signal peptide, CUB domain, EGF-like 3 (SCUBE3) - coding DNA reference sequence

(used for variant description)

(last modified December 14, 2020)


This file was created to facilitate the description of sequence variants on transcript NM_152753.2 in the SCUBE3 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_050574.1, covering SCUBE3 transcript NM_152753.2.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                                    g.5006
                                                       ccagcc       c.-1

          .         .         .         .         .         .       g.5066
 ATGGGCTCGGGGCGCGTACCCGGGCTCTGCCTGCTTGTCCTGCTGGTCCACGCCCGCGCC       c.60
 M  G  S  G  R  V  P  G  L  C  L  L  V  L  L  V  H  A  R  A         p.20

          .         .      | 02  .         .         .         .    g.18202
 GCCCAGTACAGCAAAGCCGCGCAAG | ATGTGGATGAGTGTGTGGAGGGGACTGACAACTGC    c.120
 A  Q  Y  S  K  A  A  Q  D |   V  D  E  C  V  E  G  T  D  N  C      p.40

          .         .         .         .         .         .       g.18262
 CACATCGATGCTATCTGCCAGAACACCCCGAGGTCATACAAGTGCATCTGCAAGTCTGGC       c.180
 H  I  D  A  I  C  Q  N  T  P  R  S  Y  K  C  I  C  K  S  G         p.60

          .         .         | 03         .         .         .    g.19233
 TACACAGGGGACGGCAAACACTGCAAAG | ACGTGGATGAGTGCGAGCGAGAGGATAATGCA    c.240
 Y  T  G  D  G  K  H  C  K  D |   V  D  E  C  E  R  E  D  N  A      p.80

          .         .         .         .         .         .       g.19293
 GGTTGTGTGCATGACTGTGTCAACATCCCTGGCAATTACCGGTGTACCTGCTATGATGGA       c.300
 G  C  V  H  D  C  V  N  I  P  G  N  Y  R  C  T  C  Y  D  G         p.100

          .         .         .     | 04   .         .         .    g.22338
 TTCCACCTGGCACATGACGGACACAACTGTCTGG | ATGTGGACGAGTGTGCCGAGGGCAAC    c.360
 F  H  L  A  H  D  G  H  N  C  L  D |   V  D  E  C  A  E  G  N      p.120

          .         .         .         .         .         .       g.22398
 GGCGGCTGTCAGCAGAGCTGTGTCAACATGATGGGCAGCTATGAGTGCCACTGCCGGGAA       c.420
 G  G  C  Q  Q  S  C  V  N  M  M  G  S  Y  E  C  H  C  R  E         p.140

          .         .         .         .          | 05        .    g.23448
 GGCTTCTTCCTCAGCGACAACCAGCATACCTGTATCCAGCGGCCAGAAG | AAGGAATGAAT    c.480
 G  F  F  L  S  D  N  Q  H  T  C  I  Q  R  P  E  E |   G  M  N      p.160

          .         .         .         .         .         .       g.23508
 TGCATGAACAAGAACCACGGCTGTGCCCACATTTGCCGGGAGACACCCAAGGGGGGTATT       c.540
 C  M  N  K  N  H  G  C  A  H  I  C  R  E  T  P  K  G  G  I         p.180

          .         .         .         .         .      | 06  .    g.23777
 GCCTGTGAATGCCGTCCTGGCTTTGAGCTTACCAAGAACCAACGGGACTGTAAAT | TGACA    c.600
 A  C  E  C  R  P  G  F  E  L  T  K  N  Q  R  D  C  K  L |   T      p.200

          .         .         .         .         .         .       g.23837
 TGCAACTATGGTAACGGCGGCTGCCAGCACACGTGTGATGACACAGAGCAGGGTCCCCGG       c.660
 C  N  Y  G  N  G  G  C  Q  H  T  C  D  D  T  E  Q  G  P  R         p.220

          .         .         .         .         .   | 07     .    g.28497
 TGCGGCTGCCATATCAAGTTTGTGCTCCATACCGACGGGAAGACATGCATCG | AGACCTGT    c.720
 C  G  C  H  I  K  F  V  L  H  T  D  G  K  T  C  I  E |   T  C      p.240

          .         .         .         .         .         .       g.28557
 GCTGTCAACAACGGGGGCTGTGACAGTAAGTGCCATGATGCAGCGACTGGTGTCCACTGC       c.780
 A  V  N  N  G  G  C  D  S  K  C  H  D  A  A  T  G  V  H  C         p.260

