ring finger protein 125, E3 ubiquitin protein ligase (RNF125) - coding DNA reference sequence

(used for variant description)

(last modified December 12, 2014)


This file was created to facilitate the description of sequence variants on transcript NM_017831.3 in the RNF125 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000018.9, covering RNF125 transcript NM_017831.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                         .         .                g.5022
                                       acttctgacagtggggaaagca       c.-361

 .         .         .         .         .         .                g.5082
 gctgtgtgtgatagcttggaaggtttactgctgcctcaagtcctcttctctgcagttgag       c.-301

 .         .         .         .         .         .                g.5142
 gtttcaggtttcaatcctcccaataccacaagacagagcacggggcggctgccgcctccg       c.-241

 .         .         .         .         .         .                g.5202
 cctccgcgccttaacctaggcggcttgccgaagatctcagccccgcggccgcgcgctcgc       c.-181

 .         .         .         .         .         .                g.5262
 cctgccctagaccagggttgggcgcagcggcggaggtggcttctgggctgcgcgagctgg       c.-121

 .         .         .         .         .         .                g.5322
 gagagctgggaggcggcgatcgcagctgggccgggacttccttcctccaccgcacggcaa       c.-61

 .         .         .         .         .         .                g.5382
 caaaacaaccctgcggcaggcactgagtgcttcgcagctgtctgggcgagaggcacagcg       c.-1

          .         .         .         .         .         .       g.5442
 ATGGGCTCCGTGCTGAGCACCGACAGCGGCAAATCGGCGCCCGCCTCTGCCACCGCGCGG       c.60
 M  G  S  V  L  S  T  D  S  G  K  S  A  P  A  S  A  T  A  R         p.20

          .         .         .         .         .         .       g.5502
 GCCCTGGAGCGCAGGAGGGACCCGGAGTTGCCCGTCACGTCCTTCGACTGCGCCGTGTGC       c.120
 A  L  E  R  R  R  D  P  E  L  P  V  T  S  F  D  C  A  V  C         p.40

          .         .         .         .     | 02   .         .    g.23650
 CTTGAGGTGTTACACCAGCCTGTCCGGACCCGCTGTGGCCACGT | ATTCTGCCGTTCCTGT    c.180
 L  E  V  L  H  Q  P  V  R  T  R  C  G  H  V  |  F  C  R  S  C      p.60

          .         .         .         .         .         .       g.23710
 ATTGCTACCAGTCTAAAGAACAACAAGTGGACCTGTCCTTATTGCCGGGCATATCTTCCT       c.240
 I  A  T  S  L  K  N  N  K  W  T  C  P  Y  C  R  A  Y  L  P         p.80

          .         .         .         .         .         .       g.23770
 TCAGAAGGAGTTCCAGCAACTGATGTAGCCAAAAGAATGAAATCAGAGTATAAGAACTGC       c.300
 S  E  G  V  P  A  T  D  V  A  K  R  M  K  S  E  Y  K  N  C         p.100

          .         | 03         .         .         .         .    g.28739
 GCTGAGTGTGACACCCTG | GTTTGCCTCAGTGAAATGAGGGCACATATTCGGACTTGTCAG    c.360
 A  E  C  D  T  L   | V  C  L  S  E  M  R  A  H  I  R  T  C  Q      p.120

          .         .         .         .         .    | 04    .    g.32167
 AAGTACATAGATAAGTATGGACCACTACAAGAACTTGAGGAGACAGCAGCAAG | GTGTGTA    c.420
 K  Y  I  D  K  Y  G  P  L  Q  E  L  E  E  T  A  A  R  |  C  V      p.140

          .         .         .         .         .         .       g.32227
 TGTCCCTTTTGTCAGAGGGAACTGTATGAAGACAGCTTGCTGGATCATTGTATTACTCAT       c.480
 C  P  F  C  Q  R  E  L  Y  E  D  S  L  L  D  H  C  I  T  H         p.160

          .         .     | 05   .         .         .         .    g.52456
 CACAGATCGGAACGGAGGCCTGTG | TTCTGTCCACTTTGCCGTTTAATACCCGATGAGAAT    c.540
 H  R  S  E  R  R  P  V   | F  C  P  L  C  R  L  I  P  D  E  N      p.180

          .         .         .         .         .         .       g.52516
 CCAAGCAGCTTCAGTGGCAGTTTAATAAGACATCTGCAAGTTAGTCACACTTTGTTTTAT       c.600
 P  S  S  F  S  G  S  L  I  R  H  L  Q  V  S  H  T  L  F  Y         p.200

