SAR1 homolog B (S. cerevisiae) (SAR1B) - coding DNA reference sequence

(used for variant description)

(last modified January 9, 2024)
This file was created to facilitate the description of sequence variants on transcript NM_016103.3 in the SAR1B gene based on a coding DNA reference sequence following the HGVS recommendations.
The sequence was taken from NC_000005.9, covering SAR1B transcript NM_016103.3.
Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                   .                g.5014
                                               gccggcccggaagg       c.-121

 .         .         .         .         .         .                g.5074
 ggctgatgcgaactggggccacggcagccatcgcgctttgcagttcggtctcctggtgta       c.-61

 .         .         .         .         .  | 02      .             g.13824
 cggccaacgccaagtaggggattgcgttccctccagtcgcag | accctatcagatttggat    c.-1

          .         .         .         .         .         | 03    g.16793
 ATGTCCTTCATATTTGATTGGATTTACAGTGGTTTCAGCAGTGTGCTACAGTTTTTAG | GA    c.60
 M  S  F  I  F  D  W  I  Y  S  G  F  S  S  V  L  Q  F  L  G |       p.20

          .         .         .         .         .         .       g.16853
 TTATATAAGAAAACTGGTAAACTGGTATTTCTTGGATTGGATAATGCAGGAAAAACAACA       c.120
 L  Y  K  K  T  G  K  L  V  F  L  G  L  D  N  A  G  K  T  T         p.40

          .         .         .         .         .         | 04    g.25089
 TTGCTACACATGCTAAAAGATGACAGACTTGGACAACATGTCCCAACATTACATCCCA | CT    c.180
 L  L  H  M  L  K  D  D  R  L  G  Q  H  V  P  T  L  H  P  T |       p.60

          .         .         .         .         .         .       g.25149
 TCCGAAGAACTGACCATTGCTGGCATGACGTTTACAACTTTTGATCTGGGTGGACATGTT       c.240
 S  E  E  L  T  I  A  G  M  T  F  T  T  F  D  L  G  G  H  V         p.80

      | 05   .         .         .         .         .         .    g.28225
 CAAG | CTCGAAGAGTGTGGAAAAACTACCTTCCTGCTATCAATGGCATTGTATTTCTGGTG    c.300
 Q  A |   R  R  V  W  K  N  Y  L  P  A  I  N  G  I  V  F  L  V      p.100

          .         .         .         .         | 06         .    g.29352
 GATTGTGCAGACCACGAAAGGCTGTTAGAGTCAAAAGAAGAACTTGAT | TCACTAATGACA    c.360
 D  C  A  D  H  E  R  L  L  E  S  K  E  E  L  D   | S  L  M  T      p.120

          .         .         .         .         .         .       g.29412
 GATGAAACCATTGCTAATGTGCCTATACTGATTCTTGGGAATAAGATCGACAGACCTGAA       c.420
 D  E  T  I  A  N  V  P  I  L  I  L  G  N  K  I  D  R  P  E         p.140

          .         .         .         .         .         .       g.29472
 GCCATCAGTGAAGAGAGGTTGCGAGAGATGTTTGGTTTATATGGTCAGACAACAGGAAAG       c.480
 A  I  S  E  E  R  L  R  E  M  F  G  L  Y  G  Q  T  T  G  K         p.160

  | 07       .         .         .         .         .         .    g.30837
  | GGGAGTATATCTCTGAAAGAACTGAATGCCCGACCCTTAGAAGTTTTCATGTGTAGTGTG    c.540
  | G  S  I  S  L  K  E  L  N  A  R  P  L  E  V  F  M  C  S  V      p.180

          .         .         .         .         .                 g.30894
 CTCAAAAGACAAGGTTACGGAGAAGGCTTCCGCTGGATGGCACAGTACATTGATTAA          c.597
 L  K  R  Q  G  Y  G  E  G  F  R  W  M  A  Q  Y  I  D  X            p.198

