SEC63 homolog (S. cerevisiae) (SEC63) - coding DNA reference sequence

(used for variant description)

(last modified April 7, 2020)


This file was created to facilitate the description of sequence variants on transcript NM_007214.4 in the SEC63 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_008270.1, covering SEC63 transcript NM_007214.4.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                         .         .                g.5029
                                acgtctcccttagcgagctcgctggggac       c.-241

 .         .         .         .         .         .                g.5089
 acgcagggggagggaaaactgagcggggcgggaactatctcctctcgcgagagctggcga       c.-181

 .         .         .         .         .         .                g.5149
 cggcggcggcagcggcagaggtggcggcggcgtgtccgtgagagtggcgtgggggcgggg       c.-121

 .         .         .         .         .         .                g.5209
 aggagaggcggcggcggcagtgtccaagctacgccactcgggccggggcgttgggagcgg       c.-61

 .         .         .         .         .         .                g.5269
 gagtgcagagcgtggtcgtggcggcggcggtgagaagagcgaggcggaggagggggtgcc       c.-1

          .         .         .         .         .         .       g.5329
 ATGGCCGGGCAGCAGTTCCAGTACGATGACAGTGGGAACACCTTCTTCTACTTCCTCACC       c.60
 M  A  G  Q  Q  F  Q  Y  D  D  S  G  N  T  F  F  Y  F  L  T         p.20

          .         .         .         .         .         .       g.5389
 TCCTTCGTGGGGCTCATCGTGATCCCGGCGACATACTACCTCTGGCCCCGAGATCAGAAT       c.120
 S  F  V  G  L  I  V  I  P  A  T  Y  Y  L  W  P  R  D  Q  N         p.40

      | 02   .         .         .         .         .         .    g.33820
 GCCG | AGCAAATTCGATTAAAGAATATCAGAAAAGTATATGGAAGGTGTATGTGGTATCGT    c.180
 A  E |   Q  I  R  L  K  N  I  R  K  V  Y  G  R  C  M  W  Y  R      p.60

          .         .         .         .     | 03   .         .    g.38362
 TTACGGTTATTAAAACCCCAGCCAAATATTATTCCTACAGTAAA | GAAAATAGTTCTGCTT    c.240
 L  R  L  L  K  P  Q  P  N  I  I  P  T  V  K  |  K  I  V  L  L      p.80

          .         .         .         .         .         .       g.38422
 GCAGGATGGGCATTGTTCTTATTCCTTGCATATAAAGTTTCCAAAACAGACCGAGAATAC       c.300
 A  G  W  A  L  F  L  F  L  A  Y  K  V  S  K  T  D  R  E  Y         p.100

          .         .         .          | 04        .         .    g.41390
 CAAGAATACAATCCTTATGAAGTATTAAATTTGGATCCT | GGAGCCACAGTAGCAGAAATT    c.360
 Q  E  Y  N  P  Y  E  V  L  N  L  D  P   | G  A  T  V  A  E  I      p.120

          .         .         .         .         .         .       g.41450
 AAAAAACAATATCGTTTGCTGTCACTTAAATATCATCCAGATAAAGGAGGTGATGAGGTT       c.420
 K  K  Q  Y  R  L  L  S  L  K  Y  H  P  D  K  G  G  D  E  V         p.140

          .         .         .   | 05     .         .         .    g.49879
 ATGTTCATGAGGATAGCAAAAGCTTATGCTGC | TTTAACGGATGAAGAGTCCCGGAAAAAT    c.480
 M  F  M  R  I  A  K  A  Y  A  A  |  L  T  D  E  E  S  R  K  N      p.160

          .         .         .     | 06   .         .         .    g.50530
 TGGGAAGAATTTGGAAATCCAGATGGGCCTCAAG | CCACAAGCTTTGGAATTGCCCTGCCA    c.540
 W  E  E  F  G  N  P  D  G  P  Q  A |   T  S  F  G  I  A  L  P      p.180