          .         .         .         .          | 08        .    g.30350
 ACCTGCCCTGTGGGCTTCATGCTGCAGCCAGACAGGAAGACGTGCAAAG | ATATAGATGAG    c.840
 T  C  P  V  G  F  M  L  Q  P  D  R  K  T  C  K  D |   I  D  E      p.280

          .         .         .         .         .         .       g.30410
 TGCCGCTTAAACAACGGGGGCTGTGACCATATTTGCCGCAACACAGTGGGCAGCTTCGAA       c.900
 C  R  L  N  N  G  G  C  D  H  I  C  R  N  T  V  G  S  F  E         p.300

          .         .         .         .         .   | 09     .    g.30969
 TGCAGTTGCAAGAAAGGCTATAAGCTTCTCATCAATGAGAGGAACTGCCAGG | ATATAGAC    c.960
 C  S  C  K  K  G  Y  K  L  L  I  N  E  R  N  C  Q  D |   I  D      p.320

          .         .         .         .         .         .       g.31029
 GAGTGTTCCTTTGATCGAACCTGTGACCACATATGTGTCAACACACCAGGAAGCTTCCAG       c.1020
 E  C  S  F  D  R  T  C  D  H  I  C  V  N  T  P  G  S  F  Q         p.340

          .         .         .         .          | 10        .    g.31739
 TGTCTCTGCCATCGTGGCTACCTGTTGTATGGTATCACCCACTGTGGGG | ATGTGGATGAA    c.1080
 C  L  C  H  R  G  Y  L  L  Y  G  I  T  H  C  G  D |   V  D  E      p.360

          .         .         .         .         .         .       g.31799
 TGCAGCATCAACCGGGGAGGTTGCCGCTTTGGCTGCATCAACACTCCTGGCAGCTACCAG       c.1140
 C  S  I  N  R  G  G  C  R  F  G  C  I  N  T  P  G  S  Y  Q         p.380

          .         .         .         .         .      | 11  .    g.32135
 TGTACCTGCCCAGCAGGCCAGGGTCGGCTGCACTGGAATGGCAAAGATTGCACAG | AGCCA    c.1200
 C  T  C  P  A  G  Q  G  R  L  H  W  N  G  K  D  C  T  E |   P      p.400

          .         .         .         .         .         .       g.32195
 CTGAAGTGTCAGGGCAGTCCTGGGGCCTCGAAAGCCATGCTCAGCTGCAACCGGTCTGGC       c.1260
 L  K  C  Q  G  S  P  G  A  S  K  A  M  L  S  C  N  R  S  G         p.420

          .         .         .         .         .   | 12     .    g.32401
 AAGAAGGACACCTGTGCCCTGACCTGTCCCTCCAGGGCCCGATTTTTGCCAG | AGTCTGAG    c.1320
 K  K  D  T  C  A  L  T  C  P  S  R  A  R  F  L  P  E |   S  E      p.440

          .         .         .         .         .         .       g.32461
 AATGGCTTCACGGTGAGCTGTGGGACCCCCAGCCCCAGGGCTGCTCCAGCCCGAGCTGGC       c.1380
 N  G  F  T  V  S  C  G  T  P  S  P  R  A  A  P  A  R  A  G         p.460

          .         .         .        | 13.         .         .    g.32814
 CACAATGGGAACAGCACCAACTCCAACCACTGCCATG | AGGCTGCAGTGCTGTCCATTAAA    c.1440
 H  N  G  N  S  T  N  S  N  H  C  H  E |   A  A  V  L  S  I  K      p.480

          .         .         .         .         .         .       g.32874
 CAACGGGCCTCCTTCAAGATCAAGGATGCCAAATGCCGTTTGCACCTGCGAAACAAAGGC       c.1500
 Q  R  A  S  F  K  I  K  D  A  K  C  R  L  H  L  R  N  K  G         p.500

          .         .         .     | 14   .         .         .    g.33235
 AAAACAGAGGAGGCTGGCAGAATCACAGGGCCAG | GTGGTGCCCCCTGCTCTGAATGCCAG    c.1560
 K  T  E  E  A  G  R  I  T  G  P  G |   G  A  P  C  S  E  C  Q      p.520

