ring finger and WD repeat domain 3 (RFWD3) - coding DNA reference sequence

(used for variant description)

(last modified September 8, 2017)


This file was created to facilitate the description of sequence variants on transcript NM_018124.3 in the RFWD3 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000016.9, covering RFWD3 transcript NM_018124.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                               .         .         .                g.5038
                       aagtggcagttggcgtaggtgcattcggagtgcggccg       c.-61

 .         .         .         .         .         .        | 02    g.10432
 aggtaactaccgagtcttcggcgggctcgcgagcccggccgcggcctgctggtttcag | tg    c.-1

          .         .         .         .         .         .       g.10492
 ATGGCTCATGAAGCAATGGAATATGATGTTCAGGTGCAGTTAAATCATGCCGAACAACAG       c.60
 M  A  H  E  A  M  E  Y  D  V  Q  V  Q  L  N  H  A  E  Q  Q         p.20

          .         .         .         .         .         .       g.10552
 CCAGCTCCTGCTGGCATGGCCAGCAGCCAAGGGGGACCAGCCCTCCTCCAGCCTGTTCCT       c.120
 P  A  P  A  G  M  A  S  S  Q  G  G  P  A  L  L  Q  P  V  P         p.40

          .         .         .         .         .         .       g.10612
 GCTGATGTGGTCAGCAGCCAGGGGGTACCATCCATCCTCCAGCCAGCTCCTGCTGAGGTG       c.180
 A  D  V  V  S  S  Q  G  V  P  S  I  L  Q  P  A  P  A  E  V         p.60

          .         .         .         .         .         .       g.10672
 ATCAGCAGCCAAGCGACACCACCCCTGCTCCAGCCTGCTCCGCAACTGTCTGTTGACCTG       c.240
 I  S  S  Q  A  T  P  P  L  L  Q  P  A  P  Q  L  S  V  D  L         p.80

          .         .         .         .         .         .       g.10732
 ACAGAAGTGGAGGTCTTGGGAGAAGACACTGTGGAGAACATCAATCCAAGAACTTCAGAA       c.300
 T  E  V  E  V  L  G  E  D  T  V  E  N  I  N  P  R  T  S  E         p.100

          .         .         .         .         .         .       g.10792
 CAACATAGGCAGGGATCTGATGGTAATCACACCATCCCAGCATCTTCGTTGCATTCAATG       c.360
 Q  H  R  Q  G  S  D  G  N  H  T  I  P  A  S  S  L  H  S  M         p.120

          .         .         .         .         .         .       g.10852
 ACCAACTTCATCAGCGGACTGCAGAGACTTCATGGCATGCTGGAATTCCTGAGACCTTCA       c.420
 T  N  F  I  S  G  L  Q  R  L  H  G  M  L  E  F  L  R  P  S         p.140

          .         .         .         .         .         .       g.10912
 TCTTCAAACCACAGTGTAGGGCCAATGAGAACAAGAAGGAGGGTATCTGCTTCACGGAGG       c.480
 S  S  N  H  S  V  G  P  M  R  T  R  R  R  V  S  A  S  R  R         p.160

          .         .         .         | 03         .         .    g.19781
 GCAAGAGCCGGAGGGTCTCAGAGGACAGACAGTGCCAG | GTTGAGAGCACCATTGGATGCT    c.540
 A  R  A  G  G  S  Q  R  T  D  S  A  R  |  L  R  A  P  L  D  A      p.180

          .         .         .         .         .         .       g.19841
 TACTTTCAGGTGAGCAGGACCCAGCCTGACTTGCCAGCTACCACTTATGATTCAGAGACT       c.600
 Y  F  Q  V  S  R  T  Q  P  D  L  P  A  T  T  Y  D  S  E  T         p.200

          .         .         .         .         .         .       g.19901
 AGGAATCCTGTATCTGAAGAGTTGCAGGTGTCTAGTAGTTCTGATTCTGACAGTGACAGC       c.660
 R  N  P  V  S  E  E  L  Q  V  S  S  S  S  D  S  D  S  D  S         p.220

