RFT1 homolog (S. cerevisiae) (RFT1) - coding DNA reference sequence

(used for variant description)

(last modified March 20, 2015)


This file was created to facilitate the description of sequence variants on transcript NM_052859.3 in the RFT1 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_009203.1, covering RFT1 transcript NM_052859.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
           .         .         .         .         .                g.5054
       gactaaacggagtggcggcggcatttcctggtgtctgagcctggcgcggaggct       c.-1

          .         .         .         .         .         .       g.5114
 ATGGGCAGCCAGGAGGTGCTGGGCCACGCGGCCCGGCTGGCCTCCTCCGGTCTCCTCCTG       c.60
 M  G  S  Q  E  V  L  G  H  A  A  R  L  A  S  S  G  L  L  L         p.20

     | 02    .         .         .         .         .         .    g.9517
 CAG | GTGTTGTTTCGGTTGATCACCTTTGTCTTGAATGCATTTATTCTTCGCTTCCTGTCA    c.120
 Q   | V  L  F  R  L  I  T  F  V  L  N  A  F  I  L  R  F  L  S      p.40

          .         .          | 03        .         .         .    g.11645
 AAGGAAATCGTTGGCGTAGTAAATGTAAG | ACTAACGCTGCTTTACTCAACCACCCTCTTC    c.180
 K  E  I  V  G  V  V  N  V  R  |  L  T  L  L  Y  S  T  T  L  F      p.60

          .         .         .         .         .         .       g.11705
 CTGGCCAGAGAGGCCTTCCGCAGAGCATGTCTCAGTGGGGGCACCCAGCGAGACTGGAGC       c.240
 L  A  R  E  A  F  R  R  A  C  L  S  G  G  T  Q  R  D  W  S         p.80

          .         .       | 04 .         .         .         .    g.12925
 CAGACCCTCAACCTGCTGTGGCTAAC | AGTCCCCCTGGGTGTGTTTTGGTCCTTATTCCTG    c.300
 Q  T  L  N  L  L  W  L  T  |  V  P  L  G  V  F  W  S  L  F  L      p.100

          .         .         .         .         .         .       g.12985
 GGCTGGATCTGGTTGCAGCTGCTTGAAGTGCCTGATCCTAATGTTGTCCCTCACTATGCA       c.360
 G  W  I  W  L  Q  L  L  E  V  P  D  P  N  V  V  P  H  Y  A         p.120

          .         .         .         .         .         .       g.13045
 ACTGGAGTGGTGCTGTTTGGTCTCTCGGCAGTGGTGGAGCTTCTAGGAGAGCCCTTTTGG       c.420
 T  G  V  V  L  F  G  L  S  A  V  V  E  L  L  G  E  P  F  W         p.140

          .         .         .       | 05 .         .         .    g.13678
 GTCTTGGCACAAGCACATATGTTTGTGAAGCTCAAG | GTGATTGCAGAGAGCCTGTCGGTA    c.480
 V  L  A  Q  A  H  M  F  V  K  L  K   | V  I  A  E  S  L  S  V      p.160

          .         .         .         .         .         .       g.13738
 ATTCTTAAGAGCGTTCTGACAGCTTTTCTCGTGCTGTGGTTGCCTCACTGGGGATTGTAC       c.540
 I  L  K  S  V  L  T  A  F  L  V  L  W  L  P  H  W  G  L  Y         p.180

          .         | 06         .         .         .         .    g.15475
 ATTTTCTCTTTGGCCCAG | CTTTTCTATACCACAGTTCTGGTGCTCTGCTATGTTATTTAT    c.600
 I  F  S  L  A  Q   | L  F  Y  T  T  V  L  V  L  C  Y  V  I  Y      p.200

          .         .         .         .         .         .       g.15535
 TTCACAAAGTTACTGGGTTCCCCAGAATCAACCAAGCTTCAAACTCTTCCTGTCTCCAGA       c.660
 F  T  K  L  L  G  S  P  E  S  T  K  L  Q  T  L  P  V  S  R         p.220

          .         .         .       | 07 .         .         .    g.23570
 ATAACAGATCTGTTACCCAATATTACAAGAAATGGA | GCGTTTATAAACTGGAAAGAGGCT    c.720
 I  T  D  L  L  P  N  I  T  R  N  G   | A  F  I  N  W  K  E  A      p.240

          .         .         .         .         .      | 08  .    g.28590
 AAACTGACTTGGAGTTTTTTCAAACAGTCTTTCTTGAAACAGATTTTGACAGAAG | GCGAG    c.780
 K  L  T  W  S  F  F  K  Q  S  F  L  K  Q  I  L  T  E  G |   E      p.260