          .         .         .         .         .         .       g.33295
 GTCACCTTCATCCACCTTAAGTGTGACTCCTCTCGGAAGGGCAAGGGCCGACGGGCCCGG       c.1620
 V  T  F  I  H  L  K  C  D  S  S  R  K  G  K  G  R  R  A  R         p.540

          .         .         .         .         .         .       g.33355
 ACCCCTCCAGGCAAAGAGGTCACAAGGCTCACCCTGGAACTGGAGGCAGAGGTCAGAGCC       c.1680
 T  P  P  G  K  E  V  T  R  L  T  L  E  L  E  A  E  V  R  A         p.560

          .    | 15    .         .         .         .         .    g.33655
 GAAGAAACCACAG | CCAGCTGTGGGCTGCCCTGCCTCCGACAGCGAATGGAACGGCGGCTG    c.1740
 E  E  T  T  A |   S  C  G  L  P  C  L  R  Q  R  M  E  R  R  L      p.580

          .         .         .         .         .         .       g.33715
 AAAGGATCCCTGAAGATGCTCAGAAAGTCCATCAACCAGGACCGCTTCCTGCTGCGCCTG       c.1800
 K  G  S  L  K  M  L  R  K  S  I  N  Q  D  R  F  L  L  R  L         p.600

          .         .         .         .         .         .       g.33775
 GCAGGCCTTGATTATGAGCTGGCCCACAAGCCGGGCCTGGTAGCCGGGGAGCGAGCAGAG       c.1860
 A  G  L  D  Y  E  L  A  H  K  P  G  L  V  A  G  E  R  A  E         p.620

          .         .         .         .          | 16        .    g.34192
 CCGATGGAGTCCTGTAGGCCCGGGCAGCACCGTGCTGGGACCAAGTGTG | TCAGCTGCCCG    c.1920
 P  M  E  S  C  R  P  G  Q  H  R  A  G  T  K  C  V |   S  C  P      p.640

          .         .         .         .         .         .       g.34252
 CAGGGAACGTATTACCACGGCCAGACGGAGCAGTGTGTGCCATGCCCAGCGGGCACCTTC       c.1980
 Q  G  T  Y  Y  H  G  Q  T  E  Q  C  V  P  C  P  A  G  T  F         p.660

          .         .         .         .         .         .       g.34312
 CAGGAGAGAGAAGGGCAGCTCTCCTGCGACCTTTGCCCTGGGAGTGATGCCCACGGGCCT       c.2040
 Q  E  R  E  G  Q  L  S  C  D  L  C  P  G  S  D  A  H  G  P         p.680

          .         .         .  | 17      .         .         .    g.34579
 CTTGGAGCCACCAACGTCACCACGTGTGCAG | GTCAGTGCCCACCTGGCCAACACTCTGTA    c.2100
 L  G  A  T  N  V  T  T  C  A  G |   Q  C  P  P  G  Q  H  S  V      p.700

          .         .         .         .         .         .       g.34639
 GATGGGTTCAAGCCCTGTCAGCCATGCCCACGTGGCACCTACCAACCTGAAGCAGGACGG       c.2160
 D  G  F  K  P  C  Q  P  C  P  R  G  T  Y  Q  P  E  A  G  R         p.720

          .         .         .         .         .         .       g.34699
 ACCCTATGCTTCCCTTGTGGTGGGGGCCTCACCACCAAGCATGAAGGGGCCATTTCCTTC       c.2220
 T  L  C  F  P  C  G  G  G  L  T  T  K  H  E  G  A  I  S  F         p.740

          .          | 18        .         .         .         .    g.35278
 CAAGACTGTGACACCAAAG | TCCAGTGCTCCCCAGGGCACTACTACAACACCAGCATCCAC    c.2280
 Q  D  C  D  T  K  V |   Q  C  S  P  G  H  Y  Y  N  T  S  I  H      p.760

          .         .         .         .         .         .       g.35338
 CGCTGTATTCGCTGTGCCATGGGCTCCTATCAGCCCGACTTCCGTCAGAACTTCTGCAGC       c.2340
 R  C  I  R  C  A  M  G  S  Y  Q  P  D  F  R  Q  N  F  C  S         p.780

          .         .         .         .         .         .       g.35398
 CGCTGTCCAGGAAACACAAGCACAGACTTTGATGGCTCTACCAGTGTGGCCCAATGCAAG       c.2400
 R  C  P  G  N  T  S  T  D  F  D  G  S  T  S  V  A  Q  C  K         p.800

   | 19      .         .         .         .         .         .    g.35874
 A | ATCGTCAGTGTGGTGGGGAGCTGGGTGAGTTCACTGGCTATATTGAGTCCCCCAACTAC    c.2460
 N |   R  Q  C  G  G  E  L  G  E  F  T  G  Y  I  E  S  P  N  Y      p.820

