sterol-C5-desaturase (SC5D) - coding DNA reference sequence

(used for variant description)

(last modified May 15, 2016)


This file was created to facilitate the description of sequence variants on transcript NM_006918.4 in the SC5D gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_009446.1, covering SC5D transcript NM_006918.4.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                         .         .                g.5028
                                 atctgccgtcatatcagcttatggcgcc       c.-121

 .         .         .         .         .         .                g.5088
 ggtcgctgattggctggccgctccagcctcccggcccgcttgctggctgcccagctgcta       c.-61

 .         .         .         .         .          | 02            g.15697
 ggacagtttgcagagcagtggcgtgcggagcggcggcggaccacctccag | gggctaagtg    c.-1

          .         .         .         .         .         .       g.15757
 ATGGATCTTGTACTCCGTGTTGCAGATTACTATTTTTTTACACCATACGTGTATCCAGCC       c.60
 M  D  L  V  L  R  V  A  D  Y  Y  F  F  T  P  Y  V  Y  P  A         p.20

          .         .         .         .         .         .       g.15817
 ACATGGCCAGAAGATGACATCTTCCGACAAGCTATTAGTCTTCTGATTGTAACAAATGTT       c.120
 T  W  P  E  D  D  I  F  R  Q  A  I  S  L  L  I  V  T  N  V         p.40

          .         .         .         .         .         .       g.15877
 GGTGCTTACATCCTTTATTTCTTCTGTGCAACACTGAGCTATTATTTTGTCTTCGATCAT       c.180
 G  A  Y  I  L  Y  F  F  C  A  T  L  S  Y  Y  F  V  F  D  H         p.60

          .         .         . | 03       .         .         .    g.16712
 GCATTAATGAAACATCCACAATTTTTAAAG | AATCAAGTCCGTCGAGAGATTAAGTTTACT    c.240
 A  L  M  K  H  P  Q  F  L  K   | N  Q  V  R  R  E  I  K  F  T      p.80

          .         .         .         .         .         .       g.16772
 GTCCAGGCATTGCCATGGATAAGTATTCTTACTGTTGCACTGTTCTTGCTGGAGATAAGA       c.300
 V  Q  A  L  P  W  I  S  I  L  T  V  A  L  F  L  L  E  I  R         p.100

          .         .         .         .    | 04    .         .    g.18724
 GGTTACAGCAAATTACATGATGACCTAGGAGAGTTTCCATATG | GATTGTTTGAACTTGTC    c.360
 G  Y  S  K  L  H  D  D  L  G  E  F  P  Y  G |   L  F  E  L  V      p.120

          .         .         .         .         .         .       g.18784
 GTTAGTATAATATCTTTCCTCTTTTTCACTGACATGTTCATCTACTGGATTCACAGAGGC       c.420
 V  S  I  I  S  F  L  F  F  T  D  M  F  I  Y  W  I  H  R  G         p.140

          .         .     | 05   .         .         .         .    g.19414
 CTTCATCATAGACTGGTATATAAG | CGCCTACATAAACCTCACCATATTTGGAAGATTCCT    c.480
 L  H  H  R  L  V  Y  K   | R  L  H  K  P  H  H  I  W  K  I  P      p.160

          .         .         .         .         .         .       g.19474
 ACTCCATTTGCAAGTCATGCTTTTCACCCTATTGATGGCTTTCTTCAGAGTCTACCTTAC       c.540
 T  P  F  A  S  H  A  F  H  P  I  D  G  F  L  Q  S  L  P  Y         p.180

          .         .         .         .         .         .       g.19534
 CATATATACCCTTTTATCTTTCCATTACACAAGGTGGTTTATTTAAGTCTGTACATCTTG       c.600
 H  I  Y  P  F  I  F  P  L  H  K  V  V  Y  L  S  L  Y  I  L         p.200

          .         .         .         .         .         .       g.19594
 GTTAATATCTGGACAATTTCCATTCATGACGGTGATTTTCGTGTCCCCCAAATCTTACAG       c.660
 V  N  I  W  T  I  S  I  H  D  G  D  F  R  V  P  Q  I  L  Q         p.220

