c-ros oncogene 1 , receptor tyrosine kinase (ROS1) - coding DNA reference sequence

(used for variant description)

(last modified January 12, 2018)


This file was created to facilitate the description of sequence variants on transcript NM_002944.2 in the ROS1 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_033929.1, covering ROS1 transcript NM_002944.2.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                   .                g.5019
                                          caagctttcaagcattcaa       c.-181

 .         .         .         .         .         .                g.5079
 aggtctaaatgaaaaaggctaagtattatttcaaaaggcaagtatatcctaatatagcaa       c.-121

 .         .         .         .         .         .                g.5139
 aacaaacaaagcaaaatccatcagctactcctccaattgaagtgatgaagcccaaataat       c.-61

 .         .         .         .         .         .                g.5199
 tcatatagcaaaatggagaaaattagaccggccatctaaaaatctgccattggtgaagtg       c.-1

          .         .         .         .         .         .       g.5259
 ATGAAGAACATTTACTGTCTTATTCCGAAGCTTGTCAATTTTGCAACTCTTGGCTGCCTA       c.60
 M  K  N  I  Y  C  L  I  P  K  L  V  N  F  A  T  L  G  C  L         p.20

          .         .         .         .         .         .       g.5319
 TGGATTTCTGTGGTGCAGTGTACAGTTTTAAATAGCTGCCTAAAGTCGTGTGTAACTAAT       c.120
 W  I  S  V  V  Q  C  T  V  L  N  S  C  L  K  S  C  V  T  N         p.40

     | 02    .         .         .         .         | 03         . g.14550
 CTG | GGCCAGCAGCTTGACCTTGGCACACCACATAATCTGAGTGAACCG | TGTATCCAAGGA c.180
 L   | G  Q  Q  L  D  L  G  T  P  H  N  L  S  E  P   | C  I  Q  G   p.60

          .         .         .         .         | 04         .    g.21225
 TGTCACTTTTGGAACTCTGTAGATCAGAAAAACTGTGCTTTAAAGTGT | CGGGAGTCGTGT    c.240
 C  H  F  W  N  S  V  D  Q  K  N  C  A  L  K  C   | R  E  S  C      p.80

          .         .         .         .          | 05        .    g.26438
 GAGGTTGGCTGTAGCAGCGCGGAAGGTGCATATGAAGAGGAAGTACTGG | AAAATGCAGAC    c.300
 E  V  G  C  S  S  A  E  G  A  Y  E  E  E  V  L  E |   N  A  D      p.100

          .         .         .         .         .         .       g.26498
 CTACCAACTGCTCCCTTTGCTTCTTCCATTGGAAGCCACAATATGACATTACGATGGAAA       c.360
 L  P  T  A  P  F  A  S  S  I  G  S  H  N  M  T  L  R  W  K         p.120

          .         .         .         .         .         .       g.26558
 TCTGCAAACTTCTCTGGAGTAAAATACATCATTCAGTGGAAATATGCACAACTTCTGGGA       c.420
 S  A  N  F  S  G  V  K  Y  I  I  Q  W  K  Y  A  Q  L  L  G         p.140

          .         | 06         .         .         .         .    g.27620
 AGCTGGACTTATACTAAG | ACTGTGTCCAGACCGTCCTATGTGGTCAAGCCCCTGCACCCC    c.480
 S  W  T  Y  T  K   | T  V  S  R  P  S  Y  V  V  K  P  L  H  P      p.160

          .         .         .         .         .         .       g.27680
 TTCACTGAGTACATTTTCCGAGTGGTTTGGATCTTCACAGCGCAGCTGCAGCTCTACTCC       c.540
 F  T  E  Y  I  F  R  V  V  W  I  F  T  A  Q  L  Q  L  Y  S         p.180

          .         .         .        | 07.         .         .    g.33762
 CCTCCAAGTCCCAGTTACAGGACTCATCCTCATGGAG | TTCCTGAAACTGCACCTTTGATT    c.600
 P  P  S  P  S  Y  R  T  H  P  H  G  V |   P  E  T  A  P  L  I      p.200

          .         .         .         .         .         .       g.33822
 AGGAATATTGAGAGCTCAAGTCCCGACACTGTGGAAGTCAGCTGGGATCCACCTCAATTC       c.660
 R  N  I  E  S  S  S  P  D  T  V  E  V  S  W  D  P  P  Q  F         p.220

          .         .         .         .         .         .       g.33882
 CCAGGTGGACCTATTTTGGGTTATAACTTAAGGCTGATCAGCAAAAATCAAAAATTAGAT       c.720
 P  G  G  P  I  L  G  Y  N  L  R  L  I  S  K  N  Q  K  L  D         p.240

