SAM domain and HD domain 1 (SAMHD1) - coding DNA reference sequence

(used for variant description)

(last modified July 31, 2017)


This file was created to facilitate the description of sequence variants on transcript NM_015474.3 in the SAMHD1 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_017059.1, covering SAMHD1 transcript NM_015474.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                         .         .                g.5020
                                         attgcgcctgcgcagggagc       c.-181

 .         .         .         .         .         .                g.5080
 ccaaggcaagagccgctaggctgccctgcccgaagggctcaactgtcagtgagcctgcgc       c.-121

 .         .         .         .         .         .                g.5140
 aggaggccaataggctgccaatactccttggactccccgccagggccctgctgtcagtgc       c.-61

 .         .         .         .         .         .                g.5200
 gcctgcgcgcgggtccggcgccgaggttcttgactgctgtgccggacgccaggtgtagcc       c.-1

          .         .         .         .         .         .       g.5260
 ATGCAGCGAGCCGATTCCGAGCAGCCCTCCAAGCGTCCCCGTTGCGATGACAGCCCGAGA       c.60
 M  Q  R  A  D  S  E  Q  P  S  K  R  P  R  C  D  D  S  P  R         p.20

          .         .         .         .         .         .       g.5320
 ACCCCCTCAAACACCCCTTCCGCAGAGGCAGACTGGTCCCCGGGCCTGGAACTCCATCCC       c.120
 T  P  S  N  T  P  S  A  E  A  D  W  S  P  G  L  E  L  H  P         p.40

          .         .         .         .         .         .       g.5380
 GACTACAAGACATGGGGTCCGGAGCAGGTGTGCTCCTTCCTCAGGCGCGGTGGCTTTGAA       c.180
 D  Y  K  T  W  G  P  E  Q  V  C  S  F  L  R  R  G  G  F  E         p.60

          .         .         | 02         .         .         .    g.10071
 GAGCCGGTGCTGCTGAAGAACATCCGAG | AAAATGAAATCACAGGCGCATTACTGCCTTGT    c.240
 E  P  V  L  L  K  N  I  R  E |   N  E  I  T  G  A  L  L  P  C      p.80

          .         .         .      | 03  .         .         .    g.15757
 CTTGATGAGTCTCGTTTTGAAAATCTTGGAGTAAG | TTCCTTGGGGGAGAGGAAGAAGCTG    c.300
 L  D  E  S  R  F  E  N  L  G  V  S  |  S  L  G  E  R  K  K  L      p.100

          .         .         .         .         | 04         .    g.21666
 CTTAGTTATATCCAGCGATTGGTTCAAATCCACGTTGATACAATGAAG | GTAATTAATGAT    c.360
 L  S  Y  I  Q  R  L  V  Q  I  H  V  D  T  M  K   | V  I  N  D      p.120

          .         .         .         .         .         .       g.21726
 CCTATCCATGGCCACATTGAGCTCCACCCTCTCCTCGTCCGAATCATTGATACACCTCAA       c.420
 P  I  H  G  H  I  E  L  H  P  L  L  V  R  I  I  D  T  P  Q         p.140

          .         .         .         .         .         .       g.21786
 TTTCAACGTCTTCGATACATCAAACAGCTGGGAGGTGGTTACTATGTTTTTCCAGGAGCT       c.480
 F  Q  R  L  R  Y  I  K  Q  L  G  G  G  Y  Y  V  F  P  G  A         p.160

          .         .          | 05        .         .         .    g.25999
 TCACACAATCGATTTGAGCATAGTCTAGG | GGTGGGGTATCTAGCAGGATGTCTAGTTCAC    c.540
 S  H  N  R  F  E  H  S  L  G  |  V  G  Y  L  A  G  C  L  V  H      p.180

          .         .         .         .         .         .       g.26059
 GCACTGGGTGAAAAACAACCAGAGCTGCAGATAAGTGAACGAGATGTTCTCTGTGTTCAG       c.600
 A  L  G  E  K  Q  P  E  L  Q  I  S  E  R  D  V  L  C  V  Q         p.200

          .         .      | 06  .         .         .         .    g.29626
 ATTGCTGGACTTTGTCATGATCTCG | GTCATGGGCCATTTTCTCACATGTTTGATGGACGA    c.660
 I  A  G  L  C  H  D  L  G |   H  G  P  F  S  H  M  F  D  G  R      p.220

          .         .         .       | 07 .         .         .    g.37348
 TTTATTCCACTTGCTCGCCCGGAGGTGAAATGGACG | CATGAACAAGGCTCAGTTATGATG    c.720
 F  I  P  L  A  R  P  E  V  K  W  T   | H  E  Q  G  S  V  M  M      p.240