          .         .         .         .         .         .       g.30954
 cacaaactcacattggttccaggtctcaacgttcaggcttactcagagatttgattgctc       c.*60

          .         .         .         .         .         .       g.31014
 aacatgcataacttgaattcaatagacttttgctggttataaaacagatgttttttagat       c.*120

          .         .         .         .         .         .       g.31074
 tattaatattaaatcaacttaatttgaatgagaattgaaaactgattcaagtaagtttga       c.*180

          .         .         .         .         .         .       g.31134
 gtatcacaatgttagctttctaattccataaaagtacttggtttttacagtttataatct       c.*240

          .         .         .         .         .         .       g.31194
 gacatcaccccagcgccatttgtaaagagcaactttccagcagtacatttgaagcacttt       c.*300

          .         .         .         .         .         .       g.31254
 ttaacaacatgaaactataaaccatatttaaaagctcatcatgttaaattttttatgtac       c.*360

          .         .         .         .         .         .       g.31314
 ttttctggaactagtttttaaattttagattatatgtccacctatcttaagtgtacagtt       c.*420

          .         .         .         .         .         .       g.31374
 aataattagcttattcaatgattgcatgatgccttacagttttcaataactttttttctt       c.*480

          .         .         .         .         .         .       g.31434
 atgcaaacgtcatgcaataaaacaaactctaatgtttggcatccttgttgggcaaatgtt       c.*540

          .         .         .         .         .         .       g.31494
 tcatttaaatgtgtcttatctagctagtatactctgaaaatttgagtatttaatattagg       c.*600

          .         .         .         .         .         .       g.31554
 catatgaagtggttgttgggaaaggagattccttcagaatatttagaatagcgtttaagg       c.*660

          .         .         .         .         .         .       g.31614
 ctctcaaggcttaggtatttaccatgagatggttgtggtcagttgcacctgataccatgt       c.*720

          .         .         .         .         .         .       g.31674
 atccctgaatcatgtgtatttttattagtaatgcagccactaccattgctgatggggtct       c.*780

          .         .         .         .         .         .       g.31734
 gtgtcctagtccctgtgggattggccttctgaagaaaagcacatttatggtacacaaggt       c.*840

          .         .         .         .         .         .       g.31794
 tgattctcagtttggtaggctctatagttccatcccagctgtctaattctgaagtgctcc       c.*900

          .         .         .         .         .         .       g.31854
 agtcttattggtgcccaatggggtaatctgtgcctcttccccaaaagcaatgacaggcac       c.*960

          .         .         .         .         .         .       g.31914
 cagtgtctccacatttagatatattcccagtctctgtacatttaacagtactctctgggg       c.*1020

          .         .         .         .         .         .       g.31974
 caagcaataagtaggaccttgtgtgcagtttcattgtagagacatgtatatctgaggaat       c.*1080

          .         .         .         .         .         .       g.32034
 aaaacagcttgttctgtgtcagtctgagatatgtggagattttgttcctatcctatagct       c.*1140

          .         .         .         .         .         .       g.32094
 cttttgtattctttggcatattttatatcctggtagaagaaaacaagtgcttgtttccaa       c.*1200

          .         .         .         .         .         .       g.32154
 ttttcttttttcttatttgctctcaggtagttcttactccatacaacaaagactttttgt       c.*1260

          .         .         .         .         .         .       g.32214
 ttgttgggctttttttttttttttttttttgctctgtttcattttgttttagagacgggg       c.*1320

          .         .         .         .         .         .       g.32274
 tttcaccatgttgtccaggctggtctcaaactcctgacctcaagtgatctgcccgccttg       c.*1380

          .         .         .         .         .         .       g.32334
 gcctcccaaagttctgggattataggcgtgagctaccatgcctgacctgacttttgtttt       c.*1440

          .         .         .         .         .         .       g.32394
 tagatattatgcttgccatgtgatagggcctgcaagcctcattgctaggcttactaagaa       c.*1500