          .         .         .         .         .         .       g.19961
 TCTGCAGAGTATGGAGGGGTTGTTGACCAGGCAGAGGAATCTGGAGCTGTCATTTTAGAA       c.720
 S  A  E  Y  G  G  V  V  D  Q  A  E  E  S  G  A  V  I  L  E         p.240

   | 04      .         .         .         .         .         .    g.22738
 G | AGCAACTAGCAGGTGTCTCAGCAGAGCAAGAAGTTACATGTATCGATGGAGGCAAGACC    c.780
 E |   Q  L  A  G  V  S  A  E  Q  E  V  T  C  I  D  G  G  K  T      p.260

          .   | 05     .         .         .         .         .    g.27194
 CTCCCCAAACAG | CCATCTCCCCAGAAGTCTGAGCCTCTGCTACCTTCTGCTTCTATGGAT    c.840
 L  P  K  Q   | P  S  P  Q  K  S  E  P  L  L  P  S  A  S  M  D      p.280

          .         .         .         .         .         .       g.27254
 GAGGAAGAAGGGGACACTTGTACAATATGTCTGGAACAGTGGACCAATGCTGGGGACCAC       c.900
 E  E  E  G  D  T  C  T  I  C  L  E  Q  W  T  N  A  G  D  H         p.300

          .         .         .         .         .         .       g.27314
 CGGCTCTCAGCATTACGCTGTGGGCATCTCTTTGGGTATAGGTGCATTTCCACGTGGCTT       c.960
 R  L  S  A  L  R  C  G  H  L  F  G  Y  R  C  I  S  T  W  L         p.320

          .         .        | 06.         .         .         .    g.27461
 AAAGGACAAGTACGAAAATGTCCCCAG | TGCAACAAGAAAGCCAGGCACAGTGACATTGTC    c.1020
 K  G  Q  V  R  K  C  P  Q   | C  N  K  K  A  R  H  S  D  I  V      p.340

          .         .         .         .         .          | 07    g.33912
 GTCCTTTATGCCCGAACCCTGAGAGCTTTGGACACTAGTGAACAGGAGCGCATGAAAAG | T    c.1080
 V  L  Y  A  R  T  L  R  A  L  D  T  S  E  Q  E  R  M  K  S  |      p.360

          .         .         .         .         .         .       g.33972
 TCCCTACTGAAGGAACAGATGCTAAGGAAACAGGCCGAGTTAGAATCAGCACAGTGCCGA       c.1140
 S  L  L  K  E  Q  M  L  R  K  Q  A  E  L  E  S  A  Q  C  R         p.380

          .         .         .         .         .     | 08   .    g.35310
 CTCCAACTGCAGGTCCTCACTGATAAGTGCACTAGGCTTCAAAGGCGTGTTCAG | GACTTG    c.1200
 L  Q  L  Q  V  L  T  D  K  C  T  R  L  Q  R  R  V  Q   | D  L      p.400

          .         .         .         .         .         .       g.35370
 CAAAAACTTACGTCACATCAAAGTCAGAATTTACAGCAACCCAGGGGCTCCCAAGCATGG       c.1260
 Q  K  L  T  S  H  Q  S  Q  N  L  Q  Q  P  R  G  S  Q  A  W         p.420

          .         .         .         .         .         .       g.35430
 GTCCTGAGCTGCTCACCCTCCAGCCAGGGCCAGCACAAGCACAAGTACCACTTCCAAAAG       c.1320
 V  L  S  C  S  P  S  S  Q  G  Q  H  K  H  K  Y  H  F  Q  K         p.440

          .         .         .         .         .         .       g.35490
 ACCTTCACAGTATCTCAGGCAGGAAACTGCCGGATCATGGCATACTGTGATGCTCTGAGC       c.1380
 T  F  T  V  S  Q  A  G  N  C  R  I  M  A  Y  C  D  A  L  S         p.460

