ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent) (RNASEL) - coding DNA reference sequence

(used for variant description)

(last modified July 20, 2019)


This file was created to facilitate the description of sequence variants on transcript NM_021133.3 in the RNASEL gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_009024.2, covering RNASEL transcript NM_021133.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                   .                g.2731
                                            agtgacgcagcaggagg       c.-241

 .         .         .         .         .         .                g.2791
 aaactgctcgggctgcaagcagtcttccaggctttgcggctgccaaaggaataattgaga       c.-181

 .         .      | 02  .         .         .         .             g.5047
 cgtctgagttgagcag | gtggaatgtcagaagactgagaacattgttccttcttcatactg    c.-121

 .         .         .         .         .         .                g.5107
 ctgctctgttgccagagaatcccaatttacactcaaagcttctttgattaagtgctagga       c.-61

 .         .         .         .         .         .                g.5167
 gataaatttgcattttctcaaggaaaaggctaaaagtggtagcaggtggcatttaccgtc       c.-1

          .         .         .         .         .         .       g.5227
 ATGGAGAGCAGGGATCATAACAACCCCCAGGAGGGACCCACGTCCTCCAGCGGTAGAAGG       c.60
 M  E  S  R  D  H  N  N  P  Q  E  G  P  T  S  S  S  G  R  R         p.20

          .         .         .         .         .         .       g.5287
 GCTGCAGTGGAAGACAATCACTTGCTGATTAAAGCTGTTCAAAACGAAGATGTTGACCTG       c.120
 A  A  V  E  D  N  H  L  L  I  K  A  V  Q  N  E  D  V  D  L         p.40

          .         .         .         .         .         .       g.5347
 GTCCAGCAATTGCTGGAAGGTGGAGCCAATGTTAATTTCCAGGAAGAGGAAGGGGGCTGG       c.180
 V  Q  Q  L  L  E  G  G  A  N  V  N  F  Q  E  E  E  G  G  W         p.60

          .         .         .         .         .         .       g.5407
 ACACCTCTGCATAACGCAGTACAAATGAGCAGGGAGGACATTGTGGAACTTCTGCTTCGT       c.240
 T  P  L  H  N  A  V  Q  M  S  R  E  D  I  V  E  L  L  L  R         p.80

          .         .         .         .         .         .       g.5467
 CATGGTGCTGACCCTGTTCTGAGGAAGAAGAATGGGGCCACGCCTTTTATCCTCGCAGCG       c.300
 H  G  A  D  P  V  L  R  K  K  N  G  A  T  P  F  I  L  A  A         p.100

          .         .         .         .         .         .       g.5527
 ATTGCGGGGAGCGTGAAGCTGCTGAAACTTTTCCTTTCTAAAGGAGCAGATGTCAATGAG       c.360
 I  A  G  S  V  K  L  L  K  L  F  L  S  K  G  A  D  V  N  E         p.120

          .         .         .         .         .         .       g.5587
 TGTGATTTTTATGGCTTCACAGCCTTCATGGAAGCCGCTGTGTATGGTAAGGTCAAAGCC       c.420
 C  D  F  Y  G  F  T  A  F  M  E  A  A  V  Y  G  K  V  K  A         p.140

          .         .         .         .         .         .       g.5647
 CTAAAATTCCTTTATAAGAGAGGAGCAAATGTGAATTTGAGGCGAAAGACAAAGGAGGAT       c.480
 L  K  F  L  Y  K  R  G  A  N  V  N  L  R  R  K  T  K  E  D         p.160

          .         .         .         .         .         .       g.5707
 CAAGAGCGGCTGAGGAAAGGAGGGGCCACAGCTCTCATGGACGCTGCTGAAAAAGGACAC       c.540
 Q  E  R  L  R  K  G  G  A  T  A  L  M  D  A  A  E  K  G  H         p.180

          .         .         .         .         .         .       g.5767
 GTAGAGGTCTTGAAGATTCTCCTTGATGAGATGGGGGCAGATGTAAACGCCTGTGACAAT       c.600
 V  E  V  L  K  I  L  L  D  E  M  G  A  D  V  N  A  C  D  N         p.200

          .         .         .         .         .         .       g.5827
 ATGGGCAGAAATGCCTTGATCCATGCTCTCCTGAGCTCTGACGATAGTGATGTGGAGGCT       c.660
 M  G  R  N  A  L  I  H  A  L  L  S  S  D  D  S  D  V  E  A         p.220

