seryl-tRNA synthetase 2, mitochondrial (SARS2) - coding DNA reference sequence

(used for variant description)

(last modified May 9, 2016)


This file was created to facilitate the description of sequence variants on transcript NM_001145901.1 in the SARS2 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_031865.1, covering SARS2 transcript NM_001145901.1.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                     .         .         .         .                g.5040
                     tgaagaggcgggacacagacgacgattgggcgacgaagga       c.-121

 .         .         .         .         .         .                g.5100
 ctctatcgcggtcaactttcctcaggatctgattggctcgtcacggtcaggttcgctgcc       c.-61

 .         .         .         .         .         .                g.5160
 ttgcaattggtctaaacgcggagtgggcgggacgaagtgccgccttgttcccggtccaag       c.-1

          .         .         .         .         .         .       g.5220
 ATGGCTGCGTCCATGGCGCGGCGCTTGTGGCCTTTGCTGACTCGTCGGGGGTTCCGGCCC       c.60
 M  A  A  S  M  A  R  R  L  W  P  L  L  T  R  R  G  F  R  P         p.20

          .         .         .         .         .         .       g.5280
 CGGGGAGGCTGCATCTCCAACGATAGTCCAAGGAGAAGTTTCACTACAGAGAAACGAAAC       c.120
 R  G  G  C  I  S  N  D  S  P  R  R  S  F  T  T  E  K  R  N         p.40

          .         .         .         .         .         .       g.5340
 CGGAACCTCCTGTACGAGTATGCGCGCGAGGGCTACAGCGCACTCCCTCAGCTGGACATA       c.180
 R  N  L  L  Y  E  Y  A  R  E  G  Y  S  A  L  P  Q  L  D  I         p.60

          .         .         .         .         .         .       g.5400
 GAGCGGTTCTGCGCATGCCCAGAAGAGGCCGCACACGCCCTGGAGCTCCGCAAGGGGGAG       c.240
 E  R  F  C  A  C  P  E  E  A  A  H  A  L  E  L  R  K  G  E         p.80

          .         .        | 02.         .         .         .    g.9629
 CTGCGCTCGGCGGACCTGCCCGCGATC | ATCTCGACATGGCAGGAGCTGAGGCAGCTGCAG    c.300
 L  R  S  A  D  L  P  A  I   | I  S  T  W  Q  E  L  R  Q  L  Q      p.100

          .         .         .         .         .         .       g.9689
 GAGCAGATCCGGAGCCTGGAGGAAGAGAAGGCAGCTGTGACTGAGGCAGTGCGGGCCCTG       c.360
 E  Q  I  R  S  L  E  E  E  K  A  A  V  T  E  A  V  R  A  L         p.120

     | 03    .         .         .    | 04    .         .         . g.13845
 CTG | GCAAACCAGGACAGTGGTGAAGTGCAGCAG | GTGCGGCTGGATCCAGGTGCTGGCTCC c.420
 L   | A  N  Q  D  S  G  E  V  Q  Q   | V  R  L  D  P  G  A  G  S   p.140

          .         .         .         .         . | 05       .    g.14310
 ATATTTGGTCCTACGTTCCTCCCATTCCCAGGCCAGCTTTCTCTCCTTGT | GGAGGCCCAG    c.480
 I  F  G  P  T  F  L  P  F  P  G  Q  L  S  L  L  V  |  E  A  Q      p.160

          .         .         .         .         .         .       g.14370
 CTTGAGGAGCAGTTCTACCTGCAGGCGCTGAAGCTGCCCAACCAGACCCACCCAGACGTG       c.540
 L  E  E  Q  F  Y  L  Q  A  L  K  L  P  N  Q  T  H  P  D  V         p.180

  | 06       .         .         .         .         .      | 07  . g.15752
  | CCCGTCGGGGATGAGAGCCAGGCTCGAGTGCTCCACATGGTCGGAGACAAGCCAG | TTTTC c.600
  | P  V  G  D  E  S  Q  A  R  V  L  H  M  V  G  D  K  P  V |   F   p.200

          .         .         .         .         .          | 08    g.16030
 TCCTTCCAACCTCGGGGCCACCTGGAAATTGGCGAGAAACTCGACATCATCCGTCAGAA | G    c.660
 S  F  Q  P  R  G  H  L  E  I  G  E  K  L  D  I  I  R  Q  K  |      p.220

          .         .         .         .         .         .       g.16090
 CGCCTGTCCCACGTGTCTGGCCACCGGTCCTATTACCTGCGCGGGGCTGGAGCCCTCCTG       c.720
 R  L  S  H  V  S  G  H  R  S  Y  Y  L  R  G  A  G  A  L  L         p.240

          .         .         .         .      | 09  .         .    g.17098
 CAGCACGGCCTGGTCAACTTCACATTCAACAAGCTTCTCCGCCGG | GGCTTCACCCCCATG    c.780
 Q  H  G  L  V  N  F  T  F  N  K  L  L  R  R   | G  F  T  P  M      p.260

