ring finger protein 216 (RNF216) - coding DNA reference sequence

(used for variant description)

(last modified January 17, 2023)


This file was created to facilitate the description of sequence variants on transcript NM_207111.3 in the RNF216 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000007.13, covering RNF216 transcript NM_207111.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                   .                g.5019
                                          agtgcctctatggttcttc       c.-241

 .         .         .         .         .         .                g.5079
 ctgtccttagtcgggagggggcgctgtgcgcaggcgcgaggtgacgccgcggcagggccg       c.-181

 .         .         .         .         .         .                g.5139
 gaaggagtgcagcggctgccacggagctcgcagctgcggcttctgaggagtaagcggcgc       c.-121

 .         .         .         .         .         . | 02           g.25601
 ggtagcgaaggccgccgaacctgcctggctagccggcgacttgagtgacga | ttcttttga    c.-61

 .         .         .         .         .         .                g.25661
 aacagatggtcaccatgtttagatattagcagtcccatatatgcatgtctgcatttgaaa       c.-1

          .         .         .         .         .         .       g.25721
 ATGGAAGAGGGAAACAACAATGAAGAGGTAATTCACTTGAACAACTTTCACTGCCATCGG       c.60
 M  E  E  G  N  N  N  E  E  V  I  H  L  N  N  F  H  C  H  R         p.20

         | 03.         .         .         .         .         .    g.33804
 GGACAAG | AGTGGATCAATCTCCGAGATGGGCCCATCACCATATCTGACTCCTCAGATGAG    c.120
 G  Q  E |   W  I  N  L  R  D  G  P  I  T  I  S  D  S  S  D  E      p.40

          .         .         .         .         .         .       g.33864
 GAAAGGATTCCAATGCTGGTCACCCCAGCTCCTCAGCAGCATGAAGAAGAGGACCTGGAT       c.180
 E  R  I  P  M  L  V  T  P  A  P  Q  Q  H  E  E  E  D  L  D         p.60

          .         .  | 04      .         .         .         .    g.44954
 GATGATGTCATCCTGACAGAA | ACAAATAAACCTCAGAGATCACGACCCAATCTCATCAAA    c.240
 D  D  V  I  L  T  E   | T  N  K  P  Q  R  S  R  P  N  L  I  K      p.80

          .         .         .         .         .         .       g.45014
 CCAGCTGCCCAGTGGCAAGATCTGAAAAGGTTGGGAGAAGAAAGGCCTAAAAAGTCTAGA       c.300
 P  A  A  Q  W  Q  D  L  K  R  L  G  E  E  R  P  K  K  S  R         p.100

          .         .         .         .         .         .       g.45074
 GCAGCATTTGAATCAGATAAGAGCAGCTATTTTTCAGTGTGTAACAACCCATTGTTTGAT       c.360
 A  A  F  E  S  D  K  S  S  Y  F  S  V  C  N  N  P  L  F  D         p.120

          .         .         .         .         .         .       g.45134
 TCTGGGGCACAGGATGATTCTGAGGATGACTACGGTGAATTTCTGGATCTTGGGCCTCCT       c.420
 S  G  A  Q  D  D  S  E  D  D  Y  G  E  F  L  D  L  G  P  P         p.140

          .         .         .         .         .         .       g.45194
 GGAATCTCTGAATTCACTAAGCCAAGTGGCCAAACAGAAAGAGAACCCAAGCCTGGACCG       c.480
 G  I  S  E  F  T  K  P  S  G  Q  T  E  R  E  P  K  P  G  P         p.160

          .         .         .         .         .         .       g.45254
 AGTCATAACCAAGCAGCAAATGACATTGTCAACCCCAGATCAGAGCAGAAAGTCATCATC       c.540
 S  H  N  Q  A  A  N  D  I  V  N  P  R  S  E  Q  K  V  I  I         p.180