          .   | 06     .         .         .         .         .    g.54864
 GATGATTTCATA | GATTTTAATATAATTGAGGAAGCTCTTATCCGAAGAGTCTTAGACCGG    c.660
 D  D  F  I   | D  F  N  I  I  E  E  A  L  I  R  R  V  L  D  R      p.220

          .         .         .                                     g.54903
 TCACTTCTTGAATATGTGAATCACTCGAACACCACATAA                            c.699
 S  L  L  E  Y  V  N  H  S  N  T  T  X                              p.232

          .         .         .         .         .         .       g.54963
 ttttattaaaacgaagggaaaagggaccactgaattgcaccatttaagatgctgcttgaa       c.*60

          .         .         .         .         .         .       g.55023
 caaatgggagggaagttgtcaatgattgatgggcaaaaatgtacaacacagttatgtgtt       c.*120

          .         .         .         .         .         .       g.55083
 tgtccatgtttattgttatagtgcatttaaaaactgctttaattttaatggtttaaatct       c.*180

          .         .         .         .         .         .       g.55143
 gttttacatccttgagattcttacacatctaacaacaaaaaaaattatctacatcagtca       c.*240

          .         .         .         .         .         .       g.55203
 ttgttacatggaaaagacaggtggtaggcaagtaggtggaggatctcggtttgcaaatta       c.*300

          .         .         .         .         .         .       g.55263
 gataatactctgtgtataatgctacatatcaataactaccatcatggttaggcacgataa       c.*360

          .         .         .         .         .         .       g.55323
 ctaatctttgttctgtgtaaaaaaatatggagagtgaaacaaagtgcagacattcaaaga       c.*420

          .         .         .         .         .         .       g.55383
 aataagaaatctgctccaatgctcttgttctaatctctaataggttaacgttaataatct       c.*480

          .         .         .         .         .         .       g.55443
 tgtatgggagttggaaaggaaaattttggaagtcaagaaagtccatttaggccggacgcg       c.*540

          .         .         .         .         .         .       g.55503
 gtggcttacgcttgtaatcccagcactttgggaggctgaagcaggcggatcacaaggtca       c.*600

          .         .         .         .         .         .       g.55563
 ggagttcgagaccagcctggccaacactggtctctgtgaaactccgtctctactaaaaat       c.*660

          .         .         .         .         .         .       g.55623
 acaaaaattagctggacgtgttggcgggcatctgtaataccagctacttgggaggctgag       c.*720

          .         .         .         .         .         .       g.55683
 gcagaagaatcacttgaacccgggaggcagaggttacagtgagctgagatcgcaccagta       c.*780

          .         .         .         .         .         .       g.55743
 cactccagcctgggtaacagagctagactccatctcaaaaaaaaaaaaaaaaaaaatcca       c.*840

          .         .         .         .         .         .       g.55803
 tttaaccaaattgtcttacataatactgtaacaaaacaaattttgtgttagaaaagtata       c.*900

          .         .         .         .         .         .       g.55863
 cttaattctttgactttttataactgcatacataagaattcaatatttttcaaatattta       c.*960

          .         .         .         .         .         .       g.55923
 tagcttatttagaaatatttctataatataagcaatttcttaaaaaccatcagatgatac       c.*1020

          .         .         .         .         .         .       g.55983
 ttacagtataagtattcacatccagactttttagtagaaaaccctaagggctttgatatc       c.*1080

          .         .         .         .         .         .       g.56043
 ttttttgattgtaacattttaaaaattatgaaataaaagtactgaaaaccagacacaaaa       c.*1140

          .         .         .         .         .         .       g.56103
 tttatagctgaatgccttattataaggaaatactcttttaggactcagccagtcacccca       c.*1200

          .         .         .         .         .         .       g.56163
 cgtgtcctttttgtgtcctgtcacaattacaaccccacaaaagtaactgctagactgatt       c.*1260

          .         .         .         .         .         .       g.56223
 taaatggtaatcactttgttgcatttgattactgctgccacacctaaatgcatatatcta       c.*1320

          .         .         .         .         .         .       g.56283
 tattttaatattatcaatttaaagttgttattaaatgtatattttattttacatctcttt       c.*1380

          .         .         .         .         .         .       g.56343
 tttaatctagaagttcctccttctttccagttccttaaaatttacctggtgaagaacctg       c.*1440

          .         .         .         .         .         .       g.56403
 atcctaggacctatagagtttcccatactttgtattttgctgattgcacactcatggcac       c.*1500

