related RAS viral (r-ras) oncogene homolog 2 (RRAS2) - coding DNA reference sequence

(used for variant description)

(last modified June 11, 2019)

This file was created to facilitate the description of sequence variants on transcript NM_012250.5 in the RRAS2 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_017058.1, covering RRAS2 transcript NM_012250.5.

Please note that introns are available by clicking on the exon numbers above the sequence.

 (upstream sequence)
                                                   .                g.10336
                                               cagacggccatttg       c.-301

 .         .         .         .         .         .                g.10396
 tggcggcgctggaggctgcgttcggcaggcgctgcggagacgcgtagaggagcgcgcccc       c.-241

 .         .         .         .         .         .                g.10456
 ccggccgctgccgcccctggcccgtgccgtcaccccgcttctccgcgcctcgggcggtac       c.-181

 .         .         .         .         .         .                g.10516
 ccagccagtccccagcgccgcgctaccgcgctgaccggccctccagacgcctcccggtac       c.-121

 .         .         .         .         .         .                g.10576
 ccgggaccccagcccggccgctcgcccgcagcccgccggccgcacacgtccccggagccg       c.-61

 .         .         .         .         .         .                g.10636
 ggcctagggcgggcggcagcggcggctcggcgcagtcaggctgggctctgtagcgtcccc       c.-1

          .         .         .         .         .         .       g.10696
 ATGGCCGCGGCCGGCTGGCGGGACGGCTCCGGCCAGGAGAAGTACCGGCTCGTGGTGGTC       c.60
 M  A  A  A  G  W  R  D  G  S  G  Q  E  K  Y  R  L  V  V  V         p.20

          .         .         .         .         | 02         .    g.73663
 GGCGGGGGCGGCGTGGGCAAGTCGGCGCTCACCATCCAGTTCATCCAG | TCCTATTTTGTA    c.120
 G  G  G  G  V  G  K  S  A  L  T  I  Q  F  I  Q   | S  Y  F  V      p.40

          .         .         .         .         .         .       g.73723
 ACGGATTATGATCCAACCATTGAAGATTCTTACACAAAGCAGTGTGTGATAGATGACAGA       c.180
 T  D  Y  D  P  T  I  E  D  S  Y  T  K  Q  C  V  I  D  D  R         p.60

          .       | 03 .         .         .         .         .    g.74688
 GCAGCCCGGCTAGATA | TTTTGGATACAGCAGGACAAGAAGAGTTTGGAGCCATGAGAGAA    c.240
 A  A  R  L  D  I |   L  D  T  A  G  Q  E  E  F  G  A  M  R  E      p.80

          .         .         .         .         .          | 04    g.74928
 CAGTATATGAGGACTGGCGAAGGCTTCCTGTTGGTCTTTTCAGTCACAGATAGAGGCAG | T    c.300
 Q  Y  M  R  T  G  E  G  F  L  L  V  F  S  V  T  D  R  G  S  |      p.100

          .         .         .         .         .         .       g.74988
 TTTGAAGAAATCTATAAGTTTCAAAGACAGATTCTCAGAGTAAAGGATCGTGATGAGTTC       c.360
 F  E  E  I  Y  K  F  Q  R  Q  I  L  R  V  K  D  R  D  E  F         p.120

          .         .         .         .         | 05         .    g.87798
 CCAATGATTTTAATTGGTAATAAAGCAGATCTGGATCATCAAAGACAG | GTAACACAGGAA    c.420
 P  M  I  L  I  G  N  K  A  D  L  D  H  Q  R  Q   | V  T  Q  E      p.140

          .         .         .         .         .         .       g.87858
 GAAGGACAACAGTTAGCACGGCAGCTTAAGGTAACATACATGGAGGCATCAGCAAAGATT       c.480
 E  G  Q  Q  L  A  R  Q  L  K  V  T  Y  M  E  A  S  A  K  I         p.160

          .         .         .         .        | 06.         .    g.90095
 AGGATGAATGTAGATCAAGCTTTCCATGAACTTGTCCGGGTTATCAG | GAAATTTCAAGAG    c.540
 R  M  N  V  D  Q  A  F  H  E  L  V  R  V  I  R  |  K  F  Q  E      p.180

