replication factor C (activator 1) 2, 40kDa (RFC2) - coding DNA reference sequence

(used for variant description)

(last modified May 5, 2017)


This file was created to facilitate the description of sequence variants on transcript NM_181471.2 in the RFC2 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_008102.1, covering RFC2 transcript NM_181471.2.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                   .                g.4965
                                              ggaagccagggggcg       c.-61

 .         .         .         .         .         .                g.5025
 gggcttgcgtggcggcgtcaaggggcggtgcctcgggtggcgggaagaggaggcgcgaga       c.-1

          .         .         .         .         .         .       g.5085
 ATGGAGGTGGAGGCCGTCTGTGGTGGCGCGGGCGAGGTGGAGGCCCAGGACTCTGACCCT       c.60
 M  E  V  E  A  V  C  G  G  A  G  E  V  E  A  Q  D  S  D  P         p.20

          .         .         .         .         .    | 02    .    g.6917
 GCCCCTGCCTTCAGCAAGGCCCCCGGCAGCGCCGGCCACTACGAACTGCCGTG | GGTTGAA    c.120
 A  P  A  F  S  K  A  P  G  S  A  G  H  Y  E  L  P  W  |  V  E      p.40

          .         .         .         .         .         .       g.6977
 AAATATAGGCCAGTAAAGCTGAATGAAATTGTCGGGAATGAAGACACCGTGAGCAGGCTA       c.180
 K  Y  R  P  V  K  L  N  E  I  V  G  N  E  D  T  V  S  R  L         p.60

     | 03    .         .         .         .      | 04  .         . g.10305
 GAG | GTCTTTGCAAGGGAAGGAAATGTGCCCAACATCATCATTGCG | GGCCCTCCAGGAACC c.240
 E   | V  F  A  R  E  G  N  V  P  N  I  I  I  A   | G  P  P  G  T   p.80

          .         .         .         .         .         .       g.10365
 GGCAAGACCACAAGCATTCTGTGCTTGGCCCGGGCCCTGCTGGGCCCAGCACTCAAAGAT       c.300
 G  K  T  T  S  I  L  C  L  A  R  A  L  L  G  P  A  L  K  D         p.100

          .         .         .   | 05     .         .         .    g.12673
 GCCATGTTGGAACTCAATGCTTCAAATGACAG | GGGCATTGACGTTGTGAGGAATAAAATT    c.360
 A  M  L  E  L  N  A  S  N  D  R  |  G  I  D  V  V  R  N  K  I      p.120

          .         .         .         .         .         .       g.12733
 AAAATGTTTGCTCAACAAAAAGTCACTCTTCCCAAAGGCCGACATAAGATCATCATTCTG       c.420
 K  M  F  A  Q  Q  K  V  T  L  P  K  G  R  H  K  I  I  I  L         p.140

          .     | 06   .         .         .         .         .    g.16208
 GATGAAGCAGACAG | CATGACCGACGGAGCCCAGCAAGCCTTGAGGAGAACCATGGAAATC    c.480
 D  E  A  D  S  |  M  T  D  G  A  Q  Q  A  L  R  R  T  M  E  I      p.160

          .         .         .         .         .      | 07  .    g.19318
 TACTCTAAAACCACTCGCTTCGCCCTTGCTTGTAATGCTTCGGATAAGATCATCG | AGCCC    c.540
 Y  S  K  T  T  R  F  A  L  A  C  N  A  S  D  K  I  I  E |   P      p.180

          .         .         .         .         .         .       g.19378
 ATTCAGTCCCGCTGTGCAGTCCTCCGGTACACAAAGCTGACCGACGCCCAGATCCTCACC       c.600
 I  Q  S  R  C  A  V  L  R  Y  T  K  L  T  D  A  Q  I  L  T         p.200

          .         .         .         .         .         .       g.19438
 AGGCTGATGAATGTTATCGAGAAGGAGAGGGTACCCTACACTGATGACGGCCTAGAAGCC       c.660
 R  L  M  N  V  I  E  K  E  R  V  P  Y  T  D  D  G  L  E  A         p.220