          .         .         .         .         .         .       g.45314
 TTGGAAGAAGGTAGCCTTCTTTACACAGAAAGCGATCCTTTGGAAACTCAGAACCAGTCA       c.600
 L  E  E  G  S  L  L  Y  T  E  S  D  P  L  E  T  Q  N  Q  S         p.200

          .         .         .         .         .         .       g.45374
 TCCGAAGACTCAGAGACAGAGCTGTTATCAAATCTAGGAGAGTCAGCTGCTCTAGCAGAT       c.660
 S  E  D  S  E  T  E  L  L  S  N  L  G  E  S  A  A  L  A  D         p.220

          .         .         .         .         .         .       g.45434
 GATCAGGCCATCGAAGAAGACTGCTGGTTAGATCATCCTTACTTCCAGTCTCTGAACCAA       c.720
 D  Q  A  I  E  E  D  C  W  L  D  H  P  Y  F  Q  S  L  N  Q         p.240

          .         .         .         .         .         .       g.45494
 CAGCCCCGTGAAATAACAAACCAGGTCGTTCCTCAGGAACGGCAGCCTGAAGCAGAACTG       c.780
 Q  P  R  E  I  T  N  Q  V  V  P  Q  E  R  Q  P  E  A  E  L         p.260

          .         .         .         .         .         .       g.45554
 GGCCGCTTGTTGTTTCAGCATGAATTCCCAGGGCCCGCTTTTCCAAGGCCGGAACCCCAG       c.840
 G  R  L  L  F  Q  H  E  F  P  G  P  A  F  P  R  P  E  P  Q         p.280

          .         .         .         .         .         .       g.45614
 CAAGGTGGGATTTCAGGCCCCTCTTCTCCTCAGCCTGCCCATCCTCTAGGAGAGTTTGAA       c.900
 Q  G  G  I  S  G  P  S  S  P  Q  P  A  H  P  L  G  E  F  E         p.300

          .         .         .         .         .         .       g.45674
 GACCAGCAGTTAGCAAGTGATGATGAAGAGCCAGGTCCAGCCTTTCCAATGCAAGAATCT       c.960
 D  Q  Q  L  A  S  D  D  E  E  P  G  P  A  F  P  M  Q  E  S         p.320

          .         .         .         .         .         .       g.45734
 CAAGAGCCCAATTTGGAAAACATTTGGGGGCAAGAAGCTGCAGAGGTAGATCAAGAGCTC       c.1020
 Q  E  P  N  L  E  N  I  W  G  Q  E  A  A  E  V  D  Q  E  L         p.340

          .         .     | 05   .         .         .         .    g.47414
 GTTGAACTACTAGTGAAAGAAACG | GAAGCAAGATTTCCAGATGTAGCAAATGGGTTTATT    c.1080
 V  E  L  L  V  K  E  T   | E  A  R  F  P  D  V  A  N  G  F  I      p.360

          .         .         .         .  | 06      .         .    g.55932
 GAGGAAATAATTCATTTTAAGAATTATTATGATCTGAATGT | ACTTTGTAATTTTCTTCTG    c.1140
 E  E  I  I  H  F  K  N  Y  Y  D  L  N  V  |  L  C  N  F  L  L      p.380

          .         .         .         .         .         .       g.55992
 GAAAACCCAGATTATCCAAAGAGAGAAGACAGAATCATTATAAATCCCAGTAGCAGTCTG       c.1200
 E  N  P  D  Y  P  K  R  E  D  R  I  I  I  N  P  S  S  S  L         p.400

          .         .     | 07   .         .         .         .    g.57170
 CTGGCCAGCCAAGATGAGACAAAG | TTGCCTAAAATAGACTTTTTTGACTATTCTAAATTG    c.1260
 L  A  S  Q  D  E  T  K   | L  P  K  I  D  F  F  D  Y  S  K  L      p.420