          .         .         .         .       | 09 .         .    g.39222
 TGCCTGGTGATATCACAGCCTTCTCCTCAGGCCTCTTTTCTTCCAG | GCTTTGGTGTTAAG    c.1440
 C  L  V  I  S  Q  P  S  P  Q  A  S  F  L  P  G |   F  G  V  K      p.480

          .         .         .         .         .         .       g.39282
 ATGTTGAGTACTGCCAACATGAAGAGCAGTCAGTACATTCCGATGCATGGCAAACAGATC       c.1500
 M  L  S  T  A  N  M  K  S  S  Q  Y  I  P  M  H  G  K  Q  I         p.500

          .         .         .         .         .         .       g.39342
 CGTGGACTGGCGTTTAGCAGTTACCTCAGAGGCTTGCTACTCTCTGCTTCCCTAGACAAC       c.1560
 R  G  L  A  F  S  S  Y  L  R  G  L  L  L  S  A  S  L  D  N         p.520

          .        | 10.         .         .         .         .    g.40967
 ACTATTAAACTGACCAG | CCTGGAGACAAATACCGTGGTCCAGACTTATAATGCTGGACGT    c.1620
 T  I  K  L  T  S  |  L  E  T  N  T  V  V  Q  T  Y  N  A  G  R      p.540

          .         .         .         .         .         .       g.41027
 CCTGTCTGGAGCTGTTGCTGGTGTCTTGATGAGGCTAACTACATCTATGCTGGACTGGCC       c.1680
 P  V  W  S  C  C  W  C  L  D  E  A  N  Y  I  Y  A  G  L  A         p.560

          .         .         .         .         .         .       g.41087
 AATGGTTCAATTCTGGTATATGACGTGCGAAACACGAGCAGTCATGTGCAGGAGTTAGTA       c.1740
 N  G  S  I  L  V  Y  D  V  R  N  T  S  S  H  V  Q  E  L  V         p.580

          .     | 11   .         .         .         .         .    g.43261
 GCTCAGAAAGCCAG | ATGCCCACTGGTCTCCCTGTCATACATGCCCAGAGCTGCCTCAGCT    c.1800
 A  Q  K  A  R  |  C  P  L  V  S  L  S  Y  M  P  R  A  A  S  A      p.600

          .         .         .         .         .         .       g.43321
 GCATTTCCATATGGTGGGGTGCTGGCTGGAACCTTGGAGGATGCTTCATTCTGGGAACAG       c.1860
 A  F  P  Y  G  G  V  L  A  G  T  L  E  D  A  S  F  W  E  Q         p.620

          .         .         .         .         .         .       g.43381
 AAAATGGACTTTTCTCATTGGCCTCATGTGCTGCCCTTGGAGCCAGGGGGCTGCATAGAC       c.1920
 K  M  D  F  S  H  W  P  H  V  L  P  L  E  P  G  G  C  I  D         p.640

          .         .         .         .          | 12        .    g.45338
 TTTCAGACAGAGAACAGCTCCCGGCACTGTCTTGTGACCTACAGGCCTG | ATAAAAATCAC    c.1980
 F  Q  T  E  N  S  S  R  H  C  L  V  T  Y  R  P  D |   K  N  H      p.660

          .         .         .         .         .         .       g.45398
 ACCACCATACGAAGTGTGCTGATGGAAATGTCCTACCGACTGGATGACACTGGAAATCCA       c.2040
 T  T  I  R  S  V  L  M  E  M  S  Y  R  L  D  D  T  G  N  P         p.680

          .         .         .         .         .         .       g.45458
 ATCTGCTCCTGCCAGCCTGTACATACATTTTTTGGAGGACCTACTTGCAAACTATTGACC       c.2100
 I  C  S  C  Q  P  V  H  T  F  F  G  G  P  T  C  K  L  L  T         p.700

