regulatory factor X, 6 (RFX6) - coding DNA reference sequence

(used for variant description)

(last modified November 19, 2015)


This file was created to facilitate the description of sequence variants on transcript NM_173560.3 in the RFX6 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_027699.1, covering RFX6 transcript NM_173560.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                                    g.5003
                                                          ggc       c.-61

 .         .         .         .         .         .                g.5063
 tggggctccgctggggaaccggccgagcggcgcgcgcggaggtgtccggcggccaggagg       c.-1

          .         .         .         .         .         .       g.5123
 ATGGCCAAGGTCCCGGAGCTGGAAGACACCTTCCTGCAGGCGCAGCCTGCGCCCCAACTG       c.60
 M  A  K  V  P  E  L  E  D  T  F  L  Q  A  Q  P  A  P  Q  L         p.20

          .         .         .         .         .         .       g.5183
 TCCCCGGGGATCCAGGAAGACTGCTGTGTGCAGCTCCTGGGCAAGGGCTTGCTAGTCTAT       c.120
 S  P  G  I  Q  E  D  C  C  V  Q  L  L  G  K  G  L  L  V  Y         p.40

          .         .         .         .         .         .       g.5243
 CCGGAAGAAACAGTGTACCTGGCGGCCGAAGGGCAGCCCGGGGGCGAGCAGGGCGGCGGG       c.180
 P  E  E  T  V  Y  L  A  A  E  G  Q  P  G  G  E  Q  G  G  G         p.60

          .         .         .         .    | 02    .         .    g.5600
 GAGAAAGGCGAAGACCCGGAGCTGCCGGGGGCAGTGAAATCAG | AAATGCACTTAAACAAT    c.240
 E  K  G  E  D  P  E  L  P  G  A  V  K  S  E |   M  H  L  N  N      p.80

          .         .         .         .         .         .       g.5660
 GGTAACTTTTCCTCTGAAGAAGAGGACGCCGACAACCACGACAGCAAAACCAAAGCAGCG       c.300
 G  N  F  S  S  E  E  E  D  A  D  N  H  D  S  K  T  K  A  A         p.100

          .         .         .         .         .         .       g.5720
 GATCAATACCTGTCTCAGAAGAAAACCATCACGCAGATTGTGAAGGATAAAAAGAAGCAG       c.360
 D  Q  Y  L  S  Q  K  K  T  I  T  Q  I  V  K  D  K  K  K  Q         p.120

          .         . | 03       .         .         .         .    g.8371
 ACACAGCTCACGCTGCAGTG | GCTTGAAGAGAATTACATTGTATGTGAAGGAGTTTGCTTA    c.420
 T  Q  L  T  L  Q  W  |  L  E  E  N  Y  I  V  C  E  G  V  C  L      p.140

          .         .         .         .         .         .       g.8431
 CCACGGTGCATTCTTTATGCACACTACTTAGATTTCTGTAGGAAAGAGAAATTAGAGCCA       c.480
 P  R  C  I  L  Y  A  H  Y  L  D  F  C  R  K  E  K  L  E  P         p.160

          .         .     | 04   .         .         .         .    g.10190
 GCCTGTGCGGCCACCTTTGGAAAG | ACAATTCGCCAGAAGTTTCCCCTCCTAACAACAAGG    c.540
 A  C  A  A  T  F  G  K   | T  I  R  Q  K  F  P  L  L  T  T  R      p.180

          .         .       | 05 .         .         .         .    g.21808
 CGGCTTGGAACAAGAGGCCATTCAAA | GTATCATTACTATGGGATTGGCATCAAAGAGAGC    c.600
 R  L  G  T  R  G  H  S  K  |  Y  H  Y  Y  G  I  G  I  K  E  S      p.200

          .         .         .         .     | 06   .         .    g.22983
 AGTGCATATTACCACTCCGTTTATTCTGGAAAGGGCTTGACAAG | GTTTTCTGGAAGCAAG    c.660
 S  A  Y  Y  H  S  V  Y  S  G  K  G  L  T  R  |  F  S  G  S  K      p.220

          .   | 07     .         .         .         .         .    g.38770
 CTAAAGAATGAG | GGTGGCTTCACTCGTAAATATTCGCTTAGCTCAAAAACTGGAACACTT    c.720
 L  K  N  E   | G  G  F  T  R  K  Y  S  L  S  S  K  T  G  T  L      p.240

