SEC24 family, member D (S. cerevisiae) (SEC24D) - coding DNA reference sequence

(used for variant description)

(last modified November 29, 2017)


This file was created to facilitate the description of sequence variants on transcript NM_014822.2 in the SEC24D gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_042032.1, covering SEC24D transcript NM_014822.2.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                               .         .         .                g.5032
                             gcggctggtccaagcccggcgctgggggcgcg       c.-241

 .         .         .         .         .         .                g.5092
 cagccgagaaagggtttgacgtggcagttcccagcccagctgcaactccgagcgtgagtc       c.-181

 .         .         .         .         .         .                g.5152
 caggctaaggggacgccggccggggaagaggcgcggcgggagaagcgaccgcagcgggag       c.-121

 .         .         .         .         .         .                g.5212
 cccggccaccgagggctgccggcactaggcgcagagccgccagcgctcggaagcccgcgg       c.-61

 .         .         | 02         .         .         .             g.7475
 ggtgcgggagcgggaacag | acttcttttgtagaattatcctatggaatgatattttcata    c.-1

          .         .         .         .         .         .       g.7535
 ATGAGTCAACAAGGTTACGTGGCTACACCTCCGTATTCTCAGCCTCAGCCTGGAATAGGC       c.60
 M  S  Q  Q  G  Y  V  A  T  P  P  Y  S  Q  P  Q  P  G  I  G         p.20

          .         .         .         .         .         | 03    g.16424
 CTTTCTCCACCTCATTATGGGCACTATGGGGATCCGTCGCACACAGCATCTCCAACAG | GT    c.120
 L  S  P  P  H  Y  G  H  Y  G  D  P  S  H  T  A  S  P  T  G |       p.40

          .         .         .         .         .         .       g.16484
 ATGATGAAGCCAGCAGGGCCTTTGGGGGCCACCGCCACTAGGGGAATGTTGCCTCCGGGT       c.180
 M  M  K  P  A  G  P  L  G  A  T  A  T  R  G  M  L  P  P  G         p.60

          .         .         .         .         .         .       g.16544
 CCCCCACCTCCTGGACCCCATCAGTTTGGTCAGAATGGAGCTCATGCCACTGGTCACCCT       c.240
 P  P  P  P  G  P  H  Q  F  G  Q  N  G  A  H  A  T  G  H  P         p.80

          | 04         .         .         .         .         .    g.23811
 CCCCAAAG | ATTTCCAGGCCCTCCACCTGTCAACAATGTGGCATCCTCACATGCACCATAC    c.300
 P  Q  R  |  F  P  G  P  P  P  V  N  N  V  A  S  S  H  A  P  Y      p.100

          .         .         .         .         .         .       g.23871
 CAACCCTCTGCACAATCTTCTTATCCAGGTCCTATATCCACTTCATCTGTCACCCAGCTG       c.360
 Q  P  S  A  Q  S  S  Y  P  G  P  I  S  T  S  S  V  T  Q  L         p.120

          .         .         .        | 05.         .         .    g.25468
 GGCAGCCAGCTCAGTGCTATGCAAATCAACAGCTATG | GTTCAGGCATGGCTCCTCCAAGC    c.420
 G  S  Q  L  S  A  M  Q  I  N  S  Y  G |   S  G  M  A  P  P  S      p.140

          .         .         .         .         .         .       g.25528
 CAGGGACCCCCTGGCCCTCTGTCAGCCACATCATTGCAGACTCCTCCACGACCTCCACAG       c.480
 Q  G  P  P  G  P  L  S  A  T  S  L  Q  T  P  P  R  P  P  Q         p.160

          .         .         .         .         .         .       g.25588
 CCTTCCATTTTGCAGCCTGGATCTCAAGTTCTTCCACCACCACCCACCACACTCAATGGT       c.540
 P  S  I  L  Q  P  G  S  Q  V  L  P  P  P  P  T  T  L  N  G         p.180