          .         .         .         .         .         .       g.57230
 ACCCCTCTTGACCAGCGCTGCTTCATCCAAGCTGCTGACCTCCTCATGGCCGACTTCAAA       c.1320
 T  P  L  D  Q  R  C  F  I  Q  A  A  D  L  L  M  A  D  F  K         p.440

          .         .         .         .         .         .       g.57290
 GTGCTCAGTAGTCAGGACATCAAGTGGGCCCTGCACGAGCTCAAAGGACACTATGCAATC       c.1380
 V  L  S  S  Q  D  I  K  W  A  L  H  E  L  K  G  H  Y  A  I         p.460

           | 08        .         .         .         .         .    g.61343
 ACCCGAAAG | GCCTTGTCTGATGCCATTAAAAAATGGCAGGAGCTGTCACCAGAAACCAGT    c.1440
 T  R  K   | A  L  S  D  A  I  K  K  W  Q  E  L  S  P  E  T  S      p.480

          .         .         .         .         .         .       g.61403
 GGAAAAAGGAAGAAGAGAAAACAAATGAACCAGTATTCTTACATTGATTTCAAGTTTGAA       c.1500
 G  K  R  K  K  R  K  Q  M  N  Q  Y  S  Y  I  D  F  K  F  E         p.500

      | 09   .         .         .         .         .         .    g.65614
 CAAG | GTGACATAAAAATAGAAAAGAGGATGTTCTTTCTTGAAAATAAGCGACGACATTGT    c.1560
 Q  G |   D  I  K  I  E  K  R  M  F  F  L  E  N  K  R  R  H  C      p.520

          .         .         .         .         .         .       g.65674
 AGGTCCTATGACCGACGTGCTCTCCTTCCAGCTGTGCAACAAGAGCAGGAGTTCTATGAG       c.1620
 R  S  Y  D  R  R  A  L  L  P  A  V  Q  Q  E  Q  E  F  Y  E         p.540

          .         .     | 10   .         .         .         .    g.70000
 CAGAAAATCAAAGAGATGGCAGAG | CATGAAGACTTTTTGCTTGCCCTACAGATGAATGAA    c.1680
 Q  K  I  K  E  M  A  E   | H  E  D  F  L  L  A  L  Q  M  N  E      p.560

          .      | 11  .         .         .         .         .    g.71585
 GAACAGTATCAAAAG | GATGGCCAGCTGATTGAGTGTCGCTGCTGCTATGGGGAATTTCCA    c.1740
 E  Q  Y  Q  K   | D  G  Q  L  I  E  C  R  C  C  Y  G  E  F  P      p.580

          .         .         .         .         .         .       g.71645
 TTCGAGGAGCTGACGCAGTGCGCAGATGCTCACTTGTTCTGCAAAGAGTGTCTCATCAGA       c.1800
 F  E  E  L  T  Q  C  A  D  A  H  L  F  C  K  E  C  L  I  R         p.600

          .         .         .    | 12    .         .         .    g.73894
 TATGCCCAAGAGGCAGTCTTTGGATCTGGAAAG | TTGGAGCTCAGCTGCATGGAAGGCAGC    c.1860
 Y  A  Q  E  A  V  F  G  S  G  K   | L  E  L  S  C  M  E  G  S      p.620

          .         .         .         .         .         .       g.73954
 TGCACGTGTTCGTTCCCAACCAGTGAGCTGGAGAAGGTGCTCCCCCAGACCATCCTGTAT       c.1920
 C  T  C  S  F  P  T  S  E  L  E  K  V  L  P  Q  T  I  L  Y         p.640

          .         .         .         .         .         .       g.74014
 AAGTACTATGAGCGAAAAGCCGAGGAGGAGGTTGCGGCAGCCTACGCCGACGAGCTTGTC       c.1980
 K  Y  Y  E  R  K  A  E  E  E  V  A  A  A  Y  A  D  E  L  V         p.660

    | 13     .         .         .         .         .         .    g.74949
 AG | GTGCCCGTCCTGTAGCTTTCCGGCTCTGTTGGACAGTGATGTGAAGAGGTTCAGCTGT    c.2040
 R  |  C  P  S  C  S  F  P  A  L  L  D  S  D  V  K  R  F  S  C      p.680