          .         .         .         .         .         .       g.35934
 CCGGGCAACTACCCAGCTGGTGTGGAGTGCATCTGGAACATCAACCCCCCACCCAAGCGC       c.2520
 P  G  N  Y  P  A  G  V  E  C  I  W  N  I  N  P  P  P  K  R         p.840

          .         .         .         .         .         .       g.35994
 AAGATCCTTATCGTGGTACCAGAGATCTTCCTGCCATCTGAGGATGAGTGTGGGGACGTC       c.2580
 K  I  L  I  V  V  P  E  I  F  L  P  S  E  D  E  C  G  D  V         p.860

          .          | 20        .         .         .         .    g.36572
 CTCGTCATGAGAAAGAACT | CATCCCCATCCTCCATTACCACTTATGAGACCTGCCAGACC    c.2640
 L  V  M  R  K  N  S |   S  P  S  S  I  T  T  Y  E  T  C  Q  T      p.880

          .         .         .         .         .         .       g.36632
 TACGAGCGTCCCATTGCCTTCACTGCCCGTTCCAGGAAGCTCTGGATCAACTTCAAGACA       c.2700
 Y  E  R  P  I  A  F  T  A  R  S  R  K  L  W  I  N  F  K  T         p.900

          .         .         .         .         .   | 21     .    g.36801
 AGCGAGGCCAACAGCGCCCGTGGCTTCCAGATTCCCTATGTTACCTATGATG | AGGACTAT    c.2760
 S  E  A  N  S  A  R  G  F  Q  I  P  Y  V  T  Y  D  E |   D  Y      p.920

          .         .         .         .         .         .       g.36861
 GAGCAGCTGGTAGAAGACATTGTGCGAGATGGCCGGCTCTATGCCTCTGAAAACCACCAG       c.2820
 E  Q  L  V  E  D  I  V  R  D  G  R  L  Y  A  S  E  N  H  Q         p.940

          .   | 22     .         .         .         .         .    g.39191
 GAGATTTTAAAG | GACAAGAAGCTCATCAAGGCCTTCTTTGAGGTGCTAGCCCACCCCCAG    c.2880
 E  I  L  K   | D  K  K  L  I  K  A  F  F  E  V  L  A  H  P  Q      p.960

          .         .         .         .         .         .       g.39251
 AACTACTTCAAGTACACAGAGAAACACAAGGAGATGCTGCCAAAATCCTTCATCAAGCTG       c.2940
 N  Y  F  K  Y  T  E  K  H  K  E  M  L  P  K  S  F  I  K  L         p.980

          .         .         .         .                           g.39293
 CTCCGCTCCAAAGTTTCCAGCTTCCTGAGGCCCTACAAATAG                         c.2982
 L  R  S  K  V  S  S  F  L  R  P  Y  K  X                           p.993

          .         .         .         .         .         .       g.39353
 taaccctaggctcagagacccaattttttaagcccccagactccttagccctcagagccg       c.*60

          .         .         .         .         .         .       g.39413
 gcagccccctaccctcagacaaggaactctctcctctctttttggagggaaaaaaaaaat       c.*120

          .         .         .         .         .         .       g.39473
 atcactacacaaaccaggcactctccctttctgtctttctagtttcctttccttgtctct       c.*180

          .         .         .         .         .         .       g.39533
 ctctgcctgcctctctactgttcccccttttctaacacactacctagaaaagccattcag       c.*240

          .         .         .         .         .         .       g.39593
 tactggctctagtccccgtgagatgtaaagaaacagtacagccccttccactgcccattt       c.*300

          .         .         .         .         .         .       g.39653
 taccagctcacattcccgaccccatcagcttggaagggtgctagaggcccatcaaggaag       c.*360

          .         .         .         .         .         .       g.39713
 tgggtctggtgggaaacggggaggggaaagaagggcttctgccattatagggttgtgcct       c.*420

          .         .         .         .         .         .       g.39773
 tgctagtcaggggccaaaatgtcccctggctctgctccctagggtgattctaacagccca       c.*480

