retinal outer segment membrane protein 1 (ROM1) - coding DNA reference sequence

(used for variant description)

(last modified June 16, 2017)


This file was created to facilitate the description of sequence variants on transcript NM_000327.3 in the ROM1 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_009845.1, covering ROM1 transcript NM_000327.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                                    g.5001
                                                            a       c.-541

 .         .         .         .         .         .                g.5061
 caaacaggcgccggacgcggagccgccaggaagcgcgggagggggggcgggcccgagggg       c.-481

 .         .         .         .         .         .                g.5121
 gggccgggccgcttggtaacccctccctgtccgggcctcgccgctcagtacgggggcggg       c.-421

 .         .         .         .         .         .                g.5181
 gctagccggctgaccccctggcctactcccggcctccggctccaggcccttcccggatcc       c.-361

 .         .         .         .         .         .                g.5241
 ccgcccccggattcccaggggacggggaagggagcgcccgccccgatatctccgcccccc       c.-301

 .         .         .         .         .         .                g.5301
 agcccctaacccctcagggttgagcggaccaaccccaccacttccgcgaggggcaggggc       c.-241

 .         .         .         .         .         .                g.5361
 ggggtcacaaaacgggccctcggcctaggggcggagtttctcgtaaggggcaaggccaag       c.-181

 .         .         .         .         .         .                g.5421
 gcatcttgtattggggctgacaggggggcgggttattagggctgaggatgggaggatgct       c.-121

 .         .         .         .         .         .                g.5481
 cagggtattggggtcagggtggcattagcccagctcaagccgggccgggctgactcagca       c.-61

 .         .         .         .         .         .                g.5541
 tcctgccccagccagcttccatccctgacacctctgcactcccttgggcagagatgggag       c.-1

          .         .         .         .         .         .       g.5601
 ATGGCGCCGGTGTTGCCCCTGGTGCTGCCCCTGCAGCCCCGCATCCGCCTGGCACAAGGG       c.60
 M  A  P  V  L  P  L  V  L  P  L  Q  P  R  I  R  L  A  Q  G         p.20

          .         .         .         .         .         .       g.5661
 CTCTGGCTCCTCTCCTGGCTGCTGGCGCTGGCTGGTGGCGTCATCCTCCTCTGTAGTGGG       c.120
 L  W  L  L  S  W  L  L  A  L  A  G  G  V  I  L  L  C  S  G         p.40

          .         .         .         .         .         .       g.5721
 CACCTCCTGGTCCAGCTAAGGCACCTTGGCACCTTCCTGGCTCCCTCCTGTCAGTTCCCT       c.180
 H  L  L  V  Q  L  R  H  L  G  T  F  L  A  P  S  C  Q  F  P         p.60

          .         .         .         .         .         .       g.5781
 GTCCTGCCCCAGGCTGCCCTGGCAGCGGGCGCGGTGGCTCTGGGCACAGGACTAGTGGGT       c.240
 V  L  P  Q  A  A  L  A  A  G  A  V  A  L  G  T  G  L  V  G         p.80

          .         .         .         .         .         .       g.5841
 GTAGGAGCCAGCCGGGCAAGTCTGAATGCAGCTCTATACCCTCCCTGGCGAGGGGTCCTG       c.300
 V  G  A  S  R  A  S  L  N  A  A  L  Y  P  P  W  R  G  V  L         p.100

          .         .         .         .         .         .       g.5901
 GGCCCGCTGCTGGTGGCTGGCACGGCTGGTGGGGGGGGGCTCCTGGTCGTCGCCCTCGGG       c.360
 G  P  L  L  V  A  G  T  A  G  G  G  G  L  L  V  V  A  L  G         p.120

          .         .         .         .         .         .       g.5961
 CTAGCCCTGGCTTTGCCTGGGAGTCTGGATGAGGCGCTGGAGGAGGGCCTGGTGACTGCC       c.420
 L  A  L  A  L  P  G  S  L  D  E  A  L  E  E  G  L  V  T  A         p.140

