sodium channel, non-voltage-gated 1 alpha subunit (SCNN1A) - coding DNA reference sequence

(used for variant description)

(last modified July 5, 2017)


This file was created to facilitate the description of sequence variants on transcript NM_001038.5 in the SCNN1A gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_011945.1, covering SCNN1A transcript NM_001038.5.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                     .         .         .         .                g.6667
            cttgcctgtctgcgtctaaagcccctgcccagagtccgccttctcaggt       c.-241

 .         .         .         .         .         .                g.6727
 ccagtactcccagttcacctgccctcgggagccctccttccttcggaaaactcccggctc       c.-181

 .         .         .         .         .         .                g.6787
 tgactcctcctcagcccctccccccgccctgctcacctttaattgagatgctaatgagat       c.-121

 .         .         .         .         .         .                g.6847
 tcctgtcgcttccatccctggccggccagcgggcgggctccccagccaggccgctgcacc       c.-61

 .      | 02  .         .         .         .         .             g.7574
 tgtcag | gggaacaagctggaggagcaggaccctagacctctgcagcccataccaggtctc    c.-1

          .         .         .         .         .         .       g.7634
 ATGGAGGGGAACAAGCTGGAGGAGCAGGACTCTAGCCCTCCACAGTCCACTCCAGGGCTC       c.60
 M  E  G  N  K  L  E  E  Q  D  S  S  P  P  Q  S  T  P  G  L         p.20

          .         .         .         .         .         .       g.7694
 ATGAAGGGGAACAAGCGTGAGGAGCAGGGGCTGGGCCCCGAACCTGCGGCGCCCCAGCAG       c.120
 M  K  G  N  K  R  E  E  Q  G  L  G  P  E  P  A  A  P  Q  Q         p.40

          .         .         .         .         .         .       g.7754
 CCCACGGCGGAGGAGGAGGCCCTGATCGAGTTCCACCGCTCCTACCGAGAGCTCTTCGAG       c.180
 P  T  A  E  E  E  A  L  I  E  F  H  R  S  Y  R  E  L  F  E         p.60

          .         .         .         .         .         .       g.7814
 TTCTTCTGCAACAACACCACCATCCACGGCGCCATCCGCCTGGTGTGCTCCCAGCACAAC       c.240
 F  F  C  N  N  T  T  I  H  G  A  I  R  L  V  C  S  Q  H  N         p.80

          .         .         .         .         .         .       g.7874
 CGCATGAAGACGGCCTTCTGGGCAGTGCTGTGGCTCTGCACCTTTGGCATGATGTACTGG       c.300
 R  M  K  T  A  F  W  A  V  L  W  L  C  T  F  G  M  M  Y  W         p.100

          .         .         .         .         .         .       g.7934
 CAATTCGGCCTGCTTTTCGGAGAGTACTTCAGCTACCCCGTCAGCCTCAACATCAACCTC       c.360
 Q  F  G  L  L  F  G  E  Y  F  S  Y  P  V  S  L  N  I  N  L         p.120

          .         .         .         .         .       | 03 .    g.18651
 AACTCGGACAAGCTCGTCTTCCCCGCAGTGACCATCTGCACCCTCAATCCCTACAG | GTAC    c.420
 N  S  D  K  L  V  F  P  A  V  T  I  C  T  L  N  P  Y  R  |  Y      p.140

          .         .         .         .         .         .       g.18711
 CCGGAAATTAAAGAGGAGCTGGAGGAGCTGGACCGCATCACAGAGCAGACGCTCTTTGAC       c.480
 P  E  I  K  E  E  L  E  E  L  D  R  I  T  E  Q  T  L  F  D         p.160

          .         .         .         .         .         .       g.18771
 CTGTACAAATACAGCTCCTTCACCACTCTCGTGGCCGGCTCCCGCAGCCGTCGCGACCTG       c.540
 L  Y  K  Y  S  S  F  T  T  L  V  A  G  S  R  S  R  R  D  L         p.180

          .         .         .         .         .         .       g.18831
 CGGGGGACTCTGCCGCACCCCTTGCAGCGCCTGAGGGTCCCGCCCCCGCCTCACGGGGCC       c.600
 R  G  T  L  P  H  P  L  Q  R  L  R  V  P  P  P  P  H  G  A         p.200

          .         .         .         .         .         .       g.18891
 CGTCGAGCCCGTAGCGTGGCCTCCAGCTTGCGGGACAACAACCCCCAGGTGGACTGGAAG       c.660
 R  R  A  R  S  V  A  S  S  L  R  D  N  N  P  Q  V  D  W  K         p.220

          .         .     | 04   .         .         .         .    g.20152
 GACTGGAAGATCGGCTTCCAGCTG | TGCAACCAGAACAAATCGGACTGCTTCTACCAGACA    c.720
 D  W  K  I  G  F  Q  L   | C  N  Q  N  K  S  D  C  F  Y  Q  T      p.240