          .         .         .         .         .         .       g.5887
 ATTACGCATCTGCTGCTGGACCATGGGGCTGATGTCAATGTGAGGGGAGAAAGAGGGAAG       c.720
 I  T  H  L  L  L  D  H  G  A  D  V  N  V  R  G  E  R  G  K         p.240

          .         .         .         .         .         .       g.5947
 ACTCCCCTGATCCTGGCAGTGGAGAAGAAGCACTTGGGTTTGGTGCAGAGGCTTCTGGAG       c.780
 T  P  L  I  L  A  V  E  K  K  H  L  G  L  V  Q  R  L  L  E         p.260

          .         .         .         .         .         .       g.6007
 CAAGAGCACATAGAGATTAATGACACAGACAGTGATGGCAAAACAGCACTGCTGCTTGCT       c.840
 Q  E  H  I  E  I  N  D  T  D  S  D  G  K  T  A  L  L  L  A         p.280

          .         .         .         .         .         .       g.6067
 GTTGAACTCAAACTGAAGAAAATCGCCGAGTTGCTGTGCAAACGTGGAGCCAGTACAGAT       c.900
 V  E  L  K  L  K  K  I  A  E  L  L  C  K  R  G  A  S  T  D         p.300

          .         .         .         .         .         .       g.6127
 TGTGGGGATCTTGTTATGACAGCGAGGCGGAATTATGACCATTCCCTTGTGAAGGTTCTT       c.960
 C  G  D  L  V  M  T  A  R  R  N  Y  D  H  S  L  V  K  V  L         p.320

          .         .         .         .         .         .       g.6187
 CTCTCTCATGGAGCCAAAGAAGATTTTCACCCTCCTGCTGAAGACTGGAAGCCTCAGAGC       c.1020
 L  S  H  G  A  K  E  D  F  H  P  P  A  E  D  W  K  P  Q  S         p.340

          .         .         .         .         .         .       g.6247
 TCACACTGGGGGGCAGCCCTGAAGGATCTCCACAGAATATACCGCCCTATGATTGGCAAA       c.1080
 S  H  W  G  A  A  L  K  D  L  H  R  I  Y  R  P  M  I  G  K         p.360

          .         .         .         .         .         .       g.6307
 CTCAAGTTCTTTATTGATGAAAAATACAAAATTGCTGATACTTCAGAAGGAGGCATCTAC       c.1140
 L  K  F  F  I  D  E  K  Y  K  I  A  D  T  S  E  G  G  I  Y         p.380

          .         .         .         .         .         .       g.6367
 CTGGGGTTCTATGAGAAGCAAGAAGTAGCTGTGAAGACGTTCTGTGAGGGCAGCCCACGT       c.1200
 L  G  F  Y  E  K  Q  E  V  A  V  K  T  F  C  E  G  S  P  R         p.400

          .         .         .         .         .         .       g.6427
 GCACAGCGGGAAGTCTCTTGTCTGCAAAGCAGCCGAGAGAACAGTCACTTGGTGACATTC       c.1260
 A  Q  R  E  V  S  C  L  Q  S  S  R  E  N  S  H  L  V  T  F         p.420

          .         .         .         .         .         .       g.6487
 TATGGGAGTGAGAGCCACAGGGGCCACTTGTTTGTGTGTGTCACCCTCTGTGAGCAGACT       c.1320
 Y  G  S  E  S  H  R  G  H  L  F  V  C  V  T  L  C  E  Q  T         p.440

          .         .         .         .         .         .       g.6547
 CTGGAAGCGTGTTTGGATGTGCACAGAGGGGAAGATGTGGAAAATGAGGAAGATGAATTT       c.1380
 L  E  A  C  L  D  V  H  R  G  E  D  V  E  N  E  E  D  E  F         p.460

          .         .         .         .         .         .       g.6607
 GCCCGAAATGTCCTGTCATCTATATTTAAGGCTGTTCAAGAACTACACTTGTCCTGTGGA       c.1440
 A  R  N  V  L  S  S  I  F  K  A  V  Q  E  L  H  L  S  C  G         p.480

          .         .         .         . | 03       .         .    g.7827
 TACACCCACCAGGATCTGCAACCACAAAACATCTTAATAG | ATTCTAAGAAAGCTGCTCAC    c.1500
 Y  T  H  Q  D  L  Q  P  Q  N  I  L  I  D |   S  K  K  A  A  H      p.500