          .         .         .         .         .         .       g.6021
 TTGGCTCACTACAAGGACACAGAGGTGCCTGGGCACTGTCAGGCCAAAAGGCTGGTGGAT       c.480
 L  A  H  Y  K  D  T  E  V  P  G  H  C  Q  A  K  R  L  V  D         p.160

          .         .         .         .         .         .       g.6081
 GAGCTGCAACTGAGGTACCACTGCTGCGGGCGCCACGGGTACAAGGATTGGTTTGGGGTC       c.540
 E  L  Q  L  R  Y  H  C  C  G  R  H  G  Y  K  D  W  F  G  V         p.180

          .         .         .         .         . | 02       .    g.6527
 CAGTGGGTCAGCAGCCGTTACCTGGATCCCGGTGACCGGGATGTGGCTGA | CCGGATCCAG    c.600
 Q  W  V  S  S  R  Y  L  D  P  G  D  R  D  V  A  D  |  R  I  Q      p.200

          .         .         .         .         .         .       g.6587
 AGCAATGTAGAAGGCCTATACCTGACTGATGGGGTCCCTTTCTCCTGTTGCAACCCCCAC       c.660
 S  N  V  E  G  L  Y  L  T  D  G  V  P  F  S  C  C  N  P  H         p.220

          .         .         .         .         .         .       g.6647
 TCACCCCGGCCTTGCCTGCAAAACCGTCTTTCAGACTCCTACGCCCACCCCCTGTTCGAT       c.720
 S  P  R  P  C  L  Q  N  R  L  S  D  S  Y  A  H  P  L  F  D         p.240

          .         .         .         .         .         .       g.6707
 CCCCGACAACCCAACCAAAACCTCTGGGCCCAAGGGTGCCATGAGGTGCTGCTGGAGCAC       c.780
 P  R  Q  P  N  Q  N  L  W  A  Q  G  C  H  E  V  L  L  E  H         p.260

          .         .         .         .         .        | 03.    g.6883
 TTGCAGGACTTGGCAGGCACACTGGGTAGCATGCTGGCTGTCACCTTCCTACTGCAG | GCT    c.840
 L  Q  D  L  A  G  T  L  G  S  M  L  A  V  T  F  L  L  Q   | A      p.280

          .         .         .         .         .         .       g.6943
 CTGGTGCTCCTTGGCCTGCGGTACCTGCAAACAGCACTGGAGGGGCTTGGAGGGGTCATT       c.900
 L  V  L  L  G  L  R  Y  L  Q  T  A  L  E  G  L  G  G  V  I         p.300

          .         .         .         .         .         .       g.7003
 GATGCGGGAGGAGAGACCCAGGGCTATCTCTTTCCCAGTGGGCTGAAAGATATGCTGAAA       c.960
 D  A  G  G  E  T  Q  G  Y  L  F  P  S  G  L  K  D  M  L  K         p.320

          .         .         .         .         .         .       g.7063
 ACAGCATGGCTACAGGGAGGGGTTGCCTGCAGGCCAGCACCTGAGGAGGCCCCACCAGGA       c.1020
 T  A  W  L  Q  G  G  V  A  C  R  P  A  P  E  E  A  P  P  G         p.340

          .         .         .                                     g.7099
 GAAGCACCTCCCAAGGAGGATCTATCTGAGGCCTAG                               c.1056
 E  A  P  P  K  E  D  L  S  E  A  X                                 p.351

          .         .         .         .         .         .       g.7159
 aggcctggagcttggggtgaggaagagggagggatggacaagtctgaaaacctcacaact       c.*60

          .         .         .         .         .         .       g.7219
 ccttaccaaggctccaggttggggggatcgtaggattagaggggctaaggatagtcagcg       c.*120

          .         .         .         .         .         .       g.7279
 agctggactggggtaagaaagaaaaccagatgtcctagggcctagcccttgtagtcagaa       c.*180

          .         .         .         .         .         .       g.7339
 ccaccagggaacagcaaagaacagagtgatgggaaagtgacatgagaaggcctggaggct       c.*240

          .         .         .         .                           g.7380
 gattctgatatagactcaataaagtttttggatggaagcaa                          c.*281

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Retinal outer segment membrane protein 1 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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