          .         .  | 14      .         .         .         .    g.134259
 CCTAATCCTCACTGCCGAAAG | GAAACCTGTAGGAAGTGTCAGGGACTCTGGAAAGAACAT    c.2100
 P  N  P  H  C  R  K   | E  T  C  R  K  C  Q  G  L  W  K  E  H      p.700

          .         .         .         .         .          | 15    g.145355
 AATGGCCTCACCTGTGAAGAGCTGGCTGAAAAAGACGACATCAAGTACCGTACCTCTAT | T    c.2160
 N  G  L  T  C  E  E  L  A  E  K  D  D  I  K  Y  R  T  S  I  |      p.720

          .         .         .         .         .         .       g.145415
 GAAGAAAAAATGACTGCTGCCCGCATTAGAAAATGCCACAAGTGTGGGACTGGCCTCATC       c.2220
 E  E  K  M  T  A  A  R  I  R  K  C  H  K  C  G  T  G  L  I         p.740

          .         .         .         .         .         .       g.145475
 AAATCTGAAGGCTGCAACCGCATGTCTTGCCGCTGTGGTGCCCAGATGTGCTACCTCTGT       c.2280
 K  S  E  G  C  N  R  M  S  C  R  C  G  A  Q  M  C  Y  L  C         p.760

          .         .         .         .         .         .       g.145535
 CGAGTTTCTATTAATGGATATGACCATTTCTGCCAACATCCCCGCTCACCAGGAGCCCCT       c.2340
 R  V  S  I  N  G  Y  D  H  F  C  Q  H  P  R  S  P  G  A  P         p.780

          .         .         .         .   | 16     .         .    g.162623
 TGCCAGGAGTGTTCAAGATGCTCTCTCTGGACCGATCCCACT | GAAGATGATGAGAAGCTT    c.2400
 C  Q  E  C  S  R  C  S  L  W  T  D  P  T   | E  D  D  E  K  L      p.800

          .         .         .         .         .   | 17     .    g.163559
 ATTGAGGAAATCCAGAAGGAGGCTGAAGAGGAACAGAAAAGAAAGAATGGAG | AGAACACC    c.2460
 I  E  E  I  Q  K  E  A  E  E  E  Q  K  R  K  N  G  E |   N  T      p.820

          .         .         .         .         .         .       g.163619
 TTCAAACGCATTGGACCCCCGCTGGAGAAGCCTGTGGAGAAGGTGCAGAGGGTGGAGGCC       c.2520
 F  K  R  I  G  P  P  L  E  K  P  V  E  K  V  Q  R  V  E  A         p.840

          .         .         .         .         .         .       g.163679
 CTCCCGAGGCCCGTTCCGCAGAACCTGCCACAGCCACAGATGCCACCCTATGCCTTCGCG       c.2580
 L  P  R  P  V  P  Q  N  L  P  Q  P  Q  M  P  P  Y  A  F  A         p.860

          .         .         .         .         .         .       g.163739
 CACCCACCCTTCCCCCTGCCTCCCGTGCGGCCTGTGTTCAACAACTTCCCACTCAACATG       c.2640
 H  P  P  F  P  L  P  P  V  R  P  V  F  N  N  F  P  L  N  M         p.880

          .         .         .         .         .         .       g.163799
 GGGCCTATCCCAGCCCCGTACGTGCCCCCTCTGCCCAACGTGCGGGTCAACTATGACTTC       c.2700
 G  P  I  P  A  P  Y  V  P  P  L  P  N  V  R  V  N  Y  D  F         p.900

          .         .         .         .         .         .       g.163859
 GGTCCCATCCACATGCCCCTGGAGCACAACCTGCCCATGCACTTTGGCCCCCAGCCGCGG       c.2760
 G  P  I  H  M  P  L  E  H  N  L  P  M  H  F  G  P  Q  P  R         p.920