          .         .         .         .         .         .       g.32454
 aattttagtttttcaaaagcattataatttcctaagaaactgaattctttttttatatgt       c.*1560

          .         .         .         .         .         .       g.32514
 ttgagattcccatcattagtaatataagatgaaaggtaagtgccaaaaatgtatttttaa       c.*1620

          .         .         .         .         .         .       g.32574
 agaccctcaagtttaagatttatcctgattataagccaagttttatagtatatttaacca       c.*1680

          .         .         .         .         .         .       g.32634
 attccatcaagaataattttaatatcaaaaattagtgttttctgtagccattgtccatgt       c.*1740

          .         .         .         .         .         .       g.32694
 cagagttacagtcctttttgtcattgataatataacctatgaagcagataaggattgagg       c.*1800

          .         .         .         .         .         .       g.32754
 aatatgactggaaggaattactatttagctaagctgacaaggtcgcttcttaagatgaca       c.*1860

          .         .         .         .         .         .       g.32814
 tttggtttcagtaatctgactattctgttttcactttcatcttctttctaaatgaaaaca       c.*1920

          .         .         .         .         .         .       g.32874
 aaagtgctccctcccttcctggaaacctcagtaacactatgggaaaagtagaacatgaca       c.*1980

          .         .         .         .         .         .       g.32934
 ttgcagcctattgatttcttcttccagataggtttaaagtactccttaagttctgactaa       c.*2040

          .         .         .         .         .         .       g.32994
 atagaactaagccttattaaaaataactgcctcttgttcatgttatctgtaccttcaggg       c.*2100

          .         .         .         .         .         .       g.33054
 acctgcctttcttcaagtatttcctagagtatctattatgatactgaagaagctaattat       c.*2160

          .         .         .         .         .         .       g.33114
 ttgtgttgtaaatgggtataaatgaaaaaaaaacatactggtttctctagccaggaaaaa       c.*2220

          .         .         .         .         .         .       g.33174
 tgctttctggtgtaatatatcttgctccagaaccctcattctaattgtaacactaggatc       c.*2280

          .         .         .         .         .         .       g.33234
 aaagaaacaaagtcactttgtggaccacagctaaactgtggatattttcccaaagacata       c.*2340

          .         .         .         .         .         .       g.33294
 agatttttatggcccgagcctctagaaaggaagccatgtttaggagcaaccagctttcct       c.*2400

          .         .         .         .         .         .       g.33354
 cccagctttagggggcagagttcctgagccagaggacttactgtccagctttgagaacct       c.*2460

          .         .         .         .         .         .       g.33414
 ctccagagtatatgcactgggtactgctctttttcaagagaaccaaattaagaggatggc       c.*2520

          .         .         .         .         .         .       g.33474
 aagaaacagtagaagcacagaggaaagacaactctgcatgtgcctgtgtgaatgtgtgca       c.*2580

          .         .         .         .         .         .       g.33534
 tccatggagtatttcccaggtaaatactagtactggggacataggctaattgtgtgtccc       c.*2640

          .         .         .         .         .         .       g.33594
 acactgcaagatgctagggcgtagttaacactgtggtatacatacaaatcaggcactgtc       c.*2700

          .         .         .         .         .         .       g.33654
 caaaagattttttaaaatctaaagtctgaaatgtaaaaatataaggtctcaacccacttt       c.*2760

          .         .         .         .         .         .       g.33714
 tacacttttaaagagatcccatacctgtttcactgactgccgttaattacacttttggat       c.*2820

          .         .         .         .         .         .       g.33774
 cacagctggttaaattgatagatttcagtttatctcagtgaatttttagaatggagatta       c.*2880

          .         .         .         .         .         .       g.33834
 tagcattttttaattggagaacagacatttcctaaagtatatgaaaaaaaattattcact       c.*2940

