ribosomal protein L11 (RPL11) - coding DNA reference sequence

(used for variant description)

(last modified December 29, 2018)

This file was created to facilitate the description of sequence variants on transcript NM_000975.3 in the RPL11 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_011741.1, covering RPL11 transcript NM_000975.3.

Please note that introns are available by clicking on the exon numbers above the sequence.

 (upstream sequence)
                     .         .         .         .                g.5020
                aaggccctcggccggaagctccgctttctcttcctgctctccatc       c.-1

        | 02 .         .         .         .         .         .    g.5859
 ATGGCG | CAGGATCAAGGTGAAAAGGAGAACCCCATGCGGGAACTTCGCATCCGCAAACTC    c.60
 M  A   | Q  D  Q  G  E  K  E  N  P  M  R  E  L  R  I  R  K  L      p.20

          .         .         .         .         .         .       g.5919
 TGTCTCAACATCTGTGTTGGGGAGAGTGGAGACAGACTGACGCGAGCAGCCAAGGTGTTG       c.120
 C  L  N  I  C  V  G  E  S  G  D  R  L  T  R  A  A  K  V  L         p.40

          .         .         .        | 03.         .         .    g.7026
 GAGCAGCTCACAGGGCAGACCCCTGTGTTTTCCAAAG | CTAGATACACTGTCAGATCCTTT    c.180
 E  Q  L  T  G  Q  T  P  V  F  S  K  A |   R  Y  T  V  R  S  F      p.60

          .         .         .         .         .         .       g.7086
 GGCATCCGGAGAAATGAAAAGATTGCTGTCCACTGCACAGTTCGAGGGGCCAAGGCAGAA       c.240
 G  I  R  R  N  E  K  I  A  V  H  C  T  V  R  G  A  K  A  E         p.80

          .         .     | 04   .         .         .         .    g.7892
 GAAATCTTGGAGAAGGGTCTAAAG | GTGCGGGAGTATGAGTTAAGAAAAAACAACTTCTCA    c.300
 E  I  L  E  K  G  L  K   | V  R  E  Y  E  L  R  K  N  N  F  S      p.100

          .         .         .         .         .         .       g.7952
 GATACTGGAAACTTTGGTTTTGGGATCCAGGAACACATCGATCTGGGTATCAAATATGAC       c.360
 D  T  G  N  F  G  F  G  I  Q  E  H  I  D  L  G  I  K  Y  D         p.120

          .         .         .       | 05 .         .         .    g.9018
 CCAAGCATTGGTATCTACGGCCTGGACTTCTATGTG | GTGCTGGGTAGGCCAGGTTTCAGC    c.420
 P  S  I  G  I  Y  G  L  D  F  Y  V   | V  L  G  R  P  G  F  S      p.140

          .         .         .         .         .         .       g.9078
 ATCGCAGACAAGAAGCGCAGGACAGGCTGCATTGGGGCCAAACACAGAATCAGCAAAGAG       c.480
 I  A  D  K  K  R  R  T  G  C  I  G  A  K  H  R  I  S  K  E         p.160

          .         .        | 06.         .         .              g.9573
 GAGGCCATGCGCTGGTTCCAGCAGAAG | TATGATGGGATCATCCTTCCTGGCAAATAA       c.537
 E  A  M  R  W  F  Q  Q  K   | Y  D  G  I  I  L  P  G  K  X         p.178

          .         .         .         .         .                 g.9625
 attcccgtttctatccaaaagagcaataaaaagttttcagtgaaatgtgcaa               c.*52

 (downstream sequence)

Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10^th nucleotide is indicated by a "." above the sequence. The Ribosomal protein L11 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10^th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.