          .         .         .         .         .         .       g.90155
 CAGGAATGTCCTCCTTCACCAGAACCAACACGGAAAGAAAAAGACAAGAAAGGCTGCCAT       c.600
 Q  E  C  P  P  S  P  E  P  T  R  K  E  K  D  K  K  G  C  H         p.200

          .                                                         g.90170
 TGTGTCATTTTCTAG                                                    c.615
 C  V  I  F  X                                                      p.204

          .         .         .         .         .         .       g.90230
 aatcccttcagttttagctaccaacggccaggaaaagccctcatcttctctttctctcct       c.*60

          .         .         .         .         .         .       g.90290
 cagtttacatcttgttggtacctttctagccttagacaaatgatcaccatgttagcctta       c.*120

          .         .         .         .         .         .       g.90350
 gacgaagaagctggctagtcctttctgtgaagctaatacaatggtcatttccagacaaat       c.*180

          .         .         .         .         .         .       g.90410
 ttaaaggaaacactaaggctgcttcaaagattatctgattcctttaaaatatatgtctat       c.*240

          .         .         .         .         .         .       g.90470
 atacacagacatgctctttttttaagtgcttacattttaatagagatgaatcagttttgg       c.*300

          .         .         .         .         .         .       g.90530
 aatctaagctgtttgccaagctgaagctacaggttgtgaaataatttttaacttttggaa       c.*360

          .         .         .         .         .         .       g.90590
 tcatactgcctactgttactctaaatagaaatatagggttttttttaatgtgaatttttg       c.*420

          .         .         .         .         .         .       g.90650
 cctatctttaaacatttcaatgtcagcctttgttaaccttaaatacactgaattgaatct       c.*480

          .         .         .         .         .         .       g.90710
 acaaaagtgaaccatctcagacctttactgatactacaacttttgttttctgatggccaa       c.*540

          .         .         .         .         .         .       g.90770
 aataccaaatgcctgttgtatttatggattaaaaactgcttataaaaccctgtgttacta       c.*600

          .         .         .         .         .         .       g.90830
 ctcctactcttggagatgataatattctatgtggtcaaatatttggactcatttaggact       c.*660

          .         .         .         .         .         .       g.90890
 tagatatttcagtgtacttgattttttaatttaactctttttcacagccacgctaagggt       c.*720

          .         .         .         .         .         .       g.90950
 aaaaaggaataatttccttctgtcttccttttcaagtatttctgggtaagggattcaaaa       c.*780

          .         .         .         .         .         .       g.91010
 aactaaaactgtttttgtttgtaatataaaatatggaattgatctttccagggtcagaga       c.*840

          .         .         .         .         .         .       g.91070
 tgattaatgtttttgctatatacttttatacattattttcttatcaaactagttaacaag       c.*900

          .         .         .         .         .         .       g.91130
 tatttttatatgtttgtaagcagatatgctttcatagcataccttgtgtatatgtaaaga       c.*960

          .         .         .         .         .         .       g.91190
 taagtatttaattctcactgttcacttttaactgacaaagaaaaacaagtggaaactaca       c.*1020

          .         .         .         .         .         .       g.91250
 gaaactgtggtagaacttttacttgctggtctggtcttggttgtacccatctttggccag       c.*1080

          .         .         .         .         .         .       g.91310
 tcacataactactcaagaaaccttcccaatagagtacaacaggatgagactctgaaatca       c.*1140

          .         .         .         .         .         .       g.91370
 ctttcagtattccctgctagatattgattgttatttcaagtattaagtgtaagcttttaa       c.*1200

          .         .         .         .         .         .       g.91430
 tggataattagtataactgtggatggcatctgattttgtttttaattctgtggattgtgt       c.*1260

          .         .         .         .         .         .       g.91490
 ttaagcaattcaatagtatgttcctgattttgagatgctaagtggtattgcacagttgtc       c.*1320

          .         .         .         .         .         .       g.91550
 actttatcaagtgtgtacaacagtcccatgaagtttatagagcatacccttgtatagctt       c.*1380

          .         .         .                                     g.91587
 caggtgctagaattaaaattgatctgttatcacaaga                              c.*1417

 (downstream sequence)

Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10^th nucleotide is indicated by a "." above the sequence. The Related RAS viral (r-ras) oncogene homolog 2 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10^th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.