receptor tyrosine kinase-like orphan receptor 2 (ROR2) - coding DNA reference sequence

(used for variant description)

(last modified October 9, 2020)


This file was created to facilitate the description of sequence variants on transcript NM_004560.3 in the ROR2 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_008089.1, covering ROR2 transcript NM_004560.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                   .                g.5019
                                          agccagcccttgccgtggc       c.-181

 .         .         .         .         .         .                g.5079
 cggagccgagcggcgcatccgggccggagaagaggacgacgacgaggtcctcgaagtgga       c.-121

 .         .         .         .         .         .                g.5139
 cccgtttgcgaagcgccagggagaaggaggagcggacgcatcgtagaaaggggtggtggc       c.-61

 .         .         .         .         .         .                g.5199
 gcccgaccccgcgccccggcccgaagctctgagggcttcccggcccccactgcctgcggc       c.-1

          .         .         .         .         .         .       g.5259
 ATGGCCCGGGGCTCGGCGCTCCCGCGGCGGCCGCTGCTGTGCATCCCGGCCGTCTGGGCG       c.60
 M  A  R  G  S  A  L  P  R  R  P  L  L  C  I  P  A  V  W  A         p.20

          .         .         .        | 02.         .         .    g.179367
 GCCGCCGCGCTTCTGCTCTCAGTGTCCCGGACTTCAG | GTGAAGTGGAGGTTCTGGATCCG    c.120
 A  A  A  L  L  L  S  V  S  R  T  S  G |   E  V  E  V  L  D  P      p.40

          .         .         .         .         .      | 03  .    g.197608
 AACGACCCTTTAGGACCCCTTGATGGGCAGGACGGCCCGATTCCAACTCTGAAAG | GTTAC    c.180
 N  D  P  L  G  P  L  D  G  Q  D  G  P  I  P  T  L  K  G |   Y      p.60

          .         .         .         .         .         .       g.197668
 TTTCTGAATTTTCTGGAGCCAGTAAACAATATCACCATTGTCCAAGGCCAGACGGCAATT       c.240
 F  L  N  F  L  E  P  V  N  N  I  T  I  V  Q  G  Q  T  A  I         p.80

          .         .         .         .         .         .       g.197728
 CTGCACTGCAAGGTGGCAGGAAACCCACCCCCTAACGTGCGGTGGCTAAAGAATGATGCC       c.300
 L  H  C  K  V  A  G  N  P  P  P  N  V  R  W  L  K  N  D  A         p.100

          .         .         .         .         .         .       g.197788
 CCGGTGGTGCAGGAGCCGCGGCGGATCATCATCCGGAAGACAGAATATGGTTCACGACTG       c.360
 P  V  V  Q  E  P  R  R  I  I  I  R  K  T  E  Y  G  S  R  L         p.120

          .         .         .         .         .         .       g.197848
 CGAATCCAGGACCTGGACACGACAGACACTGGCTACTACCAGTGCGTGGCCACCAACGGG       c.420
 R  I  Q  D  L  D  T  T  D  T  G  Y  Y  Q  C  V  A  T  N  G         p.140

          .         .         .         .    | 04    .         .    g.199078
 ATGAAGACCATTACCGCCACTGGCGTCCTGTTTGTGCGGCTGG | GTCCAACGCACAGCCCA    c.480
 M  K  T  I  T  A  T  G  V  L  F  V  R  L  G |   P  T  H  S  P      p.160

          .     | 05   .         .         .         .         .    g.217690
 AATCATAACTTTCA | GGATGATTACCACGAGGATGGGTTCTGCCAGCCTTACCGGGGAATT    c.540
 N  H  N  F  Q  |  D  D  Y  H  E  D  G  F  C  Q  P  Y  R  G  I      p.180

          .         .         .         .         .         .       g.217750
 GCCTGTGCACGCTTCATTGGCAACCGGACCATTTATGTGGACTCGCTTCAGATGCAGGGG       c.600
 A  C  A  R  F  I  G  N  R  T  I  Y  V  D  S  L  Q  M  Q  G         p.200

          .         .   | 06     .         .         .         .    g.221764
 GAGATTGAAAACCGAATCACAG | CGGCCTTCACCATGATCGGCACGTCTACGCACCTGTCG    c.660
 E  I  E  N  R  I  T  A |   A  F  T  M  I  G  T  S  T  H  L  S      p.220

          .         .         .         .         .         .       g.221824
 GACCAGTGCTCACAGTTCGCCATCCCATCCTTCTGCCACTTCGTGTTTCCTCTGTGCGAC       c.720
 D  Q  C  S  Q  F  A  I  P  S  F  C  H  F  V  F  P  L  C  D         p.240