          .         .         .         .       | 09 .         .    g.29665
 CGATATGTGATGACATTTTTGAATGTATTGAACTTTGGTGATCAGG | GTGTGTATGATATA    c.840
 R  Y  V  M  T  F  L  N  V  L  N  F  G  D  Q  G |   V  Y  D  I      p.280

          .         .         .         .         .         .       g.29725
 GTGAATAATCTTGGCTCCCTTGTGGCCAGATTAATTTTCCAGCCAATAGAGGAAAGTTTT       c.900
 V  N  N  L  G  S  L  V  A  R  L  I  F  Q  P  I  E  E  S  F         p.300

          .         .         .         .         .        | 10.    g.31360
 TATATATTTTTTGCTAAGGTGCTGGAGAGGGGAAAGGATGCCACACTTCAGAAGCAG | GAG    c.960
 Y  I  F  F  A  K  V  L  E  R  G  K  D  A  T  L  Q  K  Q   | E      p.320

          .         .         .         .         .         .       g.31420
 GACGTTGCTGTGGCTGCTGCAGTCTTGGAGTCCCTGCTCAAGCTGGCCCTGCTGGCCGGC       c.1020
 D  V  A  V  A  A  A  V  L  E  S  L  L  K  L  A  L  L  A  G         p.340

          .         .         .         .         .         .       g.31480
 CTGACCATCACTGTTTTTGGCTTTGCCTATTCTCAGCTGGCTCTGGATATCTACGGAGGG       c.1080
 L  T  I  T  V  F  G  F  A  Y  S  Q  L  A  L  D  I  Y  G  G         p.360

          .         .   | 11     .         .         .         .    g.36006
 ACCATGCTTAGCTCAGGATCCG | GTCCTGTTTTGCTGCGTTCCTACTGTCTCTATGTTCTC    c.1140
 T  M  L  S  S  G  S  G |   P  V  L  L  R  S  Y  C  L  Y  V  L      p.380

          .         .         .         .         .         .       g.36066
 CTGCTTGCCATCAATGGAGTGACAGAGTGTTTCACATTTGCTGCCATGAGCAAAGAGGAG       c.1200
 L  L  A  I  N  G  V  T  E  C  F  T  F  A  A  M  S  K  E  E         p.400

          | 12         .         .         .         .         .    g.42888
 GTCGACAG | GTACAATTTTGTGATGCTGGCCCTGTCCTCCTCATTCCTGGTGTTATCCTAT    c.1260
 V  D  R  |  Y  N  F  V  M  L  A  L  S  S  S  F  L  V  L  S  Y      p.420

          .         .         .         .         .         .       g.42948
 CTCTTGACCCGTTGGTGTGGCAGCGTGGGCTTCATCTTGGCCAACTGCTTTAACATGGGC       c.1320
 L  L  T  R  W  C  G  S  V  G  F  I  L  A  N  C  F  N  M  G         p.440

          .         .         .         .         .         .       g.43008
 ATTCGGATCACGCAGAGCCTTTGCTTCATCCACCGCTACTACCGAAGGAGCCCCCACAGG       c.1380
 I  R  I  T  Q  S  L  C  F  I  H  R  Y  Y  R  R  S  P  H  R         p.460

          .         .         .         .         .         .       g.43068
 CCCCTGGCTGGCCTGCACCTATCGCCAGTCCTGCTCGGGACATTTGCCCTCAGTGGTGGG       c.1440
 P  L  A  G  L  H  L  S  P  V  L  L  G  T  F  A  L  S  G  G         p.480

          .         | 13         .         .         .         .    g.43426
 GTTACTGCTGTTTCGGAG | GTATTCCTCTGCTGTGAGCAGGGCTGGCCAGCCAGACTGGCA    c.1500
 V  T  A  V  S  E   | V  F  L  C  C  E  Q  G  W  P  A  R  L  A      p.500

          .         .         .         .         .         .       g.43486
 CACATTGCTGTGGGGGCCTTCTGTCTGGGAGCAACTCTCGGGACAGCATTCCTCACAGAG       c.1560
 H  I  A  V  G  A  F  C  L  G  A  T  L  G  T  A  F  L  T  E         p.520

          .         .         .         .         .         .       g.43546
 ACCAAGCTGATCCATTTCCTCAGGACTCAGTTAGGTGTGCCCAGACGCACTGACAAAATG       c.1620
 T  K  L  I  H  F  L  R  T  Q  L  G  V  P  R  R  T  D  K  M         p.540

                                                                    g.43552
 ACATGA                                                             c.1626
 T  X                                                               p.541