          .         .         .         .         .         .       g.25648
 CCTGGTGCCTCACCTTTGCCTCTACCAATGTACAGACCAGATGGGCTCTCTGGGCCTCCT       c.600
 P  G  A  S  P  L  P  L  P  M  Y  R  P  D  G  L  S  G  P  P         p.200

          .         .         .         .         .         .       g.25708
 CCTCCAAATGCCCAGTACCAGCCCCCACCTCTTCCAGGCCAGACCTTGGGTGCTGGATAT       c.660
 P  P  N  A  Q  Y  Q  P  P  P  L  P  G  Q  T  L  G  A  G  Y         p.220

          .    | 06    .         .         .         .         .    g.26063
 CCTCCGCAGCAGG | CCAACTCTGGTCCCCAGATGGCAGGCGCACAACTGTCTTACCCAGGA    c.720
 P  P  Q  Q  A |   N  S  G  P  Q  M  A  G  A  Q  L  S  Y  P  G      p.240

          .         .         .         .         .         .       g.26123
 GGCTTCCCTGGAGGTCCTGCACAGATGGCTGGTCCGCCACAGCCCCAGAAGAAGCTGGAT       c.780
 G  F  P  G  G  P  A  Q  M  A  G  P  P  Q  P  Q  K  K  L  D         p.260

          .         .  | 07      .         .         .         .    g.35256
 CCTGACTCTATCCCTAGCCCA | ATCCAGGTGATTGAGAATGATAGAGCCAGCAGAGGAGGA    c.840
 P  D  S  I  P  S  P   | I  Q  V  I  E  N  D  R  A  S  R  G  G      p.280

          .         .         .         .         .         .       g.35316
 CAAGTTTATGCCACCAACACCAGAGGCCAGATCCCTCCCCTGGTCACTACAGATTGCATG       c.900
 Q  V  Y  A  T  N  T  R  G  Q  I  P  P  L  V  T  T  D  C  M         p.300

          .    | 08    .         .         .         .         .    g.43408
 ATACAAGACCAAG | GAAATGCCAGTCCTCGATTCATCCGTTGTACAACATACTGTTTTCCA    c.960
 I  Q  D  Q  G |   N  A  S  P  R  F  I  R  C  T  T  Y  C  F  P      p.320

          .         .         .         .         .         .       g.43468
 TGCACGTCAGATATGGCTAAGCAAGCTCAGATTCCATTAGCTGCTGTCATCAAGCCCTTT       c.1020
 C  T  S  D  M  A  K  Q  A  Q  I  P  L  A  A  V  I  K  P  F         p.340

          .         .  | 09      .         .         .         .    g.72899
 GCCACCATTCCTTCAAATGAG | AGTCCCCTTTACTTGGTAAATCACGGCGAGAGTGGACCA    c.1080
 A  T  I  P  S  N  E   | S  P  L  Y  L  V  N  H  G  E  S  G  P      p.360

          .         .         .         .         .         .       g.72959
 GTCAGATGCAACAGGTGCAAGGCCTACATGTGCCCATTTATGCAGTTCATCGAAGGAGGA       c.1140
 V  R  C  N  R  C  K  A  Y  M  C  P  F  M  Q  F  I  E  G  G         p.380

          .         .         .         . | 10       .         .    g.76274
 AGGAGATATCAGTGTGGATTTTGCAACTGTGTGAATGATG | TTCCACCATTCTATTTCCAA    c.1200
 R  R  Y  Q  C  G  F  C  N  C  V  N  D  V |   P  P  F  Y  F  Q      p.400

          .         .         .         .         .         .       g.76334
 CATCTGGACCACATTGGAAGAAGACTGGACCACTATGAGAAACCAGAGTTATCTCTAGGA       c.1260
 H  L  D  H  I  G  R  R  L  D  H  Y  E  K  P  E  L  S  L  G         p.420