          .         .         .         .         .         .       g.38830
 CTTCCAGAATTCCCCAGCGCTCAACACCTTGTATACCAAGGATGCATTTCTAAGGACAAG       c.780
 L  P  E  F  P  S  A  Q  H  L  V  Y  Q  G  C  I  S  K  D  K         p.260

  | 08       .         .         .         .         .         .    g.43855
  | GTTGATACGCTCATAATGATGTACAAAACTCACTGCCAGTGTATCCTGGACAATGCAATT    c.840
  | V  D  T  L  I  M  M  Y  K  T  H  C  Q  C  I  L  D  N  A  I      p.280

          .         | 09         .         .         .         .    g.44030
 AATGGAAACTTTGAAGAG | ATCCAGCATTTTTTATTACACTTTTGGCAAGGAATGCCTGAC    c.900
 N  G  N  F  E  E   | I  Q  H  F  L  L  H  F  W  Q  G  M  P  D      p.300

          .         .         .         .         .         .       g.44090
 CATCTCCTTCCCCTGCTCGAAAATCCTGTTATCATTGATATTTTCTGTGTTTGTGACTCA       c.960
 H  L  L  P  L  L  E  N  P  V  I  I  D  I  F  C  V  C  D  S         p.320

          .   | 10     .         .         .         .         .    g.45872
 ATTCTTTATAAG | GTTCTTACAGATGTACTCATTCCTGCAACAATGCAAGAAATGCCTGAA    c.1020
 I  L  Y  K   | V  L  T  D  V  L  I  P  A  T  M  Q  E  M  P  E      p.340

    | 11     .         .         .         .         .         .    g.46982
 AG | CTTATTAGCAGACATAAGAAATTTTGCTAAAAATTGGGAACAGTGGGTTGTTTCATCC    c.1080
 S  |  L  L  A  D  I  R  N  F  A  K  N  W  E  Q  W  V  V  S  S      p.360

          .         .         .         .         .         .       g.47042
 TTGGAAAACTTGCCAGAAGCTCTAACTGACAAGAAAATACCTATTGTGCGAAGATTTGTA       c.1140
 L  E  N  L  P  E  A  L  T  D  K  K  I  P  I  V  R  R  F  V         p.380

          .         .         .         .   | 12     .         .    g.48115
 TCTTCTCTGAAACGACAAACATCTTTCTTACATCTTGCCCAG | ATTGCCAGACCAGCTCTC    c.1200
 S  S  L  K  R  Q  T  S  F  L  H  L  A  Q   | I  A  R  P  A  L      p.400

          .         .         .         .         .         .       g.48175
 TTTGACCAGCATGTCGTTAATTCTATGGTGTCTGATATTGAAAGGGTTGATTTGAACAGC       c.1260
 F  D  Q  H  V  V  N  S  M  V  S  D  I  E  R  V  D  L  N  S         p.420

          .         .         .         .         .         .       g.48235
 ATTGGCTCTCAAGCCCTTCTTACCATTTCAGGCAGCACAGACACTGAATCTGGTATCTAC       c.1320
 I  G  S  Q  A  L  L  T  I  S  G  S  T  D  T  E  S  G  I  Y         p.440

         | 13.         .         .         .         .         .    g.49882
 ACTGAAC | ATGACTCTATCACTGTGTTCCAAGAACTGAAGGATCTCCTTAAGAAGAATGCC    c.1380
 T  E  H |   D  S  I  T  V  F  Q  E  L  K  D  L  L  K  K  N  A      p.460

          .         .         .         .         .        | 14.    g.50897
 ACTGTGGAGGCTTTTATTGAATGGTTGGATACTGTGGTAGAACAGAGAGTTATTAAG | ACC    c.1440
 T  V  E  A  F  I  E  W  L  D  T  V  V  E  Q  R  V  I  K   | T      p.480

          .         .         .         .         .         .       g.50957
 AGCAAACAAAATGGAAGGTCATTAAAGAAGAGAGCTCAAGACTTTCTGTTAAAGTGGAGT       c.1500
 S  K  Q  N  G  R  S  L  K  K  R  A  Q  D  F  L  L  K  W  S         p.500