          .         .         .         .         .          | 08    g.34592
 GCAGGGACACAGAGAACCAGTTTCCAGTTTTACTCCACTTTACCAAATACTATCTACAG | G    c.780
 A  G  T  Q  R  T  S  F  Q  F  Y  S  T  L  P  N  T  I  Y  R  |      p.260

          .         .         .         .         .         .       g.34652
 TTTTCTATTGCAGCAGTAAATGAAGTTGGTGAGGGTCCAGAAGCAGAATCTAGTATTACC       c.840
 F  S  I  A  A  V  N  E  V  G  E  G  P  E  A  E  S  S  I  T         p.280

          .       | 09 .         .         .         .         .    g.36161
 ACTTCATCTTCAGCAG | TTCAACAAGAGGAACAGTGGCTCTTTTTATCCAGAAAAACTTCT    c.900
 T  S  S  S  A  V |   Q  Q  E  E  Q  W  L  F  L  S  R  K  T  S      p.300

          .         .         .         .         .         .       g.36221
 CTAAGAAAGAGATCTTTAAAACATTTAGTAGATGAAGCACATTGCCTTCGGTTGGATGCT       c.960
 L  R  K  R  S  L  K  H  L  V  D  E  A  H  C  L  R  L  D  A         p.320

          .          | 10        .         .         .         .    g.36550
 ATATACCATAATATTACAG | GAATATCTGTTGATGTCCACCAGCAAATTGTTTATTTCTCT    c.1020
 I  Y  H  N  I  T  G |   I  S  V  D  V  H  Q  Q  I  V  Y  F  S      p.340

          .         .         .         .         .         .       g.36610
 GAAGGAACTCTCATATGGGCGAAGAAGGCTGCCAACATGTCTGATGTATCTGACCTGAGA       c.1080
 E  G  T  L  I  W  A  K  K  A  A  N  M  S  D  V  S  D  L  R         p.360

          .         .         .         .         .         .       g.36670
 ATTTTTTACAGAGGTTCAGGATTAATTTCTTCTATCTCCATAGATTGGCTTTATCAAAGA       c.1140
 I  F  Y  R  G  S  G  L  I  S  S  I  S  I  D  W  L  Y  Q  R         p.380

          .         .     | 11   .         .         .         .    g.37570
 ATGTATTTCATCATGGATGAACTG | GTATGTGTCTGTGATTTAGAGAACTGCTCAAACATC    c.1200
 M  Y  F  I  M  D  E  L   | V  C  V  C  D  L  E  N  C  S  N  I      p.400

          .         .         .         .         .         .       g.37630
 GAGGAAATTACTCCACCCTCTATTAGTGCACCTCAAAAAATTGTGGCTGATTCATACAAT       c.1260
 E  E  I  T  P  P  S  I  S  A  P  Q  K  I  V  A  D  S  Y  N         p.420

    | 12     .         .         .         .         .         .    g.41067
 GG | GTATGTCTTTTACCTCCTGAGAGATGGCATTTATAGAGCAGACCTTCCTGTACCATCT    c.1320
 G  |  Y  V  F  Y  L  L  R  D  G  I  Y  R  A  D  L  P  V  P  S      p.440

          .         .         .         .         .         .       g.41127
 GGCCGGTGTGCAGAAGCTGTGCGTATTGTGGAGAGTTGCACGTTAAAGGACTTTGCAATC       c.1380
 G  R  C  A  E  A  V  R  I  V  E  S  C  T  L  K  D  F  A  I         p.460

          .         .         .         .         .         .       g.41187
 AAGCCACAAGCCAAGCGAATCATTTACTTCAATGACACTGCCCAAGTCTTCATGTCAACA       c.1440
 K  P  Q  A  K  R  I  I  Y  F  N  D  T  A  Q  V  F  M  S  T         p.480

          .         .         .         .         .         .       g.41247
 TTTCTGGATGGCTCTGCTTCCCATCTCATCCTACCTCGCATCCCCTTTGCTGATGTGAAA       c.1500
 F  L  D  G  S  A  S  H  L  I  L  P  R  I  P  F  A  D  V  K         p.500

          .         .         .         .         .         .       g.41307
 AGTTTTGCTTGTGAAAACAATGACTTTCTTGTCACAGATGGCAAGGTCATTTTCCAACAG       c.1560
 S  F  A  C  E  N  N  D  F  L  V  T  D  G  K  V  I  F  Q  Q         p.520

          .         .         .         .         .         .       g.41367
 GATGCTTTGTCTTTTAATGAATTCATCGTGGGATGTGACCTGAGTCACATAGAAGAATTT       c.1620
 D  A  L  S  F  N  E  F  I  V  G  C  D  L  S  H  I  E  E  F         p.540

          .         .         .         .         .         .       g.41427
 GGGTTTGGTAACTTGGTCATCTTTGGCTCATCCTCCCAGCTGCACCCTCTGCCAGGCCGC       c.1680
 G  F  G  N  L  V  I  F  G  S  S  S  Q  L  H  P  L  P  G  R         p.560