          .         .         .         .         .         .       g.7887
 CTGGCAGATTTTGATAAGAGCATCAAGTGGGCTGGAGATCCACAGGAAGTCAAGAGAGAT       c.1560
 L  A  D  F  D  K  S  I  K  W  A  G  D  P  Q  E  V  K  R  D         p.520

        | 04 .         .         .         .         .         .    g.9769
 CTAGAG | GACCTTGGACGGCTGGTCCTCTATGTGGTAAAGAAGGGAAGCATCTCATTTGAG    c.1620
 L  E   | D  L  G  R  L  V  L  Y  V  V  K  K  G  S  I  S  F  E      p.540

          .         .         .         .         .         .       g.9829
 GATCTGAAAGCTCAAAGTAATGAAGAGGTGGTTCAACTTTCTCCAGATGAGGAAACTAAG       c.1680
 D  L  K  A  Q  S  N  E  E  V  V  Q  L  S  P  D  E  E  T  K         p.560

          .         .         .         .         .         .       g.9889
 GACCTCATTCATCGTCTCTTCCATCCTGGGGAACATGTGAGGGACTGTCTGAGTGACCTG       c.1740
 D  L  I  H  R  L  F  H  P  G  E  H  V  R  D  C  L  S  D  L         p.580

          .         .         .   | 05     .         .         .    g.10644
 CTGGGTCATCCCTTCTTTTGGACTTGGGAGAG | CCGCTATAGGACGCTTCGGAATGTGGGA    c.1800
 L  G  H  P  F  F  W  T  W  E  S  |  R  Y  R  T  L  R  N  V  G      p.600

          .         .         .         .         .         .       g.10704
 AATGAATCCGACATCAAAACACGAAAATCTGAAAGTGAGATCCTCAGACTACTGCAACCT       c.1860
 N  E  S  D  I  K  T  R  K  S  E  S  E  I  L  R  L  L  Q  P         p.620

          .         .         .         .      | 06  .         .    g.15599
 GGGCCTTCTGAACATTCCAAAAGTTTTGACAAGTGGACGACTAAG | ATTAATGAATGTGTT    c.1920
 G  P  S  E  H  S  K  S  F  D  K  W  T  T  K   | I  N  E  C  V      p.640

          .         .         .         .         .         .       g.15659
 ATGAAAAAAATGAATAAGTTTTATGAAAAAAGAGGCAATTTCTACCAGAACACTGTGGGT       c.1980
 M  K  K  M  N  K  F  Y  E  K  R  G  N  F  Y  Q  N  T  V  G         p.660

          .         .         .         .         .          | 07    g.16396
 GATCTGCTAAAGTTCATCCGGAATTTGGGAGAACACATTGATGAAGAAAAGCATAAAAA | G    c.2040
 D  L  L  K  F  I  R  N  L  G  E  H  I  D  E  E  K  H  K  K  |      p.680

          .         .         .         .         .         .       g.16456
 ATGAAATTAAAAATTGGAGACCCTTCCCTGTATTTTCAGAAGACATTTCCAGATCTGGTG       c.2100
 M  K  L  K  I  G  D  P  S  L  Y  F  Q  K  T  F  P  D  L  V         p.700

          .         .         .         .         .         .       g.16516
 ATCTATGTCTACACAAAACTACAGAACACAGAATATAGAAAGCATTTCCCCCAAACCCAC       c.2160
 I  Y  V  Y  T  K  L  Q  N  T  E  Y  R  K  H  F  P  Q  T  H         p.720

          .         .         .         .         .         .       g.16576
 AGTCCAAACAAGCCTCAGTGTGATGGAGCTGGTGGGGCCAGTGGGTTGGCCAGCCCTGGG       c.2220
 S  P  N  K  P  Q  C  D  G  A  G  G  A  S  G  L  A  S  P  G         p.740

                                                                    g.16582
 TGCTGA                                                             c.2226
 C  X                                                               p.741

          .         .         .         .         .         .       g.16642
 tggactgatttgctggagttcagggaactacttattagctgtagagtccttggcaaatca       c.*60

          .         .         .         .         .         .       g.16702
 caacattctgggccttttaactcaccaggttgcttgtgagggatgagttgcatagctgat       c.*120

