ring finger and SPRY domain containing 1 (RSPRY1) - coding DNA reference sequence

(used for variant description)

(last modified December 24, 2023)


This file was created to facilitate the description of sequence variants on transcript NM_133368.1 in the RSPRY1 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000016.9, covering RSPRY1 transcript NM_133368.1.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                               .         .         .                g.5038
                       ctctgcgcgtaatggcagcgccgtggcctcgcgtccat       c.-241

 .         .         .         .         .         .                g.5098
 ctttgccgttctctcggacctgtcacaaaggagtcgcgccgccgccgccgccccctccct       c.-181

 .         .         .     | 02   .         .         .             g.23210
 ccggtgggcccgggaggtagagaaa | aactgccattggatgtccagaatcccctgtagttg    c.-121

 .         .         .         .         .         .                g.23270
 ataatgttgggaataagctctgcaactttctttggcattcagttgttaaaaacaaatagg       c.-61

 .         .         .         .         .         .                g.23330
 atgcaaattcctcaactccaggttatgaaaacagtacttggaaaactgaaaactacctaa       c.-1

          .         .         .         .         .         .       g.23390
 ATGATCGTCTTTGGTTGGGCCGTGTTCTTAGCGAGCAGAAGCCTTGGCCAGGGTCTGTTG       c.60
 M  I  V  F  G  W  A  V  F  L  A  S  R  S  L  G  Q  G  L  L         p.20

          .         .         .         .         .         .       g.23450
 TTGACTCTCGAAGAGCACATAGCCCACTTCCTAGGGACTGGAGGTGCCGCTACTACCATG       c.120
 L  T  L  E  E  H  I  A  H  F  L  G  T  G  G  A  A  T  T  M         p.40

          .         .         .         .         .         .       g.23510
 GGTAATTCCTGTATCTGCCGAGATGACAGTGGAACAGATGACAGTGTTGACACCCAACAG       c.180
 G  N  S  C  I  C  R  D  D  S  G  T  D  D  S  V  D  T  Q  Q         p.60

          .         .         .         .         .         .       g.23570
 CAACAGGCCGAGAACAGTGCAGTACCCACTGCTGACACAAGGAGCCAACCACGGGACCCT       c.240
 Q  Q  A  E  N  S  A  V  P  T  A  D  T  R  S  Q  P  R  D  P         p.80

          .         .         .         .         .         .       g.23630
 GTTCGGCCACCAAGGAGGGGCCGAGGACCTCATGAGCCAAGGAGAAAGAAACAAAATGTG       c.300
 V  R  P  P  R  R  G  R  G  P  H  E  P  R  R  K  K  Q  N  V         p.100

          .         .         .         .         . | 03       .    g.26739
 GATGGGCTAGTGTTGGACACACTGGCAGTAATACGGACTCTTGTAGATAA | TGATCAGGAA    c.360
 D  G  L  V  L  D  T  L  A  V  I  R  T  L  V  D  N  |  D  Q  E      p.120

          .         .         .         .    | 04    .         .    g.27763
 CCTCCCTATTCAATGATAACATTACACGAAATGGCAGAAACAG | ATGAAGGATGGTTGGAT    c.420
 P  P  Y  S  M  I  T  L  H  E  M  A  E  T  D |   E  G  W  L  D      p.140

          .         .         .         .         .         .       g.27823
 GTTGTCCAGTCTTTAATTAGAGTTATTCCACTGGAAGATCCACTGGGACCAGCTGTTATA       c.480
 V  V  Q  S  L  I  R  V  I  P  L  E  D  P  L  G  P  A  V  I         p.160

          .         .         .       | 05 .         .         .    g.31667
 ACATTGTTACTAGATGAATGTCCATTGCCCACTAAA | GATGCACTCCAGAAATTGACTGAA    c.540
 T  L  L  L  D  E  C  P  L  P  T  K   | D  A  L  Q  K  L  T  E      p.180

          .         .         .         .         .         .       g.31727
 ATTCTCAATTTAAATGGAGAAGTAGCTTGCCAGGACTCAAGCCATCCTGCCAAACACAGG       c.600
 I  L  N  L  N  G  E  V  A  C  Q  D  S  S  H  P  A  K  H  R         p.200

          .         .         .         .    | 06    .         .    g.32576
 AACACATCTGCAGTCCTAGGCTGCTTGGCCGAGAAACTAGCAG | GTCCTGCAAGTATAGGT    c.660
 N  T  S  A  V  L  G  C  L  A  E  K  L  A  G |   P  A  S  I  G      p.220

          .         .         .         .   | 07     .         .    g.34796
 TTACTTAGCCCAGGAATACTGGAATACTTGCTACAGTGTCTG | AAGTTACAGTCCCACCCC    c.720
 L  L  S  P  G  I  L  E  Y  L  L  Q  C  L   | K  L  Q  S  H  P      p.240

          .         .         .         .          | 08        .    g.35586
 ACAGTCATGCTTTTTGCACTTATCGCACTGGAAAAGTTTGCACAGACAA | GTGAAAATAAA    c.780
 T  V  M  L  F  A  L  I  A  L  E  K  F  A  Q  T  S |   E  N  K      p.260