          .         .         .         .         .         .       g.41487
 CCGCAGGAGCTTTCGGTGCTGTTTGGCTCTCACCAGGCTCTTGTTCAATGGAAGCCTCCT       c.1740
 P  Q  E  L  S  V  L  F  G  S  H  Q  A  L  V  Q  W  K  P  P         p.580

          .          | 13        .         .         .         .    g.42862
 GCCCTTGCCATAGGAGCCA | ATGTCATCCTGATCAGTGATATTATTGAACTCTTTGAATTA    c.1800
 A  L  A  I  G  A  N |   V  I  L  I  S  D  I  I  E  L  F  E  L      p.600

          .         .         .         .         .         .       g.42922
 GGCCCTTCTGCCTGGCAGAACTGGACCTATGAGGTGAAAGTATCCACCCAAGACCCTCCT       c.1860
 G  P  S  A  W  Q  N  W  T  Y  E  V  K  V  S  T  Q  D  P  P         p.620

          .         .         .         .         .         .       g.42982
 GAAGTCACTCATATTTTCTTGAACATAAGTGGAACCATGCTGAATGTACCTGAGCTGCAG       c.1920
 E  V  T  H  I  F  L  N  I  S  G  T  M  L  N  V  P  E  L  Q         p.640

          .         .         .         .         .         .       g.43042
 AGTGCTATGAAATACAAGGTTTCTGTGAGAGCAAGTTCTCCAAAGAGGCCAGGCCCCTGG       c.1980
 S  A  M  K  Y  K  V  S  V  R  A  S  S  P  K  R  P  G  P  W         p.660

          .         .         .     | 14   .         .         .    g.43882
 TCAGAGCCCTCAGTGGGTACTACCCTGGTGCCAG | CTAGTGAACCACCATTTATCATGGCT    c.2040
 S  E  P  S  V  G  T  T  L  V  P  A |   S  E  P  P  F  I  M  A      p.680

          .         .         .         .         .         .       g.43942
 GTGAAAGAAGATGGGCTTTGGAGTAAACCATTAAATAGCTTTGGCCCAGGAGAGTTCTTA       c.2100
 V  K  E  D  G  L  W  S  K  P  L  N  S  F  G  P  G  E  F  L         p.700

          .         .      | 15  .         .         .         .    g.45029
 TCCTCTGATATAGGAAATGTGTCAG | ACATGGATTGGTATAACAACAGCCTCTACTACAGT    c.2160
 S  S  D  I  G  N  V  S  D |   M  D  W  Y  N  N  S  L  Y  Y  S      p.720

          .         .         .         .         .         .       g.45089
 GACACGAAAGGCGACGTTTTTGTGTGGCTGCTGAATGGGACGGATATCTCAGAGAATTAT       c.2220
 D  T  K  G  D  V  F  V  W  L  L  N  G  T  D  I  S  E  N  Y         p.740

          .         .         .         .         .         .       g.45149
 CACCTACCCAGCATTGCAGGAGCAGGGGCTTTAGCTTTTGAGTGGCTGGGTCACTTTCTC       c.2280
 H  L  P  S  I  A  G  A  G  A  L  A  F  E  W  L  G  H  F  L         p.760

          .         .     | 16   .         .         .         .    g.47383
 TACTGGGCTGGAAAGACATATGTG | ATACAAAGGCAGTCTGTGTTGACGGGACACACAGAC    c.2340
 Y  W  A  G  K  T  Y  V   | I  Q  R  Q  S  V  L  T  G  H  T  D      p.780

          .         .         .         .         .         .       g.47443
 ATTGTTACCCACGTGAAGCTATTGGTGAATGACATGGTGGTGGATTCAGTTGGTGGATAT       c.2400
 I  V  T  H  V  K  L  L  V  N  D  M  V  V  D  S  V  G  G  Y         p.800

          .         .         .         .         .         .       g.47503
 CTCTACTGGACCACACTCTATTCAGTGGAAAGCACCAGACTAAATGGGGAAAGTTCCCTT       c.2460
 L  Y  W  T  T  L  Y  S  V  E  S  T  R  L  N  G  E  S  S  L         p.820

          .         .         .       | 17 .         .         .    g.51720
 GTACTACAGACACAGCCTTGGTTTTCTGGGAAAAAG | GTAATTGCTCTAACTTTAGACCTC    c.2520
 V  L  Q  T  Q  P  W  F  S  G  K  K   | V  I  A  L  T  L  D  L      p.840

          .         .         .         .         .         .       g.51780
 AGTGATGGGCTCCTGTATTGGTTGGTTCAAGACAGTCAATGTATTCACCTGTACACAGCT       c.2580
 S  D  G  L  L  Y  W  L  V  Q  D  S  Q  C  I  H  L  Y  T  A         p.860

