reticulon 4 interacting protein 1 (RTN4IP1) - coding DNA reference sequence

(used for variant description)

(last modified June 26, 2017)


This file was created to facilitate the description of sequence variants on transcript NM_032730.4 in the RTN4IP1 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_047205.1, covering RTN4IP1 transcript NM_032730.4.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
           .         .         .         .         .                g.5057
    gcaaagccatcccggcggctaaggagagcgggcaggcaaggagattccgggccaggg       c.-421

 .         .         .         .         .         .                g.5117
 tcgcggcggcagtcggcaagcgttcgattctctggcgttggatcgcgagcggtgtctgct       c.-361

 .         .         .         .         .         .                g.5177
 tgtcccgccgagggctcccaggacagggcagggatctagggggtttgcgcacctgctttt       c.-301

 .         .         .         .         .         .                g.5237
 taatgccccgcccccccttttttttttaaagtggagggggtgaaagtgagggaggagaat       c.-241

 .         .         .         .         .         .                g.5297
 ggacagaatactgactggaacgttaattcgagcatttcatatgcgaagagcggaataaca       c.-181

 .         .         .         .         .         .                g.5357
 gttccgtattcttctttcagtttctccattagattagcttcattttcgaatgctccgttt       c.-121

 .         .         .         .         .         .                g.5417
 tgcatgcttaattttgaaactagcccgtggtttggcagaatttgactgaattcaggggtg       c.-61

 .         .         .         .         .         .                g.5477
 agagtttgatccagtccaagtgtatttgaatttgagcacgcagttcaaccagtgtttaca       c.-1

          .         .         .         .         .         .       g.5537
 ATGGAATTTCTGAAGACTTGTGTACTTAGAAGAAATGCATGCACTGCGGTTTGCTTCTGG       c.60
 M  E  F  L  K  T  C  V  L  R  R  N  A  C  T  A  V  C  F  W         p.20

          .         .         .         .         .         .       g.5597
 AGAAGCAAAGTTGTCCAAAAGCCTTCAGTTAGAAGGATTAGTACTACCTCTCCTAGGAGC       c.120
 R  S  K  V  V  Q  K  P  S  V  R  R  I  S  T  T  S  P  R  S         p.40

          .         .         .         .         .         .       g.5657
 ACTGTCATGCCTGCTTGGGTGATAGATAAATATGGGAAGAATGAAGTGCTTCGATTCACT       c.180
 T  V  M  P  A  W  V  I  D  K  Y  G  K  N  E  V  L  R  F  T         p.60

          .         .         .         .         .         .       g.5717
 CAGAACATGATGATGCCTATCATACACTATCCAAATGAAGTCATTGTCAAAGTTCACGCT       c.240
 Q  N  M  M  M  P  I  I  H  Y  P  N  E  V  I  V  K  V  H  A         p.80

          .         .         .     | 02   .         .         .    g.11555
 GCCAGTGTAAATCCTATAGACGTTAATATGAGAA | GTGGTTATGGAGCTACAGCTTTAAAT    c.300
 A  S  V  N  P  I  D  V  N  M  R  S |   G  Y  G  A  T  A  L  N      p.100

          .         .         .         .         .         .       g.11615
 ATGAAGCGTGATCCTTTACACGTGAAAATCAAAGGAGAAGAATTTCCTCTGACTCTGGGT       c.360
 M  K  R  D  P  L  H  V  K  I  K  G  E  E  F  P  L  T  L  G         p.120

          .         .         .         .         .         .       g.11675
 CGGGATGTCTCTGGCGTGGTGATGGAATGTGGGCTTGATGTGAAATACTTCAAGCCTGGA       c.420
 R  D  V  S  G  V  V  M  E  C  G  L  D  V  K  Y  F  K  P  G         p.140

        | 03 .         .         .         .         .         .    g.13059
 GATGAG | GTCTGGGCTGCAGTTCCTCCTTGGAAACAAGGCACTCTTTCAGAGTTTGTTGTA    c.480
 D  E   | V  W  A  A  V  P  P  W  K  Q  G  T  L  S  E  F  V  V      p.160

          .      | 04  .         .         .         .         .    g.15217
 GTCAGTGGGAATGAG | GTCTCTCACAAACCCAAATCACTCACTCATACTCAAGCTGCCTCT    c.540
 V  S  G  N  E   | V  S  H  K  P  K  S  L  T  H  T  Q  A  A  S      p.180

          .         .         .         .         .         .       g.15277
 TTGCCATATGTGGCTCTCACAGCCTGGTCTGCTATAAACAAAGTTGGTGGCCTGAATGAC       c.600
 L  P  Y  V  A  L  T  A  W  S  A  I  N  K  V  G  G  L  N  D         p.200

          .         . | 05       .         .         .         .    g.31616
 AAGAATTGCACAGGAAAACG | TGTTCTAATCTTAGGCGCTTCAGGCGGAGTTGGTACTTTT    c.660
 K  N  C  T  G  K  R  |  V  L  I  L  G  A  S  G  G  V  G  T  F      p.220

           | 06        .         .         .         .         .    g.42249
 GCTATACAG | GTAATGAAAGCATGGGATGCTCATGTGACAGCAGTTTGCTCCCAAGATGCC    c.720
 A  I  Q   | V  M  K  A  W  D  A  H  V  T  A  V  C  S  Q  D  A      p.240