          .         .         .         .         .         .       g.221884
 GCGCGCTCCCGGACACCCAAGCCGCGTGAGCTGTGCCGCGACGAGTGCGAGGTGCTGGAG       c.780
 A  R  S  R  T  P  K  P  R  E  L  C  R  D  E  C  E  V  L  E         p.260

          .         .         .         .         .         .       g.221944
 AGCGACCTGTGCCGCCAGGAGTACACCATCGCCCGCTCCAACCCGCTCATCCTCATGCGG       c.840
 S  D  L  C  R  Q  E  Y  T  I  A  R  S  N  P  L  I  L  M  R         p.280

          .         .         .         .         .         .       g.222004
 CTTCAGCTGCCCAAGTGTGAGGCGCTGCCCATGCCTGAGAGCCCCGACGCTGCCAACTGC       c.900
 L  Q  L  P  K  C  E  A  L  P  M  P  E  S  P  D  A  A  N  C         p.300

          .         .         .        | 07.         .         .    g.224030
 ATGCGCATTGGCATCCCAGCCGAGAGGCTGGGCCGCT | ACCATCAGTGCTATAACGGCTCA    c.960
 M  R  I  G  I  P  A  E  R  L  G  R  Y |   H  Q  C  Y  N  G  S      p.320

          .         .         .         .         .         .       g.224090
 GGCATGGATTACAGAGGAACGGCAAGCACCACCAAGTCAGGCCACCAGTGCCAGCCGTGG       c.1020
 G  M  D  Y  R  G  T  A  S  T  T  K  S  G  H  Q  C  Q  P  W         p.340

          .         .         .         .         .         .       g.224150
 GCCCTGCAGCACCCCCACAGCCACCACCTGTCCAGCACAGACTTCCCTGAGCTTGGAGGG       c.1080
 A  L  Q  H  P  H  S  H  H  L  S  S  T  D  F  P  E  L  G  G         p.360

          .         .         .         .         .         .       g.224210
 GGGCACGCCTACTGCCGGAACCCCGGAGGCCAGATGGAGGGCCCCTGGTGCTTTACGCAG       c.1140
 G  H  A  Y  C  R  N  P  G  G  Q  M  E  G  P  W  C  F  T  Q         p.380

          .         .         .         .    | 08    .         .    g.228436
 AATAAAAACGTACGCATGGAACTGTGTGACGTACCCTCGTGTA | GTCCCCGAGACAGCAGC    c.1200
 N  K  N  V  R  M  E  L  C  D  V  P  S  C  S |   P  R  D  S  S      p.400

          .         .         .         .         .         .       g.228496
 AAGATGGGGATTCTGTACATCTTGGTCCCCAGCATCGCAATTCCACTGGTCATCGCTTGC       c.1260
 K  M  G  I  L  Y  I  L  V  P  S  I  A  I  P  L  V  I  A  C         p.420

          .         .         .         .         .         .       g.228556
 CTTTTCTTCTTGGTTTGCATGTGCCGGAATAAGCAGAAGGCATCTGCGTCCACACCGCAG       c.1320
 L  F  F  L  V  C  M  C  R  N  K  Q  K  A  S  A  S  T  P  Q         p.440

          .         .         .         .         .         .       g.228616
 CGGCGACAGCTGATGGCCTCGCCCAGCCAAGACATGGAAATGCCCCTCATTAACCAGCAC       c.1380
 R  R  Q  L  M  A  S  P  S  Q  D  M  E  M  P  L  I  N  Q  H         p.460

        | 09 .         .         .         .         .         .    g.230109
 AAACAG | GCCAAACTCAAAGAGATCAGCCTGTCTGCGGTGAGGTTCATGGAGGAGCTGGGA    c.1440
 K  Q   | A  K  L  K  E  I  S  L  S  A  V  R  F  M  E  E  L  G      p.480

          .         .         .         .         .         .       g.230169
 GAGGACCGGTTTGGGAAAGTCTACAAAGGTCACCTGTTCGGCCCTGCCCCGGGGGAGCAG       c.1500
 E  D  R  F  G  K  V  Y  K  G  H  L  F  G  P  A  P  G  E  Q         p.500

          .         .         .         .         .         .       g.230229
 ACCCAGGCTGTGGCCATCAAAACGCTGAAGGACAAAGCGGAGGGGCCCCTGCGGGAGGAG       c.1560
 T  Q  A  V  A  I  K  T  L  K  D  K  A  E  G  P  L  R  E  E         p.520

          .         .         .         .         .         .       g.230289
 TTCCGGCATGAGGCTATGCTGCGAGCACGGCTGCAACACCCCAACGTCGTCTGCCTGCTG       c.1620
 F  R  H  E  A  M  L  R  A  R  L  Q  H  P  N  V  V  C  L  L         p.540

