RAR-related orphan receptor B (RORB) - coding DNA reference sequence

(used for variant description)

(last modified January 4, 2016)


This file was created to facilitate the description of sequence variants on transcript NM_006914.3 in the RORB gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000009.11, covering RORB transcript NM_006914.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                     .         .         .         .                g.5041
                    tctctcccctctctttctctctcgctgctcccttcctccct       c.-601

 .         .         .         .         .         .                g.5101
 gtaactgaacagtgaaaattcacattgtggatccgctaacaggcacagatgtcatgtgaa       c.-541

 .         .         .         .         .         .                g.5161
 aacgcacatgctctgccatccacaccgcctttctttcttttctttctgtttccttttttc       c.-481

 .         .         .         .         .         .                g.5221
 ccccttgttccttctccctcttctttgtaactaacaaaaccaccaccaactcctcctcct       c.-421

 .         .         .         .         .         .                g.5281
 gctgctgcccttcctcctcctcctcagtccaagtgatcacaaaagaaatcttctgagccg       c.-361

 .         .         .         .         .         .                g.5341
 gaggcggtggcattttttaaaaagcaagcacattggagagaaagaaaaagaaaaacaaaa       c.-301

 .         .         .         .         .         .                g.5401
 ccaaaacaaaacccaggcaccagacagccagaacatttttttttcacccttcctgaaaac       c.-241

 .         .         .         .         .         .                g.5461
 aaacaaacaaacaaacaatcatcaaaacagtcaccaccaacatcaaaactgttaacatag       c.-181

 .         .         .         .         .         .                g.5521
 cggcggcggcggcaaacgtcaccctgcagccacggcgtccgcctaaagggatggttttct       c.-121

 .         .         .         .         .         .                g.5581
 cggcagagcagctcttcgccgaccaccttcttcactcgtgctgagcgggatttttgggct       c.-61

 .         .         .         .         .         .                g.5641
 ctccggggttcgggctgggagcagcttcatgactacgcggagcgggagagcggccacacc       c.-1

         | 02.         .         .         .         .         .    g.137999
 ATGCGAG | CACAAATTGAAGTGATACCATGCAAAATTTGTGGCGATAAGTCCTCTGGGATC    c.60
 M  R  A |   Q  I  E  V  I  P  C  K  I  C  G  D  K  S  S  G  I      p.20

          .         .         .    | 03    .         .         .    g.142322
 CACTACGGAGTCATCACATGTGAAGGCTGCAAG | GGATTCTTTAGGAGGAGCCAGCAGAAC    c.120
 H  Y  G  V  I  T  C  E  G  C  K   | G  F  F  R  R  S  Q  Q  N      p.40

          .         .         .         .         .         .       g.142382
 AATGCTTCTTATTCCTGCCCAAGGCAGAGAAACTGTTTAATTGACAGAACGAACAGAAAC       c.180
 N  A  S  Y  S  C  P  R  Q  R  N  C  L  I  D  R  T  N  R  N         p.60

          .         .         .         .         .      | 04  .    g.150083
 CGTTGCCAACACTGCCGACTGCAGAAGTGTCTTGCCCTAGGAATGTCAAGAGATG | CTGTG    c.240
 R  C  Q  H  C  R  L  Q  K  C  L  A  L  G  M  S  R  D  A |   V      p.80

          .         .         .         .         .         .       g.150143
 AAGTTTGGGAGGATGTCCAAGAAGCAAAGGGACAGCCTGTATGCTGAGGTGCAGAAGCAC       c.300
 K  F  G  R  M  S  K  K  Q  R  D  S  L  Y  A  E  V  Q  K  H         p.100

          .         .         .         .         .         .       g.150203
 CAGCAGCGGCTGCAGGAACAGCGGCAGCAGCAGAGTGGGGAGGCAGAAGCCCTTGCCAGG       c.360
 Q  Q  R  L  Q  E  Q  R  Q  Q  Q  S  G  E  A  E  A  L  A  R         p.120

          .         .         .         .         .         .       g.150263
 GTGTACAGCAGCAGCATTAGCAACGGCCTGAGCAACCTGAACAACGAGACCAGCGGCACT       c.420
 V  Y  S  S  S  I  S  N  G  L  S  N  L  N  N  E  T  S  G  T         p.140

          .         .         .         .         .         .       g.150323
 TATGCCAACGGGCACGTCATTGACCTGCCCAAGTCTGAGGGTTATTACAACGTCGATTCC       c.480
 Y  A  N  G  H  V  I  D  L  P  K  S  E  G  Y  Y  N  V  D  S         p.160

