receptor-interacting serine-threonine kinase 4 (RIPK4) - coding DNA reference sequence

(used for variant description)

(last modified October 15, 2020)


This file was created to facilitate the description of sequence variants on transcript NM_020639.2 in the RIPK4 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_032113.2, covering RIPK4 transcript NM_020639.2.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                     .         .         .         .                g.5048
             gcacctgggcacctgggcagccgccgcggcgctggctagacgtgcgcg       c.-1

          .         .         .         .         .         .       g.5108
 ATGGAGGGCGACGGCGGGACCCCATGGGCCCTGGCGCTGCTGCGCACCTTCGACGCGGGC       c.60
 M  E  G  D  G  G  T  P  W  A  L  A  L  L  R  T  F  D  A  G         p.20

          .         .         .         .         .         .       g.5168
 GAGTTCACGGGCTGGGAGAAGGTGGGCTCGGGCGGCTTCGGGCAGGTGTACAAGGTGCGC       c.120
 E  F  T  G  W  E  K  V  G  S  G  G  F  G  Q  V  Y  K  V  R         p.40

          .         .         .         .         .         .       g.5228
 CATGTCCACTGGAAGACCTGGCTGGCCATCAAGTGCTCGCCCAGCCTGCACGTCGACGAC       c.180
 H  V  H  W  K  T  W  L  A  I  K  C  S  P  S  L  H  V  D  D         p.60

    | 02     .         .         .         .         .         .    g.15331
 AG | GGAGCGCATGGAGCTTTTGGAAGAAGCCAAGAAGATGGAGATGGCCAAGTTTCGCTAC    c.240
 R  |  E  R  M  E  L  L  E  E  A  K  K  M  E  M  A  K  F  R  Y      p.80

          .         .         .         .         .         .       g.15391
 ATCCTGCCTGTGTATGGCATCTGCCGCGAACCTGTCGGCCTGGTCATGGAGTACATGGAG       c.300
 I  L  P  V  Y  G  I  C  R  E  P  V  G  L  V  M  E  Y  M  E         p.100

          .         .         .         .         .         .       g.15451
 ACGGGCTCCCTGGAAAAGCTGCTGGCTTCGGAGCCATTGCCATGGGATCTCCGGTTCCGA       c.360
 T  G  S  L  E  K  L  L  A  S  E  P  L  P  W  D  L  R  F  R         p.120

          .         .         .         .         .         .       g.15511
 ATCATCCACGAGACGGCGGTGGGCATGAACTTCCTGCACTGCATGGCCCCGCCACTCCTG       c.420
 I  I  H  E  T  A  V  G  M  N  F  L  H  C  M  A  P  P  L  L         p.140

          .         .         .         .         .     | 03   .    g.20850
 CACCTGGACCTCAAGCCCGCGAACATCCTGCTGGATGCCCACTACCACGTCAAG | ATTTCT    c.480
 H  L  D  L  K  P  A  N  I  L  L  D  A  H  Y  H  V  K   | I  S      p.160

          .         .         .         .         .         .       g.20910
 GATTTTGGTCTGGCCAAGTGCAACGGGCTGTCCCACTCGCATGACCTCAGCATGGATGGC       c.540
 D  F  G  L  A  K  C  N  G  L  S  H  S  H  D  L  S  M  D  G         p.180

          .         .         .         .         .         .       g.20970
 CTGTTTGGCACAATCGCCTACCTCCCTCCAGAGCGCATCAGGGAGAAGAGCCGGCTCTTC       c.600
 L  F  G  T  I  A  Y  L  P  P  E  R  I  R  E  K  S  R  L  F         p.200

          .         .    | 04    .         .         .         .    g.22923
 GACACCAAGCACGATGTATACAG | CTTTGCGATCGTCATCTGGGGCGTGCTCACACAGAAG    c.660
 D  T  K  H  D  V  Y  S  |  F  A  I  V  I  W  G  V  L  T  Q  K      p.220

          .    | 05    .         .         .         .         .    g.25365
 AAGCCGTTTGCAG | ATGAGAAGAACATCCTGCACATCATGGTGAAGGTGGTGAAGGGCCAC    c.720
 K  P  F  A  D |   E  K  N  I  L  H  I  M  V  K  V  V  K  G  H      p.240

