runt-related transcription factor 1 (RUNX1) - coding DNA reference sequence

(used for variant description)

(last modified October 24, 2018)


This file was created to facilitate the description of sequence variants on transcript NM_001754.4 in the RUNX1 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_011402.2, covering RUNX1 transcript NM_001754.4.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                   .                g.940423
                                                   ctttgggcct       c.-181

 .         .         .         .         .         .                g.940483
 cataaacaaccacagaaccacaagttgggtagcctggcagtgtcagaagtctgaacccag       c.-121

 .         .         .         .         .         .                g.940543
 catagtggtcagcaggcaggacgaatcacactgaatgcaaaccacagggtttcgcagcgt       c.-61

 . | 02       .         .         .         .         .             g.940812
 g | gtaaaagaaatcattgagtcccccgccttcagaagagggtgcattttcaggaggaagcg    c.-1

          .         .         .         .         .         | 03    g.1096750
 ATGGCTTCAGACAGCATATTTGAGTCATTTCCTTCGTACCCACAGTGCTTCATGAGAG | AA    c.60
 M  A  S  D  S  I  F  E  S  F  P  S  Y  P  Q  C  F  M  R  E |       p.20

          .         .         .        | 04.         .         .    g.1102638
 TGCATACTTGGAATGAATCCTTCTAGAGACGTCCACG | ATGCCAGCACGAGCCGCCGCTTC    c.120
 C  I  L  G  M  N  P  S  R  D  V  H  D |   A  S  T  S  R  R  F      p.40

          .         .         .         .         .         .       g.1102698
 ACGCCGCCTTCCACCGCGCTGAGCCCAGGCAAGATGAGCGAGGCGTTGCCGCTGGGCGCC       c.180
 T  P  P  S  T  A  L  S  P  G  K  M  S  E  A  L  P  L  G  A         p.60

          .         .         .         .         .         .       g.1102758
 CCGGACGCCGGCGCTGCCCTGGCCGGCAAGCTGAGGAGCGGCGACCGCAGCATGGTGGAG       c.240
 P  D  A  G  A  A  L  A  G  K  L  R  S  G  D  R  S  M  V  E         p.80

          .         .         .         .         .         .       g.1102818
 GTGCTGGCCGACCACCCGGGCGAGCTGGTGCGCACCGACAGCCCCAACTTCCTCTGCTCC       c.300
 V  L  A  D  H  P  G  E  L  V  R  T  D  S  P  N  F  L  C  S         p.100

          .         .         .         .         .  | 05      .    g.1109007
 GTGCTGCCTACGCACTGGCGCTGCAACAAGACCCTGCCCATCGCTTTCAAG | GTGGTGGCC    c.360
 V  L  P  T  H  W  R  C  N  K  T  L  P  I  A  F  K   | V  V  A      p.120

          .         .         .         .         .         .       g.1109067
 CTAGGGGATGTTCCAGATGGCACTCTGGTCACTGTGATGGCTGGCAATGATGAAAACTAC       c.420
 L  G  D  V  P  D  G  T  L  V  T  V  M  A  G  N  D  E  N  Y         p.140

          .         .         .         .         .         .       g.1109127
 TCGGCTGAGCTGAGAAATGCTACCGCAGCCATGAAGAACCAGGTTGCAAGATTTAATGAC       c.480
 S  A  E  L  R  N  A  T  A  A  M  K  N  Q  V  A  R  F  N  D         p.160

          .         .         | 06         .         .         .    g.1130165
 CTCAGGTTTGTCGGTCGAAGTGGAAGAG | GGAAAAGCTTCACTCTGACCATCACTGTCTTC    c.540
 L  R  F  V  G  R  S  G  R  G |   K  S  F  T  L  T  I  T  V  F      p.180

          .         .         .         .         .         .       g.1130225
 ACAAACCCACCGCAAGTCGCCACCTACCACAGAGCCATCAAAATCACAGTGGATGGGCCC       c.600
 T  N  P  P  Q  V  A  T  Y  H  R  A  I  K  I  T  V  D  G  P         p.200