          .        | 18.         .         .         .         .    g.64608
 GTTCTTCGGGGACAGAG | CACTGGGGATACCACCATCACAGAATTTGCAGCCTGGAGTACT    c.2640
 V  L  R  G  Q  S  |  T  G  D  T  T  I  T  E  F  A  A  W  S  T      p.880

          .         .         .         .         .         .       g.64668
 TCTGAAATTTCCCAGAATGCACTGATGTACTATAGTGGTCGGCTGTTCTGGATCAATGGC       c.2700
 S  E  I  S  Q  N  A  L  M  Y  Y  S  G  R  L  F  W  I  N  G         p.900

          .         .         .         .         .         .       g.64728
 TTTAGGATTATCACAACTCAAGAAATAGGTCAGAAAACCAGTGTCTCTGTTTTGGAACCA       c.2760
 F  R  I  I  T  T  Q  E  I  G  Q  K  T  S  V  S  V  L  E  P         p.920

          .         .         .         .         .   | 19     .    g.65122
 GCCAGATTTAATCAGTTCACAATTATTCAGACATCCCTTAAGCCCCTGCCAG | GGAACTTT    c.2820
 A  R  F  N  Q  F  T  I  I  Q  T  S  L  K  P  L  P  G |   N  F      p.940

          .         .         .         .         .         .       g.65182
 TCCTTTACCCCTAAGGTTATTCCAGATTCTGTTCAAGAGTCTTCATTTAGGATTGAAGGA       c.2880
 S  F  T  P  K  V  I  P  D  S  V  Q  E  S  S  F  R  I  E  G         p.960

          .         .         .         .         .         .       g.65242
 AATGCTTCAAGTTTTCAAATCCTGTGGAATGGTCCCCCTGCGGTAGACTGGGGTGTAGTT       c.2940
 N  A  S  S  F  Q  I  L  W  N  G  P  P  A  V  D  W  G  V  V         p.980

          .         .         .    | 20    .         .         .    g.65678
 TTCTACAGTGTAGAATTTAGTGCTCATTCTAAG | TTCTTGGCTAGTGAACAACACTCTTTA    c.3000
 F  Y  S  V  E  F  S  A  H  S  K   | F  L  A  S  E  Q  H  S  L      p.1000

          .         .         .         .         .         .       g.65738
 CCTGTATTTACTGTGGAAGGACTGGAACCTTATGCCTTATTTAATCTTTCTGTCACTCCT       c.3060
 P  V  F  T  V  E  G  L  E  P  Y  A  L  F  N  L  S  V  T  P         p.1020

          .         .         .         .         .         | 21    g.67992
 TATACCTACTGGGGAAAGGGCCCCAAAACATCTCTGTCACTTCGAGCACCTGAAACAG | TT    c.3120
 Y  T  Y  W  G  K  G  P  K  T  S  L  S  L  R  A  P  E  T  V |       p.1040

          .         .         .         .         .         .       g.68052
 CCATCAGCACCAGAGAACCCCAGAATATTTATATTACCAAGTGGAAAATGCTGCAACAAG       c.3180
 P  S  A  P  E  N  P  R  I  F  I  L  P  S  G  K  C  C  N  K         p.1060

          .         .         .         .         .         .       g.68112
 AATGAAGTTGTGGTGGAATTTAGGTGGAACAAACCTAAGCATGAAAATGGGGTGTTAACA       c.3240
 N  E  V  V  V  E  F  R  W  N  K  P  K  H  E  N  G  V  L  T         p.1080

          .         .         .         .         .         .       g.68172
 AAATTTGAAATTTTCTACAATATATCCAATCAAAGTATTACAAACAAAACATGTGAAGAC       c.3300
 K  F  E  I  F  Y  N  I  S  N  Q  S  I  T  N  K  T  C  E  D         p.1100

          .         .         .         .         .         .       g.68232
 TGGATTGCTGTCAATGTCACTCCCTCAGTGATGTCTTTTCAACTTGAAGGCATGAGTCCC       c.3360
 W  I  A  V  N  V  T  P  S  V  M  S  F  Q  L  E  G  M  S  P         p.1120

          .         .  | 22      .         .         .         .    g.70489
 AGATGCTTTATTGCCTTCCAG | GTTAGGGCCTTTACATCTAAGGGGCCAGGACCATATGCT    c.3420
 R  C  F  I  A  F  Q   | V  R  A  F  T  S  K  G  P  G  P  Y  A      p.1140

          .         .      | 23  .         .         .         .    g.70879
 GACGTTGTAAAGTCTACAACATCAG | AAATCAACCCATTTCCTCACCTCATAACTCTTCTT    c.3480
 D  V  V  K  S  T  T  S  E |   I  N  P  F  P  H  L  I  T  L  L      p.1160