          .         .         .         .         .         .       g.25425
 CGCCCCGAGCTGCCGCCCGTGTGCAGAGCCCGGCCGCGCGCCTGCAGCCACCTGATACGC       c.780
 R  P  E  L  P  P  V  C  R  A  R  P  R  A  C  S  H  L  I  R         p.260

          .         .         .         .         .   | 06     .    g.26235
 CTCATGCAGCGGTGCTGGCAGGGGGATCCGCGAGTTAGGCCCACCTTCCAAG | AAATTACT    c.840
 L  M  Q  R  C  W  Q  G  D  P  R  V  R  P  T  F  Q  E |   I  T      p.280

          .         .         .         .         .         .       g.26295
 TCTGAAACCGAGGACCTGTGTGAAAAGCCTGATGACGAAGTGAAAGAAACTGCTCATGAT       c.900
 S  E  T  E  D  L  C  E  K  P  D  D  E  V  K  E  T  A  H  D         p.300

          .         .         .       | 07 .         .         .    g.27973
 CTGGACGTGAAAAGCCCCCCGGAGCCCAGGAGCGAG | GTGGTGCCTGCGAGGCTCAAGCGG    c.960
 L  D  V  K  S  P  P  E  P  R  S  E   | V  V  P  A  R  L  K  R      p.320

          .         .         .         .         .         .       g.28033
 GCCTCTGCCCCCACCTTCGATAACGACTACAGCCTCTCCGAGCTGCTCTCACAGCTGGAC       c.1020
 A  S  A  P  T  F  D  N  D  Y  S  L  S  E  L  L  S  Q  L  D         p.340

          .         .         .         .         .         .       g.28093
 TCTGGAGTTTCCCAGGCTGTCGAGGGCCCCGAGGAGCTCAGCCGCAGCTCCTCTGAGTCC       c.1080
 S  G  V  S  Q  A  V  E  G  P  E  E  L  S  R  S  S  S  E  S         p.360

          .         .         .         .         .         .       g.28153
 AAGCTGCCATCGTCCGGCAGTGGGAAGAGGCTCTCGGGGGTGTCCTCGGTGGACTCCGCC       c.1140
 K  L  P  S  S  G  S  G  K  R  L  S  G  V  S  S  V  D  S  A         p.380

          .         .         .         .         .      | 08  .    g.30097
 TTCTCTTCCAGAGGATCACTGTCGCTGTCCTTTGAGCGGGAACCTTCAACCAGCG | ATCTG    c.1200
 F  S  S  R  G  S  L  S  L  S  F  E  R  E  P  S  T  S  D |   L      p.400

          .         .         .         .         .         .       g.30157
 GGCACCACAGACGTCCAGAAGAAGAAGCTTGTGGATGCCATCGTGTCCGGGGACACCAGC       c.1260
 G  T  T  D  V  Q  K  K  K  L  V  D  A  I  V  S  G  D  T  S         p.420

          .         .         .         .         .         .       g.30217
 AAACTGATGAAGATCCTGCAGCCGCAGGACGTGGACCTGGCACTGGACAGCGGTGCCAGC       c.1320
 K  L  M  K  I  L  Q  P  Q  D  V  D  L  A  L  D  S  G  A  S         p.440

          .         .         .         .         .         .       g.30277
 CTGCTGCACCTGGCGGTGGAGGCCGGGCAAGAGGAGTGCGCCAAGTGGCTGCTGCTCAAC       c.1380
 L  L  H  L  A  V  E  A  G  Q  E  E  C  A  K  W  L  L  L  N         p.460

          .         .         .         .         .         .       g.30337
 AATGCCAACCCCAACCTGAGCAACCGTAGGGGCTCCACCCCGTTGCACATGGCCGTGGAG       c.1440
 N  A  N  P  N  L  S  N  R  R  G  S  T  P  L  H  M  A  V  E         p.480

          .         .         .         .         .         .       g.30397
 AGGAGGGTGCGGGGTGTCGTGGAGCTCCTGCTGGCGCGGAAGATCAGTGTCAACGCCAAG       c.1500
 R  R  V  R  G  V  V  E  L  L  L  A  R  K  I  S  V  N  A  K         p.500