          .         .         .         .         .         .       g.42309
 AGTGAACTTGTAAGGAAGCTTGGTGCAGACGATGTAATTGATTACAAATCTGGAAGTGTG       c.780
 S  E  L  V  R  K  L  G  A  D  D  V  I  D  Y  K  S  G  S  V         p.260

          .         .       | 07 .         .         .         .    g.46670
 GAAGAGCAGTTGAAATCCTTAAAACC | ATTTGATTTTATCCTTGATAATGTTGGCGGATCC    c.840
 E  E  Q  L  K  S  L  K  P  |  F  D  F  I  L  D  N  V  G  G  S      p.280

          .         .         .         .         .         .       g.46730
 ACTGAAACATGGGCTCCAGATTTTCTCAAGAAATGGTCAGGAGCCACCTATGTGACTTTG       c.900
 T  E  T  W  A  P  D  F  L  K  K  W  S  G  A  T  Y  V  T  L         p.300

          .         .         .         .         .         .       g.46790
 GTGACTCCTTTCCTCCTGAACATGGACCGATTGGGCATAGCAGATGGCATGTTGCAGACA       c.960
 V  T  P  F  L  L  N  M  D  R  L  G  I  A  D  G  M  L  Q  T         p.320

          .         .         . | 08       .         .         .    g.51108
 GGAGTCACTGTAGGTTCAAAGGCATTAAAG | CATTTCTGGAAAGGAGTCCATTATCGCTGG    c.1020
 G  V  T  V  G  S  K  A  L  K   | H  F  W  K  G  V  H  Y  R  W      p.340

          .         .         .         .         .         .       g.51168
 GCATTTTTCATGGCCAGTGGCCCATGTTTAGATGACATTGCAGAACTGGTGGATGCGGGA       c.1080
 A  F  F  M  A  S  G  P  C  L  D  D  I  A  E  L  V  D  A  G         p.360

     | 09    .         .         .         .         .         .    g.62452
 AAG | ATCCGGCCAGTTATTGAACAAACCTTTCCTTTTTCTAAAGTTCCAGAAGCCTTCCTG    c.1140
 K   | I  R  P  V  I  E  Q  T  F  P  F  S  K  V  P  E  A  F  L      p.380

          .         .         .         .         .                 g.62503
 AAGGTGGAAAGAGGACACGCACGAGGAAAGACTGTAATTAATGTTGTTTAA                c.1191
 K  V  E  R  G  H  A  R  G  K  T  V  I  N  V  V  X                  p.396

          .         .         .         .         .         .       g.62563
 ataaaaatgcagtttagtgattgttgacgttcttatttggtgagtgcctgtgagcccaaa       c.*60

          .         .         .         .         .         .       g.62623
 tttttttctagccatccctttcaaacatttttccagattagattatacattccatgatac       c.*120

          .         .         .         .         .         .       g.62683
 aagctttaaaaaataaacacaccattttggccagtaattgatataaaaatatcagcactt       c.*180

          .         .         .         .         .         .       g.62743
 ggatttgtctgtagtcagtagaaattcgaagttttttcaagctgttccttcacactggct       c.*240

          .         .         .         .         .         .       g.62803
 ttgcaggttgttgtggcaccttctgttttactagcttaaactactttattgtcttttttg       c.*300

          .         .         .         .         .         .       g.62863
 ttttagagacagggtctcgctgtgtcacccaggctggagtgcagtggcacaatcacagct       c.*360

          .         .         .         .         .         .       g.62923
 cactgcagccttgaccttaagcgattctcctgcttcagcctctcaagtaggtaggactac       c.*420

          .         .         .         .         .         .       g.62983
 aggtatgcatcaccacacccagctagtttttttgtatttttagtagagacagttttgcca       c.*480

          .         .         .         .         .         .       g.63043
 tgttgcccaggctggtctcaaactcctgggcttaagtgatccaccatgtcagtctcccaa       c.*540

          .         .         .         .         .         .       g.63103
 agttctgggattacaggcgtgaaccaccctgctgggcctgatcgtcttaatgtacaatac       c.*600

          .         .         .         .         .         .       g.63163
 taaaactttcagtgtatagatggatgttggcatgaagagataatttaaagctggttcctt       c.*660

          .         .         .         .         .         .       g.63223
 cttgaattcatcactgagcagctttctaactgccaaggtttccttttttgttcctccacc       c.*720

          .         .         .         .         .         .       g.63283
 ataatgtggtcaccacagctcttaaagttctaaatctcttagtgtcatatataaaaatct       c.*780

          .         .         .         .         .         .       g.63343
 gcctggtgattcatttgtttatgctcttaatattgaaaggtgagagcagagtttctaact       c.*840

          .         .         .         .         .         .       g.63403
 ttttaaaacccttacatcttgcataaggattaggcctgtttcggcaattgaaacatgctt       c.*900

          .         .         .         .         .         .       g.63463
 ctctgagggcttttccatggaaattgcagccttccaatggagcccaaagcttgccacttt       c.*960

                                                                    g.63471
 gatgtcaa                                                           c.*968

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Reticulon 4 interacting protein 1 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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