          .         .         .    | 07    .         .         .    g.51909
 GCTTGGATAGTTGACCAGAAAAACTCAATTCTG | GTTTTACTTGTATATGGATTGGCATTT    c.600
 A  W  I  V  D  Q  K  N  S  I  L   | V  L  L  V  Y  G  L  A  F      p.200

          .         .     | 08   .         .         .         .    g.54279
 ATGGTTATCCTTCCAGTTGTTGTG | GGCTCTTGGTGGTATCGCTCAATACGCTATAGTGGA    c.660
 M  V  I  L  P  V  V  V   | G  S  W  W  Y  R  S  I  R  Y  S  G      p.220

          .         .         .         .         .         .       g.54339
 GACCAGATTCTAATACGCACAACACAGATTTATACATACTTTGTTTATAAAACCCGAAAT       c.720
 D  Q  I  L  I  R  T  T  Q  I  Y  T  Y  F  V  Y  K  T  R  N         p.240

          .    | 09    .         .         .         .         .    g.56548
 ATGGATATGAAAC | GTCTTATCATGGTTTTGGCTGGAGCTTCTGAATTTGATCCTCAGTAT    c.780
 M  D  M  K  R |   L  I  M  V  L  A  G  A  S  E  F  D  P  Q  Y      p.260

          .         .         .         .         | 10         .    g.56710
 AATAAAGATGCCACAAGCAGACCAACGGATAATATTCTAATACCACAG | CTAATCAGAGAA    c.840
 N  K  D  A  T  S  R  P  T  D  N  I  L  I  P  Q   | L  I  R  E      p.280

          .         .         .         .         .         .       g.56770
 ATTGGCAGCATTAATTTAAAGAAGAATGAGCCTCCACTTACCTGCCCATATAGCCTGAAG       c.900
 I  G  S  I  N  L  K  K  N  E  P  P  L  T  C  P  Y  S  L  K         p.300

          .         .         .         .         .         .       g.56830
 GCCAGAGTTCTTTTACTGTCTCATCTTGCTAGAATGAAAATTCCTGAGACCCTTGAAGAA       c.960
 A  R  V  L  L  L  S  H  L  A  R  M  K  I  P  E  T  L  E  E         p.320

   | 11      .         .         .         .         .         .    g.58616
 G | ATCAGCAATTCATGCTAAAAAAGTGTCCTGCCCTACTTCAAGAAATGGTTAATGTAATC    c.1020
 D |   Q  Q  F  M  L  K  K  C  P  A  L  L  Q  E  M  V  N  V  I      p.340

          .         .         .     | 12   .         .         .    g.60306
 TGCCAACTAATAGTAATGGCCCGGAACCGTGAAG | AAAGGGAGTTTCGTGCTCCAACTTTG    c.1080
 C  Q  L  I  V  M  A  R  N  R  E  E |   R  E  F  R  A  P  T  L      p.360

          .         .         .         .         .         .       g.60366
 GCATCCCTAGAAAACTGCATGAAGCTTTCTCAGATGGCCGTTCAGGGACTTCAGCAATTT       c.1140
 A  S  L  E  N  C  M  K  L  S  Q  M  A  V  Q  G  L  Q  Q  F         p.380

          .         .         .         .         .         .       g.60426
 AAGTCTCCCCTTCTGCAGCTCCCTCATATTGAAGAGGACAATCTTAGACGGGTTTCTAAT       c.1200
 K  S  P  L  L  Q  L  P  H  I  E  E  D  N  L  R  R  V  S  N         p.400

           | 13        .         .         .         .         .    g.61812
 CATAAGAAG | TATAAAATTAAAACTATCCAGGATTTGGTGAGTTTAAAAGAATCAGATCGT    c.1260
 H  K  K   | Y  K  I  K  T  I  Q  D  L  V  S  L  K  E  S  D  R      p.420

          .         .         .         .         .         .       g.61872
 CACACTCTACTGCACTTCCTTGAAGATGAAAAATATGAAGAGGTTATGGCTGTCCTTGGG       c.1320
 H  T  L  L  H  F  L  E  D  E  K  Y  E  E  V  M  A  V  L  G         p.440