          .         .         .    | 08    .         .         .    g.20447
 ATCATCTTCACGGCCCAGGGAGACATGAGGCAG | GCGCTGAACAACCTGCAGTCCACCTTC    c.720
 I  I  F  T  A  Q  G  D  M  R  Q   | A  L  N  N  L  Q  S  T  F      p.240

          .         .         .          | 09        .         .    g.21987
 TCAGGATTTGGCTTCATTAACAGTGAGAACGTGTTCAAG | GTCTGTGACGAGCCCCACCCA    c.780
 S  G  F  G  F  I  N  S  E  N  V  F  K   | V  C  D  E  P  H  P      p.260

          .         .         .         .         .         .       g.22047
 CTGCTGGTAAAGGAGATGATCCAGCACTGTGTGAATGCCAACATTGACGAAGCCTACAAG       c.840
 L  L  V  K  E  M  I  Q  H  C  V  N  A  N  I  D  E  A  Y  K         p.280

  | 10       .         .         .         .         .         .    g.23823
  | ATTCTTGCTCACTTGTGGCATCTGGGCTACTCACCAGAAGATATCATTGGCAACATCTTT    c.900
  | I  L  A  H  L  W  H  L  G  Y  S  P  E  D  I  I  G  N  I  F      p.300

          .         .         .         .         .     | 11   .    g.27198
 CGAGTGTGTAAAACTTTCCAAATGGCAGAATACCTGAAACTGGAGTTTATCAAG | GAAATT    c.960
 R  V  C  K  T  F  Q  M  A  E  Y  L  K  L  E  F  I  K   | E  I      p.320

          .         .         .         .         .         .       g.27258
 GGATACACTCACATGAAAATAGCGGAAGGAGTGAACTCTCTTTTGCAGATGGCAGGCCTC       c.1020
 G  Y  T  H  M  K  I  A  E  G  V  N  S  L  L  Q  M  A  G  L         p.340

          .         .         .         .                           g.27303
 CTGGCAAGGCTGTGTCAGAAGACAATGGCCCCGGTGGCCAGTTAG                      c.1065
 L  A  R  L  C  Q  K  T  M  A  P  V  A  S  X                        p.354

          .         .         .         .         .         .       g.27363
 agcagagacttcactgactgacttacaggtgccctattctgaggtacaggagccgcggct       c.*60

          .         .         .         .         .         .       g.27423
 ttctgatgggggaaaatgccgccttaggctggagccaacatgactgtcctttaaactcca       c.*120

          .         .         .         .         .         .       g.27483
 gtggctggccaggcacggtagctcacgcctgtaatcccaacactttgggaggccgaggca       c.*180

          .         .         .         .         .         .       g.27543
 ggtggatcacctgaggtcagaagttcaagaccagcctggccaacatggggaaaccctgtc       c.*240

          .         .         .         .         .         .       g.27603
 tttactaaaaatataaaaattagctgggtgtggtggcgggcacctgtaatcccagctact       c.*300

          .         .         .         .         .         .       g.27663
 cgggaggctgtggcaggagaatcgcttgaacccaggaggtggaggttgcagtgagccaag       c.*360

          .         .         .         .         .         .       g.27723
 atcacaccattgcactccagcctgggcgacagagtctccatctggggaaaaaaattaaat       c.*420

          .         .         .         .         .         .       g.27783
 aaataaactcccgtgacttgcatgtttgcttctgggacgtctgtgccccgcaagtgtttg       c.*480

          .         .         .         .         .         .       g.27843
 agtttggcctccaccccattgatgcggtgacggggcggaaaggcgcagagaagctgaggg       c.*540

          .         .         .         .         .         .       g.27903
 cggtctctgatctgtgtgtgggttgacattttagctaataaagccttgcagtgtttgttg       c.*600

                                                                    g.27907
 gcaa                                                               c.*604

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Replication factor C (activator 1) 2, 40kDa protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

Powered by LOVD v.3.0 Build 18
©2004-2017 Leiden University Medical Center