          .                                                         g.163871
 CATCGCTTCTGA                                                       c.2772
 H  R  F  X                                                         p.923

          .         .         .         .         .         .       g.163931
 tggccccgaatccccattgagcagcacaaagcccgtttggggtaggagtgtggatggaga       c.*60

          .         .         .         .         .         .       g.163991
 accctcccccaaggctggtgtctgtaccattgcatcctaagtcagcttgaagggtaggct       c.*120

          .         .         .         .         .         .       g.164051
 ggttttcttcccacccctttcctagaagggctactgctcctggaagagtggacggatcca       c.*180

          .         .         .         .         .         .       g.164111
 taataaagacgtcccaaatggtggagttcggagagagctgcgatgtgaactgcccctccc       c.*240

          .         .         .         .         .         .       g.164171
 ctcgcatcccccaggccaccaacggcagtccttctgccttgtccatggcataggccatag       c.*300

          .         .         .         .         .         .       g.164231
 accaggtccctgctgctcacacctgggcctctcctcggagccgacccctgggtagcaagg       c.*360

          .         .         .         .         .         .       g.164291
 cagccgagagcatctccctggaggggcccacggttgggccaagggcagagggggctgcac       c.*420

          .         .         .         .         .         .       g.164351
 ctgcgggcctgggaagcattgctcagggtggggggctgggaccatggcccgcagaggcac       c.*480

          .         .         .         .         .         .       g.164411
 tgccacagctgtgagggccaagatgctgtccccccatccaaaacccgtgcgccactgcag       c.*540

          .         .         .         .         .         .       g.164471
 tgagtgttgagggcacctctcctcccctcttacacctactcagatgaggcagcagcagac       c.*600

          .         .         .         .         .         .       g.164531
 ccatctcgcggcgggggttttgttctgttgccgcctaactttctcatcctcggtctctgg       c.*660

          .         .         .         .         .         .       g.164591
 aaagtcaggctgagaaatcctttcccaggccaggccgctgcggtacactggatggttctg       c.*720

          .         .         .         .         .         .       g.164651
 aagctggcccattgaaagagcctcttaaggcagctgggacagaggcctggtggccctgct       c.*780

          .         .         .         .         .         .       g.164711
 gggcagcccaactgctgggggagacgtttctgccaccctgggtgatgagcagcttttccc       c.*840

          .         .         .         .         .         .       g.164771
 ccctggctttctgggggaggagtgggcctccttagggagacaggtgaccctgggtgccac       c.*900

          .         .         .         .         .         .       g.164831
 ccctgccccgtgtgtgccccgggtgttctcagtggttgctgaaggcaggtagagggtgct       c.*960

          .         .         .         .         .         .       g.164891
 gtccagtatcccccatgtgaaggtcacttcccttctcatggagtcagctgagcatcagct       c.*1020

          .         .         .         .         .         .       g.164951
 cagccctgccatgtccccactcaccctcctcgcctcctgtccggccctgggtttctagcg       c.*1080

          .         .         .         .         .         .       g.165011
 gtgcctgaggcatcactctggcccattgacagatgagaggtctgaagccttcctggccac       c.*1140

          .         .         .         .         .         .       g.165071
 aggcatcactttctcctcctcctcatgccctgccttgtccttgtcgtgttgccatggggt       c.*1200

          .         .         .         .         .         .       g.165131
 tctgagaggctgggagttcacagacctcagacacagctgagtccgacaaccattggggtg       c.*1260

          .         .         .         .         .         .       g.165191
 gggctgcatcagtctccggagtggcccgccacctcctgaagcagggcctggcccacccaa       c.*1320

          .         .         .         .         .         .       g.165251
 ggtgcctggggcaggcgggcaccgtcattcgctgccattggcttctcagatgtatttcaa       c.*1380

