RAD50 interactor 1 (RINT1) - coding DNA reference sequence

(used for variant description)

(last modified March 3, 2019)


This file was created to facilitate the description of sequence variants on transcript NM_021930.4 in the RINT1 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_051951.1, covering RINT1 transcript NM_021930.4.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
           .         .         .         .         .                g.5051
          ggccgttccgacctccggtcaggagggggaggaacagagcacggccggcgg       c.-181

 .         .         .         .         .         .                g.5111
 ctgcacgggcagggcctctctgggctgagaggaagaaaccagtgagacatcgagaggaag       c.-121

 .         .         .         .         .         .                g.5171
 tcgctgtggcactcagtcctacggcctccgaggctgggtagtgagtgtgtcgctggcctt       c.-61

 .         .         .         .         .         .                g.5231
 agccagactccacaggccacgctggctgcgaatggagccgaggactcgcgcggaggcgag       c.-1

          .         .         .         .   | 02     .         .    g.5757
 ATGCTACCAGCCGGCGAGATCGGCGCCTCTCCTGCAGCCCCG | TGCTGCTCTGAAAGTGGT    c.60
 M  L  P  A  G  E  I  G  A  S  P  A  A  P   | C  C  S  E  S  G      p.20

          .         .         | 03         .         .         .    g.9512
 GACGAAAGGAAGAACCTCGAGGAGAAAA | GTGACATAAATGTTACAGTTCTTATTGGAAGT    c.120
 D  E  R  K  N  L  E  E  K  S |   D  I  N  V  T  V  L  I  G  S      p.40

          .         .         .         .         .         .       g.9572
 AAACAAGTCAGTGAAGGTACAGATAATGGTGATCTCCCTTCTTATGTGTCTGCATTCATA       c.180
 K  Q  V  S  E  G  T  D  N  G  D  L  P  S  Y  V  S  A  F  I         p.60

          .         .         .         .         .         .       g.9632
 GAAAAGGAAGTTGGAAATGACCTTAAATCTTTAAAGAAACTTGATAAACTCATAGAACAG       c.240
 E  K  E  V  G  N  D  L  K  S  L  K  K  L  D  K  L  I  E  Q         p.80

          .         .         .    | 04    .         .         .    g.15350
 AGGACAGTAAGTAAAATGCAGTTAGAAGAACAG | GTACTTACAATTTCATCAGAAATTCCT    c.300
 R  T  V  S  K  M  Q  L  E  E  Q   | V  L  T  I  S  S  E  I  P      p.100

          .         .         .         .         .         .       g.15410
 AAAAGAATTCGAAGTGCCTTAAAAAATGCAGAAGAATCAAAGCAATTTCTTAATCAGTTT       c.360
 K  R  I  R  S  A  L  K  N  A  E  E  S  K  Q  F  L  N  Q  F         p.120

          .         .         .         .         .         .       g.15470
 CTGGAGCAGGAAACTCATCTCTTCAGCGCCATTAACAGCCATTTGCTGACTGCGCAACCT       c.420
 L  E  Q  E  T  H  L  F  S  A  I  N  S  H  L  L  T  A  Q  P         p.140

          .         .         .         .         .         .       g.15530
 TGGATGGACGATCTTGGAACCATGATTAGCCAGATTGAAGAGATCGAACGTCATCTTGCT       c.480
 W  M  D  D  L  G  T  M  I  S  Q  I  E  E  I  E  R  H  L  A         p.160

          .         .         .      | 05  .         .         .    g.19850
 TACCTTAAATGGATTTCACAAATTGAAGAACTAAG | TGATAACATTCAGCAATATCTGATG    c.540
 Y  L  K  W  I  S  Q  I  E  E  L  S  |  D  N  I  Q  Q  Y  L  M      p.180

          .         .         .         .         .         .       g.19910
 ACCAATAATGTACCGGAGGCAGCCTCCACTCTAGTGTCTATGGCAGAACTTGACATTAAA       c.600
 T  N  N  V  P  E  A  A  S  T  L  V  S  M  A  E  L  D  I  K         p.200

          .         .         .         .         .         .       g.19970
 CTTCAGGAATCATCTTGTACTCATCTTCTTGGTTTCATGAGAGCCACAGTTAAATTCTGG       c.660
 L  Q  E  S  S  C  T  H  L  L  G  F  M  R  A  T  V  K  F  W         p.220

          .         .          | 06        .         .         .    g.20130
 CATAAAATTCTCAAGGACAAGCTTACAAG | TGATTTTGAGGAAATTTTAGCACAGCTTCAT    c.720
 H  K  I  L  K  D  K  L  T  S  |  D  F  E  E  I  L  A  Q  L  H      p.240

          .         .         .         .         .         .       g.20190
 TGGCCATTCATCGCACCCCCTCAATCACAAACTGTTGGCTTAAGTCGACCTGCCAGTGCC       c.780
 W  P  F  I  A  P  P  Q  S  Q  T  V  G  L  S  R  P  A  S  A         p.260