          .         .         .        | 14.         .         .    g.65570
 AGTTTTCCATATGTGACCATGGATATAAAATCACAGG | TGTTAGATGATGAAGATAGCAAC    c.1380
 S  F  P  Y  V  T  M  D  I  K  S  Q  V |   L  D  D  E  D  S  N      p.460

          .         .         .         .         .         .       g.65630
 AACATCACAGTAGGATCCTTAGTTACAGTGTTGGTTAAGTTGACAAGGCAAACAATGGCT       c.1440
 N  I  T  V  G  S  L  V  T  V  L  V  K  L  T  R  Q  T  M  A         p.480

  | 15       .         .         .         .         .         .    g.69441
  | GAAGTATTTGAAAAGGAGCAGTCCATCTGTGCTGCAGAGGAACAGCCAGCAGAAGATGGG    c.1500
  | E  V  F  E  K  E  Q  S  I  C  A  A  E  E  Q  P  A  E  D  G      p.500

  | 16       .         .         .         .         .         .    g.69683
  | CAGGGTGAAACTAACAAGAACAGGACAAAAGGAGGATGGCAACAGAAGAGTAAAGGACCC    c.1560
  | Q  G  E  T  N  K  N  R  T  K  G  G  W  Q  Q  K  S  K  G  P      p.520

          .         .         .         .         .         .       g.69743
 AAGAAAACTGCTAAATCAAAAAAAAAGAAACCTTTAAAAAAAAAACCTACACCTGTGCTA       c.1620
 K  K  T  A  K  S  K  K  K  K  P  L  K  K  K  P  T  P  V  L         p.540

          .         .         .         .         .     | 17   .    g.80138
 TTACCACAGTCAAAGCAACAGAAACAAAAGCAGGCAAATGGAGTCGTTGGGAAT | GAAGCT    c.1680
 L  P  Q  S  K  Q  Q  K  Q  K  Q  A  N  G  V  V  G  N   | E  A      p.560

          .         .         .         .         .         .       g.80198
 GCAGTAAAGGAAGATGAAGAAGAAGTTTCAGATAAGGGCAGTGATTCTGAAGAAGAAGAA       c.1740
 A  V  K  E  D  E  E  E  V  S  D  K  G  S  D  S  E  E  E  E         p.580

          .         .         .         .         .         .       g.80258
 ACCAATAGAGATTCCCAAAGTGAGAAAGATGATGGTAGTGACAGAGACTCTGATAGAGAG       c.1800
 T  N  R  D  S  Q  S  E  K  D  D  G  S  D  R  D  S  D  R  E         p.600

          .         .         .    | 18    .         .         .    g.82055
 CAAGATGAAAAACAAAACAAAGATGATGAAGCA | GAGTGGCAAGAATTACAACAAAGCATA    c.1860
 Q  D  E  K  Q  N  K  D  D  E  A   | E  W  Q  E  L  Q  Q  S  I      p.620

          .         .         .         .         .         .       g.82115
 CAGCGAAAAGAGAGAGCTCTATTGGAAACCAAATCAAAAATAACACATCCTGTGTATAGC       c.1920
 Q  R  K  E  R  A  L  L  E  T  K  S  K  I  T  H  P  V  Y  S         p.640

          .      | 19  .         .         .         .         .    g.86661
 CTTTACTTTCCTGAG | GAAAAACAAGAATGGTGGTGGCTTTACATTGCAGATAGGAAGGAG    c.1980
 L  Y  F  P  E   | E  K  Q  E  W  W  W  L  Y  I  A  D  R  K  E      p.660

          .         .         .         .         .     | 20   .    g.90372
 CAGACATTAATATCCATGCCATATCATGTGTGTACGCTGAAAGATACAGAGGAG | GTAGAG    c.2040
 Q  T  L  I  S  M  P  Y  H  V  C  T  L  K  D  T  E  E   | V  E      p.680