          .    | 07    .         .         .         .         .    g.1155157
 CGAGAACCTCGAA | GACATCGGCAGAAACTAGATGATCAGACCAAGCCCGGGAGCTTGTCC    c.660
 R  E  P  R  R |   H  R  Q  K  L  D  D  Q  T  K  P  G  S  L  S      p.220

          .         .         .         .         .         .       g.1155217
 TTTTCCGAGCGGCTCAGTGAACTGGAGCAGCTGCGGCGCACAGCCATGAGGGTCAGCCCA       c.720
 F  S  E  R  L  S  E  L  E  Q  L  R  R  T  A  M  R  V  S  P         p.240

          .         .         .         .         .         .       g.1155277
 CACCACCCAGCCCCCACGCCCAACCCTCGTGCCTCCCTGAACCACTCCACTGCCTTTAAC       c.780
 H  H  P  A  P  T  P  N  P  R  A  S  L  N  H  S  T  A  F  N         p.260

          .         .      | 08  .         .         .         .    g.1190284
 CCTCAGCCTCAGAGTCAGATGCAGG | ATACAAGGCAGATCCAACCATCCCCACCGTGGTCC    c.840
 P  Q  P  Q  S  Q  M  Q  D |   T  R  Q  I  Q  P  S  P  P  W  S      p.280

          .         .         .         .         .         .       g.1190344
 TACGATCAGTCCTACCAATACCTGGGATCCATTGCCTCTCCTTCTGTGCACCCAGCAACG       c.900
 Y  D  Q  S  Y  Q  Y  L  G  S  I  A  S  P  S  V  H  P  A  T         p.300

          .         .         .         .         .         .       g.1190404
 CCCATTTCACCTGGACGTGCCAGCGGCATGACAACCCTCTCTGCAGAACTTTCCAGTCGA       c.960
 P  I  S  P  G  R  A  S  G  M  T  T  L  S  A  E  L  S  S  R         p.320

         | 09.         .         .         .         .         .    g.1197154
 CTCTCAA | CGGCACCCGACCTGACAGCGTTCAGCGACCCGCGCCAGTTCCCCGCGCTGCCC    c.1020
 L  S  T |   A  P  D  L  T  A  F  S  D  P  R  Q  F  P  A  L  P      p.340

          .         .         .         .         .         .       g.1197214
 TCCATCTCCGACCCCCGCATGCACTATCCAGGCGCCTTCACCTACTCCCCGACGCCGGTC       c.1080
 S  I  S  D  P  R  M  H  Y  P  G  A  F  T  Y  S  P  T  P  V         p.360

          .         .         .         .         .         .       g.1197274
 ACCTCGGGCATCGGCATCGGCATGTCGGCCATGGGCTCGGCCACGCGCTACCACACCTAC       c.1140
 T  S  G  I  G  I  G  M  S  A  M  G  S  A  T  R  Y  H  T  Y         p.380

          .         .         .         .         .         .       g.1197334
 CTGCCGCCGCCCTACCCCGGCTCGTCGCAAGCGCAGGGAGGCCCGTTCCAAGCCAGCTCG       c.1200
 L  P  P  P  Y  P  G  S  S  Q  A  Q  G  G  P  F  Q  A  S  S         p.400

          .         .         .         .         .         .       g.1197394
 CCCTCCTACCACCTGTACTACGGCGCCTCGGCCGGCTCCTACCAGTTCTCCATGGTGGGC       c.1260
 P  S  Y  H  L  Y  Y  G  A  S  A  G  S  Y  Q  F  S  M  V  G         p.420

          .         .         .         .         .         .       g.1197454
 GGCGAGCGCTCGCCGCCGCGCATCCTGCCGCCCTGCACCAACGCCTCCACCGGCTCCGCG       c.1320
 G  E  R  S  P  P  R  I  L  P  P  C  T  N  A  S  T  G  S  A         p.440

          .         .         .         .         .         .       g.1197514
 CTGCTCAACCCCAGCCTCCCGAACCAGAGCGACGTGGTGGAGGCCGAGGGCAGCCACAGC       c.1380
 L  L  N  P  S  L  P  N  Q  S  D  V  V  E  A  E  G  S  H  S         p.460