          .         .         .         .         .          | 07    g.21470
 CCGGAGATATACAGTTACCTGGAGACACTGTTTTGTCAGCTTTTGAAACTACAAACCTC | A    c.840
 P  E  I  Y  S  Y  L  E  T  L  F  C  Q  L  L  K  L  Q  T  S  |      p.280

          .         .         .         .         .         .       g.21530
 GATGAATTACTTACTGAGCCAAAGCAACTCCCAGAAAAATACTCTCTTCCTGCCTCCCCT       c.900
 D  E  L  L  T  E  P  K  Q  L  P  E  K  Y  S  L  P  A  S  P         p.300

          .         .         .         .         .         .       g.21590
 TCTGTCATCCTGCCCATCCAGGTTATGCTGACTCCTCTTCAGAAGAGGTTCAGGTATCAC       c.960
 S  V  I  L  P  I  Q  V  M  L  T  P  L  Q  K  R  F  R  Y  H         p.320

          .         .         .       | 08 .         .         .    g.22994
 TTCAGAGGGAACCGGCAGACTAATGTGTTAAGCAAG | CCAGAATGGTACTTGGCTCAAGTA    c.1020
 F  R  G  N  R  Q  T  N  V  L  S  K   | P  E  W  Y  L  A  Q  V      p.340

          .         .         .         .         .         .       g.23054
 CTTATGTGGATTGGAAACCATACTGAATTTCTGGATGAGAAGATTCAGCCAATATTAGAC       c.1080
 L  M  W  I  G  N  H  T  E  F  L  D  E  K  I  Q  P  I  L  D         p.360

          .         .        | 09.         .         .         .    g.23209
 AAAGTAGGCTCTTTGGTAAACGCAAGG | CTTGAATTTTCTCGGGGCCTTATGATGCTGGTT    c.1140
 K  V  G  S  L  V  N  A  R   | L  E  F  S  R  G  L  M  M  L  V      p.380

          .         .         .         .         .         .       g.23269
 CTTGAGAAGTTAGCCACTGATATTCCTTGTCTGCTATATGATGACAATCTCTTCTGTCAT       c.1200
 L  E  K  L  A  T  D  I  P  C  L  L  Y  D  D  N  L  F  C  H         p.400

          .         .         .         .         .         .       g.23329
 TTGGTGGATGAAGTACTCTTGTTTGAAAGGGAGCTACACAGTGTTCATGGCTATCCTGGC       c.1260
 L  V  D  E  V  L  L  F  E  R  E  L  H  S  V  H  G  Y  P  G         p.420

          .         .         .         .         .         .       g.23389
 ACTTTTGCTAGTTGTATGCATATTCTATCAGAGGAAACCTGTTTTCAGAGATGGTTGACG       c.1320
 T  F  A  S  C  M  H  I  L  S  E  E  T  C  F  Q  R  W  L  T         p.440

          .    | 10    .         .         .         .         .    g.24532
 GTGGAGAGAAAAT | TTGCTCTTCAAAAAATGGACTCAATGCTTTCCTCAGAAGCTGCCTGG    c.1380
 V  E  R  K  F |   A  L  Q  K  M  D  S  M  L  S  S  E  A  A  W      p.460

          .         .         .         .         .         .       g.24592
 GTATCGCAATATAAGGATATCACTGACGTGGATGAAATGAAAGTTCCAGATTGTGCAGAA       c.1440
 V  S  Q  Y  K  D  I  T  D  V  D  E  M  K  V  P  D  C  A  E         p.480

          .         .         .  | 11      .         .         .    g.27972
 ACTTTTATGACTCTACTCTTGGTTATAACTG | ACAGGTATAAAAATCTTCCCACAGCTTCC    c.1500
 T  F  M  T  L  L  L  V  I  T  D |   R  Y  K  N  L  P  T  A  S      p.500

          .         .         .         .         .         .       g.28032
 CGAAAGCTTCAGTTCCTGGAGTTACAGAAGGACTTAGTAGATGATTTTAGGATACGATTA       c.1560
 R  K  L  Q  F  L  E  L  Q  K  D  L  V  D  D  F  R  I  R  L         p.520

          .         .         .         .         .         .       g.28092
 ACACAAGTGATGAAAGAAGAGACTAGAGCTTCCCTTGGCTTTCGATACTGTGCAATTCTT       c.1620
 T  Q  V  M  K  E  E  T  R  A  S  L  G  F  R  Y  C  A  I  L         p.540

          .         .         .         .         .  | 12      .    g.36657
 AATGCTGTGAACTACATCTCAACAGTACTAGCAGATTGGGCTGACAATGTT | TTCTTTCTA    c.1680
 N  A  V  N  Y  I  S  T  V  L  A  D  W  A  D  N  V   | F  F  L      p.560