          .         .         .         .         .         .       g.16762
 atgtcagtccctggcatcgtgtattccatatgtctataacaaaagcaatatatacccaga       c.*180

          .         .         .         .         .         .       g.16822
 ctacactagtccataagctttacccactaactgggaggacattctgctaagattcctttt       c.*240

          .         .         .         .         .         .       g.16882
 gtcaattgcaccaaaagaatgagtgccttgacccctaatgctgcatatgttacaattctc       c.*300

          .         .         .         .         .         .       g.16942
 tcacttaattttcccaatgatcttgcaaaacagggattatcatccccatttaagaactga       c.*360

          .         .         .         .         .         .       g.17002
 ggaacctgagactcagagagtgtgagctactggcccaagattattcaatttatacctagc       c.*420

          .         .         .         .         .         .       g.17062
 actttataaatttatgtggtgttattggtacctctcatttgggcaccttaaaacttaact       c.*480

          .         .         .         .         .         .       g.17122
 atccttccagggctcttccagatgaggcccaaaacatatataggggttccaggaatctca       c.*540

          .         .         .         .         .         .       g.17182
 ttcattcattcagtatttattgagcatctagtataagtctgggcactggatgcatgaatt       c.*600

          .         .         .         .         .         .       g.17242
 ccactccttccagaaccaactgcattggttttccatgaccttaaggcagtagttctcaac       c.*660

          .         .         .         .         .         .       g.17302
 tggggggcaattttgcactgaagagagcatttggcagagtctgaagaagtttttggtgtc       c.*720

          .         .         .         .         .         .       g.17362
 acagctttgtggggagcatgctatggcatttagtgggtaaagaccagggatgctgccaaa       c.*780

          .         .         .         .         .         .       g.17422
 cctgccttgcacaggacagcccctgcaacaaagaattatccagacaaaaatatcaatggt       c.*840

          .         .         .         .         .         .       g.17482
 gctgaggttgagaaaacctgacttaaggggctgggatgcttttgaactagcttaaggccc       c.*900

          .         .         .         .         .         .       g.17542
 aggactgtggagtgtgtggaccaccccacagaggagggactcagatttatttactcttgc       c.*960

          .         .         .         .         .         .       g.17602
 tggatctgtagtgatggagttccttctggtgtcagccccacaggaggctcccaggcctcc       c.*1020

          .         .         .         .         .         .       g.17662
 ctcacttcccatacccagtctaggagctccttctggctcccaagcacccagagctttcct       c.*1080

          .         .         .         .         .         .       g.17722
 ccgccttttagttttggttcctccactggaatgtaggctcctcacgggcgatggctgtct       c.*1140

          .         .         .         .         .         .       g.17782
 tttcttgactttgtatcttcactgccaagcaaaaagtctgccaagtgggaatgtttaata       c.*1200

          .         .         .         .         .         .       g.17842
 aatattcattgaataatgaatgaaccatcttcgtacatgaataataatactgtcttacgt       c.*1260

          .         .         .         .         .         .       g.17902
 ttttctggtgctttataatgtatacattacatctgagtattttattttatttaattttca       c.*1320

          .         .         .         .         .         .       g.17962
 aaacaatcctttaaggtcaacattgttatccttattttgctgatgaggaaactaaggtta       c.*1380

          .         .         .         .         .         .       g.18022
 gaaacattttgatttcctctaggacgtatagctaggaagtgttactatcttgatttgaac       c.*1440

          .         .         .         .         .         .       g.18082
 aaattttctggtgctaagtctgatgttctttccatgaatcattgtggtggttgagatgga       c.*1500

          .         .         .         .         .         .       g.18142
 gctttgtaatgggaataaaacagtaccttaggttctttctgaaaaggaggtatctagcaa       c.*1560

          .         .         .         .         .         .       g.18202
 tggataaatagataccactgaatgaaattaaatgttgattaggaacaaatttaaggctta       c.*1620

          .         .         .         .         .         .       g.18262
 aaaaatactttatgagcagcaagattgctttaacttttaaaatgaagctttggttctctg       c.*1680

          .         .         .         .         .         .       g.18322
 atttgtaatgagcacctggatatgtcaattaaaatgcccatttgtgaagcttactcaata       c.*1740

          .                                                         g.18340
 aaactttaaattgtctta                                                 c.*1758

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent) protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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