGAAGAAATGA                                           c.3444
 K  G  K  S  S  K  K  X                                             p.1147

          .         .         .         .         .         .       g.82681
 aaccatttttcactagcgacagccactttttactctccctcctgaccagtccagctggtc       c.*60

          .         .         .         .         .         .       g.82741
 tagagaaagccttgttttttcccagagcaaccatgttttagcataatgggatgacctggt       c.*120

          .         .         .         .         .         .       g.82801
 gtcccattataaataaagggtggtatggctagaagggtatgagcagtaggcttatgtaca       c.*180

          .         .         .         .         .         .       g.82861
 cctcttatagaggttgataggactgcttgggtcctccactgtcctctgtcaatctagtta       c.*240

          .         .         .         .         .         .       g.82921
 gacgtgcttctgaatgactgtagaattggaactagaaactacacctgggctttggagtca       c.*300

          .         .         .         .         .         .       g.82981
 gattttagttaacaataatgagcctgggagcagtagtactaaggcgtcttttgtaggctt       c.*360

          .         .         .         .         .         .       g.83041
 aagaatttatcctaatggcctttataggaccaatgctgattttttttaaaggcagttcct       c.*420

          .         .         .         .         .         .       g.83101
 attatgtggtgaaattttgtaaataaatgattatacaaaacagtcaccacctagaactgg       c.*480

          .         .         .         .         .         .       g.83161
 gtattctttgtacattgtcagatatctttcaaagtataaattaggaataaaaatgttcca       c.*540

          .         .         .         .         .         .       g.83221
 catgatatgtgtacaaattctttttaagattgtcatcttgtacagcaaaatattatgttg       c.*600

          .         .         .         .         .         .       g.83281
 gtatattacttccttattaatttgcaaatgattggattaaaaaagctcactgtattcctt       c.*660

          .         .         .         .         .         .       g.83341
 actaacctgttgtgtgaaacataacattggcagtcgaggagtcagaactcggattcccag       c.*720

          .         .         .         .         .         .       g.83401
 cctcactccctctgtgtgtgttgaccacgtctctgctgtgaataggatttcatgcagtgg       c.*780

          .         .         .         .         .         .       g.83461
 tctgttatggggctttgcagcgtggggggctgcagaagattctcagacattcttatcctt       c.*840

          .         .         .         .         .         .       g.83521
 ctggagtctcaacccatcaggttcagaccagtaggaaccaggctgggtcaggctcttaat       c.*900

          .         .         .         .         .         .       g.83581
 ttcactatggtgggggacaaaatgaacactggcttttgttcactttgcccctgagagatc       c.*960

          .         .         .         .         .         .       g.83641
 tagtcctgtcctgtgatggcttccacaaaccctgttggaagtttgggttattcctataac       c.*1020

          .         .         .         .         .         .       g.83701
 tgtatgtgttgagtggccgtgaggctatggacctagcctggaatttagatgtctagctat       c.*1080

          .         .         .         .         .         .       g.83761
 tttttaatcttgttggtaaatgctcagaggtctgtgctacctctgtgaggtatatactaa       c.*1140

          .         .         .         .         .         .       g.83821
 aatgaatgtaaaataaggatcgtattccctgctttaaggaactggtagtcttgtttgggt       c.*1200

          .         .         .         .         .         .       g.83881
 gatgagacaaagttcttgagacatttaaactgtatttaccagtgtgaaaaatgtcattta       c.*1260

          .         .         .         .         .                 g.83933
 tggagattaattcattatggaaataaaacattgcctaagcccttgcctgctg               c.*1312

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Replication factor C (activator 1) 1, 145kDa protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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