          .         .         .         .         .         .       g.1197574
 AACTCCCCCACCAACATGGCGCCCTCCGCGCGCCTGGAGGAGGCCGTGTGGAGGCCCTAC       c.1440
 N  S  P  T  N  M  A  P  S  A  R  L  E  E  A  V  W  R  P  Y         p.480

                                                                    g.1197577
 TGA                                                                c.1443
 X                                                                  p.480

          .         .         .         .         .         .       g.1197637
 ggcgccaggcctggcccggctgggccccgcgggccgccgccttcgcctccgggcgcgcgg       c.*60

          .         .         .         .         .         .       g.1197697
 gcctcctgttcgcgacaagcccgccgggatcccgggccctgggcccggccaccgtcctgg       c.*120

          .         .         .         .         .         .       g.1197757
 ggccgagggcgcccgacggccaggatctcgctgtaggtcaggcccgcgcagcctcctgcg       c.*180

          .         .         .         .         .         .       g.1197817
 cccagaagcccacgccgccgccgtctgctggcgccccggccctcgcggaggtgtccgagg       c.*240

          .         .         .         .         .         .       g.1197877
 cgacgcacctcgagggtgtccgccggccccagcacccaggggacgcgctggaaagcaaac       c.*300

          .         .         .         .         .         .       g.1197937
 aggaagattcccggagggaaactgtgaatgcttctgatttagcaatgctgtgaataaaaa       c.*360

          .         .         .         .         .         .       g.1197997
 gaaagattttatacccttgacttaactttttaaccaagttgtttattccaaagagtgtgg       c.*420

          .         .         .         .         .         .       g.1198057
 aattttggttggggtggggggagaggagggatgcaactcgccctgtttggcatctaattc       c.*480

          .         .         .         .         .         .       g.1198117
 ttatttttaatttttccgcaccttatcaattgcaaaatgcgtatttgcatttgggtggtt       c.*540

          .         .         .         .         .         .       g.1198177
 tttatttttatatacgtttatataaatatatataaattgagcttgcttctttcttgcttt       c.*600

          .         .         .         .         .         .       g.1198237
 gaccatggaaagaaatatgattcccttttctttaagttttatttaacttttcttttggac       c.*660

          .         .         .         .         .         .       g.1198297
 ttttgggtagttgtttttttttgttttgttttgtttttttgagaaacagctacagctttg       c.*720

          .         .         .         .         .         .       g.1198357
 ggtcatttttaactactgtattcccacaaggaatccccagatatttatgtatcttgatgt       c.*780

          .         .         .         .         .         .       g.1198417
 tcagacatttatgtgttgataattttttaattatttaaatgtacttatattaagaaaaat       c.*840

          .         .         .         .         .         .       g.1198477
 atcaagtactacattttcttttgttcttgatagtagccaaagttaaatgtatcacattga       c.*900

          .         .         .         .         .         .       g.1198537
 agaaggctagaaaaaaagaatgagtaatgtgatcgcttggttatccagaagtattgttta       c.*960

          .         .         .         .         .         .       g.1198597
 cattaaactccctttcatgttaatcaaacaagtgagtagctcacgcagcaacgtttttaa       c.*1020

          .         .         .         .         .         .       g.1198657
 taggatttttagacactgagggtcactccaaggatcagaagtatggaattttctgccagg       c.*1080

          .         .         .         .         .         .       g.1198717
 ctcaacaagggtctcatatctaacttcctccttaaaacagagaaggtcaatctagttcca       c.*1140

          .         .         .         .         .         .       g.1198777
 gagggttgaggcaggtgccaataattacatctttggagaggatttgatttctgcccaggg       c.*1200

          .         .         .         .         .         .       g.1198837
 atttgctcaccccaaggtcatctgataatttcacagatgctgtgtaacagaacacagcca       c.*1260

          .         .         .         .         .         .       g.1198897
 aagtaaactgtgtaggggagccacatttacataggaaccaaatcaatgaatttaggggtt       c.*1320

          .         .         .         .         .         .       g.1198957
 acgattatagcaatttaagggcccaccagaagcaggcctcgaggagtcaatttgcctctg       c.*1380