          .         .         .         .         .         .       g.19654
 CCATTTATTAATGGCTCAGCTCATCATACAGACCACCATATGTTCTTTGACTATAATTAT       c.720
 P  F  I  N  G  S  A  H  H  T  D  H  H  M  F  F  D  Y  N  Y         p.240

          .         .         .         .         .         .       g.19714
 GGACAATATTTCACTTTGTGGGATAGGATTGGCGGCTCATTCAAAAATCCTTCATCCTTT       c.780
 G  Q  Y  F  T  L  W  D  R  I  G  G  S  F  K  N  P  S  S  F         p.260

          .         .         .         .         .         .       g.19774
 GAGGGGAAGGGACCGCTCAGTTATGTGAAGGAGATGACAGAGGGAAAGCGCAGCAGCCAT       c.840
 E  G  K  G  P  L  S  Y  V  K  E  M  T  E  G  K  R  S  S  H         p.280

          .         .         .         .         .         .       g.19834
 TCAGGAAATGGCTGTAAGAATGAAAAATTATTCAATGGAGAGTTTACAAAGACTGAATAG       c.900
 S  G  N  G  C  K  N  E  K  L  F  N  G  E  F  T  K  T  E  X         p.299

          .         .         .         .         .         .       g.19894
 attattgcccagttattcttaagtaaggacaaagaaggaaatatcatcgtatttcttttt       c.*60

          .         .         .         .         .         .       g.19954
 tttaataaggaaaaaataatatccatacagtcaagatacatagtaaatggtatcatttgg       c.*120

          .         .         .         .         .         .       g.20014
 aaatcagcatcgtgggcactgctgaggaatgatcctagtggtaggtcagaagaagatgct       c.*180

          .         .         .         .         .         .       g.20074
 gtgaacaccaggactttaatcttatgcttaaaatgccagatgttgttcgggggacaactt       c.*240

          .         .         .         .         .         .       g.20134
 gtatctttctagcagcagatctgtagtttgtatagcctcaacaacaattttaaataagat       c.*300

          .         .         .         .         .         .       g.20194
 ggagaataaattattgaggggactaggctatatgcatttgccttcatccacccatgttta       c.*360

          .         .         .         .         .         .       g.20254
 ttaagaatcattgtgcttaataataccaagactaagcaccataaccaagaaatactaatg       c.*420

          .         .         .         .         .         .       g.20314
 taaagattgtttcttgtttcaggaatggttaattcttcaacgttggtatgataatgataa       c.*480

          .         .         .         .         .         .       g.20374
 cttgttttgacttgaataaagtactacatcagtgtggaaaaaaattctgatacattagca       c.*540

          .         .         .         .         .         .       g.20434
 gctatgtaaatgacctaattgatagcaggtgtaataagactatcgtcttcctacacatag       c.*600

          .         .         .         .         .         .       g.20494
 gaggctcattctctggacacactatcacctattacattttactgattaacaaataaattg       c.*660

          .         .         .         .         .         .       g.20554
 gaatttaaaaatatcgatatcaccatgatttaatccagatctgggattatgtagctaaac       c.*720

          .         .         .         .         .         .       g.20614
 attgtgatgattattatttaaaaccattatttaataagagtaaaaatatgtgaatctgga       c.*780

          .         .         .         .         .         .       g.20674
 tatatttaaaaaaagaaatttgatgcccagataatatattaggcactactgattttttag       c.*840

          .         .         .         .         .         .       g.20734
 ttaaattgatgcactacacttttgatgtttgaagttacaaacctgtaatttttttgtaaa       c.*900

          .         .         .         .         .         .       g.20794
 ggaaataattgccaaatacctaggcccattgctgacgattagttctaaaatcttattcct       c.*960

          .         .         .         .         .         .       g.20854
 cctcttctcccctcacttttccctacttcctctgcaaaaagatttaacaaatacattcat       c.*1020

          .         .         .         .         .         .       g.20914
 aaggaaatgtgtgttgtaacaaatatattgcaaaaacatagtttgtaaaggcattctata       c.*1080

          .         .         .         .         .         .       g.20974
 agctatttatgtaaaatcaataaaagttgatcataattaaactgtatcagttgagtatta       c.*1140

          .         .         .         .         .         .       g.21034
 tagcagcacaaagtattctttgtacagattttgtgccaatttgaagccacagaaatgatg       c.*1200