          .         .         .         .         .         .       g.165311
 ggactaaagtgggctctaagatctaagatggcccggcgcggtggctcccgcctgtaatcc       c.*1440

          .         .         .         .         .         .       g.165371
 cagcactttgggaggccgaggcgggcggatgagttgaggtcgggagtttgagtccccgtc       c.*1500

          .         .         .         .         .         .       g.165431
 tctactaaaaatacaaaattagccggacaaggtggcgcatgcctataatcccaggtactc       c.*1560

          .         .         .         .         .         .       g.165491
 aggaggctgaggcaggagaatcacttgaacctgggaggcagaggttgcagtgagccaaga       c.*1620

          .         .         .         .         .         .       g.165551
 ttgtgccactgcactccagcctgagcaacaaaagcaaaactctatctttaaaaaaaaaaa       c.*1680

          .         .         .         .         .         .       g.165611
 aaaaaaaactaagatacccattctttctgcctttgcccaggatggaggctttgaagacag       c.*1740

          .         .         .         .         .         .       g.165671
 gtggtcacctggacctggggtaagggtgcgcagggaggccgggcttgggggcagcctgct       c.*1800

          .         .         .         .         .         .       g.165731
 gctatgtccttgctggcgcccatacctgttggactgcctgaactttgctactagcctgaa       c.*1860

          .         .         .         .         .         .       g.165791
 cgacagtgccttggaaaggcaggctccatgcggcagcaacaggattgtcttcggtacctt       c.*1920

          .         .         .         .         .         .       g.165851
 aaatatgctccctgtgcttccccagggaggatctctgggagcagagggcggctgtagaca       c.*1980

          .         .         .         .         .         .       g.165911
 tcacagctgaagaggtgacctcaggccctgggagcctcagctccctctgccctgtaccct       c.*2040

          .         .         .         .         .         .       g.165971
 aggcacgtggctccagcaagagccccaggcaggacaaagggagcaggcagcagctgcaga       c.*2100

          .         .         .         .         .         .       g.166031
 aacagccctagacaggtgctggcctcaaccctggcaggggagggggagcccagagtgatg       c.*2160

          .         .         .         .         .         .       g.166091
 tttctcctaaggccaaaccccaggggtgggtcatttgagaggagttccagctgttctggc       c.*2220

          .         .         .         .         .         .       g.166151
 cacactgggctggtggggaaggagcggcggcctctttccttggagggtccctgattcctg       c.*2280

          .         .         .         .         .         .       g.166211
 aggatcctccccgagccaggcacgggggaccacagggctgccgtgagcacccaccctggt       c.*2340

          .         .         .         .         .         .       g.166271
 tctccaggcccctctgtccagaggcagggcctgaacctcgggctcctgcctggaccagtg       c.*2400

          .         .         .         .         .         .       g.166331
 acagcattggggagagaagcactgggggtcttcagaccagccagcaaggggccgtgccag       c.*2460

          .         .         .         .         .         .       g.166391
 tgcccagagagcaggtcagacaacaggcaaccctgaggcagctggctccctctctctgcc       c.*2520

          .         .         .         .         .         .       g.166451
 ctgcagggcttgccgcagggcgtgaggctccccagccacagccccctcttacttgcctta       c.*2580

          .         .         .         .         .         .       g.166511
 aaactggagagaggaatctagtatttgcacttagcaaaatatttaaaaactgaaaaaaat       c.*2640

          .         .         .         .         .         .       g.166571
 gtgcatgatctgtcactttgtataaaaacaagaaacgattagttcattaaactttttctt       c.*2700

          .         .         .         .         .         .       g.166631
 taccttctggtagtaaaaatagataaaataattccgtttcaactactgtgtgtaaaaagc       c.*2760

          .         .         .         .         .                 g.166690
 ctgtatcatatgtaactgggacttttgtaaataaatgtttgtgcgctctgctccctcca        c.*2819

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Ring finger protein 216 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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