          .         .         .         .         .         .       g.35646
 TTGACTATTTCTGAATCCAGTATTAGTGACCGGCTTGTCACATTGGAGTCCTGGGCTAAT       c.840
 L  T  I  S  E  S  S  I  S  D  R  L  V  T  L  E  S  W  A  N         p.280

          .         .         .         .         .         .       g.35706
 GATCCTGATTATCTGAAACGTCAAGTTGGTTTCTGTGCCCAGTGGAGCTTAGACAATCTC       c.900
 D  P  D  Y  L  K  R  Q  V  G  F  C  A  Q  W  S  L  D  N  L         p.300

   | 09      .         .         .         .         .         .    g.39462
 T | TTTTAAAAGAAGGTAGACAGCTGACCTATGAGAAAGTGAACTTGAGTAGCATTAGGGCC    c.960
 F |   L  K  E  G  R  Q  L  T  Y  E  K  V  N  L  S  S  I  R  A      p.320

          .         .         .         .         .        | 10.    g.39946
 ATGCTGAATAGCAATGATGTCAGCGAGTACCTGAAGATCTCACCTCATGGCTTAGAG | GCT    c.1020
 M  L  N  S  N  D  V  S  E  Y  L  K  I  S  P  H  G  L  E   | A      p.340

          .         .         .         .         .         .       g.40006
 CGCTGTGATGCCTCCTCTTTTGAAAGTGTGCGTTGCACCTTTTGTGTGGATGCCGGGGTA       c.1080
 R  C  D  A  S  S  F  E  S  V  R  C  T  F  C  V  D  A  G  V         p.360

          .         .         .         .         .         .       g.40066
 TGGTACTATGAAGTAACAGTGGTCACTTCTGGCGTCATGCAGATTGGCTGGGCCACTCGA       c.1140
 W  Y  Y  E  V  T  V  V  T  S  G  V  M  Q  I  G  W  A  T  R         p.380

          .         .  | 11      .         .         .         .    g.46052
 GACAGCAAATTCCTCAATCAT | GAAGGCTACGGCATTGGGGATGATGAATACTCCTGTGCG    c.1200
 D  S  K  F  L  N  H   | E  G  Y  G  I  G  D  D  E  Y  S  C  A      p.400

          .         .         .         .         .         .       g.46112
 TATGATGGCTGCCGGCAGCTGATTTGGTACAATGCCAGAAGTAAGCCTCACATACACCCA       c.1260
 Y  D  G  C  R  Q  L  I  W  Y  N  A  R  S  K  P  H  I  H  P         p.420

          .    | 12    .         .         .         .         .    g.49429
 TGCTGGAAAGAAG | GAGATACAGTAGGATTTCTGTTAGACTTGAATGAAAAGCAAATGATC    c.1320
 C  W  K  E  G |   D  T  V  G  F  L  L  D  L  N  E  K  Q  M  I      p.440

          .         .         .         .         .       | 13 .    g.49842
 TTCTTTTTAAATGGCAACCAGCTGCCTCCTGAAAAGCAAGTCTTTTCATCTACTGT | ATCT    c.1380
 F  F  L  N  G  N  Q  L  P  P  E  K  Q  V  F  S  S  T  V  |  S      p.460

          .         .         .         .         .         .       g.49902
 GGATTTTTTGCTGCAGCTAGTTTCATGTCATATCAACAATGTGAGTTCAATTTTGGAGCA       c.1440
 G  F  F  A  A  A  S  F  M  S  Y  Q  Q  C  E  F  N  F  G  A         p.480

          .         .         .         .         .         .       g.49962
 AAACCATTCAAATACCCACCATCTATGAAATTTAGCACTTTTAATGACTACGCCTTCCTA       c.1500
 K  P  F  K  Y  P  P  S  M  K  F  S  T  F  N  D  Y  A  F  L         p.500

          .         .          | 14        .         .         .    g.53826
 ACAGCTGAAGAAAAAATCATTTTGCCAAG | GCACAGGCGTCTTGCTCTGTTGAAGCAAGTC    c.1560
 T  A  E  E  K  I  I  L  P  R  |  H  R  R  L  A  L  L  K  Q  V      p.520

          .         .         .         .         .         .       g.53886
 AGTATCCGAGAAAACTGCTGTTCCCTTTGTTGTGATGAGGTAGCAGACACACAATTGAAG       c.1620
 S  I  R  E  N  C  C  S  L  C  C  D  E  V  A  D  T  Q  L  K         p.540

          .     | 15   .         .         .         .         .    g.57596
 CCATGTGGACACAG | TGACCTGTGCATGGATTGTGCCTTGCAGCTGGAGACCTGCCCATTG    c.1680
 P  C  G  H  S  |  D  L  C  M  D  C  A  L  Q  L  E  T  C  P  L      p.560

          .         .         .         .         .                 g.57647
 TGTCGTAAAGAAATAGTATCTAGAATCAGACAGATTTCTCATATTTCATGA                c.1731
 C  R  K  E  I  V  S  R  I  R  Q  I  S  H  I  S  X                  p.576

          .         .         .         .         .         .       g.57707
 cacatgtgaagaggcatcgtggacttttttctactcaattccagccaatgttgaaaagaa       c.*60

                                                                    g.57710
 aaa                                                                c.*63

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Ring finger and SPRY domain containing 1 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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