          .         .         .         .         .         .       g.20212
 TACTCATCAGGGGTGGATGCGGTGAGGGAGTGGTACCGCTTCCACTACATCAACATCCTG       c.780
 Y  S  S  G  V  D  A  V  R  E  W  Y  R  F  H  Y  I  N  I  L         p.260

          .         .         .         .         .         .       g.20272
 TCGAGGCTGCCAGAGACTCTGCCATCCCTGGAGGAGGACACGCTGGGCAACTTCATCTTC       c.840
 S  R  L  P  E  T  L  P  S  L  E  E  D  T  L  G  N  F  I  F         p.280

          .         .         .      | 05  .         .         .    g.26502
 GCCTGCCGCTTCAACCAGGTCTCCTGCAACCAGGC | GAATTACTCTCACTTCCACCACCCG    c.900
 A  C  R  F  N  Q  V  S  C  N  Q  A  |  N  Y  S  H  F  H  H  P      p.300

          .         .         .         .         .         .       g.26562
 ATGTATGGAAACTGCTATACTTTCAATGACAAGAACAACTCCAACCTCTGGATGTCTTCC       c.960
 M  Y  G  N  C  Y  T  F  N  D  K  N  N  S  N  L  W  M  S  S         p.320

          .          | 06        .         .         .         .    g.26963
 ATGCCTGGAATCAACAACG | GTCTGTCCCTGATGCTGCGCGCAGAGCAGAATGACTTCATT    c.1020
 M  P  G  I  N  N  G |   L  S  L  M  L  R  A  E  Q  N  D  F  I      p.340

          .         .         .         .         .         .       g.27023
 CCCCTGCTGTCCACAGTGACTGGGGCCCGGGTAATGGTGCACGGGCAGGATGAACCTGCC       c.1080
 P  L  L  S  T  V  T  G  A  R  V  M  V  H  G  Q  D  E  P  A         p.360

          .         .         .         .         .         .       g.27083
 TTTATGGATGATGGTGGCTTTAACTTGCGGCCTGGCGTGGAGACCTCCATCAGCATGAGG       c.1140
 F  M  D  D  G  G  F  N  L  R  P  G  V  E  T  S  I  S  M  R         p.380

     | 07    .         .         .         .         .         .    g.27566
 AAG | GAAACCCTGGACAGACTTGGGGGCGATTATGGCGACTGCACCAAGAATGGCAGTGAT    c.1200
 K   | E  T  L  D  R  L  G  G  D  Y  G  D  C  T  K  N  G  S  D      p.400

          .         .         .         .   | 08     .         .    g.27820
 GTTCCTGTTGAGAACCTTTACCCTTCAAAGTACACACAGCAG | GTGTGTATTCACTCCTGC    c.1260
 V  P  V  E  N  L  Y  P  S  K  Y  T  Q  Q   | V  C  I  H  S  C      p.420

          .         .         .         .         .         .       g.27880
 TTCCAGGAGAGCATGATCAAGGAGTGTGGCTGTGCCTACATCTTCTATCCGCGGCCCCAG       c.1320
 F  Q  E  S  M  I  K  E  C  G  C  A  Y  I  F  Y  P  R  P  Q         p.440

          .         .         .         . | 09       .         .    g.32972
 AACGTGGAGTACTGTGACTACAGAAAGCACAGTTCCTGGG | GGTACTGCTACTATAAGCTC    c.1380
 N  V  E  Y  C  D  Y  R  K  H  S  S  W  G |   Y  C  Y  Y  K  L      p.460

          .         .         .         .         .          | 10    g.33137
 CAGGTTGACTTCTCCTCAGACCACCTGGGCTGTTTCACCAAGTGCCGGAAGCCATGCAG | C    c.1440
 Q  V  D  F  S  S  D  H  L  G  C  F  T  K  C  R  K  P  C  S  |      p.480

          .         .         .         .         .        | 11.    g.33355
 GTGACCAGCTACCAGCTCTCTGCTGGTTACTCACGATGGCCCTCGGTGACATCCCAG | GAA    c.1500
 V  T  S  Y  Q  L  S  A  G  Y  S  R  W  P  S  V  T  S  Q   | E      p.500

          .         .         .         .         .    | 12    .    g.33562
 TGGGTCTTCCAGATGCTATCGCGACAGAACAATTACACCGTCAACAACAAGAG | AAATGGA    c.1560
 W  V  F  Q  M  L  S  R  Q  N  N  Y  T  V  N  N  K  R  |  N  G      p.520

          .         .         .         .         .         .       g.33622
 GTGGCCAAAGTCAACATCTTCTTCAAGGAGCTGAACTACAAAACCAATTCTGAGTCTCCC       c.1620
 V  A  K  V  N  I  F  F  K  E  L  N  Y  K  T  N  S  E  S  P         p.540

           | 13        .         .         .         .         .    g.34155
 TCTGTCACG | ATGGTCACCCTCCTGTCCAACCTGGGCAGCCAGTGGAGCCTGTGGTTCGGC    c.1680
 S  V  T   | M  V  T  L  L  S  N  L  G  S  Q  W  S  L  W  F  G      p.560