          .         .         .         .         .         .       g.39833
 gggtcctgccaaagaagcctttgatttacaggcttaatgccagcaccagtcctctggggc       c.*540

          .         .         .         .         .         .       g.39893
 acatggtttgagctctggacttcccacatggccagctttcttgtctatacagatcctctc       c.*600

          .         .         .         .         .         .       g.39953
 tttctttccctacgtctgcctggggtctactccataagggtttacaaatggcccacaaca       c.*660

          .         .         .         .         .         .       g.40013
 ctgagttagtggacaccggctaaatgaggaagagcagcaggcattgtcatggtgaatgcc       c.*720

          .         .         .         .         .         .       g.40073
 ccgctgtagctccctgagagaaagactgtaactctgcaggacagaaacaaggttttaaag       c.*780

          .         .         .         .         .         .       g.40133
 cattgccaaaaaaaagaaaacagaaagaaaaaatgtatcatctaaaggactagacacaga       c.*840

          .         .         .         .         .         .       g.40193
 acaattggaagtcaacttcaaacactaatcccttttcttgtcttccctggcccagccacc       c.*900

          .         .         .         .         .         .       g.40253
 tcctcagccccatgtgatgctccctgggggagccctactccccttgctacatgttgtcct       c.*960

          .         .         .         .         .         .       g.40313
 taaacatggttattgacctgaagccagcctaggccttgccctacagttgtttttcccttg       c.*1020

          .         .         .         .         .         .       g.40373
 tagccccagctggcttgtgggcttcaccaaagaggaccccactctgaagccagcctggag       c.*1080

          .         .         .         .         .         .       g.40433
 ccacctacctctggcctcaggctgtgggcagcaaaaggaatgtgtgtgcacttggcgagc       c.*1140

          .         .         .         .         .         .       g.40493
 ctcctgcccaccctgtccacacctaataagtgcaatcattttgagtctttctatgttgtc       c.*1200

          .         .         .         .         .         .       g.40553
 tagacggaggggtttttgttttctgggtttgttttttgtttttgtttcttcttcctctat       c.*1260

          .         .         .         .         .         .       g.40613
 tagcaaaaccctatttatagctgcccaagagaaaagagtgtatgtttggagtggaagaaa       c.*1320

          .         .         .         .         .         .       g.40673
 atcggttttgaatctcatgaaccttgagtgctggagcatctgatctgtctctatgccacc       c.*1380

          .         .         .         .         .         .       g.40733
 actggccacctagagcccttggctgtggtaatccagggtaattgcgcagaggcatctgat       c.*1440

          .         .         .         .         .         .       g.40793
 gtgtaggaaagtaattctggggatttgatggagcagaaaggagagagacctatgtttgct       c.*1500

          .         .         .         .         .         .       g.40853
 aaaccaatcttgctatccctatgcctctccatggagtcagtgtggacctcatgattatag       c.*1560

          .         .         .         .         .         .       g.40913
 aggccaatggaactggtcagtgattctctaccccaagtagggaaaacctccatcttttcc       c.*1620

          .         .         .         .         .         .       g.40973
 ctgtcttcatcctgttatcccctggtgtacacatggaagaggaccaggacataccacctg       c.*1680

          .         .         .         .         .         .       g.41033
 gggatgggctgactcagggtcccgaggccagagacaaagctgtgggagccaagaataaga       c.*1740

          .         .         .         .         .         .       g.41093
 cagaaggcatcagatatttgcctggctctggtcacttccctttgaagttgacttcaagct       c.*1800

          .         .         .         .         .         .       g.41153
 tagcttcctcaactactgtttttcagaaggaagaaagaatcaaatggaagaagaatcaag       c.*1860

          .         .         .         .         .         .       g.41213
 tccatgcccaagcccaaagcctgcacacattctgcccttaatccaagtgttgcctataaa       c.*1920

          .         .         .         .         .         .       g.41273
 attattttctgttttctcactctagttcccccaaagctgtagtcccaatcaatcaaaggc       c.*1980

          .         .         .         .         .         .       g.41333
 taccaactgagtcctcaggttcatttcttttttttttttttttctttttaactctcctgg       c.*2040

          .         .         .         .         .         .       g.41393
 taactcacagaacagctcaggttcatttctaggtgactgtcctaggctactgctccccca       c.*2100

          .         .                                               g.41420
 ggagactcaacactaaataaaggagtc                                        c.*2127

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Signal peptide, CUB domain, EGF-like 3 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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