          .         .         .         .         .         .       g.150383
 GGTCAGCCGTCCCCTGATCAGTCAGGACTTGACATGACTGGAATCAAACAGATAAAGCAA       c.540
 G  Q  P  S  P  D  Q  S  G  L  D  M  T  G  I  K  Q  I  K  Q         p.180

          .         .         .         .         .         .       g.150443
 GAACCTATCTATGACCTCACATCCGTACCCAACTTGTTTACCTATAGCTCTTTCAACAAT       c.600
 E  P  I  Y  D  L  T  S  V  P  N  L  F  T  Y  S  S  F  N  N         p.200

          .         .         .        | 05.         .         .    g.168304
 GGGCAGTTAGCACCAGGGATAACCATGACTGAAATCG | ACCGAATTGCACAGAACATCATT    c.660
 G  Q  L  A  P  G  I  T  M  T  E  I  D |   R  I  A  Q  N  I  I      p.220

          .         .         .         .         .         .       g.168364
 AAGTCCCATTTGGAGACATGTCAATACACCATGGAAGAGCTGCACCAGCTGGCGTGGCAG       c.720
 K  S  H  L  E  T  C  Q  Y  T  M  E  E  L  H  Q  L  A  W  Q         p.240

          .         .         .          | 06        .         .    g.170159
 ACCCACACCTATGAAGAAATTAAAGCATATCAAAGCAAG | TCCAGGGAAGCACTGTGGCAA    c.780
 T  H  T  Y  E  E  I  K  A  Y  Q  S  K   | S  R  E  A  L  W  Q      p.260

          .         .         .         .         .         .       g.170219
 CAATGTGCCATCCAGATCACTCACGCCATCCAATACGTGGTGGAGTTTGCAAAGCGGATA       c.840
 Q  C  A  I  Q  I  T  H  A  I  Q  Y  V  V  E  F  A  K  R  I         p.280

          .         .         .         .         .   | 07     .    g.173160
 ACAGGCTTCATGGAGCTCTGTCAAAATGATCAAATTCTACTTCTGAAGTCAG | GTTGCTTG    c.900
 T  G  F  M  E  L  C  Q  N  D  Q  I  L  L  L  K  S  G |   C  L      p.300

          .         .         .         .         .         .       g.173220
 GAAGTGGTTTTAGTGAGAATGTGCCGTGCCTTCAACCCATTAAACAACACTGTTCTGTTT       c.960
 E  V  V  L  V  R  M  C  R  A  F  N  P  L  N  N  T  V  L  F         p.320

          .         .         .         . | 08       .         .    g.175475
 GAAGGAAAATATGGAGGAATGCAAATGTTCAAAGCCTTAG | GTTCTGATGACCTAGTGAAT    c.1020
 E  G  K  Y  G  G  M  Q  M  F  K  A  L  G |   S  D  D  L  V  N      p.340

          .         .         .         .         .         .       g.175535
 GAAGCATTTGACTTTGCAAAGAATTTGTGTTCCTTGCAGCTGACCGAGGAGGAGATCGCT       c.1080
 E  A  F  D  F  A  K  N  L  C  S  L  Q  L  T  E  E  E  I  A         p.360

          .         .         .  | 09      .         .         .    g.179482
 TTGTTCTCATCTGCTGTTCTGATATCTCCAG | ACCGAGCCTGGCTTATAGAACCAAGGAAA    c.1140
 L  F  S  S  A  V  L  I  S  P  D |   R  A  W  L  I  E  P  R  K      p.380

          .         .         .         .         .         .       g.179542
 GTCCAGAAGCTTCAGGAAAAAATTTATTTTGCACTTCAACATGTGATTCAGAAGAATCAC       c.1200
 V  Q  K  L  Q  E  K  I  Y  F  A  L  Q  H  V  I  Q  K  N  H         p.400

          .         .     | 10   .         .         .         .    g.193163
 CTGGATGATGAGACCTTGGCAAAG | TTAATAGCCAAGATACCAACCATCACGGCAGTTTGC    c.1260
 L  D  D  E  T  L  A  K   | L  I  A  K  I  P  T  I  T  A  V  C      p.420

          .         .         .         .         .         .       g.193223
 AACTTGCACGGGGAGAAGCTGCAGGTATTTAAGCAATCTCATCCAGAGATAGTGAATACA       c.1320
 N  L  H  G  E  K  L  Q  V  F  K  Q  S  H  P  E  I  V  N  T         p.440