          .         .         .         .         .         .       g.1199017
 tgtgcctcagtggagacaagtgggaaaacatggtcccacctgtgcgagaccccctgtcct       c.*1440

          .         .         .         .         .         .       g.1199077
 gtgctgctcactcaacaacatctttgtgttgctttcaccaggctgagaccctaccctatg       c.*1500

          .         .         .         .         .         .       g.1199137
 gggtatatgggcttttacctgtgcaccagtgtgacaggaaagattcatgtcactactgtc       c.*1560

          .         .         .         .         .         .       g.1199197
 cgtggctacaattcaaaggtatccaatgtcgctgtaaattttatggcactatttttattg       c.*1620

          .         .         .         .         .         .       g.1199257
 gaggatttggtcagaatgcagttgttgtacaactcataaatactaactgctgattttgac       c.*1680

          .         .         .         .         .         .       g.1199317
 acatgtgtgctccaaatgatctggtggttatttaacgtacctcttaaaattcgttgaaac       c.*1740

          .         .         .         .         .         .       g.1199377
 gatttcaggtcaactctgaagagtatttgaaagcaggacttcagaacagtgtttgatttt       c.*1800

          .         .         .         .         .         .       g.1199437
 tattttataaatttaagcattcaaattaggcaaatctttggctgcaggcagcaaaaacag       c.*1860

          .         .         .         .         .         .       g.1199497
 ctggacttatttaaaacaacttgtttttgagttttcttatatatatattgattatttgtt       c.*1920

          .         .         .         .         .         .       g.1199557
 ttacacacatgcagtagcactttggtaagagttaaagagtaaagcagcttatgttgtcag       c.*1980

          .         .         .         .         .         .       g.1199617
 gtcgttcttatctagagaagagctatagcagatctcggacaaactcagaatatattcact       c.*2040

          .         .         .         .         .         .       g.1199677
 ttcatttttgacaggattccctccacaactcagtttcatatattattccgtattacattt       c.*2100

          .         .         .         .         .         .       g.1199737
 ttgcagctaaattaccataaaatgtcagcaaatgtaaaaatttaatttctgaaaagcacc       c.*2160

          .         .         .         .         .         .       g.1199797
 attagcccatttcccccaaattaaacgtaaatgttttttttcagcacatgttaccatgtc       c.*2220

          .         .         .         .         .         .       g.1199857
 tgacctgcaaaaatgctggagaaaaatgaaggaaaaaattatgtttttcagtttaattct       c.*2280

          .         .         .         .         .         .       g.1199917
 gttaactgaagatattccaactcaaaaccagcctcatgctctgattagataatcttttac       c.*2340

          .         .         .         .         .         .       g.1199977
 attgaacctttactctcaaagccatgtgtggagggggcttgtcactattgtaggctcact       c.*2400

          .         .         .         .         .         .       g.1200037
 ggattggtcatttagagtttcacagactcttaccagcatatatagtatttaattgtttca       c.*2460

          .         .         .         .         .         .       g.1200097
 aaaaaaatcaaactgtagttgttttggcgataggtctcacgcaacacatttttgtatgtg       c.*2520

          .         .         .         .         .         .       g.1200157
 tgtgtgtgtgcgtgtgtgtgtgtgtgtgtgaaaaattgcattcattgacttcaggtagat       c.*2580

          .         .         .         .         .         .       g.1200217
 taaggtatctttttattcattgccctcaggaaagttaaggtatcaatgagacccttaagc       c.*2640

          .         .         .         .         .         .       g.1200277
 caatcatgtaataactgcatgtgtctggtccaggagaagtattgaataagccatttctac       c.*2700

          .         .         .         .         .         .       g.1200337
 tgcttactcatgtccctatttatgatttcaacatggatacatatttcagttctttctttt       c.*2760

          .         .         .         .         .         .       g.1200397
 tctcactatctgaaaatacatttccctccctctcttccccccaatatctccctttttttc       c.*2820

          .         .         .         .         .         .       g.1200457
 tctcttcctctatcttccaaaccccactttctccctcctccttttcctgtgttctcttaa       c.*2880