          .         .         .         .         .         .       g.45518
 AAAAATGCCATTTTCCAAAGCCCAGAGAATGATGGCAACATCCTGGTGTGTACTGGGGAT       c.2160
 K  N  A  I  F  Q  S  P  E  N  D  G  N  I  L  V  C  T  G  D         p.720

          .         .  | 13      .         .         .         .    g.47849
 GAAGCAGCAAATTCTGCCCTG | CTGTGGGATGCTGCCAGTGGCTCGTTGCTCCAGGACCTA    c.2220
 E  A  A  N  S  A  L   | L  W  D  A  A  S  G  S  L  L  Q  D  L      p.740

          .         .         .         .         .         .       g.47909
 CAGACCGATCAGCCTGTGTTGGACATCTGCCCATTTGAGGTGAACCGTAACAGCTACTTG       c.2280
 Q  T  D  Q  P  V  L  D  I  C  P  F  E  V  N  R  N  S  Y  L         p.760

          .         .         .         .                           g.47954
 GCTACCTTAACAGAGAAGATGGTCCACATCTATAAGTGGGAGTGA                      c.2325
 A  T  L  T  E  K  M  V  H  I  Y  K  W  E  X                        p.774

          .         .         .         .         .         .       g.48014
 ctgtggtctcgaaaccttgaaggcatgctgctggttagatgttgtttgctagcgcctagc       c.*60

          .         .         .         .         .         .       g.48074
 agccccaagcaagatccctgtttattgtctgcagtctagaacattgggaatcatggtttg       c.*120

          .         .         .         .         .         .       g.48134
 tttgcattagtatgattctaggaccctaggtcactgagacactacagattgtgtatctgt       c.*180

          .         .         .         .         .         .       g.48194
 tatgtccactaaaagagtaattgatgggtactttatctacattatccatttcttgggttt       c.*240

          .         .         .         .         .         .       g.48254
 aaagccttcattaaccattattgtatgttggaaattcttattttctttattttctgtgtg       c.*300

          .         .         .         .         .         .       g.48314
 actttctggaccttagagagtgtcctctcatcatctaggatgtgagtgggcatcaagcat       c.*360

          .         .         .         .         .         .       g.48374
 tttctggggaatatgacatcccatctgagttgtcctgtcacttaagtatccttgaaggga       c.*420

          .         .         .         .         .         .       g.48434
 ctaaccatcgtcttggtactgatttgatgcaacgtagatgtaaaagagtattattcagtt       c.*480

          .         .         .         .         .         .       g.48494
 gaacacaagagggcactgtagaaccttgtgtccggtttatttctgaccttgaaggctgac       c.*540

          .         .         .         .         .         .       g.48554
 aatcttttagtaacttgtctcatctccacacaagtgtgtgatagcacacctgggtgtgct       c.*600

          .         .         .         .         .         .       g.48614
 ttgtggcaataacacttgtgttccaggtgtgaagtgctgggacattggcaggcccagtga       c.*660

          .         .         .         .         .         .       g.48674
 tggaagcagctagtgaacgattccctttgctaatgcctagtgcattaagttcattgcttt       c.*720

          .         .         .         .         .         .       g.48734
 gcgaaaggtaaggaaagaggccagttgtttgagcggtggggaagattttgttttttctag       c.*780

          .         .         .         .         .         .       g.48794
 ccagcttaggatctcaggattggttttatccaagctagtgctttgaagaacactatctct       c.*840

          .         .         .         .         .         .       g.48854
 tgccaggaaaagatgagtgataggtcaaagcttttacttgagtctcccctagtgtcagag       c.*900

          .         .         .         .         .         .       g.48914
 atcaggagaaaagacataagagaatttacaaaagctattcagactgctattgaaaacatg       c.*960

          .         .         .         .         .         .       g.48974
 agaagaacttgtctcccattttgagagttcctatctaaataaagccaattcctcagactg       c.*1020

          .         .         .         .         .         .       g.49034
 aggggctgttcttaagtgttctttatacattccagttatccagttaaagccttccccatg       c.*1080