          .         .         .         .         .         .       g.90432
 CTGAAGTTTCCTGCACCAGGCAAGCCTGGAAATTATCAGTATACTGTGTTTCTGAGATCA       c.2100
 L  K  F  P  A  P  G  K  P  G  N  Y  Q  Y  T  V  F  L  R  S         p.700

          .         .         .          | 21        .         .    g.91452
 GACTCCTATATGGGTTTGGATCAGATTAAACCATTGAAG | TTGGAAGTTCATGAGGCTAAG    c.2160
 D  S  Y  M  G  L  D  Q  I  K  P  L  K   | L  E  V  H  E  A  K      p.720

          .         .         .         .         .         .       g.91512
 CCTGTGCCAGAAAATCACCCACAGTGGGATACAGCAATAGAGGGGGATGAAGACCAGGAG       c.2220
 P  V  P  E  N  H  P  Q  W  D  T  A  I  E  G  D  E  D  Q  E         p.740

          .         .         .         .         .         .       g.91572
 GACAGTGAGGGCTTTGAAGATAGCTTTGAGGAAGAAGAGGAGGAAGAAGAAGATGATGAC       c.2280
 D  S  E  G  F  E  D  S  F  E  E  E  E  E  E  E  E  D  D  D         p.760

                                                                    g.91575
 TAA                                                                c.2283
 X                                                                  p.760

          .         .         .         .         .         .       g.91635
 gcagtactctgaatggaccacagtgtttgcacatatttgcaattttttgctgttttggaa       c.*60

          .         .         .         .         .         .       g.91695
 gtgtatcataaaccagaaacagtacagaactgatgttgagggaggtgtagtttttttact       c.*120

          .         .         .         .         .         .       g.91755
 cttgaaatgggtgcataatataactaggcagtggcggtgccttggtacaacctgaaaaat       c.*180

          .         .         .         .         .         .       g.91815
 gttaaggcttattgaaacctttcaagtaggggatggtacatttatttcatctgcaaatga       c.*240

          .         .         .         .         .         .       g.91875
 taataaatcctttgttattataactgtccagaagtgtgggctatgtattatctgatcagt       c.*300

          .         .         .         .         .         .       g.91935
 ctatggtcccagtaaaagtaaagatgcaggaaacacagtctgtaaatgagcgacttttct       c.*360

          .         .         .         .         .         .       g.91995
 ttgttcagctttagttttagcaaacaccacaaatatgttttaagtaacatcgctcaagtt       c.*420

          .         .         .         .         .         .       g.92055
 taagtaacatcgctcaagttgataatctcttgataagctctgttgttgacattttgcagt       c.*480

          .         .         .         .         .         .       g.92115
 gatacaacagctccactcatagatttaaacttttatttttacttatcttggtcataagtt       c.*540

          .         .         .         .         .         .       g.92175
 ggcattctctcacattccacatgatatagagggctacgttttggaattttccttttctta       c.*600

          .         .         .         .         .         .       g.92235
 attgcccagagttatcagacagattataaaaatggcttttaatggcttaaaccatttcta       c.*660

          .         .         .         .         .         .       g.92295
 aacctctatcttagcagatcaatgcaggatctaattcttttgataagttctagctctaaa       c.*720

          .         .         .         .         .         .       g.92355
 agtgatagtgggactgtatgttttctgatactggtggcttatgttattaaacctttttta       c.*780

          .         .         .         .         .         .       g.92415
 aaaaaggttcactctaaaagctgaactacatccttagttttcagtctacttgactctatc       c.*840

          .         .         .         .         .         .       g.92475
 aggagctttttaaggaaagtaagtataacatgcaaaggaagctttttttgtattcatttt       c.*900

          .         .         .         .         .         .       g.92535
 ggactcctgtcaataaaaatagaagtttgttgactcgttttatgtttcaatggtgtgtgt       c.*960

          .         .         .         .         .         .       g.92595
 ctttttactatcaggacataaatagggcaatccacttctttatttttcaactaaagattg       c.*1020