          .         .         .         .         .         .       g.21094
 tggattgttaattgtgttttagaacatccccggacactcagtgtcacagggggaaagaag       c.*1260

          .         .         .         .         .         .       g.21154
 tgggtaccacattctgtttatatttcacattttaactagatttgagtgtttttagcaaga       c.*1320

          .         .         .         .         .         .       g.21214
 aatcagtcttaaaatctaatgtctgggatccagaagaaaatgtctttaatctgtgagtta       c.*1380

          .         .         .         .         .         .       g.21274
 ttgtcacaatgtcatcttatttaaatgtaccaattagcattttgtaataggcaaatgtca       c.*1440

          .         .         .         .         .         .       g.21334
 tttagtgcttttcaccaatcccactcacccccggtgctccgccttgcctaagaaaaagaa       c.*1500

          .         .         .         .         .         .       g.21394
 attaaggagaagtaaactttatttcctaatataatgtcagctgatatttattgagctttt       c.*1560

          .         .         .         .         .         .       g.21454
 cctctttgcccagagactaggacccaaagaagttaagtaactattcccaggtttatttct       c.*1620

          .         .         .         .         .         .       g.21514
 ctctcatatgatgtcccatgtggatgtttgtggtcagtggacagctttccacctagtctt       c.*1680

          .         .         .         .         .         .       g.21574
 tctgcgacccaggctccttcctcttggggctctgcctttctctcagtccatagagccctc       c.*1740

          .         .         .         .         .         .       g.21634
 tttgttgaaagagcacataggaaaagaaggaaaagtctgtgtggaaaatgtttctgggtc       c.*1800

          .         .         .         .         .         .       g.21694
 aggcctggaagtggtgcatatctcttccgcccatgttcctttggacagaactccgtcaca       c.*1860

          .         .         .         .         .         .       g.21754
 tggcccacctagagagattttgggaaatgtgtccagctgtgtgcctgggaggaagggggc       c.*1920

          .         .         .         .         .         .       g.21814
 accattttcttgagcagctagacagtttgccgtatttgtggtgttctcctcttgttgatg       c.*1980

          .         .         .         .         .         .       g.21874
 ttgaaatggtgaatgagccataaagtatttcaggttatccacacactaatcatctcagtg       c.*2040

          .         .         .         .         .         .       g.21934
 tctttaattcttaactccaatatgaatgtttaaagcttcctctagattcttattcctata       c.*2100

          .         .         .         .         .         .       g.21994
 taactaatagagaagaaaggacagcttcctatggggaagacagaggcttcctcatagatg       c.*2160

          .         .         .         .         .         .       g.22054
 ttaggaataatcaaacttgcccctgccctttcacccgtctcaaattctggtcttttaaag       c.*2220

          .         .         .         .         .         .       g.22114
 cagcgttatgttaagtagtcctaacattgtaatatacagtactgccacattctcctactt       c.*2280

          .         .         .         .         .         .       g.22174
 tctattagaggaagtcagagaatatttatggaagtgaggacccaaattaccttctacaga       c.*2340

          .         .         .         .         .         .       g.22234
 tgacttttatagttacaggacagaaagtgaaaatcaaggttacgttttctacttttgtgg       c.*2400

          .         .         .         .         .         .       g.22294
 tagaaattgagaagtgggtggatatggttcgagaagacctttcagaaacacagagactga       c.*2460

          .         .         .         .         .         .       g.22354
 gtctttgtcttccatgctgtctctgcagtactgagtgaatttccttatacccttgtatca       c.*2520

          .         .         .         .         .         .       g.22414
 tgttttcctcccatcttctagaagctggggacagatttggaagagaattacacaagttca       c.*2580

          .         .         .         .         .         .       g.22474
 gttttttgatacatggattttacagtgcatgcaggttatttatgtagagaggaggtctgg       c.*2640

          .         .         .         .         .         .       g.22534
 gagaaagatggaaactagggagatgactgagaacaaagatatttgggattaacacagata       c.*2700

          .         .         .         .         .         .       g.22594
 gaagaaaagtttgaaaccatgagattgtcacagcatgaaaaaagatattcaaagacacta       c.*2760