          .         .         .       | 11 .         .         .    g.83350
 TCTTATGAATATGTTGCCACTTTGGATTATTGCAGA | AAGAGTAAGCCTCCCAACCCACCA    c.1320
 S  Y  E  Y  V  A  T  L  D  Y  C  R   | K  S  K  P  P  N  P  P      p.440

          .         .         .         .         .         .       g.83410
 GCCTTTATCTTCATGATTGATGTTTCATATAGTAACATAAAGAATGGACTTGTCAAGCTC       c.1380
 A  F  I  F  M  I  D  V  S  Y  S  N  I  K  N  G  L  V  K  L         p.460

          .         .         .         .  | 12      .         .    g.88302
 ATATGTGAAGAACTGAAGACCATGCTGGAAAAAATTCCAAA | GGAAGAGCAAGAAGAGACG    c.1440
 I  C  E  E  L  K  T  M  L  E  K  I  P  K  |  E  E  Q  E  E  T      p.480

          .         .         .         .         .         .       g.88362
 TCTGCAATTCGAGTGGGTTTTATCACATATAACAAAGTTCTCCATTTCTTTAATGTGAAG       c.1500
 S  A  I  R  V  G  F  I  T  Y  N  K  V  L  H  F  F  N  V  K         p.500

          .         .         .         .         .         .       g.88422
 AGTAATCTGGCCCAGCCTCAGATGATGGTGGTGACTGATGTTGGAGAAGTCTTTGTTCCT       c.1560
 S  N  L  A  Q  P  Q  M  M  V  V  T  D  V  G  E  V  F  V  P         p.520

          .         .         .         .         .    | 13    .    g.89089
 TTGTTGGATGGTTTCCTTGTCAACTATCAAGAATCCCAATCTGTGATTCATAA | TTTGTTG    c.1620
 L  L  D  G  F  L  V  N  Y  Q  E  S  Q  S  V  I  H  N  |  L  L      p.540

          .         .         .         .         .         .       g.89149
 GACCAGATTCCAGACATGTTTGCAGACTCTAATGAAAATGAGACTGTCTTTGCTCCTGTC       c.1680
 D  Q  I  P  D  M  F  A  D  S  N  E  N  E  T  V  F  A  P  V         p.560

          .         .        | 14.         .         .         .    g.96144
 ATCCAGGCTGGCATGGAAGCACTAAAG | GCAGCAGACTGTCCTGGGAAGCTGTTCATCTTC    c.1740
 I  Q  A  G  M  E  A  L  K   | A  A  D  C  P  G  K  L  F  I  F      p.580

          .         .         .         .         .         .       g.96204
 CATTCTTCCTTGCCAACTGCTGAAGCACCAGGGAAGCTCAAAAACAGAGATGACAAAAAA       c.1800
 H  S  S  L  P  T  A  E  A  P  G  K  L  K  N  R  D  D  K  K         p.600

          .         .     | 15   .         .         .         .    g.97049
 CTGGTTAATACAGACAAAGAGAAG | ATACTTTTCCAGCCCCAAACAAATGTCTATGACTCA    c.1860
 L  V  N  T  D  K  E  K   | I  L  F  Q  P  Q  T  N  V  Y  D  S      p.620

          .         .         .         .         .         .       g.97109
 TTGGCCAAGGACTGCGTGGCTCACGGCTGCTCTGTGACACTCTTCCTCTTTCCTAGTCAG       c.1920
 L  A  K  D  C  V  A  H  G  C  S  V  T  L  F  L  F  P  S  Q         p.640

          .         .         .         .         .         .       g.97169
 TATGTGGACGTGGCCTCGCTGGGGCTGGTTCCTCAGCTCACTGGAGGAACCCTTTACAAA       c.1980
 Y  V  D  V  A  S  L  G  L  V  P  Q  L  T  G  G  T  L  Y  K         p.660