          .         .         .         .         .         .       g.92655
 aatagtattgtacattactgctaaagtgactgctatttctgtatactgtagaaaaaccca       c.*1080

          .         .         .         .         .         .       g.92715
 ggagtgagagggatttcccctcatagtacaactggaaggatagtgcttgtaaagagtaga       c.*1140

          .         .         .         .         .         .       g.92775
 gatgtgtacatgatgaatcattgagggagggtggatatttttattcctagatatggagga       c.*1200

          .         .         .         .         .         .       g.92835
 aacataagtctgtagtattataaaactgattgtaataattctttcctatcaaaatctcca       c.*1260

          .         .         .         .         .         .       g.92895
 taggtcaaaatattgttggaatactaaaatttgcaaccttgtttactttaaaaggttgcc       c.*1320

          .         .         .         .         .         .       g.92955
 actttcagtgcagaatactaccggcatcttgttactgcaatagttggaaataaaatgtga       c.*1380

          .         .         .         .         .         .       g.93015
 aaattagcaaaaccatgaatggtttttttggttctaaatttaagatgtaatatttcctat       c.*1440

          .         .         .         .         .         .       g.93075
 aaaagggtgaaagcagtttctttctctataacctcaatcaccagtttagtgagagccttt       c.*1500

          .         .         .         .         .         .       g.93135
 cttggcaggcaggaggcagtgtcactgaggatttttttcatttacttcattgtacaagta       c.*1560

          .         .         .         .         .         .       g.93195
 ggagggtgggtttaattttcaaatcaggttctgctgtgaagcaccagtgtcttgaggcag       c.*1620

          .         .         .         .         .         .       g.93255
 ctactgattacctaagtgtggtggcagggggtaagccagctggtgtcaagtgaaaggagg       c.*1680

          .         .         .         .         .         .       g.93315
 gattagagaaaacaggtgtggcacgaaggcaaggaaactgagcagacaagacagaacaat       c.*1740

          .         .         .         .         .         .       g.93375
 gtgtagaatgcatatttcctagttttcttgaaagatttcaagaaaagttgtttttttttt       c.*1800

          .         .         .         .         .         .       g.93435
 tctagtggctactttgccttaaagaggctttataagttcattcacacagctggcttctct       c.*1860

          .         .         .         .         .         .       g.93495
 ggttttaagattctggagaggatgataacctagtaacaccacagtgcttaaaaaaaaaaa       c.*1920

          .         .         .         .         .         .       g.93555
 aaaaaaaaaaactaccatcaccagaaaattccaccagtttgttttccttttctctttgtg       c.*1980

          .         .         .         .         .         .       g.93615
 tgatgtgtatgtacttcccaactaagtaaaataaaatttcctctagtgagtgctttaggt       c.*2040

          .         .         .         .         .         .       g.93675
 aacctctttccatatggcagtagtgaaagaactgagccttcagttgatagttcttctctc       c.*2100

          .         .         .         .         .         .       g.93735
 tccagcaagtcgctaaactccacatcccttcgtttttcctctggaatgagaataacaaac       c.*2160

          .         .         .         .         .         .       g.93795
 tatcctagtttgcatttaatctaatggaaacttgagcaaagtttcaattttcttcctata       c.*2220

          .         .         .         .         .         .       g.93855
 aagaaactgacattttgtcaacaattgatgagcctatagatcatacagtgtataggaagt       c.*2280

          .         .         .         .         .         .       g.93915
 gaaattgaaacagttaaattatgtgatatttttctctaattggtaaagtacctattaaaa       c.*2340

          .         .         .         .         .         .       g.93975
 tacagctgttcatgaggagacttaccacaattcaaagtgtagcagttgtgtattttagca       c.*2400

          .         .         .         .         .         .       g.94035
 ttataatatttgattgaggccctgaggtgttaatatctcaatctcagagttagatgttca       c.*2460