          .         .         .         .         .         .       g.49094
 tgaagctgatgtttgattccagtttcctttgatttgcctccctaaccttttctagggctc       c.*1140

          .         .         .         .         .         .       g.49154
 agtttgtatttctttgccttgcctcagactactttgccaacccacttccacaacagaata       c.*1200

          .         .         .         .         .         .       g.49214
 tgcttcaagatgtgggcaggtcagtgtcctgttcatgggagaaaatggcttaacagtctg       c.*1260

          .         .         .         .         .         .       g.49274
 attttctcaaatgattattgaagagttgttatcgtttttattataaaacacttctgacct       c.*1320

          .         .         .         .         .         .       g.49334
 gtcaattcaagagctgtttctaggatctttctctccggcaaggggttgttgcactagatt       c.*1380

          .         .         .         .         .         .       g.49394
 tccccagagttccaagttctagttgtgccttttaatgaccctttaatattttaggacata       c.*1440

          .         .         .         .         .         .       g.49454
 attttttccttttttaaatttttttgtagaaatagatgtttcactacgttgtccaggctg       c.*1500

          .         .         .         .         .         .       g.49514
 gtcttggactcctggcctcaagcaatcctcccacctcagcctcctaaagtgccaaaatta       c.*1560

          .         .         .         .         .         .       g.49574
 taggcgtgagccactgcacccggcccctatttgaagacgtcttttgtaaaagctagcttc       c.*1620

          .         .         .         .         .         .       g.49634
 tagaacctgagaaaagctcttttctcagaggagatactccttttgatatgttaatgatta       c.*1680

          .         .         .         .         .         .       g.49694
 agagtggttgcccaggcctagtttcagtggcagaataggattggaattaaaaagcagaac       c.*1740

          .         .         .         .         .         .       g.49754
 tcatctggcttcagcagattgccaccaagaggatacaggtggtcaggtcctggctggctt       c.*1800

          .         .         .         .         .         .       g.49814
 tgtctttgggcctgggcaggcttaggatttgactttctttgaagtacctgatgctgattg       c.*1860

          .         .         .         .         .         .       g.49874
 attccactaatagtaggaagcaagagacttaactatgagggacgttatgtgaatcttaag       c.*1920

          .         .         .         .         .         .       g.49934
 tcttaccagtccttgcattagtacattaaatttggatgttttggaagcaaattcatacga       c.*1980

          .         .         .         .         .         .       g.49994
 tcgtgagtgatttctccaaagaaaaaaagccttgtccagcctgaccaacatggtgaaacc       c.*2040

          .         .         .         .         .         .       g.50054
 ccatctctactaaaaatacaaaaattaactgggtgcagtggtgcgcatgcctgtagtccc       c.*2100

          .         .         .         .         .         .       g.50114
 agctacttgggaggctgaggcaggagaattgcttgaaccctgggaggcagaggttgcagt       c.*2160

          .         .         .         .         .         .       g.50174
 gagtcgagatcgcgccactgcactccagcctcggtgacagagcaagactccatctcaaaa       c.*2220

          .         .         .         .         .         .       g.50234
 aaaacaaacaaacaaaaaaaaaccctgatgccattcccagtccccgttgtaggacatcac       c.*2280

          .         .         .         .         .         .       g.50294
 atttataaatccaggctttagtcttctgggctccaccagtctctgccccaccatattcct       c.*2340

          .         .         .         .         .         .       g.50354
 ttgtcactacctctaagtttttttccccacttgaggatttggagttaaacgaactcaaaa       c.*2400

          .         .         .         .         .         .       g.50414
 tgtcttgtcattgtatgtattcttgcccctgctttgaaaacagggccatgggaactctgt       c.*2460

          .         .         .         .         .         .       g.50474
 ttatgccctgttttaatgtttctgttttatgttttactgttaatatgaaaataaagaatt       c.*2520

                                                                    g.50483
 tgctatgta                                                          c.*2529

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Ring finger and WD repeat domain 3 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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