          .         .         .         .         .         .       g.56463
 ggttcagcacattgccctgtcctctcgatattagcacacagtgcaggttcaggcacattg       c.*1560

          .         .         .         .         .         .       g.56523
 aatttgagaagacttaggttcagtcctttggcaagactgtaaatcacggtgtctttcttt       c.*1620

          .         .         .         .         .         .       g.56583
 ccttcctccttcttctctctctctctctctctctctttccttttctttctctttttttca       c.*1680

          .         .         .         .         .         .       g.56643
 gagttgcactctgttgcccaggctggagtacagtggcacgatctcgactcactgcaacct       c.*1740

          .         .         .         .         .         .       g.56703
 ccatctcccgggttcaagcagttctcctgtttcagcctcccaagtagctgggactacagg       c.*1800

          .         .         .         .         .         .       g.56763
 tgcacgccaccatgcccggctaatttttgtatttttagtagaggggtttcaccataatgg       c.*1860

          .         .         .         .         .         .       g.56823
 tcaggctggtcttgaactcctgaactcaagtgatccaccagccttggcctcccaaaatgc       c.*1920

          .         .         .         .         .         .       g.56883
 tgggattacaggcatgagccaccatgcccagctaatttttgtatttttagtagagacagg       c.*1980

          .         .         .         .         .         .       g.56943
 gtttcaccataatagccaggctggtctcaaactccttaccttgtgatccgcccacctcag       c.*2040

          .         .         .         .         .         .       g.57003
 ccttccaaagtgctgggattataggcgtgagccactgtgcccggcctacagggtttttat       c.*2100

          .         .         .         .         .         .       g.57063
 ctaacctttctgttacaactgtacctctccttctgtactgaaagtcctggttttcaagaa       c.*2160

          .         .         .         .         .         .       g.57123
 cacagggcacgatagaattagaacatcccacaattactcatttcttttatttatcttaca       c.*2220

          .         .         .         .         .         .       g.57183
 cttacagctgtctcagaataacaatagaaatacaaccacaaataatatggcaattgaaac       c.*2280

          .         .         .         .         .         .       g.57243
 aattaaaaagttttcatttgcttttctcattctttcccaatttttttttttttttgagat       c.*2340

          .         .         .         .         .         .       g.57303
 ggagtctcgcgctcttgttgcccaggctggagtgcaatggcacgatctcggctcactgca       c.*2400

          .         .         .         .         .         .       g.57363
 acctctgcctcctggattcaagcaattctcctgcctcagcttcccgagtagctgggatta       c.*2460

          .         .         .         .         .         .       g.57423
 taggcatgcgccaccacgccctgctaattttgtatttttagtagagtcaggatttctcca       c.*2520

          .         .         .         .         .         .       g.57483
 cattggtcaggctggcctcaaactctcgacctcaggtgatccgcctgcctcggcctccca       c.*2580

          .         .         .         .         .         .       g.57543
 aagtgctgggattacaggtgtgagccactgcgcccgacatcccaatttttaaaatagtta       c.*2640

          .         .         .         .         .         .       g.57603
 tactatgtcaacattttcagaacatactggtatagcatactgtactttcttccttttatc       c.*2700

          .         .         .         .         .         .       g.57663
 ccccatttattcttagttcttcaactatatatttaacacttgcccccagttttgttttgt       c.*2760

          .         .         .         .         .         .       g.57723
 tttgttttgaggaggaatcttgctctgttgcccaggctggagtgcagtggtgtgatcttg       c.*2820

          .         .         .         .         .         .       g.57783
 gctcactgcaacctccgcctcccgggttcaagtgattctcctgcctcagcctctcgagta       c.*2880

          .         .         .         .         .         .       g.57843
 gctgggattacaagtgggcaccaccacacccggctaattgttgtatttttagtagagatg       c.*2940

          .         .         .         .         .         .       g.57903
 ggttttgccatgttggccaggctggttttgaactcctgacctcaagtgatccacctgtgt       c.*3000

          .         .         .         .         .         .       g.57963
 tggcctcctaaagtactgggattacaggtgtgtgccaccgcgccaggcaattgcccccag       c.*3060

          .         .         .         .         .         .       g.58023
 tttttatttgatggctctgactgtttctcatatctgactctttaattatgaatccagggc       c.*3120

          .         .         .         .         .         .       g.58083
 atagattagtatctccatcttgtaaggatgcaaagaagccatgaaaataagtaatatcaa       c.*3180