          .      | 16  .         .         .         .         .    g.100179
 TACAACAATTTCCAG | ATGCACTTGGATAGACAACAATTTTTGAACGACCTCAGAAATGAT    c.2040
 Y  N  N  F  Q   | M  H  L  D  R  Q  Q  F  L  N  D  L  R  N  D      p.680

          .         .         .         .         .   | 17     .    g.100371
 ATTGAAAAGAAAATAGGCTTTGATGCTATTATGAGGGTTCGTACCAGCACAG | GTTTCAGA    c.2100
 I  E  K  K  I  G  F  D  A  I  M  R  V  R  T  S  T  G |   F  R      p.700

          .         .         .         .         .         .       g.100431
 GCCACTGATTTCTTTGGTGGAATCTTGATGAACAACACCACCGATGTAGAAATGGCTGCC       c.2160
 A  T  D  F  F  G  G  I  L  M  N  N  T  T  D  V  E  M  A  A         p.720

          .         .         .         .         .         .       g.100491
 ATCGATTGTGACAAGGCAGTGACCGTGGAGTTCAAGCACGATGACAAACTCAGTGAAGAC       c.2220
 I  D  C  D  K  A  V  T  V  E  F  K  H  D  D  K  L  S  E  D         p.740

          .         | 18         .         .         .         .    g.101926
 AGTGGAGCCTTAATCCAG | TGTGCTGTGCTTTACACGACAATCAGTGGTCAAAGAAGACTT    c.2280
 S  G  A  L  I  Q   | C  A  V  L  Y  T  T  I  S  G  Q  R  R  L      p.760

          .         .         .         .         .         .       g.101986
 CGGATTCACAATCTTGGCTTAAACTGCAGCTCTCAGCTAGCTGATCTTTATAAGAGCTGT       c.2340
 R  I  H  N  L  G  L  N  C  S  S  Q  L  A  D  L  Y  K  S  C         p.780

          .         .         .        | 19.         .         .    g.102815
 GAGACAGATGCTCTTATCAACTTCTTTGCCAAGTCAG | CTTTTAAAGCAGTTCTCCACCAG    c.2400
 E  T  D  A  L  I  N  F  F  A  K  S  A |   F  K  A  V  L  H  Q      p.800

          .         .         .         .         .         .       g.102875
 CCTTTGAAGGTCATCCGGGAAATTCTAGTTAATCAGACTGCCCATATGTTGGCATGTTAC       c.2460
 P  L  K  V  I  R  E  I  L  V  N  Q  T  A  H  M  L  A  C  Y         p.820

          .         .         .       | 20 .         .         .    g.108283
 CGGAAGAATTGTGCAAGTCCTTCTGCAGCAAGCCAG | CTTATTCTACCAGATTCCATGAAA    c.2520
 R  K  N  C  A  S  P  S  A  A  S  Q   | L  I  L  P  D  S  M  K      p.840

          .         .         .         .         .         .       g.108343
 GTATTGCCAGTGTACATGAATTGCTTGTTGAAAAACTGTGTACTACTCAGCAGACCAGAG       c.2580
 V  L  P  V  Y  M  N  C  L  L  K  N  C  V  L  L  S  R  P  E         p.860

          .         .         .         .         .         .       g.108403
 ATCTCAACTGATGAACGAGCATACCAGAGACAGCTGGTCATGACCATGGGTGTGGCTGAC       c.2640
 I  S  T  D  E  R  A  Y  Q  R  Q  L  V  M  T  M  G  V  A  D         p.880

          .         .         .       | 21 .         .         .    g.109688
 TCTCAGCTTTTCTTCTACCCACAACTTCTGCCCATA | CACACGTTAGATGTCAAGAGTACA    c.2700
 S  Q  L  F  F  Y  P  Q  L  L  P  I   | H  T  L  D  V  K  S  T      p.900