          .         .         .         .         .      | 15  .    g.52461
 TTTTTTGGTGCTCGAGTAATGCATAATCTCACCTTGAACAATGCATCCAGTTTTG | GTTCT    c.1560
 F  F  G  A  R  V  M  H  N  L  T  L  N  N  A  S  S  F  G |   S      p.520

          .         .         .         .         .         .       g.52521
 TTTCATTTGATTCGAATGCTTCTCGATGAATACATTCTCCTGGCCATGGAGACCCAGTTT       c.1620
 F  H  L  I  R  M  L  L  D  E  Y  I  L  L  A  M  E  T  Q  F         p.540

          .         .         .         .         .         | 16    g.53242
 AATAATGACAAAGAGCAGGAGTTACAGAATTTATTGGACAAGTATATGAAGAATTCAG | AT    c.1680
 N  N  D  K  E  Q  E  L  Q  N  L  L  D  K  Y  M  K  N  S  D |       p.560

          .         .         .         .         .         .       g.53302
 GCGAGTAAAGCTGCTTTCACTGCTTCTCCGAGTTCATGCTTTCTGGCCAACCGTAATAAA       c.1740
 A  S  K  A  A  F  T  A  S  P  S  S  C  F  L  A  N  R  N  K         p.580

          .         .         .         .         .         .       g.53362
 GGGAGCATGGTTTCCAGCGACGCTGTGAAGAATGAAAGCCACGTGGAGACAACCTATCTC       c.1800
 G  S  M  V  S  S  D  A  V  K  N  E  S  H  V  E  T  T  Y  L         p.600

          .         .         .         .         .         .       g.53422
 CCTCTGCCATCCAGTCAACCTGGAGGCCTAGGCCCTGCTCTGCACCAGTTCCCTGCTGGG       c.1860
 P  L  P  S  S  Q  P  G  G  L  G  P  A  L  H  Q  F  P  A  G         p.620

          .         .      | 17  .         .         .         .    g.54849
 AACACAGACAACATGCCGCTCACAG | GTCAAATGGAGCTTTCACAGATTGCTGGTCATCTG    c.1920
 N  T  D  N  M  P  L  T  G |   Q  M  E  L  S  Q  I  A  G  H  L      p.640

          .         .         .         .         .         .       g.54909
 ATGACACCACCCATTTCTCCAGCCATGGCAAGCCGAGGAAGTGTCATTAACCAAGGACCA       c.1980
 M  T  P  P  I  S  P  A  M  A  S  R  G  S  V  I  N  Q  G  P         p.660

          .         .         .         .         .         .       g.54969
 ATGGCAGGGAGGCCCCCAAGTGTGGGCCCAGTACTGTCAGCTCCATCACACTGCTCCACA       c.2040
 M  A  G  R  P  P  S  V  G  P  V  L  S  A  P  S  H  C  S  T         p.680

          .         .         .         .         .         .       g.55029
 TACCCAGAGCCCATTTATCCCACTCTCCCTCAAGCCAATCATGACTTTTATAGCACCAGC       c.2100
 Y  P  E  P  I  Y  P  T  L  P  Q  A  N  H  D  F  Y  S  T  S         p.700

          .         .         .         .         .         .       g.55089
 TCTAACTACCAGACTGTGTTTAGGGCACAGCCCCACTCCACATCAGGACTCTATCCTCAT       c.2160
 S  N  Y  Q  T  V  F  R  A  Q  P  H  S  T  S  G  L  Y  P  H         p.720

          .         .         .         .         .         .       g.55149
 CACACCGAGCATGGTCGATGCATGGCTTGGACTGAACAGCAGCTTTCAAGAGACTTCTTC       c.2220
 H  T  E  H  G  R  C  M  A  W  T  E  Q  Q  L  S  R  D  F  F         p.740

          .         .         .         .         .         .       g.55209
 AGTGGCAGCTGTGCGGGGTCTCCATATAACTCCCGGCCACCGTCTAGCTATGGCCCATCC       c.2280
 S  G  S  C  A  G  S  P  Y  N  S  R  P  P  S  S  Y  G  P  S         p.760

          .         .         .         .         .         .       g.55269
 CTGCAAGCCCAGGATTCACACAATATGCAGTTTTTAAATACAGGAAGCTTCAATTTCTTG       c.2340
 L  Q  A  Q  D  S  H  N  M  Q  F  L  N  T  G  S  F  N  F  L         p.780