          .         .         .         .         .         .       g.230349
 GGCGTGGTGACCAAGGACCAGCCCCTGAGCATGATCTTCAGCTACTGTTCGCACGGCGAC       c.1680
 G  V  V  T  K  D  Q  P  L  S  M  I  F  S  Y  C  S  H  G  D         p.560

          .         .         .         .         .         .       g.230409
 CTCCACGAATTCCTGGTCATGCGCTCGCCGCACTCGGACGTGGGCAGCACCGATGATGAC       c.1740
 L  H  E  F  L  V  M  R  S  P  H  S  D  V  G  S  T  D  D  D         p.580

          .         .         .         .         .         .       g.230469
 CGCACGGTGAAGTCCGCCCTGGAGCCCCCCGACTTCGTGCACCTTGTGGCACAGATCGCG       c.1800
 R  T  V  K  S  A  L  E  P  P  D  F  V  H  L  V  A  Q  I  A         p.600

          .         .         .         .         .         .       g.230529
 GCGGGGATGGAGTACCTATCCAGCCACCACGTGGTTCACAAGGACCTGGCCACCCGCAAT       c.1860
 A  G  M  E  Y  L  S  S  H  H  V  V  H  K  D  L  A  T  R  N         p.620

          .         .         .         .         .         .       g.230589
 GTGCTAGTGTACGACAAGCTGAACGTGAAGATCTCAGACTTGGGCCTCTTCCGAGAGGTG       c.1920
 V  L  V  Y  D  K  L  N  V  K  I  S  D  L  G  L  F  R  E  V         p.640

          .         .         .         .         .         .       g.230649
 TATGCCGCCGATTACTACAAGCTGCTGGGGAACTCGCTGCTGCCTATCCGCTGGATGGCC       c.1980
 Y  A  A  D  Y  Y  K  L  L  G  N  S  L  L  P  I  R  W  M  A         p.660

          .         .         .         .         .         .       g.230709
 CCAGAGGCCATCATGTACGGCAAGTTCTCCATCGACTCAGACATCTGGTCCTACGGTGTG       c.2040
 P  E  A  I  M  Y  G  K  F  S  I  D  S  D  I  W  S  Y  G  V         p.680

          .         .         .         .         .         .       g.230769
 GTCCTGTGGGAGGTCTTCAGCTACGGCCTGCAGCCCTACTGCGGGTACTCCAACCAGGAT       c.2100
 V  L  W  E  V  F  S  Y  G  L  Q  P  Y  C  G  Y  S  N  Q  D         p.700

          .         .         .         .         .         .       g.230829
 GTGGTGGAGATGATCCGGAACCGGCAGGTGCTGCCTTGCCCCGATGACTGTCCCGCCTGG       c.2160
 V  V  E  M  I  R  N  R  Q  V  L  P  C  P  D  D  C  P  A  W         p.720

          .         .         .         .         .         .       g.230889
 GTGTATGCCCTCATGATCGAGTGCTGGAACGAGTTCCCCAGCCGGCGGCCCCGCTTCAAG       c.2220
 V  Y  A  L  M  I  E  C  W  N  E  F  P  S  R  R  P  R  F  K         p.740

          .         .         .         .         .         .       g.230949
 GACATCCACAGCCGGCTCCGAGCCTGGGGCAACCTTTCCAACTACAACAGCTCGGCGCAG       c.2280
 D  I  H  S  R  L  R  A  W  G  N  L  S  N  Y  N  S  S  A  Q         p.760

          .         .         .         .         .         .       g.231009
 ACCTCGGGGGCCAGCAACACCACGCAGACCAGCTCCCTGAGCACCAGCCCAGTGAGCAAT       c.2340
 T  S  G  A  S  N  T  T  Q  T  S  S  L  S  T  S  P  V  S  N         p.780

          .         .         .         .         .         .       g.231069
 GTGAGCAACGCCCGCTACGTGGGGCCCAAGCAGAAGGCCCCGCCCTTCCCACAGCCCCAG       c.2400
 V  S  N  A  R  Y  V  G  P  K  Q  K  A  P  P  F  P  Q  P  Q         p.800

          .         .         .         .         .         .       g.231129
 TTCATCCCCATGAAGGGCCAGATCAGACCCATGGTGCCCCCGCCGCAGCTCTACGTCCCC       c.2460
 F  I  P  M  K  G  Q  I  R  P  M  V  P  P  P  Q  L  Y  V  P         p.820

          .         .         .         .         .         .       g.231189
 GTCAACGGCTACCAGCCGGTGCCGGCCTATGGGGCCTACCTGCCCAACTTCTACCCGGTG       c.2520
 V  N  G  Y  Q  P  V  P  A  Y  G  A  Y  L  P  N  F  Y  P  V         p.840