          .         .         .         .         .         .       g.30457
 GATGAGGACCAGTGGACAGCCCTCCACTTTGCAGCCCAGAACGGGGACGAGTCTAGCACA       c.1560
 D  E  D  Q  W  T  A  L  H  F  A  A  Q  N  G  D  E  S  S  T         p.520

          .         .         .         .         .         .       g.30517
 CGGCTGCTGTTGGAGAAGAACGCCTCGGTCAACGAGGTGGACTTTGAGGGCCGGACGCCC       c.1620
 R  L  L  L  E  K  N  A  S  V  N  E  V  D  F  E  G  R  T  P         p.540

          .         .         .         .         .         .       g.30577
 ATGCACGTGGCCTGCCAGCACGGGCAGGAGAATATCGTGCGCATCCTGCTGCGCCGAGGC       c.1680
 M  H  V  A  C  Q  H  G  Q  E  N  I  V  R  I  L  L  R  R  G         p.560

          .         .         .         .         .         .       g.30637
 GTGGACGTGAGCCTGCAGGGCAAGGATGCCTGGCTGCCACTGCACTACGCTGCCTGGCAG       c.1740
 V  D  V  S  L  Q  G  K  D  A  W  L  P  L  H  Y  A  A  W  Q         p.580

          .         .         .         .         .         .       g.30697
 GGCCACCTGCCCATCGTCAAGCTGCTGGCCAAGCAGCCGGGGGTGAGTGTGAACGCCCAG       c.1800
 G  H  L  P  I  V  K  L  L  A  K  Q  P  G  V  S  V  N  A  Q         p.600

          .         .         .         .         .         .       g.30757
 ACGCTGGATGGGAGGACGCCATTGCACCTGGCCGCACAGCGCGGGCACTACCGCGTGGCC       c.1860
 T  L  D  G  R  T  P  L  H  L  A  A  Q  R  G  H  Y  R  V  A         p.620

          .         .         .         .         .         .       g.30817
 CGCATCCTCATCGACCTGTGCTCCGACGTCAACGTCTGCAGCCTGCTGGCACAGACACCC       c.1920
 R  I  L  I  D  L  C  S  D  V  N  V  C  S  L  L  A  Q  T  P         p.640

          .         .         .         .         .         .       g.30877
 CTGCACGTGGCCGCGGAGACGGGGCACACGAGCACTGCCAGGCTGCTCCTGCATCGGGGC       c.1980
 L  H  V  A  A  E  T  G  H  T  S  T  A  R  L  L  L  H  R  G         p.660

          .         .         .         .         .         .       g.30937
 GCTGGCAAGGAGGCCATGACCTCAGACGGCTACACCGCTCTGCACCTGGCTGCCCGCAAC       c.2040
 A  G  K  E  A  M  T  S  D  G  Y  T  A  L  H  L  A  A  R  N         p.680

          .         .         .         .         .         .       g.30997
 GGACACCTGGCCACTGTCAAGCTGCTTGTCGAGGAGAAGGCCGATGTGCTGGCCCGGGGA       c.2100
 G  H  L  A  T  V  K  L  L  V  E  E  K  A  D  V  L  A  R  G         p.700

          .         .         .         .         .         .       g.31057
 CCCCTGAACCAGACGGCGCTGCACCTGGCTGCCGCCCACGGGCACTCGGAGGTGGTGGAG       c.2160
 P  L  N  Q  T  A  L  H  L  A  A  A  H  G  H  S  E  V  V  E         p.720

          .         .         .         .         .         .       g.31117
 GAGTTGGTCAGCGCCGATGTCATTGACCTGTTCGACGAGCAGGGGCTCAGCGCGCTGCAC       c.2220
 E  L  V  S  A  D  V  I  D  L  F  D  E  Q  G  L  S  A  L  H         p.740

          .         .         .         .         .         .       g.31177
 CTGGCCGCCCAGGGCCGGCACGCACAGACGGTGGAGACTCTGCTCAGGCATGGGGCCCAC       c.2280
 L  A  A  Q  G  R  H  A  Q  T  V  E  T  L  L  R  H  G  A  H         p.760

          .         .         .         .         .         .       g.31237
 ATCAACCTGCAGAGCCTCAAGTTCCAGGGCGGCCATGGCCCCGCCGCCACGCTCCTGCGG       c.2340
 I  N  L  Q  S  L  K  F  Q  G  G  H  G  P  A  A  T  L  L  R         p.780