          .         .         .         .         .         | 18    g.56548
 AGCAACACAGGAGCTGCCAGCTGCCAAGGAGCAACACTGCCTCCTAATTCACCAAATG | GA    c.2400
 S  N  T  G  A  A  S  C  Q  G  A  T  L  P  P  N  S  P  N  G |       p.800

          .         .         .         .         .         .       g.56608
 TACTATGGAAGCAACATAAACTACCCAGAGTCTCACAGGCTCGGATCAATGGTGAATCAG       c.2460
 Y  Y  G  S  N  I  N  Y  P  E  S  H  R  L  G  S  M  V  N  Q         p.820

          .         .         .         .         .         .       g.56668
 CACGTTTCTGTCATCAGCAGCATTCGTTCACTGCCCCCCTACAGTGACATCCACGATCCA       c.2520
 H  V  S  V  I  S  S  I  R  S  L  P  P  Y  S  D  I  H  D  P         p.840

          .         .         .         .         .         .       g.56728
 CTTAACATTTTAGATGACAGTGGTAGAAAACAGACCAGCTCGTTTTACACAGACACATCA       c.2580
 L  N  I  L  D  D  S  G  R  K  Q  T  S  S  F  Y  T  D  T  S         p.860

          .         .         .  | 19      .         .         .    g.59147
 TCTCCAGTTGCATGTCGAACTCCAGTCCTAG | CTTCCAGTTTGCAAACCCCAATTCCTTCT    c.2640
 S  P  V  A  C  R  T  P  V  L  A |   S  S  L  Q  T  P  I  P  S      p.880

          .         .         .         .         .         .       g.59207
 TCCTCATCCCAATGTATGTATGGAACTTCCAACCAGTATCCAGCTCAAGAAACCCTGGAC       c.2700
 S  S  S  Q  C  M  Y  G  T  S  N  Q  Y  P  A  Q  E  T  L  D         p.900

          .         .         .         .         .         .       g.59267
 TCCCATGGAACAAGCAGTAGAGAAATGGTGTCCTCTTTACCACCTATCAACACTGTGTTC       c.2760
 S  H  G  T  S  S  R  E  M  V  S  S  L  P  P  I  N  T  V  F         p.920

          .         .                                               g.59294
 ATGGGAACAGCAGCTGGAGGCACTTAA                                        c.2787
 M  G  T  A  A  G  G  T  X                                          p.928

          .         .         .         .         .         .       g.59354
 accaccaatgtgggagggggtgctaaaactttaaaaaaaatctctactgtgcaaatatca       c.*60

          .         .         .         .         .         .       g.59414
 ttattcactcagacttccataagagtaaataaaaatgaatatgcagtggctgacattgtt       c.*120

          .         .         .         .         .         .       g.59474
 ttaaagtcactggtactatggacaactccatagtgaatggagatacttgcagagcttgtc       c.*180

          .         .         .         .         .         .       g.59534
 atgcacactaagagtttaaaatgtgagctcattattaatcatagtttcaaaattatcaaa       c.*240

          .         .         .         .         .         .       g.59594
 taaaaccagtgaagatctgaagatgcaaacatttcaactatgaagatttacatttcactt       c.*300

          .         .         .         .         .         .       g.59654
 tctaatttattaaacatctgtgtgcctttttatctttggtttcttttaaaaagtatattt       c.*360

          .         .         .         .         .         .       g.59714
 aatgcctttacaatacctttaatttattaggatctcagaatcattgtttactatccctta       c.*420

          .         .         .         .         .         .       g.59774
 tttgacaaaaagtcaaatgtgtatgttctacctccaacggaaatgtttacaaggtcaaga       c.*480

          .         .         .         .         .         .       g.59834
 cttaattcaattcagacaagaccaaagttgcttgacttcaattcctgtgcattagtgtga       c.*540

          .         .         .         .         .         .       g.59894
 tgatttctgtcacatagcagcattccgattctatgtaactgaatggagatgataagtgct       c.*600

          .         .         .         .         .                 g.59951
 ttcccctctttatttaaaaaagattaaaaggaataaaagaaataatgtatggaaata          c.*657

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Regulatory factor X, 6 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

Powered by LOVD v.3.0 Build 14
©2004-2015 Leiden University Medical Center