          .         .         .         .         .         .       g.34215
 TCCTCGGTGTTGTCTGTGGTGGAGATGGCTGAGCTCGTCTTTGACCTGCTGGTCATCATG       c.1740
 S  S  V  L  S  V  V  E  M  A  E  L  V  F  D  L  L  V  I  M         p.580

          .         .         .         .         .         .       g.34275
 TTCCTCATGCTGCTCCGAAGGTTCCGAAGCCGATACTGGTCTCCAGGCCGAGGGGGCAGG       c.1800
 F  L  M  L  L  R  R  F  R  S  R  Y  W  S  P  G  R  G  G  R         p.600

          .         .         .         .         .         .       g.34335
 GGTGCTCAGGAGGTAGCCTCCACCCTGGCATCCTCCCCTCCTTCCCACTTCTGCCCCCAC       c.1860
 G  A  Q  E  V  A  S  T  L  A  S  S  P  P  S  H  F  C  P  H         p.620

          .         .         .         .         .         .       g.34395
 CCCATGTCTCTGTCCTTGTCCCAGCCAGGCCCTGCTCCCTCTCCAGCCTTGACAGCCCCT       c.1920
 P  M  S  L  S  L  S  Q  P  G  P  A  P  S  P  A  L  T  A  P         p.640

          .         .         .         .         .         .       g.34455
 CCCCCTGCCTATGCCACCCTGGGCCCCCGCCCATCTCCAGGGGGCTCTGCAGGGGCCAGT       c.1980
 P  P  A  Y  A  T  L  G  P  R  P  S  P  G  G  S  A  G  A  S         p.660

          .         .         .                                     g.34485
 TCCTCCACCTGTCCTCTGGGGGGGCCCTGA                                     c.2010
 S  S  T  C  P  L  G  G  P  X                                       p.669

          .         .         .         .         .         .       g.34545
 gagggaaggagaggtttctcacaccaaggcagatgctcctctggtgggagggtgctggcc       c.*60

          .         .         .         .         .         .       g.34605
 ctggcaagattgaaggatgtgcagggcttcctctcagagccgcccaaactgccgttgatg       c.*120

          .         .         .         .         .         .       g.34665
 tgtggaggggaagcaagatgggtaagggctcaggaagttgctccaagaacagtagctgat       c.*180

          .         .         .         .         .         .       g.34725
 gaagctgcccagaagtgccttggctccagccctgtaccccttggtactgcctctgaacac       c.*240

          .         .         .         .         .         .       g.34785
 tctggtttccccacccaactgcggctaagtctctttttcccttggatcagccaagcgaaa       c.*300

          .         .         .         .         .         .       g.34845
 cttggagctttgacaaggaactttcctaagaaaccgctgataaccaggacaaaacacaac       c.*360

          .         .         .         .         .         .       g.34905
 caagggtacacgcaggcatgcacgggtttcctgcccagcgacggcttaagccagcccccg       c.*420

          .         .         .         .         .         .       g.34965
 actggcctggccacactgctctccagtagcacagatgtctgctcctcctcttgaacttgg       c.*480

          .         .         .         .         .         .       g.35025
 gtgggaaaccccacccaaaagccccctttgttacttaggcaattccccttccctgactcc       c.*540

          .         .         .         .         .         .       g.35085
 cgagggctagggctagagcagacccgggtaagtaaaggcagacccagggctcctctagcc       c.*600

          .         .         .         .         .         .       g.35145
 tcatacccgtgccctcacagagccatgccccggcacctctgccctgtgtctttcatacct       c.*660

          .         .         .         .         .         .       g.35205
 ctacatgtctgcttgagatatttcctcagcctgaaagtttccccaaccatctgccagaga       c.*720

          .         .         .         .         .         .       g.35265
 actcctatgcatcccttagaaccctgctcagacaccattacttttgtgaacgcttctgcc       c.*780

          .         .         .         .         .         .       g.35325
 acatcttgtcttccccaaaattgatcactccgccttctcctgggctcccgtagcacacta       c.*840

          .         .         .         .         .         .       g.35385
 taacatctgctggagtgttgctgttgcaccatactttcttgtacatttgtgtctcccttc       c.*900

          .         .         .         .         .         .       g.35445
 ccaactagactgtaagtgccttgcggtcagggactgaatcttgcccgtttatgtatgctc       c.*960

          .         .         .         .         .         .       g.35505
 catgtctagcccatcatcctgcttggagcaagtaggcaggagctcaataaatgtttgttg       c.*1020

          .                                                         g.35515
 catgaaggaa                                                         c.*1030

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Sodium channel, non-voltage-gated 1 alpha subunit protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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