          .         .         .         .         .         .       g.43612
 cttcagggaagcctggacacccgaggcacctggaccagctatgggtagttctgtgggtgg       c.*60

          .         .         .         .         .         .       g.43672
 aacacattctgtgtaagagccccactgagggctctgcagcggagtgacagcaaccccaga       c.*120

          .         .         .         .         .         .       g.43732
 gatgaggcaccagagagtgccactgcatgagacacctgtgaccattcgaagtctgaaatg       c.*180

          .         .         .         .         .         .       g.43792
 cggggggggagtttcatttttaagtgaagaccaaaagccctttaaaaataatagtttttt       c.*240

          .         .         .         .         .         .       g.43852
 atcattttatagtaatcagcattttctcttttactaatatactcattccttttgcgtatg       c.*300

          .         .         .         .         .         .       g.43912
 attggcctttggagctacatgctccaacaaactatatcttaattgttaactgttaataat       c.*360

          .         .         .         .         .         .       g.43972
 tatctggcccagaaaaagagatgcagtgattttacccttcacaggaatattgaacttctt       c.*420

          .         .         .         .         .         .       g.44032
 ctgtaaaagagagagagaaacctctctctctcatgcaccacatggaaacagagtgtggcc       c.*480

          .         .         .         .         .         .       g.44092
 ctgaagttgtggctttctttgtgtcaaaactgtggtctgagtttttagagaaggaaaaat       c.*540

          .         .         .         .         .         .       g.44152
 gctactcagtgagaaatccaagaaatgaaaccaggaaggttttcagatcacatttcccag       c.*600

          .         .         .         .         .         .       g.44212
 agtgagttcgggagaatcttgcctgtcgtgatcacactgttccccgccgccccaggtcag       c.*660

          .         .         .         .         .         .       g.44272
 cacatacttgacccagagtgggctctcaggatttgttgattgaagggtgggtgaaagctg       c.*720

          .         .         .         .         .         .       g.44332
 gctggagactcctggcctggccacctgcaagaggcggactttgaagaaaactgtgatcca       c.*780

          .         .         .         .         .         .       g.44392
 gttgagccactttgtccctgaggggaatgctgctttgcagctttctgtaacttctcacat       c.*840

          .         .         .         .         .         .       g.44452
 gggaattgcactggtgacagataaggtttaacagatgtacttttttatcctcagaataag       c.*900

          .         .         .         .         .         .       g.44512
 acaaggcaaactctatatggctagtattactgagtcaggtccctcccgttgacccattaa       c.*960

          .         .         .         .         .         .       g.44572
 ttccagcattgatcaatacaaccaaattccagccccaggacaagagtggcaggcatgggg       c.*1020

          .         .         .         .         .         .       g.44632
 gcctggtactccaggctacagtgtgagcccaggtgttctgcaccttgcagcctgcacact       c.*1080

          .         .         .         .         .         .       g.44692
 gcaggtgaaatcatgagcagtgttctggagtgtgaagtgtttttatttttttgttaatgt       c.*1140

          .         .         .         .         .         .       g.44752
 attaattccttttagatattaacccccctcagaactatatgcacaaactataacttggat       c.*1200

          .         .         .         .         .         .       g.44812
 gttaataatcctgtcactcagtgccccaaaccttctgtgtctacacctagagagagggcc       c.*1260

          .         .         .         .         .         .       g.44872
 agtaagggcaactcctatcatgcattaaaatgcatgtatttaaatctgcttgcccagagc       c.*1320

          .         .         .         .         .         .       g.44932
 cagtacccaggggctaaggattaagacctgtcagtacaccaagactggggcccagtcacc       c.*1380

          .         .         .         .         .         .       g.44992
 tggcaggtttttatctactcagagggagaatgctttgcactaagtgggagaaaagcagct       c.*1440

          .         .         .         .         .         .       g.45052
 aaatgcaaggtgtcctgagcaattagaggacctccaaagcatggcctcagtcatgccttc       c.*1500

          .         .         .         .         .         .       g.45112
 atcgggcaaggtcaggccagctcagaaaaatggatggtcccatagggtcaagtggagcac       c.*1560

          .         .         .         .         .         .       g.45172
 acacggaaggcagtcctccttccctcccatgtcctttctctgtccctggcatccacagaa       c.*1620

          .         .         .         .         .         .       g.45232
 agggaccttcagtcctcatgagctgcttctctgcagctgctgatcaccctcccggaaccc       c.*1680

          .         .         .         .         .         .       g.45292
 tgcacctatcccgtgcccacctgaccccagactcaagcatgatcctcattctacctgcct       c.*1740