          .         .         .         .         .         .       g.22654
 accaacttgaggggtgcagtggtctgaatgtgtcctccaaaattcaaatgtggaaatgta       c.*2820

          .         .         .         .         .         .       g.22714
 tttgccagtgagatagtatgtagaggtggggccttgaggaagtgattaagtcatgagggc       c.*2880

          .         .         .         .         .         .       g.22774
 tctgggattaatgacttaaaaagaggtgtgaggcagctgttcagcccttctgtctcctgt       c.*2940

          .         .         .         .         .         .       g.22834
 ccctttttttttttttttttttgagatggagtcttgctctgttgccccaggctggagtgc       c.*3000

          .         .         .         .         .         .       g.22894
 agtggcgtgatcttggttcactgcaagctccacctcccgggttcacgccattctcctgcc       c.*3060

          .         .         .         .         .         .       g.22954
 tcagcctcccgagtagctgggactacaggtgcccgccaccaccacgcccggctaattttt       c.*3120

          .         .         .         .         .         .       g.23014
 tatatttttagtagagatggggtttcaccgtgttagccaggatggtcttgatctcctgac       c.*3180

          .         .         .         .         .         .       g.23074
 ctcatgatctgcctgcctcggcctcccaaagtgctgggattataggtgtgagccaccatg       c.*3240

          .         .         .         .         .         .       g.23134
 cccagccccttctgtcccttctaacgtgaggacccagcaacaaggtaccatcttgaaagc       c.*3300

          .         .         .         .         .         .       g.23194
 agcaactggggactcagcagacaccaaaccaactggtgcttaaccgtgacttcccagcct       c.*3360

          .         .         .         .         .         .       g.23254
 ccagagctgtaagaaaataaatttctattatttatagattacccagttgaagatactttg       c.*3420

          .         .         .         .         .         .       g.23314
 ttaaggcagtacaaatggactaagacaagggggaagaaatttgcattcctgatcttccca       c.*3480

          .         .         .         .         .         .       g.23374
 acttcttcaaattcacaacacttgaatgacagtcttatttcagcacttactgctatcacc       c.*3540

          .         .         .         .         .         .       g.23434
 tattacttttatgtgtgtcttacctatttgagatgccagattccttggaagtagagaccg       c.*3600

          .         .         .         .         .         .       g.23494
 tgtctgaatcatcattgtattaaaccactcatccttaacaaatgcccaagccatggttaa       c.*3660

          .         .         .         .         .         .       g.23554
 agttcaataaatactttgttgaatttattaataaaatggcagaaatgtcattctcttcca       c.*3720

          .         .         .         .         .         .       g.23614
 tatatgtttaataaatccctgataggtgctaagcactgcactaggtaaaaattctcttct       c.*3780

          .         .         .         .         .         .       g.23674
 gatgctgtctttttggccaaccatttttttatcatttattcattagctgacatttgctaa       c.*3840

          .         .         .         .         .         .       g.23734
 gtgctttggaggggtcaaaaggggaagtaatgagaaatcaaagatggtccctacatcaag       c.*3900

          .         .         .         .         .         .       g.23794
 gataaactatctttttttagtcactcaaagtcataaccctttggaaacaaaacccaccag       c.*3960

          .         .         .         .         .         .       g.23854
 taccccagattttgaccacagatgaatcagtactacaaggactggttagagggttgaatg       c.*4020

          .         .         .         .         .         .       g.23914
 aatctgtatactcagcacttaacacagcactctgggtaaaagaaaaaagatcctcaaaga       c.*4080

          .         .         .         .         .         .       g.23974
 tattagttggttacatcaagaaaggacaaacttaggttaatctataacttcatctcagag       c.*4140

          .         .         .         .         .         .       g.24034
 gaacaggaactttggagataaacagggctctgccacttgcaagttgcaccatccctggtt       c.*4200

          .         .         .         .         .         .       g.24094
 tctccatctgtaaattgattaaaacactgcctatctaataagattaaataagttagaagc       c.*4260

          .         .         .         .         .         .       g.24154
 attcagttaaatgtcaactgaaactattgttcatgtaaattgtgcttgatgctttttctt       c.*4320