          .                                                         g.31252
 CGAAGCAAGACCTAG                                                    c.2355
 R  S  K  T  X                                                      p.784

          .         .         .         .         .         .       g.31312
 ctggctgcctgcggagaccgggggtccacgtggggctcttgtcctgtcctgtgttcctcg       c.*60

          .         .         .         .         .         .       g.31372
 tggggatggaacgatcctgcgtggggccctgttgtggcttacctaaatgttaaccaagca       c.*120

          .         .         .         .         .         .       g.31432
 gaggtgacatggtgccatcaggaggcggctgctgctgaccggagtgtcccctccaggtga       c.*180

          .         .         .         .         .         .       g.31492
 agctggctcaggtgcacatgcccgctccatcatcgatctaggcacctgctgtctgaaggg       c.*240

          .         .         .         .         .         .       g.31552
 accgtgggtcagaatcatttcgttgtgctcctaatgggtcgctgaggctggtctctcagt       c.*300

          .         .         .         .         .         .       g.31612
 gatgaagccccaggcgtggaagcatccactctctcctgaggcgagccaccttgggttgct       c.*360

          .         .         .         .         .         .       g.31672
 ggagctcaccagtcttgagggaggtgcaggggaaactgtgttttttatcttcatacatga       c.*420

          .         .         .         .         .         .       g.31732
 cggtgggcagagaggcctgtcttaaagtttccatggaattgttttataaaatatcttaag       c.*480

          .         .         .         .         .         .       g.31792
 agatgaataccttatcagctgttgcttgaaacctgttaaaaatgttcataacattggata       c.*540

          .         .         .         .         .         .       g.31852
 gtctagtctctaaatgatgactaagtagtggggttggctttgaaaacaatgttttatgca       c.*600

          .         .         .         .         .         .       g.31912
 acaaggaacgaatggtagcagccagctttgcggggcgtatgtgtggccagctcttaacca       c.*660

          .         .         .         .         .         .       g.31972
 ttccagtctattacttgggtgagtccttgtggacaaccacacacacgtgcccacatggta       c.*720

          .         .         .         .         .         .       g.32032
 ctagctgccgttcgtttctcgttgcctaagatgttttggcaactctagagccacaggcct       c.*780

          .         .         .         .         .         .       g.32092
 aagtcattaaaaaattctccctttgtaacctcagtgctggggactgaggcgagccccctc       c.*840

          .         .         .         .         .         .       g.32152
 aggtcgctggagtgcaccagtcttggggaagaggtgcaggagaagctgtgttttttatct       c.*900

          .         .         .         .         .         .       g.32212
 ccacacgcagtatgaagataaaattacatagtattacctagacatagacagtattaccta       c.*960

          .         .         .         .         .         .       g.32272
 ggtagatgcactgctcacctgcgcccttcccagctctcatttttgttaggtgatttggga       c.*1020

          .         .         .         .         .         .       g.32332
 tagggatagtgttttggggtatggggggagtgtttctgacctgctttgcagacgtgcctc       c.*1080

          .         .         .         .         .         .       g.32392
 cgcacctcagcagtttggggtgtggccccagggcggttcttggatgtaaaagatgtggcc       c.*1140

          .         .         .         .         .         .       g.32452
 atctagcctcgtaacttcactgtcacctgtgtcccatagggtgccttctgaatactgtta       c.*1200

          .         .         .         .         .         .       g.32512
 ttagaataagtttgttgcagaacgtgaccctgcgtgcaaacatgtaccgtggcctggtat       c.*1260

          .         .         .         .         .         .       g.32572
 atgatagagattgatattaatgtaccatgtatgttaatgtgaatctgtgggcaggatact       c.*1320

          .         .         .         .         .         .       g.32632
 tttccatggcaggaaatatccaagctgttgaaactggctatgttttaatatgcctcattg       c.*1380

          .         .         .         .         .         .       g.32692
 tgcctttactgttgtgtggactgcgtgagggacaagaagttccatttgatgtcaataaag       c.*1440

          .         .                                               g.32721
 caaagtacttgcctacttttttgaagctg                                      c.*1469

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Receptor-interacting serine-threonine kinase 4 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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