          .         .         .         .         .         .       g.58143
 ctcctgaggataaaacgttacttgactagagttagctttttaattgtaatcatttataaa       c.*3240

          .         .         .         .         .         .       g.58203
 cttctttgttccttacatataagcatagtcataaccatggtacccaaaattttctataag       c.*3300

          .         .         .         .         .         .       g.58263
 ttattgtaactccttaaaggtcttgctacagttcttttatccagtacaaataattgggaa       c.*3360

          .         .         .         .         .         .       g.58323
 aatgtaaagctgaatgaaatctagtgagcctcatatcctcccttttagatattgatttta       c.*3420

          .         .         .         .         .         .       g.58383
 agtttgcttttcacagctgctaaaaagtaacaactgatttttagttccacaacctctctt       c.*3480

          .         .         .         .         .         .       g.58443
 tcttcaatttagatggatcatacaataaagcaaaatctggctggttacagtggctcacac       c.*3540

          .         .         .         .         .         .       g.58503
 ctataatcccagcactttgggaggctgaggtggagggtctcatgagcccaggagttcaag       c.*3600

          .         .         .         .         .         .       g.58563
 accaacctgggcaatatagtgagactctttctatttaaacaaaaacaaaaacaaacaaac       c.*3660

          .         .         .         .         .         .       g.58623
 aaacaaacaaaaagctgggcatgatgcacacctttagtttcagctactaaggaggctgag       c.*3720

          .         .         .         .         .         .       g.58683
 gttggaggatcacttgagcctaggaggtcaacactgcagtgagctatgatcatgctactg       c.*3780

          .         .         .         .         .         .       g.58743
 ccctccagcctgggcaacagagcaagaccctgtctccaaaaacataaataattaaatata       c.*3840

          .         .         .         .         .         .       g.58803
 aataaaaataaagcaaaatctgttgggaaacgagaaaaaggagaggaatttttcaggaat       c.*3900

          .         .         .         .         .         .       g.58863
 aatcataaaaagaaatgatcatcagactgaaagtccagagcctgagaaatgaaaacatat       c.*3960

          .         .         .         .         .         .       g.58923
 ttttaagcattggtgttgaccatgcagacaaacttttgttaattcagagcgatacaaaag       c.*4020

          .         .         .         .         .         .       g.58983
 gcactttgaatctataaaacttgaaaaagttaaaaattgtatgtcggataaagctttaag       c.*4080

          .         .         .         .         .         .       g.59043
 tcatctgtcactattaacctcagtgcagcaattctgactcctgtgcctggattcctttta       c.*4140

          .         .         .         .         .         .       g.59103
 tgataattttgccacctacaggacagattaggtgctggtcgcctgaattattttgtgttc       c.*4200

          .         .         .         .         .         .       g.59163
 tgaattattttgagctctaaaatggtaaagtacaaatactcattgttttactgtgccttt       c.*4260

          .         .         .         .         .         .       g.59223
 ggccttttataaaaaggtatttataattcgttgataaaaaccaatatttgaagctgttga       c.*4320

          .         .         .         .         .         .       g.59283
 ttaccaacaaaaaagtttcactctctttatagtgcttcaggatacaactttttcagggcc       c.*4380

          .         .         .         .         .         .       g.59343
 ttattagagaaaaactgattcacatgttattcttctaaagctaaattattaaaatgtagg       c.*4440

          .         .         .         .         .         .       g.59403
 ttgaaagattggattgattgtgaatctacactaaagatatggttccaggcagacctcctt       c.*4500

          .         .         .         .         .         .       g.59463
 agagacctccaggcagacctccttactgtcttcagtgatgtttaatttcattactgttac       c.*4560

          .         .         .         .         .         .       g.59523
 tgggtgccaagtgtctttcatttggaagtgaacttactccagttattgaatgtttatcat       c.*4620

          .         .         .         .         .         .       g.59583
 atcataatttgcatttttccaacattgaaggtattttaaaaagtcactaagagattcatt       c.*4680

          .         .         .         .         .         .       g.59643
 cttttattattcaactacaaaaaaatagtgtaatgatcagaatttaaaatgtgtgattct       c.*4740

          .         .         .         .         .         .       g.59703
 ttttcttctgtaagtatgtattgctatgataaataaaaaatggcaggaccattgttttta       c.*4800

                                                                    g.59710
 ttaaaat                                                            c.*4807

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Ring finger protein 125, E3 ubiquitin protein ligase protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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