          .         .         .         .         .         .       g.37408
 TTTGAGCACCTTATTAATTCTAATGGAATTAAGCCTGTCATGGAACAATATGGTCTCATC       c.780
 F  E  H  L  I  N  S  N  G  I  K  P  V  M  E  Q  Y  G  L  I         p.260

          .         .         .         .         .         .       g.37468
 CCTGAAGAAGATATTTGCTTTATAAAGGAACAAATTGTAGGACCACTTGAATCACCTGTC       c.840
 P  E  E  D  I  C  F  I  K  E  Q  I  V  G  P  L  E  S  P  V         p.280

          .   | 08     .         .         .         .         .    g.39842
 GAAGATTCATTG | TGGCCATATAAAGGGCGTCCTGAAAACAAAAGCTTCCTTTATGAGATA    c.900
 E  D  S  L   | W  P  Y  K  G  R  P  E  N  K  S  F  L  Y  E  I      p.300

          .         .         .         .         .    | 09    .    g.40020
 GTATCTAATAAAAGAAATGGCATTGATGTGGACAAATGGGATTATTTTGCCAG | GGACTGC    c.960
 V  S  N  K  R  N  G  I  D  V  D  K  W  D  Y  F  A  R  |  D  C      p.320

          .         .         .         .         .         .       g.40080
 CATCATCTTGGAATCCAAAATAATTTTGATTACAAGCGCTTTATTAAGTTTGCCCGTGTC       c.1020
 H  H  L  G  I  Q  N  N  F  D  Y  K  R  F  I  K  F  A  R  V         p.340

          .         .         .         .   | 10     .         .    g.44309
 TGTGAAGTAGACAATGAGTTGCGTATTTGTGCTAGAGATAAG | GAAGTTGGAAATCTGTAT    c.1080
 C  E  V  D  N  E  L  R  I  C  A  R  D  K   | E  V  G  N  L  Y      p.360

          .         .         .         .         .         .       g.44369
 GACATGTTCCACACTCGCAACTCTTTACACCGTAGAGCTTATCAACACAAAGTTGGCAAC       c.1140
 D  M  F  H  T  R  N  S  L  H  R  R  A  Y  Q  H  K  V  G  N         p.380

          .     | 11   .         .         .         .         .    g.45556
 ATTATTGATACAAT | GATTACAGATGCTTTCCTCAAAGCAGATGACTACATAGAGATTACA    c.1200
 I  I  D  T  M  |  I  T  D  A  F  L  K  A  D  D  Y  I  E  I  T      p.400

          .         .         .         .         .         .       g.45616
 GGTGCTGGAGGAAAAAAGTATCGCATTTCTACAGCAATTGACGACATGGAAGCCTATACT       c.1260
 G  A  G  G  K  K  Y  R  I  S  T  A  I  D  D  M  E  A  Y  T         p.420

          . | 12       .         .         .         .         .    g.51390
 AAGCTGACAG | ATAACATTTTTCTGGAGATTTTATACTCTACTGATCCCAAATTGAAAGAC    c.1320
 K  L  T  D |   N  I  F  L  E  I  L  Y  S  T  D  P  K  L  K  D      p.440

          .         .         .         .         .         .       g.51450
 GCACGAGAGATTTTAAAACAAATTGAATACCGTAATCTATTCAAGTATGTGGGTGAGACG       c.1380
 A  R  E  I  L  K  Q  I  E  Y  R  N  L  F  K  Y  V  G  E  T         p.460

          .         .         . | 13       .         .         .    g.52624
 CAGCCAACAGGACAAATAAAGATTAAAAGG | GAGGACTATGAATCTCTTCCAAAAGAGGTT    c.1440
 Q  P  T  G  Q  I  K  I  K  R   | E  D  Y  E  S  L  P  K  E  V      p.480

          .         .         .         .         .         .       g.52684
 GCCAGTGCTAAACCCAAAGTATTGCTAGACGTGAAACTGAAGGCTGAAGATTTTATAGTG       c.1500
 A  S  A  K  P  K  V  L  L  D  V  K  L  K  A  E  D  F  I  V         p.500

     | 14    .         .         .         .         .         .    g.58356
 GAT | GTTATCAACATGGATTATGGAATGCAAGAAAAGAATCCAATTGATCATGTTAGCTTC    c.1560
 D   | V  I  N  M  D  Y  G  M  Q  E  K  N  P  I  D  H  V  S  F      p.520