          .         .         .         .         .         .       g.193283
 CTGTTTCCTCCGTTATACAAGGAGCTCTTTAATCCTGACTGTGCCACCGGCTGCAAATGA       c.1380
 L  F  P  P  L  Y  K  E  L  F  N  P  D  C  A  T  G  C  K  X         p.459

          .         .         .         .         .         .       g.193343
 aggggacaagagaactgtctcatagtcatggaatgcatcaccattaagacaaaagcaatg       c.*60

          .         .         .         .         .         .       g.193403
 tgttcatgaagacttaagaaaaatgtcactactgcaacattaggaatgtcctgcacttaa       c.*120

          .         .         .         .         .         .       g.193463
 tagaattatttttcaccgctacagtttgaagaatgtaaatatgcacctgagtggggctct       c.*180

          .         .         .         .         .         .       g.193523
 tttatttgtttgtttgtttttgaaatgaccataaatatacaaatataggacactgggtgt       c.*240

          .         .         .         .         .         .       g.193583
 tatcctttttttaattttattcgggtatgttttgggagacaactgtttatagaattttat       c.*300

          .         .         .         .         .         .       g.193643
 tgtagatatatacaagaaaagagcggtactttacatgattacttttcctgttgattgttc       c.*360

          .         .         .         .         .         .       g.193703
 aaatataatttaagaaaattccacttaataggcttacctatttctatgtttttaggtagt       c.*420

          .         .         .         .         .         .       g.193763
 tgatgcatgtgtaaatttgtagctgtcttggaaagtactgtgcatgtatgtaataagtat       c.*480

          .         .         .         .         .         .       g.193823
 ataatatgtgagaatattatatatgactattacttatacatgcacatgcactgtggctta       c.*540

          .         .         .         .         .         .       g.193883
 aataccatacctactagcaatggaggttcagtcaggctctcttctatgatttaccttctg       c.*600

          .         .         .         .         .         .       g.193943
 tgttatatgttacctttatgttagacaatcaggattttgttttcccagccagagttttca       c.*660

          .         .         .         .         .         .       g.194003
 tctatagtcaatggcaggacggtaccaactcagagttaagtctacaaaggaataaacata       c.*720

          .         .         .         .         .         .       g.194063
 atgtgtggcctctatatacaaactctatttctgtcaatgacatcaaagccttgtcaagat       c.*780

          .         .         .         .         .         .       g.194123
 ggttcatattgggaaggagacagtattttaagccattttcctgtttcaagaattaggcca       c.*840

          .         .         .         .         .         .       g.194183
 cagataacattgcaaggtccaagacttttttgaccaaacagtagatattttctatttttc       c.*900

          .         .         .         .         .         .       g.194243
 accagaacacataaaaacactttttttcttttggatttctggttgtgaaacaagcttgat       c.*960

          .         .         .         .         .         .       g.194303
 ttcagtgcttattgtgtcttcaactgaaaaatacaatctgtggattatgactaccagcaa       c.*1020

          .         .         .         .         .         .       g.194363
 tttttttctaggaaagttaaaagaataaatcagaacccagggcaacaatgccatttcatg       c.*1080

          .         .         .         .         .         .       g.194423
 taaacattttctctctcaccatgttttggcaagaaaaggtagaaagagaagacccagagt       c.*1140

          .         .         .         .         .         .       g.194483
 gaagaagtaattctttatattcctttctttaatgtatttgttaggaaaagtggcaataaa       c.*1200

          .         .         .         .         .         .       g.194543
 gggggaggcatattataaaatgctataatataaaaatgtagcaaaaacttgacagactag       c.*1260

          .         .         .         .         .         .       g.194603
 aaaaaaaaagatctgtgttattctagggaactaatgtaccccaaagccaaaactaattcc       c.*1320

          .         .         .         .         .         .       g.194663
 tgtgaagtttacagttacatcatccatttaccctagaattatttttttagcaacttttag       c.*1380

          .         .         .         .         .         .       g.194723
 aaataaagaatacaactgtgacattaggatcagagattttagacttccttgtacaaattc       c.*1440

          .         .         .         .         .         .       g.194783
 tcacttctccacctgctcaccaatgaaattaatcataagaaaagcatatattccaagaaa       c.*1500

          .         .         .         .         .         .       g.194843
 tttgttctgcctgtgtcctggaggcctatacctctgttattttctgatacaaaataaaac       c.*1560

          .         .                                               g.194866
 ttaaaaaaaagaaaacaagctaa                                            c.*1583

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The RAR-related orphan receptor B protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

Powered by LOVD v.3.0 Build 14c
©2004-2016 Leiden University Medical Center