          .         .         .         .         .         .       g.70939
 GGTAACAAGATAGTTTTTTTAGATATGGATCAAAATCAAGTTGTGTGGACGTTTTCAGCA       c.3540
 G  N  K  I  V  F  L  D  M  D  Q  N  Q  V  V  W  T  F  S  A         p.1180

          .         .         .         .         .         .       g.70999
 GAAAGAGTTATCAGTGCCGTTTGCTACACAGCTGATAATGAGATGGGATATTATGCTGAA       c.3600
 E  R  V  I  S  A  V  C  Y  T  A  D  N  E  M  G  Y  Y  A  E         p.1200

          .         .         .         .         | 24         .    g.72858
 GGGGACTCACTCTTTCTTCTGCACTTGCACAATCGCTCTAGCTCTGAG | CTTTTCCAAGAT    c.3660
 G  D  S  L  F  L  L  H  L  H  N  R  S  S  S  E   | L  F  Q  D      p.1220

          .         .         .         .         .         .       g.72918
 TCACTGGTTTTTGATATCACAGTTATTACAATTGACTGGATTTCAAGGCACCTCTACTTT       c.3720
 S  L  V  F  D  I  T  V  I  T  I  D  W  I  S  R  H  L  Y  F         p.1240

          .         .         .         .         .         .       g.72978
 GCACTGAAAGAATCACAAAATGGAATGCAAGTATTTGATGTTGATCTTGAACACAAGGTG       c.3780
 A  L  K  E  S  Q  N  G  M  Q  V  F  D  V  D  L  E  H  K  V         p.1260

          .         .         .         .         .         .       g.73038
 AAATATCCCAGAGAGGTGAAGATTCACAATAGGAATTCAACAATAATTTCTTTTTCTGTA       c.3840
 K  Y  P  R  E  V  K  I  H  N  R  N  S  T  I  I  S  F  S  V         p.1280

          .     | 25   .         .         .         .         .    g.73986
 TATCCTCTTTTAAG | TCGCTTGTATTGGACAGAAGTTTCCAATTTTGGCTACCAGATGTTC    c.3900
 Y  P  L  L  S  |  R  L  Y  W  T  E  V  S  N  F  G  Y  Q  M  F      p.1300

          .         .         .         .         .         .       g.74046
 TACTACAGTATTATCAGTCACACCTTGCACCGAATTCTGCAACCCACAGCTACAAACCAA       c.3960
 Y  Y  S  I  I  S  H  T  L  H  R  I  L  Q  P  T  A  T  N  Q         p.1320

          .         .         .         .         .         .       g.74106
 CAAAACAAAAGGAATCAATGTTCTTGTAATGTGACTGAATTTGAGTTAAGTGGAGCAATG       c.4020
 Q  N  K  R  N  Q  C  S  C  N  V  T  E  F  E  L  S  G  A  M         p.1340

          .         .         .         .         .         .       g.74166
 GCTATTGATACCTCTAACCTAGAGAAACCATTGATATACTTTGCCAAAGCACAAGAGATC       c.4080
 A  I  D  T  S  N  L  E  K  P  L  I  Y  F  A  K  A  Q  E  I         p.1360

          .         .         .         .         .         .       g.74226
 TGGGCAATGGATCTGGAAGGCTGTCAGTGTTGGAGAGTTATCACAGTACCTGCTATGCTC       c.4140
 W  A  M  D  L  E  G  C  Q  C  W  R  V  I  T  V  P  A  M  L         p.1380

   | 26      .         .         .         .         .         .    g.77745
 G | CAGGAAAAACCCTTGTTAGCTTAACTGTGGATGGAGATCTTATATACTGGATCATCACA    c.4200
 A |   G  K  T  L  V  S  L  T  V  D  G  D  L  I  Y  W  I  I  T      p.1400

          .         .         .         .         .         .       g.77805
 GCAAAGGACAGCACACAGATTTATCAGGCAAAGAAAGGAAATGGGGCCATCGTTTCCCAG       c.4260
 A  K  D  S  T  Q  I  Y  Q  A  K  K  G  N  G  A  I  V  S  Q         p.1420

          .         .         .         .         .         .       g.77865
 GTGAAGGCCCTAAGGAGTAGGCATATCTTGGCTTACAGTTCAGTTATGCAGCCTTTTCCA       c.4320
 V  K  A  L  R  S  R  H  I  L  A  Y  S  S  V  M  Q  P  F  P         p.1440

   | 27      .         .         .         .         .         .    g.86652
 G | ATAAAGCGTTTCTGTCTCTAGCTTCAGACACTGTGGAACCAACTATACTTAATGCCACT    c.4380
 D |   K  A  F  L  S  L  A  S  D  T  V  E  P  T  I  L  N  A  T      p.1460

          .         .         .         .         .         .       g.86712
 AACACTAGCCTCACAATCAGATTACCTCTGGCCAAGACAAACCTCACATGGTATGGCATC       c.4440
 N  T  S  L  T  I  R  L  P  L  A  K  T  N  L  T  W  Y  G  I         p.1480