          .         .         .         .         .         .       g.1200517
 gcagatagcacatacccccacccagtaccaaatttcagaacacaagaaggtccagttctt       c.*2940

          .         .         .         .         .         .       g.1200577
 cccccttcacataaaggaacatggtttgtcagcctttctcctgtttatgggtttcttcca       c.*3000

          .         .         .         .         .         .       g.1200637
 gcagaacagagacattgccaaccatattggatctgcttgctgtccaaaccagcaaacttt       c.*3060

          .         .         .         .         .         .       g.1200697
 cctgggcaaatcacaatcagtgagtaaatagacagcctttctgctgccttgggtttctgt       c.*3120

          .         .         .         .         .         .       g.1200757
 gcagataaacagaaatgctctgattagaaaggaaatgaatggttccactcaaatgtcctg       c.*3180

          .         .         .         .         .         .       g.1200817
 caatttaggattgcagatttctgccttgaaatacctgtttctttgggacattccgtcctg       c.*3240

          .         .         .         .         .         .       g.1200877
 atgatttttatttttgttggtttttatttttggggggaatgacatgtttgggtcttttat       c.*3300

          .         .         .         .         .         .       g.1200937
 acatgaaaatttgtttgacaataatctcacaaaacatattttacatctgaacaaaatgcc       c.*3360

          .         .         .         .         .         .       g.1200997
 tttttgtttaccgtagcgtatacatttgttttgggatttttgtgtgtttgttgggaattt       c.*3420

          .         .         .         .         .         .       g.1201057
 tgtttttagccaggtcagtattgatgaggctgatcatttggctctttttttccttccaga       c.*3480

          .         .         .         .         .         .       g.1201117
 agagttgcatcaacaaagttaattgtatttatgtatgtaaatagattttaagcttcatta       c.*3540

          .         .         .         .         .         .       g.1201177
 taaaatattgttaatgcctataactttttttcaatttttttgtgtgtgtttctaaggact       c.*3600

          .         .         .         .         .         .       g.1201237
 ttttcttaggtttgctaaatactgtagggaaaaaaatgcttctttctactttgtttattt       c.*3660

          .         .         .         .         .         .       g.1201297
 tagactttaaaatgagctacttcttattcacttttgtaaacagctaatagcatggttcca       c.*3720

          .         .         .         .         .         .       g.1201357
 attttttttaagttcactttttttgttctaggggaaatgaatgtgcaaaaaaagaaaaag       c.*3780

          .         .         .         .         .         .       g.1201417
 aactgttggttatttgtgttattctggatgtataaaaatcaatggaaaaaaataaacttt       c.*3840

          .         .         .         .         .         .       g.1201477
 caaattgaaatgacggtataacacatctactgaaaaagcaacgggaaatgtggtcctatt       c.*3900

          .         .         .         .         .         .       g.1201537
 taagccagcccccacctagggtctatttgtgtggcagttattgggtttggtcacaaaaca       c.*3960

          .         .         .         .         .         .       g.1201597
 tcctgaaaattcgtgcgtgggcttctttctccctggtacaaacgtatggaatgcttctta       c.*4020

          .         .         .         .         .         .       g.1201657
 aaggggaactgtcaagctggtgtcttcagccagatgacatgagagaatatcccagaaccc       c.*4080

          .         .         .         .         .         .       g.1201717
 tctctccaaggtgtttctagatagcacaggagagcaggcactgcactgtccacagtccac       c.*4140

          .         .         .         .         .         .       g.1201777
 ggtacacagtcgggtgggccgcctcccctctcctgggagcattcgtcgtgcccagcctga       c.*4200

          .         .         .         .         .         .       g.1201837
 gcagggcagctggactgctgctgttcaggagccaccagagccttcctctctttgtaccac       c.*4260

          .         .         .         .         .         .       g.1201897
 agtttcttctgtaaatccagtgttacaatcagtgtgaatggcaaataaacagtttgacaa       c.*4320

          .                                                         g.1201911
 gtacatacaccata                                                     c.*4334

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Runt-related transcription factor 1 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

Powered by LOVD v.3.0 Build 21
©2004-2018 Leiden University Medical Center