          .         .         .         .         .         .       g.33894
 gttggtttaaaccagtatctttgtatgagtgccaaagatatatgaacacagatactgcct       c.*3000

          .         .         .         .         .         .       g.33954
 gtgcagacctaaattttagttttgtgtacctggatccatatacaaattttttgtggttta       c.*3060

          .         .         .         .         .         .       g.34014
 tagcataaaagcagaacgttgtttctttcttagttttcaaccggctcatcttttgttttt       c.*3120

          .         .         .         .         .         .       g.34074
 gttttttgtttttttgttttttgttttttttgagatggagtcttgctttgttgcccaggc       c.*3180

          .         .         .         .         .         .       g.34134
 tagagtgcagtggcacaatctctgcttactgcaacctccacctccggggttcaagtgatt       c.*3240

          .         .         .         .         .         .       g.34194
 ctcctgcctcagcctcctgagtagctgggactacaggcgcgcaccaccatgcccggctaa       c.*3300

          .         .         .         .         .         .       g.34254
 tttttgtatttttagtagagatggggtttcactatgttggccaggctggtctcgaactcc       c.*3360

          .         .         .         .         .         .       g.34314
 tgacctcgtgatctgcccacctcagcctcccaaagtgctgggattacaggcgtgagccgc       c.*3420

          .         .         .         .         .         .       g.34374
 catgcccggccaattttcaactggcccatactttatagtgatggaaagcgcataaactac       c.*3480

          .         .         .         .         .         .       g.34434
 ttgtaaatcattaaaatagggtgataactgtgataatagtgtttcttgcattctagaaaa       c.*3540

          .         .         .         .         .         .       g.34494
 ttattttattaactacattcaaaacccagcatttcacaggttccatcattagaaacagta       c.*3600

          .         .         .         .         .         .       g.34554
 tagttctagttaacatgattggagagtttcaggggaaaggtttacattttctgaaactgt       c.*3660

          .         .         .         .         .         .       g.34614
 atttggtatgtgactcaatgtggtatttcagtcttgttagtcacttacatgactgacgtt       c.*3720

          .         .         .         .         .         .       g.34674
 tgcaaggatttattgccaagtaaaatttgaccagagtgcactgagaatagctacataagg       c.*3780

          .         .         .         .         .         .       g.34734
 ggaaatctctcaaaattccttctgttcatttaatttggagcatattgtttaaatcatttt       c.*3840

          .         .         .         .         .         .       g.34794
 aaacatatgtaaaaagttgaagcattaaaaaatcttcaagaaacaatgaaaaaatagaaa       c.*3900

          .         .         .         .         .         .       g.34854
 ttagcaaacataagtttcttaatgcaaaattaatagtgaataaaatatagcctacattaa       c.*3960

          .         .         .         .         .         .       g.34914
 aagccagaggctttgctataaatataagagtttagaaaaacagtgtgcttcaattaagga       c.*4020

          .         .         .         .         .         .       g.34974
 ctaaattatcaaaactgcatgtttgttttttcttttcttttcttttttttttgagatgaa       c.*4080

          .         .         .         .         .         .       g.35034
 gtctcactctgttgcccaggctggagtgcagtggtgcgatcttggctcactgcaacctct       c.*4140

          .         .         .         .         .         .       g.35094
 gcttcccaggttcaagcgattctcgtgcctcaccatcccgagtagctgggattacaggtg       c.*4200

          .         .         .         .         .         .       g.35154
 caccacaccatgcccagttaatttttgtatttttagtagagacagggtttcattatttgg       c.*4260

          .         .         .         .         .         .       g.35214
 ccaggctggtctcgagctcctgatcttaagtgatccactcgcctcggcctcccaaagtgc       c.*4320

          .         .         .         .         .         .       g.35274
 tgggattatacacatgagccactgtgcccagcctaaaactacatgttgaagcttccggtc       c.*4380