          .         .         .         .         .         .       g.86772
 ACCAGCCCTACTCCAACATACCTGGTTTATTATGCAGAAGTTAATGACAGGAAAAACAGC       c.4500
 T  S  P  T  P  T  Y  L  V  Y  Y  A  E  V  N  D  R  K  N  S         p.1500

          .         .     | 28   .         .         .         .    g.88347
 TCTGACTTGAAATATAGAATTCTG | GAATTTCAGGACAGTATAGCTCTTATTGAAGATTTA    c.4560
 S  D  L  K  Y  R  I  L   | E  F  Q  D  S  I  A  L  I  E  D  L      p.1520

          .         .         .         .         .         .       g.88407
 CAACCATTTTCAACATACATGATACAGATAGCTGTAAAAAATTATTATTCAGATCCTTTG       c.4620
 Q  P  F  S  T  Y  M  I  Q  I  A  V  K  N  Y  Y  S  D  P  L         p.1540

          .         .         .         .          | 29        .    g.89234
 GAACATTTACCACCAGGAAAAGAGATTTGGGGAAAAACTAAAAATGGAG | TACCAGAGGCA    c.4680
 E  H  L  P  P  G  K  E  I  W  G  K  T  K  N  G  V |   P  E  A      p.1560

          .         .         .         .         .         .       g.89294
 GTGCAGCTCATTAATACAACTGTGCGGTCAGACACCAGCCTCATTATATCTTGGAGAGAA       c.4740
 V  Q  L  I  N  T  T  V  R  S  D  T  S  L  I  I  S  W  R  E         p.1580

          .         .         .         .         .         .       g.89354
 TCTCACAAGCCAAATGGACCTAAAGAATCAGTCCGTTATCAGTTGGCAATCTCACACCTG       c.4800
 S  H  K  P  N  G  P  K  E  S  V  R  Y  Q  L  A  I  S  H  L         p.1600

          .         .         .         .         .         .       g.89414
 GCCCTAATTCCTGAAACTCCTCTAAGACAAAGTGAATTTCCAAATGGAAGGCTCACTCTC       c.4860
 A  L  I  P  E  T  P  L  R  Q  S  E  F  P  N  G  R  L  T  L         p.1620

          .         .         .         .   | 30     .         .    g.89562
 CTTGTTACTAGACTGTCTGGTGGAAATATTTATGTGTTAAAG | GTTCTTGCCTGCCACTCT    c.4920
 L  V  T  R  L  S  G  G  N  I  Y  V  L  K   | V  L  A  C  H  S      p.1640

          .         .         .         .         .         .       g.89622
 GAGGAAATGTGGTGTACAGAGAGTCATCCTGTCACTGTGGAAATGTTTAACACACCAGAG       c.4980
 E  E  M  W  C  T  E  S  H  P  V  T  V  E  M  F  N  T  P  E         p.1660

          .         .         .         .         .         .       g.89682
 AAACCTTATTCCTTGGTTCCAGAGAACACTAGTTTGCAATTTAATTGGAAGGCTCCATTG       c.5040
 K  P  Y  S  L  V  P  E  N  T  S  L  Q  F  N  W  K  A  P  L         p.1680

          .         .         .          | 31        .         .    g.93536
 AATGTTAACCTCATCAGATTTTGGGTTGAGCTACAGAAG | TGGAAATACAATGAGTTTTAC    c.5100
 N  V  N  L  I  R  F  W  V  E  L  Q  K   | W  K  Y  N  E  F  Y      p.1700

          .         .         .         .         .         .       g.93596
 CATGTTAAAACTTCATGCAGCCAAGGTCCTGCTTATGTCTGTAATATCACAAATCTACAA       c.5160
 H  V  K  T  S  C  S  Q  G  P  A  Y  V  C  N  I  T  N  L  Q         p.1720

          .         .         .         .         .         .       g.93656
 CCTTATACTTCATATAATGTCAGAGTAGTGGTGGTTTATAAGACGGGAGAAAATAGCACC       c.5220
 P  Y  T  S  Y  N  V  R  V  V  V  V  Y  K  T  G  E  N  S  T         p.1740

          .         .         | 32         .         .         .    g.101441
 TCACTTCCAGAAAGCTTTAAGACAAAAG | CTGGAGTCCCAAATAAACCAGGCATTCCCAAA    c.5280
 S  L  P  E  S  F  K  T  K  A |   G  V  P  N  K  P  G  I  P  K      p.1760

          .         .         .         .         .         .       g.101501
 TTACTAGAAGGGAGTAAAAATTCAATACAGTGGGAGAAAGCTGAAGATAATGGATGTAGA       c.5340
 L  L  E  G  S  K  N  S  I  Q  W  E  K  A  E  D  N  G  C  R         p.1780