          .         .         .         .         .         .       g.94095
 tgtcctttttgaattttttaaacatttttcataattttttttttaagttagggagcacat       c.*2520

          .         .         .         .         .         .       g.94155
 tgagtgaagttctctgtgtagaacaataccttctgctctgcttctcccagctttcactga       c.*2580

          .         .         .         .         .         .       g.94215
 gggctggaaaaggacaggcctgtccagctgtactgtcccactgtgtatggggaagctcag       c.*2640

          .         .         .         .         .         .       g.94275
 gctctggtggaagcagggggcgtggatgtcaaacaactgatgtggaaacagggagggaga       c.*2700

          .         .         .         .         .         .       g.94335
 gatataatgaggctctctaggcatgttatttttgaccacaagttttgttcagtttgcttc       c.*2760

          .         .         .         .         .         .       g.94395
 agccaatccaaaccatatactagagtgttctgtagtcacaattcttatttcaaatgtaat       c.*2820

          .         .         .         .         .         .       g.94455
 tcagcaccttacataatttttgagaggttgtcattcatcacatatttactgagtttctat       c.*2880

          .         .         .         .         .         .       g.94515
 gtgccaggctctgtgactggatactggagctatcaaaatgaaaaaaatagtgttaagaac       c.*2940

          .         .         .         .         .         .       g.94575
 tcactcgctggtgttagagcaggtagatgagtggcaatccatttaaatccatttgccttg       c.*3000

          .         .         .         .         .         .       g.94635
 gctattatttggaatgcctttttttttttttagtctatctactgtaggcagaagaattat       c.*3060

          .         .         .         .         .         .       g.94695
 ttctttaggggctagctgtttattttgctggcctttttttctctctttctctttttcttc       c.*3120

          .         .         .         .         .         .       g.94755
 ttaagacggagtctcgctctgtcctccaggctggaggagtgcagtggcacgatctcagct       c.*3180

          .         .         .         .         .         .       g.94815
 cactgcaacctccgcctcccagcttcaagcgattcttctgcctcagcctcctgagtagct       c.*3240

          .         .         .         .         .         .       g.94875
 gggactgcaggtgcatgccaccacacccagctaattttttaatttttagtagagatggga       c.*3300

          .         .         .         .         .         .       g.94935
 ttttgccacgttgtccagcctggtctcgaactcctggcctcaagtgatcagccctcctca       c.*3360

          .         .         .         .         .         .       g.94995
 gcctcccaaagtgctggcattacaggcatgagccactgcgcccagcctgttgggtttttt       c.*3420

          .         .         .         .         .         .       g.95055
 tggaaaaaaaacaaaaacaacaaatcatcatcctttcctttaaaatgttttttttttttt       c.*3480

          .         .         .         .         .         .       g.95115
 aagaaacaattttcccacaaacggtctgatttaactccatgaaatcctctatttagactg       c.*3540

          .         .         .         .         .         .       g.95175
 ccttaaagtgaaataactgttggtgaaccataacattttgccagctgtgtagtgattagt       c.*3600

          .         .         .         .         .         .       g.95235
 ccaaatatgtctcaagaagttagcaccaagcattctcatccatttaaacttgatgctagg       c.*3660

          .         .         .         .         .         .       g.95295
 gctattttgcaaaacttaaaaagatgcgatcttgtacatatttctgtaacctgagctgaa       c.*3720

          .         .         .         .         .         .       g.95355
 aacccaaataacaatcattgacatactttagggctattgtttcaggtgggggtgtataca       c.*3780

          .         .         .         .         .         .       g.95415
 tcccaggggcgtggagatgatcaatccattgaggaagtattaagatgattatttgtattt       c.*3840

          .         .         .         .         .         .       g.95475
 aatctcatccttttaaatttctatttttgtgtgttttataatgtacataatatattgtac       c.*3900

          .         .         .         .                           g.95523
 aattgtacacttctattatttataaataaacatttattggtgcattaa                   c.*3948

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The SEC63 homolog (S. cerevisiae) protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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