          .         .         .         .         .         .       g.24214
 tctagattcaatgattattgtcattttacctccataggccctcaatagaaatcagttgca       c.*4380

          .         .         .         .         .         .       g.24274
 gagggcagaagcctagatattttcaccttaaaattggagggtgaaagacattgaggtgaa       c.*4440

          .         .         .         .         .         .       g.24334
 gtagagatagagggtacacagaaaaatcgtataagtaaaactaacatcgttaacattatt       c.*4500

          .         .         .         .         .         .       g.24394
 tactgtaagttatctttgtaagagtggtaaaatacattgtgttgttaaataatttcattt       c.*4560

          .         .         .         .         .         .       g.24454
 aaaaaatgcatcactttgtgtgtttttatattgctaaaaccataaggccagtctacaagg       c.*4620

          .         .         .         .         .         .       g.24514
 tttgtagataaaatagaaacataccttccttgaaaagcagaataaattttttaaaggcag       c.*4680

          .         .         .         .         .         .       g.24574
 gaaggaagtgtttgaaccatgtgtcaacaagctttactgtcaaagcaggcttttggtatg       c.*4740

          .         .         .         .         .         .       g.24634
 ggaagaaaaatacttataaatacttgttttaatatttgctttattaaaatacatttaaaa       c.*4800

          .         .         .         .         .         .       g.24694
 tacagcatttttaaatctctaagctcaacttgaagatataagaacagtaaatttgataaa       c.*4860

          .         .         .         .         .         .       g.24754
 aatgagaaattacattcccatttctttaacaatttgtaaattccaattatcctgaacatt       c.*4920

          .         .         .         .         .         .       g.24814
 taataccatttacatattttattaatcacattttcttaaacatttgataagagatttaat       c.*4980

          .         .         .         .         .         .       g.24874
 attttgatccaactaccaaaaaagcagacttgtgtacttgacagatttttctaaacactt       c.*5040

          .         .         .         .         .         .       g.24934
 cacaactcacgattcaaacaaagacaaaatagcatatcaaaagttaatcactcagttgga       c.*5100

          .         .         .         .         .         .       g.24994
 aagcactcataccataggcttttattcatttcttgaataattttgttatatcttcctctt       c.*5160

          .         .         .         .         .         .       g.25054
 ttaggctgcaatgagctataattgcactactgcactccacgctgggtgacagagcaagac       c.*5220

          .         .         .         .         .         .       g.25114
 cctatctctaaaaataaaaaagtatatatatataaaaatatcttcctctattataattta       c.*5280

          .         .         .         .         .         .       g.25174
 actcattaagccatttatttagatgtaaacttgcccccctgacatgtggtatgaaacaaa       c.*5340

          .         .         .         .         .         .       g.25234
 tagaaacctagaaatttagtgcatattcaaatattaagacagacactggtgtggtgactt       c.*5400

          .         .         .         .         .         .       g.25294
 ttgtctgtcgcttcattgggacgttttttctttctgatcaacttaatgaaattataattt       c.*5460

          .         .         .         .         .         .       g.25354
 actataattaagtgtagccatttttactgtagagttcaatgatctttgatgaacgtgtac       c.*5520

          .         .         .         .         .         .       g.25414
 acccatgtaaccaccacccccaatcaaagtaaagaacattttcttaccagaataaatttc       c.*5580

          .         .         .         .         .         .       g.25474
 ctctccgtttgcagtcattctccccagccctaggtcaccactgatccaccttctgttact       c.*5640

          .         .         .         .         .         .       g.25534
 ggaaggttagttttcttccctgatttagaatttcatataaattaaatcagatagtatata       c.*5700

          .         .         .         .         .         .       g.25594
 ctcttgtgtttagtttctttagcttaacatgtttagagatatttgctgttgcctgtgtct       c.*5760

          .         .         .         .         .         .       g.25654
 gtagctttttgttttcattgctgaatagtatttcattgtaatataccacagttggtttat       c.*5820

          .         .         .         .         .         .       g.25714
 gtatttgctgatgaatatttgtgttatttccagcgtgggattattatgaataaagttgct       c.*5880

          .                                                         g.25732
 acaaacatttgtatacaa                                                 c.*5898

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Sterol-C5-desaturase protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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