          .         .         .         .         .         .       g.36717
 CAACTTCAACAGGCTGCACTGGAGGTGTTTGCAGAGAATAATACTCTGAGTAAATTGCAG       c.1740
 Q  L  Q  Q  A  A  L  E  V  F  A  E  N  N  T  L  S  K  L  Q         p.580

          .         .         .         .         .         .       g.36777
 CTAGGACAGCTAGCCTCTATGGAGAGCTCTGTCTTTGATGACATGATTAACCTCTTAGAA       c.1800
 L  G  Q  L  A  S  M  E  S  S  V  F  D  D  M  I  N  L  L  E         p.600

          .         .         .         .         .         .       g.36837
 CGTTTAAAGCATGATATGTTGACCCGTCAAGTAGACCACGTTTTTAGAGAAGTTAAAGAT       c.1860
 R  L  K  H  D  M  L  T  R  Q  V  D  H  V  F  R  E  V  K  D         p.620

          .         .       | 13 .         .         .         .    g.38226
 GCTGCAAAATTGTATAAAAAAGAAAG | ATGGTTGTCCTTGCCATCTCAGTCAGAGCAGGCA    c.1920
 A  A  K  L  Y  K  K  E  R  |  W  L  S  L  P  S  Q  S  E  Q  A      p.640

          .         .         .         .         .         .       g.38286
 GTGATGTCCCTGTCCAGTTCGGCTTGCCCGTTGCTGCTGACGTTACGAGACCATTTACTT       c.1980
 V  M  S  L  S  S  S  A  C  P  L  L  L  T  L  R  D  H  L  L         p.660

          .         .         .         .         .         .       g.38346
 CAGTTGGAGCAGCAGCTTTGTTTCTCCTTATTTAAAATTTTCTGGCAAATGCTTGTAGAG       c.2040
 Q  L  E  Q  Q  L  C  F  S  L  F  K  I  F  W  Q  M  L  V  E         p.680

          .         .        | 14.         .         .         .    g.38478
 AAGCTGGATGTATACATCTACCAAGAA | ATAATTCTTGCTAATCACTTCAATGAAGGAGGA    c.2100
 K  L  D  V  Y  I  Y  Q  E   | I  I  L  A  N  H  F  N  E  G  G      p.700

          .         .         .         .         .         .       g.38538
 GCAGCCCAGCTGCAGTTTGATATGACTCGGAATCTTTTCCCTTTGTTTTCTCACTATTGC       c.2160
 A  A  Q  L  Q  F  D  M  T  R  N  L  F  P  L  F  S  H  Y  C         p.720

          .         .       | 15 .         .         .         .    g.40068
 AAGAGACCAGAAAATTATTTTAAACA | TATAAAAGAAGCCTGTATTGTTTTGAATTTGAAC    c.2220
 K  R  P  E  N  Y  F  K  H  |  I  K  E  A  C  I  V  L  N  L  N      p.740

          .         .         .         .         .         .       g.40128
 GTCGGTTCTGCACTACTGCTGAAAGATGTACTGCAGTCAGCTTCAGGGCAGCTTCCTGCC       c.2280
 V  G  S  A  L  L  L  K  D  V  L  Q  S  A  S  G  Q  L  P  A         p.760

          .         .         .         .         .         .       g.40188
 ACAGCAGCATTAAATGAAGTTGGAATTTACAAACTGGCTCAACAAGATGTTGAGATTCTA       c.2340
 T  A  A  L  N  E  V  G  I  Y  K  L  A  Q  Q  D  V  E  I  L         p.780

          .         .         .                                     g.40227
 CTTAATTTGAGGACAAATTGGCCTAATACTGGAAAATAA                            c.2379
 L  N  L  R  T  N  W  P  N  T  G  K  X                              p.792

          .         .         .         .         .         .       g.40287
 tgtctttcagaaaaaggtttctttggtttttgtttctaagaaagaggaagccaattggat       c.*60

          .         .         .         .         .         .       g.40347
 ttcaagttatatgatgaaattctgaattaatgaaactggaaaactttatagaattactta       c.*120

          .         .         .         .         .         .       g.40407
 ttatcttggatttatggtgttattaaaatgctgaccatatttccttcatcctcttgttcc       c.*180

          .         .         .         .         .         .       g.40467
 taaggaaacaaaaacagaaaacgaaacaatgaaaactcaattctatttacaagtataaat       c.*240

          .         .         .         .         .         .       g.40527
 gctgagtatgtctgttgaagacgagcagagatattaaattataaccaactttcaatttcc       c.*300

          .         .         .         .         .         .       g.40587
 tgtgctaattaagggaaattctgttgtggataatcaaacatagccaataaatttttttaa       c.*360

                                                                    g.40593
 aactcc                                                             c.*366

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The RAD50 interactor 1 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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