          .         .         .         .         .         .       g.35334
 atttccattattatccttcttttgaaattcaagttagtgctttttaaccaaataaaagaa       c.*4440

          .         .         .         .         .         .       g.35394
 gaaccagctcttgggatatgtgactctgcctctgtataaagtgactggaattttgttaaa       c.*4500

          .         .         .         .         .         .       g.35454
 accgtgtttccacttctgaaccctgttaccattccccctcacaaatccccacccaacacc       c.*4560

          .         .         .         .         .         .       g.35514
 tggattttaaagatcctccagtgtcaagggaagccacagagtctattaaagaggcagttc       c.*4620

          .         .         .         .         .         .       g.35574
 tgaaccaattaatttttgtccttataatttagagcattaaatagctaatatatttaatgg       c.*4680

          .         .         .         .         .         .       g.35634
 cactaattgttgttcacggctttcatcatacttttaaacagaatccaaagtattcaaagg       c.*4740

          .         .         .         .         .         .       g.35694
 aaagtaagcgaagttatccaaagccaactttgtttcaggtgtgtcccctgccccaaatag       c.*4800

          .         .         .         .         .         .       g.35754
 attttagggcagaaatagaaaactgagtttacacagaactatttttggaaaagctgcact       c.*4860

          .         .         .         .         .         .       g.35814
 ggagtagatggattcttcttcagcatacttttttgtttgtttgtttgagatggagtcttg       c.*4920

          .         .         .         .         .         .       g.35874
 ctttgtcacccaggctggagtgcagtggtgtgatctccactcactgcaacctccacctcc       c.*4980

          .         .         .         .         .         .       g.35934
 cagcttcaagtgattctcctgcctcaaccttccaagtagcttggattacaggcgtgcgcc       c.*5040

          .         .         .         .         .         .       g.35994
 accacagctggctaatatttgtattgttagtagagacagggtttcaccatgttgtccagg       c.*5100

          .         .         .         .         .         .       g.36054
 cttgtcgaacttctgacctcacgtgatccacctgcctcagcctcccaaagtgctagatta       c.*5160

          .         .         .         .         .         .       g.36114
 taggcgtgaaccactgcgcccggccagcatgcattttaaaagtggcttagatttagtttt       c.*5220

          .         .         .         .         .         .       g.36174
 aaatattttggggtgaaaggcaggaacagttctgtttttgacatacaggttttctttggg       c.*5280

          .         .         .         .         .         .       g.36234
 attgttttcattttcaagtatagattcatgtcagaatggccaacttaacgtgggtttctg       c.*5340

          .         .         .         .         .         .       g.36294
 tattccctggtgttgctcttaacctgaactcataatcagttgccatactgaggcaagagc       c.*5400

          .         .         .         .         .         .       g.36354
 actcagggtgaacatagtcaagttactttaaaagtgataaaagtgtttttccatggtgaa       c.*5460

          .         .         .         .         .         .       g.36414
 accttcagtatttggctgaatgtaaagtatgttgaagtggtatattgatggtaagttgtt       c.*5520

          .         .         .         .         .         .       g.36474
 aatcactaaccttgtttgcacttttgtacaccactgcttgcactaggatcttggtgtgaa       c.*5580

          .         .         .         .         .         .       g.36534
 ttttcaattgttttacagtgtatacagattattaaggataatttatataaagatgtttct       c.*5640

          .         .         .         .         .         .       g.36594
 gtttaactttgtgtgttttacaacaaagagctataatagatggttaaacgtttttgaatt       c.*5700

          .         .         .         .         .         .       g.36654
 gtgtttatatgttagtttgattatgttctattatcttttcacctgccatgaatttgagtg       c.*5760

          .         .         .         .                           g.36695
 ttaggaagggaaaaataaaatactaatctggtcttgaagaa                          c.*5801

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10^th nucleotide is indicated by a "." above the sequence. The SAR1 homolog B (S. cerevisiae) protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10^th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.