          .         .         .    | 10    .         .         .    g.17393
 ACGGTGCCAGACCTTCTCCGCGGAGCAGTGTTT | GAAGGCTGTGGGATGACACCAAATGCC    c.840
 T  V  P  D  L  L  R  G  A  V  F   | E  G  C  G  M  T  P  N  A      p.280

          .         .         .         .         .         .       g.17453
 AACCCATCCCAAATTTACAACATCGACCCTGCCCGCTTCAAAGATCTCAACCTGGCTGGA       c.900
 N  P  S  Q  I  Y  N  I  D  P  A  R  F  K  D  L  N  L  A  G         p.300

          .         .   | 11     .         .         .         .    g.17795
 ACAGCGGAGGTGGGGCTTGCAG | GCTACTTCATGGACCACACCGTGGCCTTCAGGGACCTG    c.960
 T  A  E  V  G  L  A  G |   Y  F  M  D  H  T  V  A  F  R  D  L      p.320

          | 12         .         .         .         .         .    g.17940
 CCAGTCAG | GATGGTTTGCTCCAGCACCTGCTACCGGGCAGAGACAAACACGGGACAGGAA    c.1020
 P  V  R  |  M  V  C  S  S  T  C  Y  R  A  E  T  N  T  G  Q  E      p.340

          .         .         .       | 13 .         .         .    g.18087
 CCCCGGGGGCTGTATCGAGTACACCACTTCACCAAG | GTGGAGATGTTTGGGGTGACAGGC    c.1080
 P  R  G  L  Y  R  V  H  H  F  T  K   | V  E  M  F  G  V  T  G      p.360

          .         .         .         .         .         .       g.18147
 CCTGGGCTGGAGCAGAGCTCACAGCTGCTGGAGGAGTTCCTGTCCCTTCAGATGGAGATC       c.1140
 P  G  L  E  Q  S  S  Q  L  L  E  E  F  L  S  L  Q  M  E  I         p.380

          .         .       | 14 .         .         .         .    g.19616
 TTGACAGAGCTGGGCTTGCACTTCCG | GGTCCTGGATATGCCCACCCAAGAACTGGGCCTC    c.1200
 L  T  E  L  G  L  H  F  R  |  V  L  D  M  P  T  Q  E  L  G  L      p.400

          .         .         .         .         .         .       g.19676
 CCCGCCTACCGCAAGTTTGACATTGAGGCCTGGATGCCAGGCCGAGGCCGCTTTGGAGAG       c.1260
 P  A  Y  R  K  F  D  I  E  A  W  M  P  G  R  G  R  F  G  E         p.420

  | 15       .         .         .         .         .         .    g.19827
  | GTCACCAGTGCTTCCAACTGCACAGACTTCCAGAGCCGCCGCCTCCACATCATGTTCCAG    c.1320
  | V  T  S  A  S  N  C  T  D  F  Q  S  R  R  L  H  I  M  F  Q      p.440

          .         .         .    | 16    .         .         .    g.20017
 ACCGAGGCTGGGGAGCTGCAGTTTGCCCACACG | GTGAACGCCACCGCCTGTGCTGTCCCC    c.1380
 T  E  A  G  E  L  Q  F  A  H  T   | V  N  A  T  A  C  A  V  P      p.460

          .         .         .          | 17        .         .    g.20168
 CGCCTTCTCATCGCGCTCCTGGAGAGTAACCAGCAGAAG | GACGGCTCAGTGCTCGTGCCC    c.1440
 R  L  L  I  A  L  L  E  S  N  Q  Q  K   | D  G  S  V  L  V  P      p.480

          .         .         .         .         .         .       g.20228
 CCTGCCCTCCAGTCCTACCTCGGCACTGATCGGATCACAGCCCCTACCCACGTGCCTCTC       c.1500
 P  A  L  Q  S  Y  L  G  T  D  R  I  T  A  P  T  H  V  P  L         p.500

          .         .         .         .         .         .       g.20288
 CAGTACATCGGCCCCAACCAGCCCCGGAAGCCTGGGCTGCCTGGCCAGCCTGCTGTAAGC       c.1560
 Q  Y  I  G  P  N  Q  P  R  K  P  G  L  P  G  Q  P  A  V  S         p.520

                                                                    g.20291
 TAA                                                                c.1563
 X                                                                  p.520

          .         .         .         .         .         .       g.20351
 gaacccacccacagcagccctcgggggtgtcactgcttcctggagttcaggagaccccgg       c.*60

          .         .         .         .         .         .       g.20411
 acacctgggacctgtgttgctgagcccgtcctgacatctgtgttcttcctgtcagctcca       c.*120

          .         .         .         .         .         .       g.20471
 cgcccgggcccctggaccacggggtccacctctcctctgtccttgctgcctcagagtcag       c.*180

          .         .         .         .         .         .       g.20531
 tcactgaccctgttatcattgagggtcccagtgggaagcaggacgtctgggctttacggt       c.*240

          .         .         .         .         .         .       g.20591
 tctagggacaggagaagcagaggaagaggcttccatccctccttccttctttcctcctac       c.*300

          .         .         .         .                           g.20633
 agtgctgagcaaaaagtccccaataaatggtcaggacaaagg                         c.*342

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Seryl-tRNA synthetase 2, mitochondrial protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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