          .         .       | 33 .         .         .         .    g.104475
 ATTACATACTATATCCTTGAGATAAG | AAAGAGCACTTCAAATAATTTACAGAACCAGAAT    c.5400
 I  T  Y  Y  I  L  E  I  R  |  K  S  T  S  N  N  L  Q  N  Q  N      p.1800

          .         .         .         .         .         .       g.104535
 TTAAGGTGGAAGATGACATTTAATGGATCCTGCAGTAGTGTTTGCACATGGAAGTCCAAA       c.5460
 L  R  W  K  M  T  F  N  G  S  C  S  S  V  C  T  W  K  S  K         p.1820

          .         .         .         .         .         .       g.104595
 AACCTGAAAGGAATATTTCAGTTCAGAGTAGTAGCTGCAAATAATCTAGGGTTTGGTGAA       c.5520
 N  L  K  G  I  F  Q  F  R  V  V  A  A  N  N  L  G  F  G  E         p.1840

          .         .         .        | 34.         .         .    g.106463
 TATAGTGGAATCAGTGAGAATATTATATTAGTTGGAG | ATGATTTTTGGATACCAGAAACA    c.5580
 Y  S  G  I  S  E  N  I  I  L  V  G  D |   D  F  W  I  P  E  T      p.1860

          .         .         .         .         .         .       g.106523
 AGTTTCATACTTACTATTATAGTTGGAATATTTCTGGTTGTTACAATCCCACTGACCTTT       c.5640
 S  F  I  L  T  I  I  V  G  I  F  L  V  V  T  I  P  L  T  F         p.1880

   | 35      .         .         .         .         .         .    g.109520
 G | TCTGGCATAGAAGATTAAAGAATCAAAAAAGTGCCAAGGAAGGGGTGACAGTGCTTATA    c.5700
 V |   W  H  R  R  L  K  N  Q  K  S  A  K  E  G  V  T  V  L  I      p.1900

          .         .         .         .         .         .       g.109580
 AACGAAGACAAAGAGTTGGCTGAGCTGCGAGGTCTGGCAGCCGGAGTAGGCCTGGCTAAT       c.5760
 N  E  D  K  E  L  A  E  L  R  G  L  A  A  G  V  G  L  A  N         p.1920

          .        | 36.         .         .         .         .    g.110868
 GCCTGCTATGCAATACA | TACTCTTCCAACCCAAGAGGAGATTGAAAATCTTCCTGCCTTC    c.5820
 A  C  Y  A  I  H  |  T  L  P  T  Q  E  E  I  E  N  L  P  A  F      p.1940

          .         .         .         .         .         .       g.110928
 CCTCGGGAAAAACTGACTCTGCGTCTCTTGCTGGGAAGTGGAGCCTTTGGAGAAGTGTAT       c.5880
 P  R  E  K  L  T  L  R  L  L  L  G  S  G  A  F  G  E  V  Y         p.1960

          .         .         .         .         .         .       g.110988
 GAAGGAACAGCAGTGGACATCTTAGGAGTTGGAAGTGGAGAAATCAAAGTAGCAGTGAAG       c.5940
 E  G  T  A  V  D  I  L  G  V  G  S  G  E  I  K  V  A  V  K         p.1980

  | 37       .         .         .         .         .         .    g.112663
  | ACTTTGAAGAAGGGTTCCACAGACCAGGAGAAGATTGAATTCCTGAAGGAGGCACATCTG    c.6000
  | T  L  K  K  G  S  T  D  Q  E  K  I  E  F  L  K  E  A  H  L      p.2000

       | 38  .         .         .         .         .         .    g.113638
 ATGAG | CAAATTTAATCATCCCAACATTCTGAAGCAGCTTGGAGTTTGTCTGCTGAATGAA    c.6060
 M  S  |  K  F  N  H  P  N  I  L  K  Q  L  G  V  C  L  L  N  E      p.2020

          .         .         .         .         .         .       g.113698
 CCCCAATACATTATCCTGGAACTGATGGAGGGAGGAGACCTTCTTACTTATTTGCGTAAA       c.6120
 P  Q  Y  I  I  L  E  L  M  E  G  G  D  L  L  T  Y  L  R  K         p.2040

          .      | 39  .         .         .         .         .    g.119783
 GCCCGGATGGCAACG | TTTTATGGTCCTTTACTCACCTTGGTTGACCTTGTAGACCTGTGT    c.6180
 A  R  M  A  T   | F  Y  G  P  L  L  T  L  V  D  L  V  D  L  C      p.2060

          .         .         .         .         .    | 40    .    g.120581
 GTAGATATTTCAAAAGGCTGTGTCTACTTGGAACGGATGCATTTCATTCACAG | GGATCTG    c.6240
 V  D  I  S  K  G  C  V  Y  L  E  R  M  H  F  I  H  R  |  D  L      p.2080