          .         .         .         .         | 15         .    g.58896
 TATTGTAAGACTGCCCCCAACAGAGCAATCAGGATTACTAAAAACCAG | GTTTCACAACTT    c.1620
 Y  C  K  T  A  P  N  R  A  I  R  I  T  K  N  Q   | V  S  Q  L      p.540

          .         .         .         .         .         .       g.58956
 CTGCCAGAGAAATTTGCAGAGCAGCTGATTCGAGTATATTGTAAGAAGGTGGACAGAAAG       c.1680
 L  P  E  K  F  A  E  Q  L  I  R  V  Y  C  K  K  V  D  R  K         p.560

          .         .         .         .         .         .       g.59016
 AGTTTGTATGCCGCAAGACAATATTTTGTTCAGTGGTGTGCAGACAGAAATTTCACCAAG       c.1740
 S  L  Y  A  A  R  Q  Y  F  V  Q  W  C  A  D  R  N  F  T  K         p.580

        | 16 .         .         .         .         .         .    g.63831
 CCGCAG | GATGGCGATGTTATAGCCCCACTCATAACACCTCAAAAAAAGGAATGGAACGAC    c.1800
 P  Q   | D  G  D  V  I  A  P  L  I  T  P  Q  K  K  E  W  N  D      p.600

          .         .         .         .         .         .       g.63891
 AGTACTTCAGTCCAAAATCCAACTCGCCTCCGAGAAGCATCCAAAAGCAGAGTCCAGCTT       c.1860
 S  T  S  V  Q  N  P  T  R  L  R  E  A  S  K  S  R  V  Q  L         p.620

          .         .                                               g.63912
 TTTAAAGATGACCCAATGTGA                                              c.1881
 F  K  D  D  P  M  X                                                p.626

          .         .         .         .         .         .       g.63972
 atgtctgtagtcagttgtttacaaactccctctcctgcacaattcatttagaggcttcaa       c.*60

          .         .         .         .         .         .       g.64032
 tcatagaattctgcaaattaatgacaactcatgctttaattttgtattttgaatgtacac       c.*120

          .         .         .         .         .         .       g.64092
 gcatgctgaagctaagtaacttttaatcaaagaaataagatggtattaggcaaatcttac       c.*180

          .         .         .         .         .         .       g.64152
 tatactatgaaaagcattaccttgcctatttttaatattattaaagcctttctccttcag       c.*240

          .         .         .         .         .         .       g.64212
 tagtctattttcttagaataacaactcttttatctattctgaactctattttttttcttt       c.*300

          .         .         .         .         .         .       g.64272
 tttaagagacaaggttttgctctgttgcccagcttggactcgaactttcctgggctcaag       c.*360

          .         .         .         .         .         .       g.64332
 cgaccctcctgcctcagccccccaagtagctgggactaaagtcatgtgccaccacaccca       c.*420

          .         .         .         .         .         .       g.64392
 gcttactctgaacttttatgacagatgattgttttttgtttttaatgtagaaatgagaca       c.*480

          .         .         .         .         .         .       g.64452
 agggtacaaattggaactagaaattgacattgtcattgacaaacatggctaaaaacaaaa       c.*540

          .         .         .         .         .         .       g.64512
 catcaaatcctgcccccgtgaagagttccctgtcacctcaagtttgaggatagtcctcta       c.*600

          .         .         .         .         .         .       g.64572
 agagtgacctaagcataagtgaaagacacctcccctcacccttctagccccctacaaggt       c.*660

          .         .         .         .         .         .       g.64632
 gccaggttggggtaaagagttggagatgatggccaggagtggcctccaacacgctggtga       c.*720

          .         .         .         .         .         .       g.64692
 gaggcctgattaggttttggggaagatctgagagctctggcctcttcgtgagtggaacat       c.*780

          .         .         .         .         .         .       g.64752
 aaagccgcctcttgttgggagatcctaccccagtgacagaggaatcccccaaactaggct       c.*840

          .         .         .         .         .         .       g.64812
 gtgccctggctccgtggcggctccagacccgggtagtgcctttgtcccctgaatactcac       c.*900

          .         .         .         .         .         .       g.64872
 tcccccggtccagagggccttcccactgcccagcctggagaaggcctcccctgacctgct       c.*960

          .         .         .         .         .         .       g.64932
 ctctcagtatcctggagagctggccagaggccatcacaggcatcatcctcagagctcctc       c.*1020

          .         .         .         .         .         .       g.64992
 agacctgggactttgtttttgctggttcagtgcattttgtgtatttaagagcaaacacta       c.*1080

          .         .                                               g.65020
 gccaggcgtggcggcgtgtgcctgtagt                                       c.*1108

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The SAM domain and HD domain 1 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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