          .         .         .         .         .         .       g.45352
 cggaatcacctggattgcaagtcagaacatggcttcccaggacccactccaggccttcag       c.*1800

          .         .         .         .         .         .       g.45412
 ggtctgtgtctcccaggaggagggctctgagattggcttttctggcaagcccacgtggct       c.*1860

          .         .         .         .         .         .       g.45472
 ttgatgccaccaaggttggcatgccccattgtcttccttcgtgacaggcccaggaccatc       c.*1920

          .         .         .         .         .         .       g.45532
 atgctcatgctcacagtgcctgttctctgctccaggaacagagctgctgctctacaagca       c.*1980

          .         .         .         .         .         .       g.45592
 gccttgtgactccggggtctctgggagcaggactccccaggcttgtgctctctcagcttg       c.*2040

          .         .         .         .         .         .       g.45652
 agagaggctctatgtctgaaggcagtgctcactctctcatccctcccctgctgttcgccc       c.*2100

          .         .         .         .         .         .       g.45712
 agtgctgctgtcagggccagctcctcttgaaagacagccagccgcaaaggcagcccaggg       c.*2160

          .         .         .         .         .         .       g.45772
 cttcttccggtgtcctgcttccctgtatctagggagagttgtacatgtggctgcgtgttt       c.*2220

          .         .         .         .         .         .       g.45832
 tcccaggactagccctgccgcctgggctgtcagcactttggcagcaggtcctctgtggtt       c.*2280

          .         .         .         .         .         .       g.45892
 ctctgcctctggtgcctccctaaagctcagctggacctgaccaggcctctggcatttccc       c.*2340

          .         .         .         .         .         .       g.45952
 ctgctggaccccctagagccacagctgtgcctcagggagcttgcatacatgtgggccagc       c.*2400

          .         .         .         .         .         .       g.46012
 ctgcctcactttacccaagtggatttggggagcagaaatcatacttttggctttcaatac       c.*2460

          .         .         .         .         .         .       g.46072
 cacttatagtgaggctacttctccatggaaacaagtctctgaggcacaacctttatgaaa       c.*2520

          .         .         .         .         .         .       g.46132
 ggaaggagcattcgttggtgagaagaacagtatcgctgacttcctgtgctcctctggcca       c.*2580

          .         .         .         .         .         .       g.46192
 caggtaactgttggtcacttcagatttggcttggggtctctcagtgaggagctgctgctg       c.*2640

          .         .         .         .         .         .       g.46252
 tgctgtttaatgcttacctgatggcaacttctggctctggaaccgctactctgccctgtt       c.*2700

          .         .         .         .         .         .       g.46312
 cccagccacttcccaacctgattcaagcagggcccctccttcctcctgtctttatttatt       c.*2760

          .         .         .         .         .         .       g.46372
 tatttattgagacagagtctcactctgtcgcccaggctggagtgcagtagcgcgatctcg       c.*2820

          .         .         .         .         .         .       g.46432
 gctcactgcgagctctgcctcctgggttcaagcgattctcttgcctcagcctcctgagta       c.*2880

          .         .         .         .         .         .       g.46492
 gctggggctacaggcgcctgccaccacacccggctaatttttgtatttttagtagagaca       c.*2940

          .         .         .         .         .         .       g.46552
 gggtttcaccatattggccaggctggtcttgaactcctgaccttgtgatccgcccgcctc       c.*3000

          .         .         .         .         .         .       g.46612
 agcctcccaaagtgctgggattacaggcgtgagccaccgctcctggcctattcttttctt       c.*3060

          .         .         .         .         .         .       g.46672
 ttcagagacaaggtctcactctctcctctcgcccaggctggagtgcagtggtgtcatcat       c.*3120

          .         .         .         .         .         .       g.46732
 agctcattgcagcctcaaactcctgggctcaagcaatcctcccacctcagcctcctgagt       c.*3180

          .         .         .         .         .         .       g.46792
 agctgggatcacaggtgtgtgctacctcacccagctaatttctaatttttttttgtagag       c.*3240

          .         .         .         .         .         .       g.46852
 actggatctcactgttgccttgaactcctgggctcaagtgatcctcctgcctcagcctcc       c.*3300

          .         .         .         .         .         .       g.46912
 caaagtgctgggattccagaccagccattttttttccttaatcatgcattcctgttgcta       c.*3360

          .         .         .         .         .         .       g.46972
 gtttcacatcagtcccctggtttaataagaaataaaatattttcttcacacttttgaaaa       c.*3420

 

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The RFT1 homolog (S. cerevisiae) protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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