          .         .         .         .         .         .       g.120641
 GCAGCTAGAAATTGCCTTGTTTCCGTGAAAGACTATACCAGTCCACGGATAGTGAAGATT       c.6300
 A  A  R  N  C  L  V  S  V  K  D  Y  T  S  P  R  I  V  K  I         p.2100

          .         .         .         .         .         .       g.120701
 GGAGACTTTGGACTCGCCAGAGACATCTATAAAAATGATTACTATAGAAAGAGAGGGGAA       c.6360
 G  D  F  G  L  A  R  D  I  Y  K  N  D  Y  Y  R  K  R  G  E         p.2120

          .         .         .         .         .         .       g.120761
 GGCCTGCTCCCAGTTCGGTGGATGGCTCCAGAAAGTTTGATGGATGGAATCTTCACTACT       c.6420
 G  L  L  P  V  R  W  M  A  P  E  S  L  M  D  G  I  F  T  T         p.2140

          .     | 41   .         .         .         .         .    g.121973
 CAATCTGATGTATG | GTCTTTTGGAATTCTGATTTGGGAGATTTTAACTCTTGGTCATCAG    c.6480
 Q  S  D  V  W  |  S  F  G  I  L  I  W  E  I  L  T  L  G  H  Q      p.2160

          .         .         .         .         .         .       g.122033
 CCTTATCCAGCTCATTCCAACCTTGATGTGTTAAACTATGTGCAAACAGGAGGGAGACTG       c.6540
 P  Y  P  A  H  S  N  L  D  V  L  N  Y  V  Q  T  G  G  R  L         p.2180

          .         .          | 42        .         .         .    g.129749
 GAGCCACCAAGAAATTGTCCTGATGATCT | GTGGAATTTAATGACCCAGTGCTGGGCTCAA    c.6600
 E  P  P  R  N  C  P  D  D  L  |  W  N  L  M  T  Q  C  W  A  Q      p.2200

          .         .         .         .         .         .       g.129809
 GAACCCGACCAAAGACCTACTTTTCATAGAATTCAGGACCAACTTCAGTTATTCAGAAAT       c.6660
 E  P  D  Q  R  P  T  F  H  R  I  Q  D  Q  L  Q  L  F  R  N         p.2220

          .         .         .         .         .         .       g.129869
 TTTTTCTTAAATAGCATTTATAAGTCCAGAGATGAAGCAAACAACAGTGGAGTCATAAAT       c.6720
 F  F  L  N  S  I  Y  K  S  R  D  E  A  N  N  S  G  V  I  N         p.2240

          .    | 43    .         .         .         .         .    g.142100
 GAAAGCTTTGAAG | GTGAAGATGGCGATGTGATTTGTTTGAATTCAGATGACATTATGCCA    c.6780
 E  S  F  E  G |   E  D  G  D  V  I  C  L  N  S  D  D  I  M  P      p.2260

          .         .         .         .         .         .       g.142160
 GTTGCTTTAATGGAAACGAAGAACCGAGAAGGGTTAAACTATATGGTACTTGCTACAGAA       c.6840
 V  A  L  M  E  T  K  N  R  E  G  L  N  Y  M  V  L  A  T  E         p.2280

          .         .         .         .         .         .       g.142220
 TGTGGCCAAGGTGAAGAAAAGTCTGAGGGTCCTCTAGGCTCCCAGGAATCTGAATCTTGT       c.6900
 C  G  Q  G  E  E  K  S  E  G  P  L  G  S  Q  E  S  E  S  C         p.2300

          .         .         .         .         .         .       g.142280
 GGTCTGAGGAAAGAAGAGAAGGAACCACATGCAGACAAAGATTTCTGCCAAGAAAAACAA       c.6960
 G  L  R  K  E  E  K  E  P  H  A  D  K  D  F  C  Q  E  K  Q         p.2320

          .         .         .         .         .         .       g.142340
 GTGGCTTACTGCCCTTCTGGCAAGCCTGAAGGCCTGAACTATGCCTGTCTCACTCACAGT       c.7020
 V  A  Y  C  P  S  G  K  P  E  G  L  N  Y  A  C  L  T  H  S         p.2340

          .         .                                               g.142364
 GGATATGGAGATGGGTCTGATTAA                                           c.7044
 G  Y  G  D  G  S  D  X                                             p.2347

          .         .         .         .         .         .       g.142424
 tagcgttgtttgggaaatagagagttgagataaacactctcattcagtagttactgaaag       c.*60

          .         .         .         .         .         .       g.142484
 aaaactctgctagaatgataaatgtcatggtggtctataactccaaataaacaatgcaac       c.*120

                                                                    g.142489
 gttcc                                                              c.*125

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The C-ros oncogene 1 , receptor tyrosine kinase protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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