          .         .         .         .         .         .       g.231249
 CAGATCCCAATGCAGATGGCCCCGCAGCAGGTGCCTCCTCAGATGGTCCCCAAGCCCAGC       c.2580
 Q  I  P  M  Q  M  A  P  Q  Q  V  P  P  Q  M  V  P  K  P  S         p.860

          .         .         .         .         .         .       g.231309
 TCACACCACAGTGGCAGTGGCTCCACCAGCACAGGCTACGTCACCACGGCCCCCTCCAAC       c.2640
 S  H  H  S  G  S  G  S  T  S  T  G  Y  V  T  T  A  P  S  N         p.880

          .         .         .         .         .         .       g.231369
 ACATCCATGGCAGACAGGGCAGCCCTGCTCTCAGAGGGCGCTGATGACACACAGAACGCC       c.2700
 T  S  M  A  D  R  A  A  L  L  S  E  G  A  D  D  T  Q  N  A         p.900

          .         .         .         .         .         .       g.231429
 CCAGAAGATGGGGCCCAGAGCACCGTGCAGGAAGCAGAGGAGGAGGAGGAAGGCTCTGTC       c.2760
 P  E  D  G  A  Q  S  T  V  Q  E  A  E  E  E  E  E  G  S  V         p.920

          .         .         .         .         .         .       g.231489
 CCAGAGACTGAGCTGCTGGGGGACTGTGACACTCTGCAGGTGGACGAGGCCCAAGTCCAG       c.2820
 P  E  T  E  L  L  G  D  C  D  T  L  Q  V  D  E  A  Q  V  Q         p.940

          .                                                         g.231501
 CTGGAAGCTTGA                                                       c.2832
 L  E  A  X                                                         p.943

          .         .         .         .         .         .       g.231561
 gtggcaccagggcccggggttcggggatagaagccccgccgagaccccacagggacctca       c.*60

          .         .         .         .         .         .       g.231621
 gtcacctttgagaagacaccatactcagcaatcacaagagcccgccggccagtgggcttg       c.*120

          .         .         .         .         .         .       g.231681
 tttgcagactgggtgaggtggagccctgctcctctctgtcctctgacacagagagctgcc       c.*180

          .         .         .         .         .         .       g.231741
 ctgcctaggagcacccaagccaggcagggggtctggcagcacggcgtcctggggagcagg       c.*240

          .         .         .         .         .         .       g.231801
 acacatggtcatccccagggctgtatacattgattctggtggtagactggtagtgagcag       c.*300

          .         .         .         .         .         .       g.231861
 caaatgcctttcaagaaaataggtggcagcttcactccatgtcatatatggagtgaatat       c.*360

          .         .         .         .         .         .       g.231921
 ttcaaaacgttgggaataagggcctgcaaaaggcagcgaggaggcacctcgggtcttgag       c.*420

          .         .         .         .         .         .       g.231981
 gttcctgacaaccgatctggtctgttggtttgaggatgaaggggctccatttctgctgcc       c.*480

          .         .         .         .         .         .       g.232041
 tccctgctgagaatattctccctttagcagccaaagattcgctggaacggaggctgccct       c.*540

          .         .         .         .         .         .       g.232101
 ctgctgcctgttggggtcggaagacaaggggcttctgaaatgggagttcctgagatacaa       c.*600

          .         .         .         .         .         .       g.232161
 caaaatgtgtgccttcaaagaaactgacagctttgtatttggtgaaatggttttaattat       c.*660

          .         .         .         .         .         .       g.232221
 actccatgtgtattttgcccactttttttgggaattcaagggaaagtgtttcttgggttt       c.*720

          .         .         .         .         .         .       g.232281
 ggaatgttcagaggaagcagtattgtacagaacacggtattgttatttttgttaagaatc       c.*780

          .         .         .         .         .         .       g.232341
 atgtacagagcttaaatgtaatttatatgtttttaatatgccattttcattgaagtattt       c.*840

          .         .         .         .         .         .       g.232401
 tggtcttaagatgactttagtaatttaactgtttatgttacccacgttgggatccagttg       c.*900

          .         .         .         .         .         .       g.232461
 gtcttggtttgcttctctctgtaccacgtgcacatgaggtccattcattttacagcccct       c.*960

          .         .         .         .         .         .       g.232521
 gttacacacagacccacaggcagccgtctgtgccccgcacacattgttggtcctatttgt       c.*1020

          .         .         .         .                           g.232567
 aaatcccacacccggtgtatccaataaagtgaaacaaagcatgtga                     c.*1066

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Receptor tyrosine kinase-like orphan receptor 2 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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