          .         .         .         .         .         .       g.109748
 ATGTTACCTGCTGCCGTTCGTTGCTCTGAGTCCCGTCTTTCAGAAGAAGGAATATTCTTA       c.2760
 M  L  P  A  A  V  R  C  S  E  S  R  L  S  E  E  G  I  F  L         p.920

          .         .         .         .         .         .       g.109808
 CTGGCTAATGGTCTACACATGTTCCTGTGGTTGGGAGTAAGCAGCCCACCAGAACTGATC       c.2820
 L  A  N  G  L  H  M  F  L  W  L  G  V  S  S  P  P  E  L  I         p.940

          .         .         .         .         | 22         .    g.112533
 CAAGGAATATTTAATGTGCCATCTTTTGCACATATCAACACAGATATG | ACATTGCTGCCT    c.2880
 Q  G  I  F  N  V  P  S  F  A  H  I  N  T  D  M   | T  L  L  P      p.960

          .         .         .         .         .         .       g.112593
 GAAGTGGGAAACCCATACTCTCAACAACTCAGAATGATAATGGGTATTATCCAACAAAAG       c.2940
 E  V  G  N  P  Y  S  Q  Q  L  R  M  I  M  G  I  I  Q  Q  K         p.980

          .         | 23         .         .         .         .    g.117558
 AGGCCATATTCAATGAAG | CTCACAATTGTAAAGCAGCGAGAACAACCAGAAATGGTTTTC    c.3000
 R  P  Y  S  M  K   | L  T  I  V  K  Q  R  E  Q  P  E  M  V  F      p.1000

          .         .         .         .         .         .       g.117618
 CGACAGTTCCTGGTAGAAGACAAAGGACTTTACGGAGGCTCTTCTTATGTGGATTTCCTT       c.3060
 R  Q  F  L  V  E  D  K  G  L  Y  G  G  S  S  Y  V  D  F  L         p.1020

          .         .         .                                     g.117657
 TGTTGTGTTCACAAGGAGATCTGTCAGCTGCTTAATTAA                            c.3099
 C  C  V  H  K  E  I  C  Q  L  L  N  X                              p.1032

          .         .         .         .         .         .       g.117717
 ttgaaacttctctgtcattgatgttgcatttccaaggagataatctccttcttggtgcct       c.*60

          .         .         .         .         .         .       g.117777
 aattttctagatgataataggctagttttgatttcttgctcattttcagaataactttcc       c.*120

          .         .         .         .         .         .       g.117837
 aggaagagatggcatttagaacttcagctttggtgctcaggtataaagccaattaaggta       c.*180

          .         .         .         .         .         .       g.117897
 caattgtaccataaagggaacaatctgtttctgattgcacagtttctaatttttaaaact       c.*240

          .         .         .         .         .         .       g.117957
 gatgtggtttgcatttcataaaaggcaaagtttacagaaccataaacattctcaattttc       c.*300

          .         .         .         .         .         .       g.118017
 tttatgctagacatataaattatttttcaaactgtatagatttggggtaaaaagttgtct       c.*360

          .         .         .         .         .         .       g.118077
 cagttcctctcccaattgcaatgagaaaaaaaagcttaatttttacattatacttaattt       c.*420

          .         .         .         .         .         .       g.118137
 tctaaaaccatgtaactccattgaacacatttttcaacttaaggtctgcatagcagactt       c.*480

          .         .         .         .         .         .       g.118197
 ttaataaccttgggatttatctggtagaacaatatgtgttctacatttttttcataatta       c.*540

          .         .         .         .         .         .       g.118257
 tatattgtgtatgttaaaactattttccagttgttttgtctgtaaaactgtctttatcaa       c.*600

          .         .         .         .         .         .       g.118317
 tatgcttaatggttctttgtacaattttgaaagtttctacctgtatataatggatgttaa       c.*660

          .         .         .                                     g.118349
 ccagtatcaataaatcacttcgtataatctta                                   c.*692

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The SEC24 family, member D (S. cerevisiae) protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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